SpoU_methylase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4HSU2_LEIIN

TriTrypDb:

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HSU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSU2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000154	rRNA modification	6	1
GO:0006364	rRNA processing	8	1
GO:0009451	RNA modification	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043412	macromolecule modification	4	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0008168	methyltransferase activity	4	11
GO:0008173	RNA methyltransferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0008649	rRNA methyltransferase activity	5	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016435	rRNA (guanine) methyltransferase activity	6	1
GO:0140102	catalytic activity, acting on a rRNA	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	168	170	PF00675	0.651
CLV_NRD_NRD_1	209	211	PF00675	0.479
CLV_NRD_NRD_1	356	358	PF00675	0.686
CLV_NRD_NRD_1	495	497	PF00675	0.594
CLV_PCSK_KEX2_1	168	170	PF00082	0.624
CLV_PCSK_KEX2_1	209	211	PF00082	0.479
CLV_PCSK_KEX2_1	356	358	PF00082	0.689
CLV_PCSK_KEX2_1	495	497	PF00082	0.594
CLV_PCSK_SKI1_1	14	18	PF00082	0.642
CLV_PCSK_SKI1_1	181	185	PF00082	0.490
CLV_PCSK_SKI1_1	270	274	PF00082	0.290
CLV_PCSK_SKI1_1	403	407	PF00082	0.409
DEG_APCC_DBOX_1	107	115	PF00400	0.432
DEG_APCC_DBOX_1	198	206	PF00400	0.417
DEG_SPOP_SBC_1	309	313	PF00917	0.565
DOC_CYCLIN_RxL_1	400	411	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	190	196	PF00134	0.512
DOC_MAPK_gen_1	209	216	PF00069	0.442
DOC_MAPK_gen_1	499	507	PF00069	0.615
DOC_MAPK_MEF2A_6	188	196	PF00069	0.418
DOC_MAPK_MEF2A_6	359	368	PF00069	0.569
DOC_MAPK_MEF2A_6	501	509	PF00069	0.481
DOC_PP1_SILK_1	266	271	PF00149	0.562
DOC_PP2B_LxvP_1	190	193	PF13499	0.514
DOC_USP7_MATH_1	144	148	PF00917	0.745
DOC_USP7_MATH_1	244	248	PF00917	0.651
DOC_USP7_MATH_1	291	295	PF00917	0.501
DOC_USP7_MATH_1	3	7	PF00917	0.655
DOC_USP7_MATH_1	309	313	PF00917	0.461
DOC_USP7_MATH_1	327	331	PF00917	0.377
DOC_USP7_MATH_1	472	476	PF00917	0.725
DOC_USP7_MATH_1	477	481	PF00917	0.641
DOC_USP7_MATH_1	82	86	PF00917	0.767
DOC_USP7_MATH_1	91	95	PF00917	0.579
DOC_WW_Pin1_4	25	30	PF00397	0.578
DOC_WW_Pin1_4	427	432	PF00397	0.534
DOC_WW_Pin1_4	70	75	PF00397	0.706
LIG_14-3-3_CanoR_1	176	183	PF00244	0.500
LIG_14-3-3_CanoR_1	284	293	PF00244	0.516
LIG_14-3-3_CanoR_1	295	301	PF00244	0.425
LIG_Actin_WH2_2	37	54	PF00022	0.533
LIG_Actin_WH2_2	421	439	PF00022	0.585
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_BRCT_BRCA1_1	296	300	PF00533	0.513
LIG_BRCT_BRCA1_1	312	316	PF00533	0.513
LIG_FHA_1	11	17	PF00498	0.658
LIG_FHA_1	288	294	PF00498	0.490
LIG_FHA_1	296	302	PF00498	0.491
LIG_FHA_1	452	458	PF00498	0.668
LIG_FHA_1	48	54	PF00498	0.443
LIG_FHA_1	62	68	PF00498	0.681
LIG_LIR_Gen_1	175	185	PF02991	0.468
LIG_LIR_Nem_3	175	180	PF02991	0.480
LIG_LIR_Nem_3	271	277	PF02991	0.482
LIG_SH2_CRK	142	146	PF00017	0.565
LIG_SH2_CRK	177	181	PF00017	0.515
LIG_SH2_CRK	38	42	PF00017	0.539
LIG_SH2_NCK_1	142	146	PF00017	0.565
LIG_SH2_STAP1	38	42	PF00017	0.539
LIG_SH2_STAT3	221	224	PF00017	0.562
LIG_SH2_STAT5	115	118	PF00017	0.466
LIG_SH2_STAT5	177	180	PF00017	0.476
LIG_SH3_3	28	34	PF00018	0.516
LIG_SUMO_SIM_anti_2	339	346	PF11976	0.543
LIG_SxIP_EBH_1	23	32	PF03271	0.564
LIG_TRAF2_1	120	123	PF00917	0.602
LIG_TRAF2_1	447	450	PF00917	0.713
LIG_TRAF2_1	66	69	PF00917	0.579
LIG_TYR_ITIM	140	145	PF00017	0.560
LIG_WW_1	35	38	PF00397	0.600
MOD_CDK_SPK_2	427	432	PF00069	0.577
MOD_CDK_SPxxK_3	25	32	PF00069	0.621
MOD_CK1_1	175	181	PF00069	0.572
MOD_CK1_1	294	300	PF00069	0.513
MOD_CK1_1	310	316	PF00069	0.461
MOD_CK1_1	330	336	PF00069	0.384
MOD_CK1_1	371	377	PF00069	0.763
MOD_CK1_1	380	386	PF00069	0.770
MOD_CK1_1	480	486	PF00069	0.678
MOD_CK1_1	78	84	PF00069	0.776
MOD_CK2_1	117	123	PF00069	0.530
MOD_CK2_1	336	342	PF00069	0.630
MOD_CK2_1	444	450	PF00069	0.774
MOD_GlcNHglycan	22	25	PF01048	0.569
MOD_GlcNHglycan	246	249	PF01048	0.613
MOD_GlcNHglycan	312	315	PF01048	0.351
MOD_GlcNHglycan	325	328	PF01048	0.545
MOD_GlcNHglycan	338	341	PF01048	0.494
MOD_GlcNHglycan	361	364	PF01048	0.714
MOD_GlcNHglycan	372	376	PF01048	0.763
MOD_GlcNHglycan	382	385	PF01048	0.781
MOD_GlcNHglycan	479	482	PF01048	0.719
MOD_GlcNHglycan	5	8	PF01048	0.678
MOD_GlcNHglycan	75	78	PF01048	0.772
MOD_GSK3_1	145	152	PF00069	0.770
MOD_GSK3_1	240	247	PF00069	0.719
MOD_GSK3_1	287	294	PF00069	0.493
MOD_GSK3_1	323	330	PF00069	0.648
MOD_GSK3_1	343	350	PF00069	0.358
MOD_GSK3_1	43	50	PF00069	0.453
MOD_GSK3_1	473	480	PF00069	0.747
MOD_GSK3_1	78	85	PF00069	0.766
MOD_N-GLC_1	145	150	PF02516	0.702
MOD_N-GLC_1	19	24	PF02516	0.526
MOD_N-GLC_1	359	364	PF02516	0.707
MOD_N-GLC_2	396	398	PF02516	0.573
MOD_NEK2_1	10	15	PF00069	0.625
MOD_NEK2_1	131	136	PF00069	0.658
MOD_NEK2_1	186	191	PF00069	0.547
MOD_NEK2_1	216	221	PF00069	0.443
MOD_NEK2_1	317	322	PF00069	0.468
MOD_NEK2_1	331	336	PF00069	0.571
MOD_NEK2_1	347	352	PF00069	0.356
MOD_NEK2_1	436	441	PF00069	0.618
MOD_NEK2_1	473	478	PF00069	0.724
MOD_PKA_2	10	16	PF00069	0.552
MOD_PKA_2	175	181	PF00069	0.509
MOD_PKA_2	294	300	PF00069	0.487
MOD_PKA_2	317	323	PF00069	0.577
MOD_PKA_2	436	442	PF00069	0.607
MOD_PKB_1	357	365	PF00069	0.563
MOD_Plk_1	117	123	PF00069	0.604
MOD_Plk_1	216	222	PF00069	0.452
MOD_Plk_1	377	383	PF00069	0.791
MOD_Plk_1	473	479	PF00069	0.751
MOD_Plk_1	503	509	PF00069	0.481
MOD_Plk_4	249	255	PF00069	0.525
MOD_Plk_4	343	349	PF00069	0.482
MOD_Plk_4	43	49	PF00069	0.402
MOD_Plk_4	99	105	PF00069	0.684
MOD_ProDKin_1	25	31	PF00069	0.572
MOD_ProDKin_1	427	433	PF00069	0.536
MOD_ProDKin_1	70	76	PF00069	0.704
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.650
TRG_ENDOCYTIC_2	142	145	PF00928	0.566
TRG_ENDOCYTIC_2	177	180	PF00928	0.403
TRG_ENDOCYTIC_2	38	41	PF00928	0.541
TRG_ER_diArg_1	167	169	PF00400	0.703
TRG_ER_diArg_1	494	496	PF00400	0.551
TRG_NLS_MonoExtN_4	168	173	PF00514	0.619
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3C1	Leptomonas seymouri	49%	100%
A0A1X0NKH6	Trypanosomatidae	29%	100%
A0A3R7KE58	Trypanosoma rangeli	33%	100%
A0A3S5H5Q8	Leishmania donovani	100%	100%
A4H4L6	Leishmania braziliensis	73%	100%
C9ZTF4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AKS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QJ28	Leishmania major	93%	100%
V5BT12	Trypanosoma cruzi	31%	100%