Nucleotidyltransferase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HSU0_LEIIN

TriTrypDb:

LINF_060010400

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HSU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSU0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	300	304	PF00656	0.589
CLV_NRD_NRD_1	16	18	PF00675	0.365
CLV_NRD_NRD_1	79	81	PF00675	0.488
CLV_NRD_NRD_1	95	97	PF00675	0.340
CLV_PCSK_KEX2_1	115	117	PF00082	0.278
CLV_PCSK_KEX2_1	168	170	PF00082	0.297
CLV_PCSK_KEX2_1	79	81	PF00082	0.476
CLV_PCSK_KEX2_1	95	97	PF00082	0.343
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.435
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.297
CLV_PCSK_PC7_1	164	170	PF00082	0.288
CLV_PCSK_SKI1_1	168	172	PF00082	0.402
CLV_PCSK_SKI1_1	17	21	PF00082	0.363
CLV_Separin_Metazoa	51	55	PF03568	0.365
DOC_CYCLIN_RxL_1	13	23	PF00134	0.453
DOC_MAPK_gen_1	102	111	PF00069	0.351
DOC_MAPK_gen_1	135	144	PF00069	0.413
DOC_MAPK_gen_1	79	87	PF00069	0.419
DOC_MAPK_gen_1	95	101	PF00069	0.291
DOC_MAPK_HePTP_8	99	111	PF00069	0.466
DOC_MAPK_MEF2A_6	102	111	PF00069	0.390
DOC_MAPK_MEF2A_6	135	144	PF00069	0.402
DOC_MAPK_NFAT4_5	104	112	PF00069	0.354
DOC_USP7_MATH_1	170	174	PF00917	0.407
DOC_USP7_MATH_1	178	182	PF00917	0.411
DOC_USP7_MATH_1	270	274	PF00917	0.506
DOC_USP7_MATH_1	282	286	PF00917	0.496
DOC_USP7_MATH_1	57	61	PF00917	0.547
DOC_WW_Pin1_4	278	283	PF00397	0.573
LIG_14-3-3_CanoR_1	139	145	PF00244	0.362
LIG_DLG_GKlike_1	102	109	PF00625	0.471
LIG_FHA_1	253	259	PF00498	0.505
LIG_FHA_1	92	98	PF00498	0.482
LIG_FHA_2	122	128	PF00498	0.612
LIG_FHA_2	282	288	PF00498	0.592
LIG_FHA_2	45	51	PF00498	0.378
LIG_HCF-1_HBM_1	231	234	PF13415	0.403
LIG_IBAR_NPY_1	245	247	PF08397	0.511
LIG_IRF3_LxIS_1	136	143	PF10401	0.429
LIG_LIR_Gen_1	173	184	PF02991	0.481
LIG_LIR_Gen_1	285	296	PF02991	0.579
LIG_LIR_Nem_3	173	179	PF02991	0.514
LIG_LIR_Nem_3	231	237	PF02991	0.467
LIG_LIR_Nem_3	285	291	PF02991	0.584
LIG_PCNA_yPIPBox_3	183	196	PF02747	0.412
LIG_SH2_CRK	176	180	PF00017	0.419
LIG_SH2_CRK	223	227	PF00017	0.556
LIG_SH2_STAP1	146	150	PF00017	0.457
LIG_SH2_STAP1	176	180	PF00017	0.419
LIG_SH2_STAP1	234	238	PF00017	0.450
LIG_SH2_STAT5	247	250	PF00017	0.538
LIG_SH2_STAT5	9	12	PF00017	0.369
LIG_SH3_3	197	203	PF00018	0.502
LIG_TRAF2_1	319	322	PF00917	0.566
MOD_CK1_1	273	279	PF00069	0.718
MOD_CK1_1	281	287	PF00069	0.649
MOD_CK2_1	281	287	PF00069	0.708
MOD_CK2_1	316	322	PF00069	0.570
MOD_CK2_1	44	50	PF00069	0.425
MOD_GlcNHglycan	172	175	PF01048	0.545
MOD_GlcNHglycan	176	179	PF01048	0.523
MOD_GlcNHglycan	191	195	PF01048	0.503
MOD_GlcNHglycan	276	279	PF01048	0.706
MOD_GlcNHglycan	59	62	PF01048	0.630
MOD_GSK3_1	170	177	PF00069	0.522
MOD_GSK3_1	270	277	PF00069	0.680
MOD_GSK3_1	278	285	PF00069	0.621
MOD_GSK3_1	287	294	PF00069	0.486
MOD_GSK3_1	312	319	PF00069	0.573
MOD_N-GLC_1	312	317	PF02516	0.652
MOD_NEK2_1	140	145	PF00069	0.358
MOD_NEK2_1	179	184	PF00069	0.568
MOD_PIKK_1	270	276	PF00454	0.595
MOD_PIKK_1	317	323	PF00454	0.569
MOD_PKA_2	140	146	PF00069	0.357
MOD_PKA_2	174	180	PF00069	0.413
MOD_PKA_2	317	323	PF00069	0.647
MOD_PKA_2	57	63	PF00069	0.629
MOD_Plk_1	102	108	PF00069	0.483
MOD_Plk_1	291	297	PF00069	0.678
MOD_Plk_2-3	287	293	PF00069	0.735
MOD_Plk_2-3	44	50	PF00069	0.397
MOD_Plk_4	202	208	PF00069	0.395
MOD_Plk_4	210	216	PF00069	0.404
MOD_ProDKin_1	278	284	PF00069	0.574
TRG_ENDOCYTIC_2	176	179	PF00928	0.532
TRG_ENDOCYTIC_2	212	215	PF00928	0.486
TRG_ENDOCYTIC_2	223	226	PF00928	0.404
TRG_ENDOCYTIC_2	238	241	PF00928	0.392
TRG_ENDOCYTIC_2	9	12	PF00928	0.351
TRG_ER_diArg_1	134	137	PF00400	0.574
TRG_ER_diArg_1	139	142	PF00400	0.373
TRG_ER_diArg_1	79	81	PF00400	0.465
TRG_ER_diArg_1	95	97	PF00400	0.346
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVD6	Leptomonas seymouri	58%	99%
A0A0S4KF96	Bodo saltans	30%	100%
A0A1X0NKJ3	Trypanosomatidae	44%	100%
A0A3S5H5Q7	Leishmania donovani	100%	100%
A4H4L4	Leishmania braziliensis	84%	98%
C9ZTF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AKS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QJ30	Leishmania major	96%	100%
V5B7V1	Trypanosoma cruzi	48%	100%