Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HST7_LEIIN

TriTrypDb:

LINF_060010000

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HST7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HST7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.599
CLV_C14_Caspase3-7	208	212	PF00656	0.656
CLV_C14_Caspase3-7	28	32	PF00656	0.742
CLV_C14_Caspase3-7	69	73	PF00656	0.634
CLV_NRD_NRD_1	212	214	PF00675	0.635
CLV_NRD_NRD_1	247	249	PF00675	0.609
CLV_NRD_NRD_1	303	305	PF00675	0.648
CLV_NRD_NRD_1	330	332	PF00675	0.707
CLV_NRD_NRD_1	5	7	PF00675	0.563
CLV_NRD_NRD_1	97	99	PF00675	0.662
CLV_PCSK_FUR_1	185	189	PF00082	0.561
CLV_PCSK_FUR_1	330	334	PF00082	0.686
CLV_PCSK_KEX2_1	187	189	PF00082	0.559
CLV_PCSK_KEX2_1	246	248	PF00082	0.608
CLV_PCSK_KEX2_1	330	332	PF00082	0.720
CLV_PCSK_KEX2_1	5	7	PF00082	0.562
CLV_PCSK_KEX2_1	97	99	PF00082	0.662
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.559
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.719
CLV_PCSK_SKI1_1	138	142	PF00082	0.553
CLV_Separin_Metazoa	195	199	PF03568	0.548
DEG_APCC_DBOX_1	257	265	PF00400	0.515
DEG_Nend_Nbox_1	1	3	PF02207	0.545
DEG_SPOP_SBC_1	10	14	PF00917	0.626
DEG_SPOP_SBC_1	264	268	PF00917	0.587
DEG_SPOP_SBC_1	49	53	PF00917	0.607
DEG_SPOP_SBC_1	64	68	PF00917	0.681
DEG_SPOP_SBC_1	71	75	PF00917	0.599
DEG_SPOP_SBC_1	82	86	PF00917	0.509
DOC_ANK_TNKS_1	448	455	PF00023	0.569
DOC_MAPK_DCC_7	338	347	PF00069	0.601
DOC_MAPK_HePTP_8	210	226	PF00069	0.553
DOC_MAPK_MEF2A_6	219	226	PF00069	0.678
DOC_MAPK_MEF2A_6	338	347	PF00069	0.601
DOC_MAPK_NFAT4_5	219	227	PF00069	0.678
DOC_PP4_FxxP_1	18	21	PF00568	0.642
DOC_USP7_MATH_1	105	109	PF00917	0.600
DOC_USP7_MATH_1	159	163	PF00917	0.695
DOC_USP7_MATH_1	336	340	PF00917	0.710
DOC_USP7_MATH_1	423	427	PF00917	0.698
DOC_USP7_MATH_1	64	68	PF00917	0.609
DOC_USP7_MATH_1	70	74	PF00917	0.588
DOC_USP7_UBL2_3	318	322	PF12436	0.545
DOC_USP7_UBL2_3	388	392	PF12436	0.667
DOC_WW_Pin1_4	163	168	PF00397	0.716
DOC_WW_Pin1_4	265	270	PF00397	0.591
LIG_14-3-3_CanoR_1	138	144	PF00244	0.687
LIG_14-3-3_CanoR_1	188	197	PF00244	0.532
LIG_14-3-3_CanoR_1	258	262	PF00244	0.555
LIG_14-3-3_CanoR_1	265	269	PF00244	0.560
LIG_14-3-3_CanoR_1	302	308	PF00244	0.585
LIG_14-3-3_CanoR_1	44	50	PF00244	0.678
LIG_14-3-3_CanoR_1	444	449	PF00244	0.546
LIG_14-3-3_CanoR_1	5	11	PF00244	0.571
LIG_14-3-3_CanoR_1	89	95	PF00244	0.569
LIG_BRCT_BRCA1_1	14	18	PF00533	0.635
LIG_BRCT_BRCA1_1	408	412	PF00533	0.611
LIG_FHA_1	155	161	PF00498	0.619
LIG_FHA_1	178	184	PF00498	0.639
LIG_FHA_1	381	387	PF00498	0.549
LIG_FHA_1	66	72	PF00498	0.627
LIG_FHA_2	140	146	PF00498	0.587
LIG_FHA_2	151	157	PF00498	0.543
LIG_FHA_2	206	212	PF00498	0.629
LIG_FHA_2	347	353	PF00498	0.609
LIG_FHA_2	76	82	PF00498	0.640
LIG_LIR_Apic_2	15	21	PF02991	0.638
LIG_LIR_Gen_1	76	83	PF02991	0.653
LIG_LIR_Nem_3	40	46	PF02991	0.619
LIG_LIR_Nem_3	76	82	PF02991	0.652
LIG_SH2_CRK	373	377	PF00017	0.579
LIG_SH2_CRK	43	47	PF00017	0.627
LIG_SH2_CRK	7	11	PF00017	0.610
LIG_SH2_GRB2like	373	376	PF00017	0.577
LIG_SH2_NCK_1	7	11	PF00017	0.610
LIG_SH2_STAT5	326	329	PF00017	0.682
LIG_SH3_3	158	164	PF00018	0.636
LIG_SH3_3	194	200	PF00018	0.609
LIG_SH3_3	234	240	PF00018	0.597
LIG_TRAF2_1	192	195	PF00917	0.559
LIG_TRAF2_1	240	243	PF00917	0.605
LIG_TRAF2_1	366	369	PF00917	0.555
LIG_WRC_WIRS_1	140	145	PF05994	0.579
LIG_WW_3	94	98	PF00397	0.633
MOD_CDC14_SPxK_1	268	271	PF00782	0.652
MOD_CDK_SPxK_1	265	271	PF00069	0.648
MOD_CK1_1	103	109	PF00069	0.583
MOD_CK1_1	150	156	PF00069	0.703
MOD_CK1_1	177	183	PF00069	0.616
MOD_CK1_1	19	25	PF00069	0.636
MOD_CK1_1	257	263	PF00069	0.525
MOD_CK1_1	34	40	PF00069	0.740
MOD_CK1_1	42	48	PF00069	0.725
MOD_CK1_1	52	58	PF00069	0.621
MOD_CK1_1	66	72	PF00069	0.672
MOD_CK1_1	73	79	PF00069	0.623
MOD_CK1_1	8	14	PF00069	0.648
MOD_CK1_1	87	93	PF00069	0.666
MOD_CK2_1	103	109	PF00069	0.626
MOD_CK2_1	139	145	PF00069	0.546
MOD_CK2_1	189	195	PF00069	0.589
MOD_CK2_1	346	352	PF00069	0.757
MOD_CK2_1	363	369	PF00069	0.531
MOD_DYRK1A_RPxSP_1	265	269	PF00069	0.509
MOD_GlcNHglycan	102	105	PF01048	0.633
MOD_GlcNHglycan	119	122	PF01048	0.720
MOD_GlcNHglycan	14	17	PF01048	0.577
MOD_GlcNHglycan	150	153	PF01048	0.655
MOD_GlcNHglycan	161	164	PF01048	0.723
MOD_GlcNHglycan	27	30	PF01048	0.601
MOD_GlcNHglycan	274	277	PF01048	0.620
MOD_GlcNHglycan	315	318	PF01048	0.507
MOD_GlcNHglycan	38	42	PF01048	0.595
MOD_GlcNHglycan	401	404	PF01048	0.538
MOD_GlcNHglycan	425	428	PF01048	0.614
MOD_GlcNHglycan	54	57	PF01048	0.755
MOD_GlcNHglycan	68	71	PF01048	0.606
MOD_GlcNHglycan	86	89	PF01048	0.517
MOD_GlcNHglycan	92	95	PF01048	0.604
MOD_GSK3_1	113	120	PF00069	0.721
MOD_GSK3_1	139	146	PF00069	0.651
MOD_GSK3_1	150	157	PF00069	0.751
MOD_GSK3_1	159	166	PF00069	0.774
MOD_GSK3_1	19	26	PF00069	0.625
MOD_GSK3_1	222	229	PF00069	0.706
MOD_GSK3_1	292	299	PF00069	0.670
MOD_GSK3_1	44	51	PF00069	0.682
MOD_GSK3_1	5	12	PF00069	0.633
MOD_GSK3_1	52	59	PF00069	0.672
MOD_GSK3_1	60	67	PF00069	0.591
MOD_GSK3_1	71	78	PF00069	0.605
MOD_GSK3_1	83	90	PF00069	0.807
MOD_LATS_1	4	10	PF00433	0.660
MOD_N-GLC_1	177	182	PF02516	0.642
MOD_N-GLC_1	29	34	PF02516	0.638
MOD_N-GLC_2	346	348	PF02516	0.548
MOD_NEK2_1	143	148	PF00069	0.616
MOD_NEK2_1	222	227	PF00069	0.616
MOD_NEK2_1	263	268	PF00069	0.543
MOD_NEK2_1	406	411	PF00069	0.677
MOD_NEK2_1	50	55	PF00069	0.580
MOD_NEK2_1	83	88	PF00069	0.648
MOD_NEK2_2	136	141	PF00069	0.543
MOD_PK_1	444	450	PF00069	0.523
MOD_PK_1	6	12	PF00069	0.613
MOD_PKA_1	5	11	PF00069	0.611
MOD_PKA_2	257	263	PF00069	0.563
MOD_PKA_2	264	270	PF00069	0.575
MOD_PKA_2	303	309	PF00069	0.646
MOD_PKA_2	5	11	PF00069	0.611
MOD_Plk_1	206	212	PF00069	0.644
MOD_Plk_1	406	412	PF00069	0.631
MOD_Plk_4	222	228	PF00069	0.611
MOD_Plk_4	303	309	PF00069	0.583
MOD_Plk_4	31	37	PF00069	0.612
MOD_Plk_4	45	51	PF00069	0.678
MOD_ProDKin_1	163	169	PF00069	0.713
MOD_ProDKin_1	265	271	PF00069	0.595
TRG_ENDOCYTIC_2	326	329	PF00928	0.539
TRG_ENDOCYTIC_2	373	376	PF00928	0.625
TRG_ENDOCYTIC_2	43	46	PF00928	0.628
TRG_ENDOCYTIC_2	7	10	PF00928	0.608
TRG_ER_diArg_1	246	248	PF00400	0.605
TRG_ER_diArg_1	329	331	PF00400	0.736
TRG_ER_diArg_1	5	7	PF00400	0.558
TRG_ER_diArg_1	96	98	PF00400	0.638
TRG_NLS_MonoExtN_4	330	335	PF00514	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T5	Leptomonas seymouri	38%	92%
A0A3S5H5Q5	Leishmania donovani	100%	100%
A4H4L1	Leishmania braziliensis	53%	100%
E9AKS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q4QJ33	Leishmania major	82%	100%