LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

TPR_REGION domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_REGION domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HST6_LEIIN
TriTrypDb:
LINF_060009900
Length:
992

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005929 cilium 4 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0110165 cellular anatomical entity 1 1
GO:0120025 plasma membrane bounded cell projection 3 1

Phosphorylation

Promastigote: 330

Expansion

Sequence features

A4HST6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HST6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 483 487 PF00656 0.683
CLV_C14_Caspase3-7 605 609 PF00656 0.726
CLV_C14_Caspase3-7 920 924 PF00656 0.724
CLV_C14_Caspase3-7 942 946 PF00656 0.762
CLV_NRD_NRD_1 293 295 PF00675 0.643
CLV_NRD_NRD_1 296 298 PF00675 0.624
CLV_NRD_NRD_1 413 415 PF00675 0.693
CLV_NRD_NRD_1 659 661 PF00675 0.773
CLV_PCSK_FUR_1 294 298 PF00082 0.660
CLV_PCSK_KEX2_1 292 294 PF00082 0.625
CLV_PCSK_KEX2_1 296 298 PF00082 0.608
CLV_PCSK_KEX2_1 413 415 PF00082 0.693
CLV_PCSK_KEX2_1 655 657 PF00082 0.827
CLV_PCSK_KEX2_1 770 772 PF00082 0.667
CLV_PCSK_PC1ET2_1 655 657 PF00082 0.749
CLV_PCSK_PC1ET2_1 770 772 PF00082 0.667
CLV_PCSK_PC7_1 292 298 PF00082 0.655
CLV_PCSK_PC7_1 651 657 PF00082 0.721
CLV_PCSK_SKI1_1 234 238 PF00082 0.537
CLV_PCSK_SKI1_1 25 29 PF00082 0.668
CLV_PCSK_SKI1_1 413 417 PF00082 0.648
CLV_PCSK_SKI1_1 426 430 PF00082 0.744
CLV_PCSK_SKI1_1 803 807 PF00082 0.708
CLV_PCSK_SKI1_1 927 931 PF00082 0.749
CLV_Separin_Metazoa 187 191 PF03568 0.623
DEG_APCC_DBOX_1 24 32 PF00400 0.714
DEG_APCC_DBOX_1 429 437 PF00400 0.775
DEG_APCC_DBOX_1 926 934 PF00400 0.754
DEG_Nend_Nbox_1 1 3 PF02207 0.815
DEG_SCF_FBW7_2 133 140 PF00400 0.591
DEG_SPOP_SBC_1 546 550 PF00917 0.731
DEG_SPOP_SBC_1 814 818 PF00917 0.748
DEG_SPOP_SBC_1 916 920 PF00917 0.732
DEG_SPOP_SBC_1 971 975 PF00917 0.772
DOC_CKS1_1 134 139 PF01111 0.614
DOC_CKS1_1 840 845 PF01111 0.712
DOC_CYCLIN_yCln2_LP_2 429 435 PF00134 0.775
DOC_CYCLIN_yCln2_LP_2 87 93 PF00134 0.714
DOC_MAPK_MEF2A_6 464 471 PF00069 0.585
DOC_MAPK_MEF2A_6 703 710 PF00069 0.838
DOC_PP2B_LxvP_1 429 432 PF13499 0.657
DOC_PP2B_LxvP_1 75 78 PF13499 0.803
DOC_PP2B_LxvP_1 807 810 PF13499 0.625
DOC_PP2B_LxvP_1 823 826 PF13499 0.803
DOC_PP2B_LxvP_1 87 90 PF13499 0.634
DOC_PP4_FxxP_1 207 210 PF00568 0.543
DOC_PP4_FxxP_1 883 886 PF00568 0.718
DOC_USP7_MATH_1 162 166 PF00917 0.461
DOC_USP7_MATH_1 253 257 PF00917 0.469
DOC_USP7_MATH_1 368 372 PF00917 0.603
DOC_USP7_MATH_1 37 41 PF00917 0.780
DOC_USP7_MATH_1 517 521 PF00917 0.783
DOC_USP7_MATH_1 546 550 PF00917 0.716
DOC_USP7_MATH_1 606 610 PF00917 0.677
DOC_USP7_MATH_1 671 675 PF00917 0.797
DOC_USP7_MATH_1 776 780 PF00917 0.782
DOC_USP7_MATH_1 78 82 PF00917 0.738
DOC_USP7_MATH_1 794 798 PF00917 0.773
DOC_USP7_MATH_1 915 919 PF00917 0.730
DOC_USP7_MATH_1 972 976 PF00917 0.795
DOC_USP7_MATH_1 984 988 PF00917 0.604
DOC_USP7_MATH_2 822 828 PF00917 0.786
DOC_USP7_UBL2_3 529 533 PF12436 0.762
DOC_WW_Pin1_4 133 138 PF00397 0.641
DOC_WW_Pin1_4 175 180 PF00397 0.707
DOC_WW_Pin1_4 251 256 PF00397 0.516
DOC_WW_Pin1_4 33 38 PF00397 0.763
DOC_WW_Pin1_4 485 490 PF00397 0.664
DOC_WW_Pin1_4 564 569 PF00397 0.776
DOC_WW_Pin1_4 630 635 PF00397 0.663
DOC_WW_Pin1_4 717 722 PF00397 0.731
DOC_WW_Pin1_4 780 785 PF00397 0.738
DOC_WW_Pin1_4 839 844 PF00397 0.811
DOC_WW_Pin1_4 85 90 PF00397 0.833
DOC_WW_Pin1_4 974 979 PF00397 0.748
LIG_14-3-3_CanoR_1 190 199 PF00244 0.538
LIG_14-3-3_CanoR_1 297 306 PF00244 0.670
LIG_14-3-3_CanoR_1 389 397 PF00244 0.559
LIG_14-3-3_CanoR_1 56 60 PF00244 0.783
LIG_14-3-3_CanoR_1 587 591 PF00244 0.665
LIG_14-3-3_CanoR_1 70 76 PF00244 0.604
LIG_14-3-3_CanoR_1 962 968 PF00244 0.762
LIG_14-3-3_CterR_2 988 992 PF00244 0.815
LIG_BIR_III_4 945 949 PF00653 0.768
LIG_CtBP_PxDLS_1 707 711 PF00389 0.757
LIG_deltaCOP1_diTrp_1 350 357 PF00928 0.604
LIG_FHA_1 17 23 PF00498 0.595
LIG_FHA_1 176 182 PF00498 0.696
LIG_FHA_1 215 221 PF00498 0.593
LIG_FHA_1 301 307 PF00498 0.685
LIG_FHA_1 329 335 PF00498 0.633
LIG_FHA_1 376 382 PF00498 0.598
LIG_FHA_1 389 395 PF00498 0.459
LIG_FHA_1 70 76 PF00498 0.696
LIG_FHA_1 794 800 PF00498 0.805
LIG_FHA_1 858 864 PF00498 0.650
LIG_FHA_1 892 898 PF00498 0.745
LIG_FHA_1 9 15 PF00498 0.688
LIG_FHA_2 744 750 PF00498 0.639
LIG_FHA_2 918 924 PF00498 0.824
LIG_FHA_2 980 986 PF00498 0.707
LIG_LIR_Apic_2 206 210 PF02991 0.563
LIG_LIR_Apic_2 555 561 PF02991 0.758
LIG_LIR_Gen_1 155 163 PF02991 0.547
LIG_LIR_Gen_1 193 204 PF02991 0.529
LIG_LIR_Nem_3 155 161 PF02991 0.636
LIG_LIR_Nem_3 193 199 PF02991 0.515
LIG_LIR_Nem_3 407 412 PF02991 0.573
LIG_LIR_Nem_3 817 823 PF02991 0.802
LIG_MYND_1 133 137 PF01753 0.667
LIG_MYND_1 839 843 PF01753 0.612
LIG_PCNA_yPIPBox_3 529 542 PF02747 0.753
LIG_Pex14_2 864 868 PF04695 0.635
LIG_PTAP_UEV_1 772 777 PF05743 0.755
LIG_SH2_CRK 158 162 PF00017 0.650
LIG_SH2_CRK 265 269 PF00017 0.499
LIG_SH2_CRK 558 562 PF00017 0.681
LIG_SH2_CRK 566 570 PF00017 0.730
LIG_SH2_GRB2like 377 380 PF00017 0.652
LIG_SH2_NCK_1 158 162 PF00017 0.552
LIG_SH2_NCK_1 566 570 PF00017 0.726
LIG_SH2_NCK_1 889 893 PF00017 0.700
LIG_SH2_NCK_1 9 13 PF00017 0.763
LIG_SH2_SRC 574 577 PF00017 0.754
LIG_SH2_STAP1 158 162 PF00017 0.552
LIG_SH2_STAP1 377 381 PF00017 0.648
LIG_SH2_STAP1 574 578 PF00017 0.837
LIG_SH2_STAT3 498 501 PF00017 0.823
LIG_SH2_STAT5 377 380 PF00017 0.582
LIG_SH2_STAT5 875 878 PF00017 0.775
LIG_SH2_STAT5 889 892 PF00017 0.506
LIG_SH3_1 770 776 PF00018 0.660
LIG_SH3_2 765 770 PF14604 0.640
LIG_SH3_3 127 133 PF00018 0.780
LIG_SH3_3 429 435 PF00018 0.674
LIG_SH3_3 688 694 PF00018 0.733
LIG_SH3_3 762 768 PF00018 0.807
LIG_SH3_3 770 776 PF00018 0.672
LIG_SH3_3 83 89 PF00018 0.732
LIG_SH3_3 92 98 PF00018 0.719
LIG_SH3_3 925 931 PF00018 0.807
LIG_SUMO_SIM_par_1 821 828 PF11976 0.786
LIG_TRAF2_1 184 187 PF00917 0.684
LIG_TRAF2_1 390 393 PF00917 0.540
LIG_UBA3_1 211 216 PF00899 0.618
LIG_WRC_WIRS_1 406 411 PF05994 0.671
MOD_CDC14_SPxK_1 977 980 PF00782 0.615
MOD_CDK_SPK_2 974 979 PF00069 0.715
MOD_CDK_SPxK_1 974 980 PF00069 0.754
MOD_CK1_1 165 171 PF00069 0.546
MOD_CK1_1 371 377 PF00069 0.597
MOD_CK1_1 40 46 PF00069 0.760
MOD_CK1_1 515 521 PF00069 0.634
MOD_CK1_1 536 542 PF00069 0.731
MOD_CK1_1 620 626 PF00069 0.845
MOD_CK1_1 627 633 PF00069 0.829
MOD_CK1_1 659 665 PF00069 0.692
MOD_CK1_1 675 681 PF00069 0.592
MOD_CK1_1 752 758 PF00069 0.791
MOD_CK1_1 81 87 PF00069 0.834
MOD_CK1_1 857 863 PF00069 0.756
MOD_CK1_1 937 943 PF00069 0.818
MOD_CK1_1 966 972 PF00069 0.807
MOD_CK1_1 974 980 PF00069 0.688
MOD_CK2_1 235 241 PF00069 0.528
MOD_CK2_1 344 350 PF00069 0.570
MOD_CK2_1 935 941 PF00069 0.818
MOD_CK2_1 979 985 PF00069 0.709
MOD_Cter_Amidation 653 656 PF01082 0.755
MOD_GlcNHglycan 14 17 PF01048 0.602
MOD_GlcNHglycan 164 167 PF01048 0.504
MOD_GlcNHglycan 200 205 PF01048 0.549
MOD_GlcNHglycan 308 311 PF01048 0.635
MOD_GlcNHglycan 315 318 PF01048 0.714
MOD_GlcNHglycan 508 511 PF01048 0.812
MOD_GlcNHglycan 514 517 PF01048 0.660
MOD_GlcNHglycan 525 528 PF01048 0.760
MOD_GlcNHglycan 535 538 PF01048 0.718
MOD_GlcNHglycan 554 557 PF01048 0.578
MOD_GlcNHglycan 570 573 PF01048 0.788
MOD_GlcNHglycan 576 579 PF01048 0.733
MOD_GlcNHglycan 582 585 PF01048 0.619
MOD_GlcNHglycan 59 62 PF01048 0.783
MOD_GlcNHglycan 594 598 PF01048 0.583
MOD_GlcNHglycan 604 607 PF01048 0.707
MOD_GlcNHglycan 626 629 PF01048 0.773
MOD_GlcNHglycan 773 776 PF01048 0.829
MOD_GlcNHglycan 784 787 PF01048 0.627
MOD_GlcNHglycan 790 793 PF01048 0.537
MOD_GlcNHglycan 80 83 PF01048 0.537
MOD_GlcNHglycan 811 814 PF01048 0.709
MOD_GlcNHglycan 832 835 PF01048 0.801
MOD_GlcNHglycan 847 850 PF01048 0.590
MOD_GlcNHglycan 855 859 PF01048 0.745
MOD_GlcNHglycan 923 926 PF01048 0.747
MOD_GlcNHglycan 937 940 PF01048 0.710
MOD_GlcNHglycan 974 977 PF01048 0.719
MOD_GSK3_1 161 168 PF00069 0.627
MOD_GSK3_1 175 182 PF00069 0.684
MOD_GSK3_1 27 34 PF00069 0.586
MOD_GSK3_1 364 371 PF00069 0.501
MOD_GSK3_1 37 44 PF00069 0.768
MOD_GSK3_1 375 382 PF00069 0.491
MOD_GSK3_1 452 459 PF00069 0.624
MOD_GSK3_1 511 518 PF00069 0.737
MOD_GSK3_1 521 528 PF00069 0.681
MOD_GSK3_1 541 548 PF00069 0.693
MOD_GSK3_1 55 62 PF00069 0.584
MOD_GSK3_1 564 571 PF00069 0.821
MOD_GSK3_1 574 581 PF00069 0.664
MOD_GSK3_1 582 589 PF00069 0.679
MOD_GSK3_1 602 609 PF00069 0.677
MOD_GSK3_1 620 627 PF00069 0.614
MOD_GSK3_1 671 678 PF00069 0.725
MOD_GSK3_1 748 755 PF00069 0.752
MOD_GSK3_1 776 783 PF00069 0.698
MOD_GSK3_1 8 15 PF00069 0.696
MOD_GSK3_1 809 816 PF00069 0.791
MOD_GSK3_1 81 88 PF00069 0.833
MOD_GSK3_1 887 894 PF00069 0.704
MOD_GSK3_1 904 911 PF00069 0.550
MOD_GSK3_1 915 922 PF00069 0.674
MOD_GSK3_1 929 936 PF00069 0.591
MOD_GSK3_1 962 969 PF00069 0.799
MOD_GSK3_1 970 977 PF00069 0.696
MOD_GSK3_1 979 986 PF00069 0.549
MOD_LATS_1 454 460 PF00433 0.598
MOD_N-GLC_1 175 180 PF02516 0.699
MOD_N-GLC_1 298 303 PF02516 0.690
MOD_N-GLC_1 512 517 PF02516 0.691
MOD_N-GLC_1 521 526 PF02516 0.691
MOD_N-GLC_2 260 262 PF02516 0.466
MOD_NEK2_1 215 220 PF00069 0.491
MOD_NEK2_1 284 289 PF00069 0.478
MOD_NEK2_1 298 303 PF00069 0.558
MOD_NEK2_1 306 311 PF00069 0.572
MOD_NEK2_1 467 472 PF00069 0.497
MOD_NEK2_1 504 509 PF00069 0.810
MOD_NEK2_1 541 546 PF00069 0.640
MOD_NEK2_1 547 552 PF00069 0.570
MOD_NEK2_1 55 60 PF00069 0.778
MOD_NEK2_1 580 585 PF00069 0.797
MOD_NEK2_1 8 13 PF00069 0.688
MOD_NEK2_1 933 938 PF00069 0.754
MOD_NEK2_1 983 988 PF00069 0.807
MOD_PIKK_1 344 350 PF00454 0.619
MOD_PIKK_1 388 394 PF00454 0.540
MOD_PIKK_1 536 542 PF00454 0.810
MOD_PIKK_1 758 764 PF00454 0.800
MOD_PIKK_1 917 923 PF00454 0.768
MOD_PKA_1 979 985 PF00069 0.709
MOD_PKA_2 368 374 PF00069 0.597
MOD_PKA_2 388 394 PF00069 0.312
MOD_PKA_2 55 61 PF00069 0.697
MOD_PKA_2 586 592 PF00069 0.709
MOD_PKA_2 659 665 PF00069 0.776
MOD_PKA_2 69 75 PF00069 0.612
MOD_PKA_2 749 755 PF00069 0.640
MOD_PKA_2 766 772 PF00069 0.593
MOD_PKB_1 521 529 PF00069 0.762
MOD_Plk_1 113 119 PF00069 0.783
MOD_Plk_1 31 37 PF00069 0.697
MOD_Plk_1 984 990 PF00069 0.808
MOD_Plk_4 165 171 PF00069 0.616
MOD_Plk_4 379 385 PF00069 0.630
MOD_Plk_4 755 761 PF00069 0.704
MOD_Plk_4 816 822 PF00069 0.745
MOD_ProDKin_1 133 139 PF00069 0.626
MOD_ProDKin_1 175 181 PF00069 0.703
MOD_ProDKin_1 251 257 PF00069 0.511
MOD_ProDKin_1 33 39 PF00069 0.766
MOD_ProDKin_1 485 491 PF00069 0.669
MOD_ProDKin_1 564 570 PF00069 0.778
MOD_ProDKin_1 630 636 PF00069 0.660
MOD_ProDKin_1 717 723 PF00069 0.731
MOD_ProDKin_1 780 786 PF00069 0.737
MOD_ProDKin_1 839 845 PF00069 0.811
MOD_ProDKin_1 85 91 PF00069 0.833
MOD_ProDKin_1 974 980 PF00069 0.748
MOD_SUMO_rev_2 213 218 PF00179 0.609
TRG_DiLeu_BaEn_3 186 192 PF01217 0.523
TRG_DiLeu_BaLyEn_6 207 212 PF01217 0.651
TRG_DiLeu_BaLyEn_6 560 565 PF01217 0.655
TRG_ENDOCYTIC_2 158 161 PF00928 0.647
TRG_ENDOCYTIC_2 196 199 PF00928 0.515
TRG_ENDOCYTIC_2 265 268 PF00928 0.489
TRG_ENDOCYTIC_2 820 823 PF00928 0.807
TRG_ENDOCYTIC_2 888 891 PF00928 0.684
TRG_ER_diArg_1 292 294 PF00400 0.639
TRG_ER_diArg_1 296 298 PF00400 0.608
TRG_ER_diArg_1 412 414 PF00400 0.679
TRG_NES_CRM1_1 145 155 PF08389 0.607
TRG_NES_CRM1_1 280 291 PF08389 0.501
TRG_Pf-PMV_PEXEL_1 190 194 PF00026 0.621
TRG_Pf-PMV_PEXEL_1 244 248 PF00026 0.535
TRG_Pf-PMV_PEXEL_1 286 291 PF00026 0.507

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3R7KMM4 Trypanosoma rangeli 35% 100%
A0A3S7WPE9 Leishmania donovani 98% 100%
A4H4L0 Leishmania braziliensis 69% 95%
E9AKS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 99%
Q4QJ34 Leishmania major 91% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS