Kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Kinesin

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HST5_LEIIN

TriTrypDb:

LINF_060009800

Length:

691

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005819	spindle	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HST5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HST5

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003774	cytoskeletal motor activity	1	2
GO:0003777	microtubule motor activity	2	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0005524	ATP binding	5	2
GO:0008017	microtubule binding	5	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:0140657	ATP-dependent activity	1	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.723
CLV_NRD_NRD_1	281	283	PF00675	0.585
CLV_NRD_NRD_1	304	306	PF00675	0.401
CLV_NRD_NRD_1	424	426	PF00675	0.498
CLV_NRD_NRD_1	469	471	PF00675	0.547
CLV_NRD_NRD_1	517	519	PF00675	0.544
CLV_NRD_NRD_1	607	609	PF00675	0.483
CLV_NRD_NRD_1	637	639	PF00675	0.611
CLV_PCSK_FUR_1	422	426	PF00082	0.498
CLV_PCSK_FUR_1	635	639	PF00082	0.567
CLV_PCSK_KEX2_1	304	306	PF00082	0.401
CLV_PCSK_KEX2_1	424	426	PF00082	0.498
CLV_PCSK_KEX2_1	517	519	PF00082	0.435
CLV_PCSK_KEX2_1	609	611	PF00082	0.494
CLV_PCSK_KEX2_1	637	639	PF00082	0.611
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.503
CLV_PCSK_SKI1_1	275	279	PF00082	0.518
CLV_PCSK_SKI1_1	409	413	PF00082	0.482
CLV_PCSK_SKI1_1	42	46	PF00082	0.536
CLV_PCSK_SKI1_1	60	64	PF00082	0.486
DEG_APCC_KENBOX_2	196	200	PF00400	0.732
DEG_Nend_UBRbox_2	1	3	PF02207	0.577
DEG_SCF_TRCP1_1	82	88	PF00400	0.542
DEG_SPOP_SBC_1	13	17	PF00917	0.809
DEG_SPOP_SBC_1	62	66	PF00917	0.675
DEG_SPOP_SBC_1	86	90	PF00917	0.556
DOC_CYCLIN_yCln2_LP_2	356	362	PF00134	0.396
DOC_MAPK_DCC_7	352	362	PF00069	0.418
DOC_MAPK_gen_1	304	312	PF00069	0.360
DOC_MAPK_gen_1	608	619	PF00069	0.557
DOC_MAPK_MEF2A_6	540	548	PF00069	0.429
DOC_PP4_FxxP_1	255	258	PF00568	0.466
DOC_USP7_MATH_1	127	131	PF00917	0.393
DOC_USP7_MATH_1	14	18	PF00917	0.716
DOC_USP7_MATH_1	158	162	PF00917	0.572
DOC_USP7_MATH_1	21	25	PF00917	0.739
DOC_USP7_MATH_1	273	277	PF00917	0.512
DOC_USP7_MATH_1	337	341	PF00917	0.557
DOC_USP7_MATH_1	450	454	PF00917	0.652
DOC_USP7_MATH_1	593	597	PF00917	0.417
DOC_USP7_MATH_1	62	66	PF00917	0.672
DOC_USP7_MATH_1	80	84	PF00917	0.741
DOC_USP7_MATH_1	86	90	PF00917	0.726
DOC_USP7_MATH_1	93	97	PF00917	0.738
DOC_USP7_UBL2_3	42	46	PF12436	0.563
DOC_WW_Pin1_4	15	20	PF00397	0.708
DOC_WW_Pin1_4	154	159	PF00397	0.449
LIG_14-3-3_CanoR_1	113	121	PF00244	0.523
LIG_14-3-3_CanoR_1	150	155	PF00244	0.421
LIG_14-3-3_CanoR_1	304	308	PF00244	0.388
LIG_14-3-3_CanoR_1	352	357	PF00244	0.402
LIG_14-3-3_CanoR_1	388	396	PF00244	0.374
LIG_14-3-3_CanoR_1	540	548	PF00244	0.567
LIG_14-3-3_CanoR_1	6	11	PF00244	0.672
LIG_14-3-3_CanoR_1	60	70	PF00244	0.559
LIG_14-3-3_CanoR_1	626	633	PF00244	0.558
LIG_14-3-3_CanoR_1	643	651	PF00244	0.472
LIG_14-3-3_CterR_2	686	691	PF00244	0.608
LIG_Actin_WH2_2	562	577	PF00022	0.486
LIG_BIR_III_4	193	197	PF00653	0.662
LIG_BRCT_BRCA1_1	102	106	PF00533	0.458
LIG_BRCT_BRCA1_1	136	140	PF00533	0.375
LIG_BRCT_BRCA1_1	509	513	PF00533	0.543
LIG_EH1_1	396	404	PF00400	0.497
LIG_FHA_1	222	228	PF00498	0.591
LIG_FHA_1	285	291	PF00498	0.352
LIG_FHA_1	352	358	PF00498	0.335
LIG_FHA_1	464	470	PF00498	0.435
LIG_FHA_1	507	513	PF00498	0.503
LIG_FHA_1	628	634	PF00498	0.566
LIG_FHA_2	193	199	PF00498	0.749
LIG_FHA_2	309	315	PF00498	0.333
LIG_FHA_2	353	359	PF00498	0.362
LIG_FHA_2	502	508	PF00498	0.572
LIG_LIR_Apic_2	153	158	PF02991	0.425
LIG_LIR_Apic_2	254	258	PF02991	0.467
LIG_LIR_Gen_1	137	146	PF02991	0.421
LIG_LIR_Gen_1	309	318	PF02991	0.336
LIG_LIR_Gen_1	510	519	PF02991	0.544
LIG_LIR_Gen_1	64	75	PF02991	0.516
LIG_LIR_Nem_3	137	141	PF02991	0.460
LIG_LIR_Nem_3	228	234	PF02991	0.489
LIG_LIR_Nem_3	309	315	PF02991	0.337
LIG_LIR_Nem_3	510	516	PF02991	0.545
LIG_LIR_Nem_3	64	70	PF02991	0.528
LIG_NRBOX	352	358	PF00104	0.335
LIG_Pex14_1	102	106	PF04695	0.457
LIG_SH2_CRK	155	159	PF00017	0.442
LIG_SH2_CRK	67	71	PF00017	0.518
LIG_SH2_NCK_1	10	14	PF00017	0.643
LIG_SH2_NCK_1	296	300	PF00017	0.439
LIG_SH2_PTP2	138	141	PF00017	0.497
LIG_SH2_PTP2	364	367	PF00017	0.382
LIG_SH2_SRC	121	124	PF00017	0.448
LIG_SH2_SRC	296	299	PF00017	0.433
LIG_SH2_STAP1	10	14	PF00017	0.619
LIG_SH2_STAP1	121	125	PF00017	0.522
LIG_SH2_STAT5	138	141	PF00017	0.370
LIG_SH2_STAT5	364	367	PF00017	0.393
LIG_SH2_STAT5	572	575	PF00017	0.498
LIG_SH2_STAT5	67	70	PF00017	0.565
LIG_SH3_3	121	127	PF00018	0.393
LIG_SH3_3	139	145	PF00018	0.293
LIG_SH3_3	250	256	PF00018	0.443
LIG_SH3_3	259	265	PF00018	0.409
LIG_SH3_3	274	280	PF00018	0.324
LIG_SH3_3	292	298	PF00018	0.354
LIG_SH3_3	670	676	PF00018	0.656
LIG_SH3_3	69	75	PF00018	0.649
LIG_SUMO_SIM_par_1	366	372	PF11976	0.482
LIG_TYR_ITIM	362	367	PF00017	0.413
LIG_UBA3_1	173	182	PF00899	0.552
LIG_UBA3_1	603	611	PF00899	0.512
MOD_CK1_1	130	136	PF00069	0.457
MOD_CK1_1	148	154	PF00069	0.316
MOD_CK1_1	15	21	PF00069	0.715
MOD_CK1_1	207	213	PF00069	0.658
MOD_CK1_1	306	312	PF00069	0.358
MOD_CK1_1	369	375	PF00069	0.382
MOD_CK1_1	382	388	PF00069	0.400
MOD_CK1_1	391	397	PF00069	0.530
MOD_CK1_1	47	53	PF00069	0.579
MOD_CK1_1	639	645	PF00069	0.508
MOD_CK1_1	65	71	PF00069	0.406
MOD_CK1_1	663	669	PF00069	0.646
MOD_CK1_1	682	688	PF00069	0.469
MOD_CK1_1	87	93	PF00069	0.779
MOD_CK1_1	95	101	PF00069	0.731
MOD_CK2_1	192	198	PF00069	0.771
MOD_CK2_1	210	216	PF00069	0.474
MOD_CK2_1	352	358	PF00069	0.350
MOD_CK2_1	501	507	PF00069	0.524
MOD_CK2_1	53	59	PF00069	0.553
MOD_CK2_1	546	552	PF00069	0.426
MOD_Cter_Amidation	302	305	PF01082	0.446
MOD_Cter_Amidation	606	609	PF01082	0.551
MOD_GlcNHglycan	133	136	PF01048	0.420
MOD_GlcNHglycan	147	150	PF01048	0.366
MOD_GlcNHglycan	212	215	PF01048	0.776
MOD_GlcNHglycan	23	26	PF01048	0.786
MOD_GlcNHglycan	341	344	PF01048	0.593
MOD_GlcNHglycan	373	376	PF01048	0.446
MOD_GlcNHglycan	547	551	PF01048	0.535
MOD_GlcNHglycan	55	58	PF01048	0.634
MOD_GlcNHglycan	575	578	PF01048	0.581
MOD_GlcNHglycan	644	647	PF01048	0.617
MOD_GlcNHglycan	681	684	PF01048	0.688
MOD_GlcNHglycan	686	689	PF01048	0.621
MOD_GlcNHglycan	82	85	PF01048	0.770
MOD_GlcNHglycan	97	100	PF01048	0.568
MOD_GSK3_1	127	134	PF00069	0.440
MOD_GSK3_1	15	22	PF00069	0.632
MOD_GSK3_1	150	157	PF00069	0.435
MOD_GSK3_1	2	9	PF00069	0.597
MOD_GSK3_1	202	209	PF00069	0.794
MOD_GSK3_1	216	223	PF00069	0.523
MOD_GSK3_1	299	306	PF00069	0.487
MOD_GSK3_1	348	355	PF00069	0.431
MOD_GSK3_1	530	537	PF00069	0.510
MOD_GSK3_1	58	65	PF00069	0.544
MOD_GSK3_1	593	600	PF00069	0.590
MOD_GSK3_1	650	657	PF00069	0.563
MOD_GSK3_1	659	666	PF00069	0.567
MOD_GSK3_1	80	87	PF00069	0.631
MOD_LATS_1	51	57	PF00433	0.532
MOD_N-GLC_1	106	111	PF02516	0.441
MOD_N-GLC_1	130	135	PF02516	0.515
MOD_N-GLC_1	450	455	PF02516	0.528
MOD_NEK2_1	106	111	PF00069	0.457
MOD_NEK2_1	348	353	PF00069	0.524
MOD_NEK2_1	379	384	PF00069	0.407
MOD_NEK2_1	4	9	PF00069	0.631
MOD_NEK2_1	463	468	PF00069	0.552
MOD_NEK2_1	535	540	PF00069	0.589
MOD_NEK2_1	546	551	PF00069	0.495
MOD_NEK2_1	654	659	PF00069	0.650
MOD_PIKK_1	100	106	PF00454	0.657
MOD_PIKK_1	148	154	PF00454	0.437
MOD_PIKK_1	202	208	PF00454	0.663
MOD_PIKK_1	507	513	PF00454	0.460
MOD_PIKK_1	528	534	PF00454	0.457
MOD_PIKK_1	535	541	PF00454	0.450
MOD_PIKK_1	587	593	PF00454	0.612
MOD_PIKK_1	667	673	PF00454	0.679
MOD_PIKK_1	674	680	PF00454	0.624
MOD_PIKK_1	8	14	PF00454	0.725
MOD_PIKK_1	87	93	PF00454	0.727
MOD_PKA_2	303	309	PF00069	0.390
MOD_PKA_2	351	357	PF00069	0.435
MOD_PKA_2	442	448	PF00069	0.470
MOD_PKA_2	539	545	PF00069	0.566
MOD_PKA_2	625	631	PF00069	0.536
MOD_PKA_2	636	642	PF00069	0.501
MOD_PKA_2	654	660	PF00069	0.560
MOD_Plk_1	106	112	PF00069	0.442
MOD_Plk_1	285	291	PF00069	0.352
MOD_Plk_1	324	330	PF00069	0.420
MOD_Plk_1	546	552	PF00069	0.426
MOD_Plk_1	587	593	PF00069	0.512
MOD_Plk_4	134	140	PF00069	0.427
MOD_Plk_4	150	156	PF00069	0.381
MOD_Plk_4	273	279	PF00069	0.483
MOD_Plk_4	308	314	PF00069	0.383
MOD_Plk_4	352	358	PF00069	0.339
MOD_ProDKin_1	15	21	PF00069	0.706
MOD_ProDKin_1	154	160	PF00069	0.454
MOD_SUMO_rev_2	276	285	PF00179	0.530
MOD_SUMO_rev_2	547	555	PF00179	0.496
TRG_DiLeu_BaEn_1	325	330	PF01217	0.343
TRG_DiLeu_BaEn_4	514	520	PF01217	0.458
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.440
TRG_ENDOCYTIC_2	121	124	PF00928	0.404
TRG_ENDOCYTIC_2	138	141	PF00928	0.370
TRG_ENDOCYTIC_2	231	234	PF00928	0.482
TRG_ENDOCYTIC_2	296	299	PF00928	0.389
TRG_ENDOCYTIC_2	364	367	PF00928	0.382
TRG_ENDOCYTIC_2	67	70	PF00928	0.506
TRG_ER_diArg_1	265	268	PF00400	0.467
TRG_ER_diArg_1	421	424	PF00400	0.502
TRG_ER_diArg_1	516	518	PF00400	0.546
TRG_ER_diArg_1	610	613	PF00400	0.532
TRG_ER_diArg_1	637	640	PF00400	0.613
TRG_ER_diArg_1	70	73	PF00400	0.552
TRG_NLS_MonoCore_2	607	612	PF00514	0.578
TRG_NLS_MonoExtC_3	607	612	PF00514	0.528
TRG_NLS_MonoExtN_4	608	613	PF00514	0.505
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	517	521	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC06	Leptomonas seymouri	72%	99%
A0A0S4KIG4	Bodo saltans	28%	94%
A0A1X0NKL3	Trypanosomatidae	54%	100%
A0A3R7LWH4	Trypanosoma rangeli	52%	100%
A0A3S5H5Q4	Leishmania donovani	100%	100%
A4H4K9	Leishmania braziliensis	89%	99%
C9ZTE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AKS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QJ35	Leishmania major	97%	100%
V5DPG4	Trypanosoma cruzi	52%	100%