Putative 60S ribosomal protein L19

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ribosomal protein L19e - putative

Species:

Leishmania infantum

UniProt:

A4HST3_LEIIN

TriTrypDb:

LINF_060009400

Length:

238

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S ribosomal L19

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0015934	large ribosomal subunit	4	13
GO:0022625	cytosolic large ribosomal subunit	5	13
GO:0032991	protein-containing complex	1	13
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0044391	ribosomal subunit	3	13

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Expansion

Sequence features

A4HST3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HST3

Function

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Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	13
GO:0006518	peptide metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009058	biosynthetic process	2	13
GO:0009059	macromolecule biosynthetic process	4	13
GO:0009987	cellular process	1	13
GO:0019538	protein metabolic process	3	13
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	13

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003723	RNA binding	4	13
GO:0003735	structural constituent of ribosome	2	13
GO:0005198	structural molecule activity	1	13
GO:0005488	binding	1	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.296
CLV_NRD_NRD_1	106	108	PF00675	0.296
CLV_NRD_NRD_1	173	175	PF00675	0.512
CLV_NRD_NRD_1	178	180	PF00675	0.528
CLV_NRD_NRD_1	189	191	PF00675	0.567
CLV_NRD_NRD_1	37	39	PF00675	0.296
CLV_NRD_NRD_1	41	43	PF00675	0.296
CLV_NRD_NRD_1	51	53	PF00675	0.296
CLV_NRD_NRD_1	63	65	PF00675	0.273
CLV_NRD_NRD_1	80	82	PF00675	0.211

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTS2	Leptomonas seymouri	94%	92%
A0A1X0NL07	Trypanosomatidae	83%	90%
A0A3R7MF58	Trypanosoma rangeli	87%	80%
A0A3S5H5Q3	Leishmania donovani	100%	97%
A4H4K5	Leishmania braziliensis	97%	100%
A4H4K7	Leishmania braziliensis	97%	88%
A4HST1	Leishmania infantum	100%	100%
C9ZTD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	85%	92%
D0VWQ5	Canis lupus familiaris	56%	100%
E9AKR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%

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