C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HST2_LEIIN

TriTrypDb:

LINF_060009500

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HST2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HST2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	156	158	PF00675	0.605
CLV_NRD_NRD_1	29	31	PF00675	0.562
CLV_NRD_NRD_1	61	63	PF00675	0.617
CLV_NRD_NRD_1	94	96	PF00675	0.709
CLV_PCSK_FUR_1	154	158	PF00082	0.572
CLV_PCSK_KEX2_1	149	151	PF00082	0.571
CLV_PCSK_KEX2_1	156	158	PF00082	0.579
CLV_PCSK_KEX2_1	29	31	PF00082	0.505
CLV_PCSK_KEX2_1	41	43	PF00082	0.518
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.637
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.546
CLV_PCSK_SKI1_1	180	184	PF00082	0.516
CLV_PCSK_SKI1_1	22	26	PF00082	0.564
CLV_PCSK_SKI1_1	57	61	PF00082	0.552
DEG_SPOP_SBC_1	120	124	PF00917	0.693
DEG_SPOP_SBC_1	70	74	PF00917	0.795
DEG_SPOP_SBC_1	85	89	PF00917	0.759
DOC_MAPK_gen_1	179	186	PF00069	0.520
DOC_MAPK_MEF2A_6	131	140	PF00069	0.646
DOC_USP7_MATH_1	112	116	PF00917	0.749
DOC_USP7_MATH_1	120	124	PF00917	0.791
DOC_USP7_MATH_1	125	129	PF00917	0.584
DOC_USP7_MATH_1	70	74	PF00917	0.698
DOC_USP7_UBL2_3	145	149	PF12436	0.624
LIG_APCC_ABBA_1	18	23	PF00400	0.537
LIG_BIR_II_1	1	5	PF00653	0.643
LIG_CtBP_PxDLS_1	137	141	PF00389	0.532
LIG_FHA_1	103	109	PF00498	0.579
LIG_FHA_1	3	9	PF00498	0.599
LIG_FHA_1	54	60	PF00498	0.567
LIG_FHA_1	85	91	PF00498	0.796
LIG_FHA_2	89	95	PF00498	0.719
LIG_SH2_SRC	107	110	PF00017	0.580
LIG_SH2_STAT5	10	13	PF00017	0.530
LIG_SH2_STAT5	107	110	PF00017	0.580
LIG_SUMO_SIM_par_1	136	141	PF11976	0.630
MOD_CK1_1	173	179	PF00069	0.554
MOD_CK1_1	2	8	PF00069	0.613
MOD_CK1_1	74	80	PF00069	0.740
MOD_CK2_1	88	94	PF00069	0.715
MOD_Cter_Amidation	177	180	PF01082	0.513
MOD_GlcNHglycan	115	118	PF01048	0.794
MOD_GlcNHglycan	123	126	PF01048	0.766
MOD_GSK3_1	121	128	PF00069	0.780
MOD_GSK3_1	136	143	PF00069	0.468
MOD_GSK3_1	169	176	PF00069	0.532
MOD_GSK3_1	70	77	PF00069	0.703
MOD_GSK3_1	84	91	PF00069	0.718
MOD_NEK2_1	121	126	PF00069	0.689
MOD_NEK2_1	140	145	PF00069	0.492
MOD_NEK2_1	35	40	PF00069	0.689
MOD_NEK2_2	126	131	PF00069	0.701
MOD_PIKK_1	35	41	PF00454	0.686
MOD_PIKK_1	71	77	PF00454	0.725
MOD_PKA_2	53	59	PF00069	0.672
MOD_Plk_1	102	108	PF00069	0.657
MOD_Plk_4	170	176	PF00069	0.630
MOD_SUMO_rev_2	172	181	PF00179	0.527
TRG_DiLeu_BaEn_1	55	60	PF01217	0.569
TRG_ER_diArg_1	154	157	PF00400	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II80	Leptomonas seymouri	53%	92%
A0A3S5H5Q2	Leishmania donovani	100%	100%
A4H4K6	Leishmania braziliensis	80%	100%
E9AKR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QJ38	Leishmania major	96%	100%