LeishMANIAdb
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Putative glutamine synthetase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative glutamine synthetase
Gene product:
glutamine synthetase - putative
Species:
Leishmania infantum
UniProt:
A4HSS8_LEIIN
TriTrypDb:
LINF_060009000 *
Length:
484

Annotations

Annotations by Jardim et al.

Amino acid metabolism, glutamine synthetase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 1
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HSS8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSS8

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 13
GO:0006520 amino acid metabolic process 3 13
GO:0006541 glutamine metabolic process 6 13
GO:0006542 glutamine biosynthetic process 7 13
GO:0006807 nitrogen compound metabolic process 2 13
GO:0008152 metabolic process 1 13
GO:0008652 amino acid biosynthetic process 4 13
GO:0009058 biosynthetic process 2 13
GO:0009064 glutamine family amino acid metabolic process 5 13
GO:0009084 glutamine family amino acid biosynthetic process 6 13
GO:0009987 cellular process 1 13
GO:0016053 organic acid biosynthetic process 4 13
GO:0019752 carboxylic acid metabolic process 5 13
GO:0043436 oxoacid metabolic process 4 13
GO:0044237 cellular metabolic process 2 13
GO:0044238 primary metabolic process 2 13
GO:0044249 cellular biosynthetic process 3 13
GO:0044281 small molecule metabolic process 2 13
GO:0044283 small molecule biosynthetic process 3 13
GO:0046394 carboxylic acid biosynthetic process 5 13
GO:0071704 organic substance metabolic process 2 13
GO:1901564 organonitrogen compound metabolic process 3 13
GO:1901566 organonitrogen compound biosynthetic process 4 13
GO:1901576 organic substance biosynthetic process 3 13
GO:1901605 alpha-amino acid metabolic process 4 13
GO:1901607 alpha-amino acid biosynthetic process 5 13
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 13
GO:0004356 glutamate-ammonia ligase activity 6 13
GO:0016211 ammonia ligase activity 5 13
GO:0016874 ligase activity 2 13
GO:0016879 ligase activity, forming carbon-nitrogen bonds 3 13
GO:0016880 acid-ammonia (or amide) ligase activity 4 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 122 126 PF00656 0.436
CLV_C14_Caspase3-7 336 340 PF00656 0.484
CLV_NRD_NRD_1 18 20 PF00675 0.397
CLV_NRD_NRD_1 276 278 PF00675 0.226
CLV_NRD_NRD_1 440 442 PF00675 0.221
CLV_PCSK_KEX2_1 18 20 PF00082 0.397
CLV_PCSK_KEX2_1 440 442 PF00082 0.208
CLV_PCSK_PC7_1 14 20 PF00082 0.401
CLV_PCSK_SKI1_1 149 153 PF00082 0.225
CLV_PCSK_SKI1_1 326 330 PF00082 0.216
CLV_PCSK_SKI1_1 480 484 PF00082 0.538
DEG_APCC_DBOX_1 325 333 PF00400 0.425
DEG_Nend_UBRbox_1 1 4 PF02207 0.451
DEG_SPOP_SBC_1 190 194 PF00917 0.467
DOC_CKS1_1 462 467 PF01111 0.448
DOC_CYCLIN_yCln2_LP_2 178 184 PF00134 0.449
DOC_MAPK_DCC_7 191 201 PF00069 0.425
DOC_MAPK_gen_1 131 139 PF00069 0.436
DOC_MAPK_gen_1 18 24 PF00069 0.392
DOC_MAPK_MEF2A_6 18 26 PF00069 0.411
DOC_PP1_RVXF_1 385 392 PF00149 0.449
DOC_PP2B_PxIxI_1 196 202 PF00149 0.425
DOC_PP4_FxxP_1 258 261 PF00568 0.434
DOC_USP7_MATH_1 190 194 PF00917 0.465
DOC_USP7_MATH_1 428 432 PF00917 0.511
DOC_USP7_MATH_1 86 90 PF00917 0.408
DOC_USP7_UBL2_3 383 387 PF12436 0.484
DOC_WW_Pin1_4 299 304 PF00397 0.488
DOC_WW_Pin1_4 461 466 PF00397 0.411
DOC_WW_Pin1_4 468 473 PF00397 0.372
DOC_WW_Pin1_4 87 92 PF00397 0.651
LIG_14-3-3_CanoR_1 115 119 PF00244 0.416
LIG_14-3-3_CanoR_1 191 199 PF00244 0.403
LIG_14-3-3_CanoR_1 218 225 PF00244 0.448
LIG_14-3-3_CanoR_1 37 41 PF00244 0.409
LIG_14-3-3_CanoR_1 380 386 PF00244 0.449
LIG_14-3-3_CanoR_1 419 426 PF00244 0.465
LIG_14-3-3_CanoR_1 454 462 PF00244 0.416
LIG_BIR_III_2 445 449 PF00653 0.436
LIG_BRCT_BRCA1_1 452 456 PF00533 0.436
LIG_deltaCOP1_diTrp_1 475 483 PF00928 0.390
LIG_FHA_1 111 117 PF00498 0.451
LIG_FHA_1 134 140 PF00498 0.416
LIG_FHA_1 173 179 PF00498 0.430
LIG_FHA_1 404 410 PF00498 0.455
LIG_FHA_1 42 48 PF00498 0.604
LIG_FHA_1 450 456 PF00498 0.482
LIG_FHA_1 462 468 PF00498 0.259
LIG_FHA_1 99 105 PF00498 0.672
LIG_FHA_2 218 224 PF00498 0.440
LIG_FHA_2 295 301 PF00498 0.425
LIG_FHA_2 363 369 PF00498 0.436
LIG_IRF3_LxIS_1 288 295 PF10401 0.484
LIG_LIR_Gen_1 117 125 PF02991 0.415
LIG_LIR_Gen_1 56 64 PF02991 0.548
LIG_LIR_Nem_3 117 121 PF02991 0.415
LIG_LIR_Nem_3 231 237 PF02991 0.354
LIG_LIR_Nem_3 56 61 PF02991 0.543
LIG_LYPXL_yS_3 75 78 PF13949 0.395
LIG_NRBOX 328 334 PF00104 0.507
LIG_PCNA_yPIPBox_3 321 331 PF02747 0.425
LIG_Pex14_1 275 279 PF04695 0.522
LIG_PTB_Apo_2 151 158 PF02174 0.522
LIG_REV1ctd_RIR_1 61 70 PF16727 0.398
LIG_SH2_CRK 69 73 PF00017 0.398
LIG_SH2_PTP2 118 121 PF00017 0.416
LIG_SH2_SRC 206 209 PF00017 0.501
LIG_SH2_STAP1 284 288 PF00017 0.413
LIG_SH2_STAT3 138 141 PF00017 0.507
LIG_SH2_STAT3 67 70 PF00017 0.372
LIG_SH2_STAT5 118 121 PF00017 0.416
LIG_SH2_STAT5 138 141 PF00017 0.416
LIG_SH2_STAT5 206 209 PF00017 0.484
LIG_SH2_STAT5 241 244 PF00017 0.453
LIG_SH2_STAT5 266 269 PF00017 0.415
LIG_SH2_STAT5 377 380 PF00017 0.416
LIG_SH2_STAT5 449 452 PF00017 0.416
LIG_SH3_3 70 76 PF00018 0.396
LIG_SUMO_SIM_par_1 198 204 PF11976 0.425
LIG_SxIP_EBH_1 191 202 PF03271 0.507
LIG_TYR_ITIM 116 121 PF00017 0.425
LIG_TYR_ITIM 73 78 PF00017 0.394
LIG_UBA3_1 77 85 PF00899 0.398
MOD_CK1_1 217 223 PF00069 0.452
MOD_CK1_1 268 274 PF00069 0.507
MOD_CK1_1 36 42 PF00069 0.634
MOD_CK1_1 361 367 PF00069 0.465
MOD_CK1_1 407 413 PF00069 0.507
MOD_CK1_1 89 95 PF00069 0.423
MOD_CK2_1 217 223 PF00069 0.444
MOD_CK2_1 294 300 PF00069 0.425
MOD_CK2_1 362 368 PF00069 0.427
MOD_Cter_Amidation 275 278 PF01082 0.225
MOD_GlcNHglycan 121 124 PF01048 0.245
MOD_GlcNHglycan 208 211 PF01048 0.415
MOD_GlcNHglycan 272 275 PF01048 0.320
MOD_GlcNHglycan 294 297 PF01048 0.225
MOD_GlcNHglycan 353 356 PF01048 0.216
MOD_GlcNHglycan 411 415 PF01048 0.277
MOD_GSK3_1 106 113 PF00069 0.475
MOD_GSK3_1 119 126 PF00069 0.363
MOD_GSK3_1 129 136 PF00069 0.407
MOD_GSK3_1 206 213 PF00069 0.488
MOD_GSK3_1 217 224 PF00069 0.487
MOD_GSK3_1 266 273 PF00069 0.498
MOD_GSK3_1 351 358 PF00069 0.416
MOD_GSK3_1 379 386 PF00069 0.499
MOD_GSK3_1 403 410 PF00069 0.446
MOD_GSK3_1 415 422 PF00069 0.359
MOD_GSK3_1 86 93 PF00069 0.635
MOD_GSK3_1 98 105 PF00069 0.611
MOD_N-GLC_1 292 297 PF02516 0.236
MOD_N-GLC_1 351 356 PF02516 0.211
MOD_N-GLC_1 358 363 PF02516 0.212
MOD_NEK2_1 106 111 PF00069 0.565
MOD_NEK2_1 162 167 PF00069 0.412
MOD_NEK2_1 292 297 PF00069 0.438
MOD_NEK2_1 381 386 PF00069 0.407
MOD_NEK2_1 41 46 PF00069 0.391
MOD_NEK2_1 450 455 PF00069 0.425
MOD_NEK2_1 53 58 PF00069 0.342
MOD_PIKK_1 137 143 PF00454 0.522
MOD_PIKK_1 6 12 PF00454 0.456
MOD_PK_1 419 425 PF00069 0.416
MOD_PKA_2 114 120 PF00069 0.268
MOD_PKA_2 190 196 PF00069 0.425
MOD_PKA_2 217 223 PF00069 0.465
MOD_PKA_2 36 42 PF00069 0.405
MOD_PKA_2 379 385 PF00069 0.502
MOD_PKA_2 398 404 PF00069 0.310
MOD_PKA_2 418 424 PF00069 0.286
MOD_PKA_2 6 12 PF00069 0.437
MOD_Plk_1 133 139 PF00069 0.416
MOD_Plk_2-3 463 469 PF00069 0.519
MOD_Plk_4 114 120 PF00069 0.268
MOD_Plk_4 36 42 PF00069 0.405
MOD_ProDKin_1 299 305 PF00069 0.488
MOD_ProDKin_1 461 467 PF00069 0.406
MOD_ProDKin_1 468 474 PF00069 0.368
MOD_ProDKin_1 87 93 PF00069 0.653
TRG_DiLeu_BaEn_2 237 243 PF01217 0.425
TRG_DiLeu_BaLyEn_6 328 333 PF01217 0.505
TRG_DiLeu_BaLyEn_6 73 78 PF01217 0.545
TRG_ENDOCYTIC_2 118 121 PF00928 0.415
TRG_ENDOCYTIC_2 241 244 PF00928 0.455
TRG_ENDOCYTIC_2 69 72 PF00928 0.547
TRG_ENDOCYTIC_2 75 78 PF00928 0.542
TRG_ER_diArg_1 440 442 PF00400 0.416
TRG_Pf-PMV_PEXEL_1 331 335 PF00026 0.216

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6V5 Leptomonas seymouri 85% 100%
A0A0S4IX33 Bodo saltans 63% 100%
A0A1X0NKP6 Trypanosomatidae 75% 100%
A0A1X0NL55 Trypanosomatidae 75% 100%
A0A3R7R8D5 Trypanosoma rangeli 74% 100%
A0A3S5H5P8 Leishmania donovani 100% 100%
A4H4K2 Leishmania braziliensis 92% 100%
C9ZTD4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 69% 100%
E9AKR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
O00088 Agaricus bisporus 45% 100%
O04867 Alnus glutinosa 44% 100%
O22504 Daucus carota 45% 100%
O22506 Daucus carota 47% 100%
O82560 Glycine max 47% 100%
P00965 Phaseolus vulgaris 46% 100%
P04078 Medicago sativa 44% 100%
P04770 Phaseolus vulgaris 44% 100%
P04771 Phaseolus vulgaris 43% 100%
P04772 Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) 39% 100%
P04773 Cricetulus griseus 43% 100%
P07694 Pisum sativum 44% 100%
P08281 Pisum sativum 44% 100%
P08282 Pisum sativum 44% 100%
P09606 Rattus norvegicus 45% 100%
P0CN84 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 45% 100%
P0CN85 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 45% 100%
P12424 Nicotiana plumbaginifolia 45% 100%
P13564 Hordeum vulgare 46% 100%
P14654 Oryza sativa subsp. japonica 46% 100%
P14655 Oryza sativa subsp. japonica 45% 100%
P14656 Oryza sativa subsp. japonica 44% 100%
P15102 Phaseolus vulgaris 46% 100%
P15103 Bos taurus 44% 100%
P15104 Homo sapiens 45% 100%
P15105 Mus musculus 46% 100%
P16580 Gallus gallus 45% 100%
P19432 Streptomyces viridochromogenes 43% 100%
P20477 Drosophila melanogaster 40% 100%
P20478 Drosophila melanogaster 45% 100%
P20805 Frankia alni 41% 100%
P22878 Streptomyces hygroscopicus 40% 100%
P23712 Lactuca sativa 45% 100%
P24099 Glycine max 44% 100%
P25462 Zea mays 45% 100%
P32288 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 46% 100%
P32289 Vigna aconitifolia 45% 100%
P34497 Caenorhabditis elegans 46% 100%
P38559 Zea mays 45% 100%
P38560 Zea mays 44% 100%
P38561 Zea mays 46% 100%
P38562 Zea mays 45% 100%
P38563 Zea mays 45% 100%
P41320 Squalus acanthias 41% 100%
P45626 Rhizobium meliloti 39% 100%
P46410 Sus scrofa 45% 100%
P51118 Vitis vinifera 46% 100%
P51119 Vitis vinifera 45% 100%
P51121 Xenopus laevis 47% 100%
P52782 Lupinus luteus 46% 100%
P52783 Pinus sylvestris 43% 100%
P64246 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 23% 100%
P9WN36 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 23% 100%
P9WN37 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 23% 100%
Q02154 Rhizobium leguminosarum bv. phaseoli 39% 100%
Q04831 Panulirus argus 46% 100%
Q06378 Hordeum vulgare 44% 100%
Q09179 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 45% 100%
Q12613 Colletotrichum gloeosporioides 47% 100%
Q42624 Brassica napus 45% 100%
Q42688 Chlamydomonas reinhardtii 42% 100%
Q42689 Chlamydomonas reinhardtii 43% 100%
Q42899 Lotus japonicus 45% 100%
Q43066 Pisum sativum 45% 100%
Q43127 Arabidopsis thaliana 47% 100%
Q43785 Medicago sativa 43% 100%
Q4QJ42 Leishmania major 96% 100%
Q4R7U3 Macaca fascicularis 46% 100%
Q4W8D0 Oryza sativa subsp. japonica 43% 100%
Q56WN1 Arabidopsis thaliana 43% 100%
Q5UR44 Acanthamoeba polyphaga mimivirus 46% 100%
Q60182 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 25% 100%
Q6B4U7 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 43% 100%
Q6C3E0 Yarrowia lipolytica (strain CLIB 122 / E 150) 45% 100%
Q6FMT6 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 45% 100%
Q75BT9 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 47% 100%
Q86ZF9 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 49% 100%
Q86ZU6 Tuber borchii 45% 100%
Q874T6 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 47% 100%
Q8GXW5 Arabidopsis thaliana 45% 100%
Q8HZM5 Canis lupus familiaris 45% 100%
Q8J1R3 Suillus bovinus 43% 100%
Q8LCE1 Arabidopsis thaliana 44% 100%
Q8PY99 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) 24% 100%
Q8X169 Amanita muscaria 44% 100%
Q96UV5 Hebeloma cylindrosporum 46% 100%
Q96V52 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 45% 100%
Q9C2U9 Gibberella fujikuroi 46% 100%
Q9FMD9 Arabidopsis thaliana 45% 100%
Q9LVI8 Arabidopsis thaliana 45% 100%
Q9QY94 Acomys cahirinus 45% 100%
Q9UUN6 Fusarium solani subsp. phaseoli 47% 100%
Q9XQ94 Medicago sativa 45% 100%
V5CHQ8 Trypanosoma cruzi 75% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS