Putative folate/biopterin transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pteridine transporter (truncated) - putative

Species:

Leishmania infantum

UniProt:

A4HSS2_LEIIN

TriTrypDb:

LINF_060008400

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 71
NetGPI	no	yes: 0, no: 71

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	72
GO:0110165	cellular anatomical entity	1	72
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4HSS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSS2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.683
CLV_NRD_NRD_1	209	211	PF00675	0.225
CLV_NRD_NRD_1	661	663	PF00675	0.469
CLV_NRD_NRD_1	665	667	PF00675	0.467
CLV_PCSK_KEX2_1	150	152	PF00082	0.291
CLV_PCSK_KEX2_1	208	210	PF00082	0.250
CLV_PCSK_KEX2_1	285	287	PF00082	0.293
CLV_PCSK_KEX2_1	525	527	PF00082	0.520
CLV_PCSK_KEX2_1	665	667	PF00082	0.479
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.291
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.354
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.520
CLV_PCSK_PC7_1	205	211	PF00082	0.210
CLV_PCSK_SKI1_1	55	59	PF00082	0.285
DEG_APCC_DBOX_1	19	27	PF00400	0.673
DOC_CDC14_PxL_1	424	432	PF14671	0.200
DOC_CDC14_PxL_1	611	619	PF14671	0.330
DOC_CYCLIN_yCln2_LP_2	318	324	PF00134	0.393
DOC_CYCLIN_yCln2_LP_2	628	634	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	636	642	PF00134	0.492
DOC_MAPK_gen_1	525	533	PF00069	0.322
DOC_MAPK_HePTP_8	239	251	PF00069	0.219
DOC_MAPK_MEF2A_6	242	251	PF00069	0.319
DOC_MAPK_MEF2A_6	525	533	PF00069	0.356
DOC_PP1_RVXF_1	125	131	PF00149	0.605
DOC_PP2B_LxvP_1	446	449	PF13499	0.373
DOC_PP2B_LxvP_1	628	631	PF13499	0.354
DOC_PP4_FxxP_1	599	602	PF00568	0.263
DOC_SPAK_OSR1_1	111	115	PF12202	0.412
DOC_USP7_MATH_1	137	141	PF00917	0.528
DOC_USP7_MATH_1	303	307	PF00917	0.524
DOC_USP7_MATH_1	432	436	PF00917	0.581
DOC_USP7_MATH_1	451	455	PF00917	0.324
DOC_USP7_MATH_1	567	571	PF00917	0.485
DOC_USP7_MATH_1	586	590	PF00917	0.438
LIG_14-3-3_CanoR_1	20	29	PF00244	0.568
LIG_14-3-3_CanoR_1	503	507	PF00244	0.490
LIG_14-3-3_CanoR_1	80	86	PF00244	0.510
LIG_APCC_ABBA_1	538	543	PF00400	0.245
LIG_BIR_II_1	1	5	PF00653	0.748
LIG_BRCT_BRCA1_1	258	262	PF00533	0.272
LIG_BRCT_BRCA1_1	434	438	PF00533	0.490
LIG_BRCT_BRCA1_1	439	443	PF00533	0.431
LIG_BRCT_BRCA1_1	469	473	PF00533	0.316
LIG_BRCT_BRCA1_1	500	504	PF00533	0.459
LIG_CaM_NSCaTE_8	222	229	PF13499	0.240
LIG_CSL_BTD_1	554	557	PF09270	0.396
LIG_FHA_1	253	259	PF00498	0.423
LIG_FHA_1	507	513	PF00498	0.324
LIG_FHA_1	556	562	PF00498	0.242
LIG_FHA_1	80	86	PF00498	0.601
LIG_FHA_2	270	276	PF00498	0.606
LIG_FHA_2	342	348	PF00498	0.441
LIG_FHA_2	349	355	PF00498	0.447
LIG_FHA_2	602	608	PF00498	0.219
LIG_LIR_Apic_2	46	52	PF02991	0.618
LIG_LIR_Apic_2	598	602	PF02991	0.301
LIG_LIR_Gen_1	200	211	PF02991	0.518
LIG_LIR_Gen_1	404	414	PF02991	0.294
LIG_LIR_Gen_1	440	451	PF02991	0.335
LIG_LIR_Gen_1	501	512	PF02991	0.484
LIG_LIR_Gen_1	517	524	PF02991	0.333
LIG_LIR_Gen_1	572	581	PF02991	0.510
LIG_LIR_Gen_1	608	619	PF02991	0.265
LIG_LIR_Gen_1	633	642	PF02991	0.280
LIG_LIR_Nem_3	165	171	PF02991	0.312
LIG_LIR_Nem_3	200	206	PF02991	0.527
LIG_LIR_Nem_3	219	225	PF02991	0.344
LIG_LIR_Nem_3	404	409	PF02991	0.288
LIG_LIR_Nem_3	435	441	PF02991	0.368
LIG_LIR_Nem_3	470	474	PF02991	0.295
LIG_LIR_Nem_3	505	511	PF02991	0.305
LIG_LIR_Nem_3	517	522	PF02991	0.333
LIG_LIR_Nem_3	572	578	PF02991	0.471
LIG_LIR_Nem_3	608	614	PF02991	0.263
LIG_LIR_Nem_3	633	637	PF02991	0.280
LIG_LRP6_Inhibitor_1	648	654	PF00058	0.188
LIG_LYPXL_SIV_4	328	336	PF13949	0.384
LIG_MLH1_MIPbox_1	434	438	PF16413	0.570
LIG_MYND_3	61	65	PF01753	0.456
LIG_Pex14_1	220	224	PF04695	0.373
LIG_Pex14_1	406	410	PF04695	0.284
LIG_Pex14_1	425	429	PF04695	0.327
LIG_Pex14_2	108	112	PF04695	0.406
LIG_Pex14_2	186	190	PF04695	0.373
LIG_Pex14_2	263	267	PF04695	0.284
LIG_Pex14_2	439	443	PF04695	0.364
LIG_Pex14_2	469	473	PF04695	0.305
LIG_Pex14_2	493	497	PF04695	0.363
LIG_Pex14_2	504	508	PF04695	0.364
LIG_SH2_CRK	119	123	PF00017	0.511
LIG_SH2_CRK	168	172	PF00017	0.320
LIG_SH2_CRK	203	207	PF00017	0.514
LIG_SH2_CRK	385	389	PF00017	0.344
LIG_SH2_CRK	410	414	PF00017	0.354
LIG_SH2_CRK	441	445	PF00017	0.337
LIG_SH2_CRK	474	478	PF00017	0.297
LIG_SH2_CRK	575	579	PF00017	0.218
LIG_SH2_CRK	97	101	PF00017	0.526
LIG_SH2_GRB2like	329	332	PF00017	0.391
LIG_SH2_NCK_1	410	414	PF00017	0.415
LIG_SH2_NCK_1	474	478	PF00017	0.299
LIG_SH2_NCK_1	575	579	PF00017	0.298
LIG_SH2_NCK_1	97	101	PF00017	0.391
LIG_SH2_PTP2	49	52	PF00017	0.604
LIG_SH2_PTP2	530	533	PF00017	0.399
LIG_SH2_SRC	49	52	PF00017	0.610
LIG_SH2_STAP1	148	152	PF00017	0.500
LIG_SH2_STAP1	203	207	PF00017	0.485
LIG_SH2_STAP1	385	389	PF00017	0.392
LIG_SH2_STAP1	410	414	PF00017	0.282
LIG_SH2_STAP1	441	445	PF00017	0.326
LIG_SH2_STAP1	547	551	PF00017	0.404
LIG_SH2_STAP1	575	579	PF00017	0.338
LIG_SH2_STAT3	510	513	PF00017	0.357
LIG_SH2_STAT5	148	151	PF00017	0.497
LIG_SH2_STAT5	153	156	PF00017	0.339
LIG_SH2_STAT5	437	440	PF00017	0.348
LIG_SH2_STAT5	445	448	PF00017	0.338
LIG_SH2_STAT5	471	474	PF00017	0.260
LIG_SH2_STAT5	49	52	PF00017	0.602
LIG_SH2_STAT5	495	498	PF00017	0.450
LIG_SH2_STAT5	510	513	PF00017	0.259
LIG_SH2_STAT5	530	533	PF00017	0.301
LIG_SH2_STAT5	539	542	PF00017	0.293
LIG_SH2_STAT5	552	555	PF00017	0.378
LIG_SH2_STAT5	89	92	PF00017	0.516
LIG_SH3_1	665	671	PF00018	0.597
LIG_SH3_3	461	467	PF00018	0.279
LIG_SH3_3	632	638	PF00018	0.389
LIG_SH3_3	665	671	PF00018	0.715
LIG_SUMO_SIM_anti_2	411	417	PF11976	0.397
LIG_SUMO_SIM_anti_2	520	525	PF11976	0.314
LIG_SUMO_SIM_anti_2	558	563	PF11976	0.250
LIG_SUMO_SIM_par_1	557	563	PF11976	0.327
LIG_TRAF2_1	43	46	PF00917	0.603
LIG_TRFH_1	634	638	PF08558	0.290
LIG_TYR_ITIM	117	122	PF00017	0.298
LIG_TYR_ITIM	166	171	PF00017	0.376
LIG_TYR_ITIM	408	413	PF00017	0.373
LIG_TYR_ITIM	472	477	PF00017	0.337
LIG_TYR_ITIM	95	100	PF00017	0.409
LIG_WRC_WIRS_1	187	192	PF05994	0.242
LIG_WRC_WIRS_1	298	303	PF05994	0.186
LIG_WRC_WIRS_1	452	457	PF05994	0.334
MOD_CK1_1	106	112	PF00069	0.336
MOD_CK1_1	213	219	PF00069	0.355
MOD_CK1_1	392	398	PF00069	0.345
MOD_CK1_1	498	504	PF00069	0.350
MOD_CK2_1	237	243	PF00069	0.186
MOD_CK2_1	269	275	PF00069	0.498
MOD_CK2_1	303	309	PF00069	0.453
MOD_CMANNOS	220	223	PF00535	0.250
MOD_GlcNHglycan	114	117	PF01048	0.276
MOD_GlcNHglycan	175	179	PF01048	0.350
MOD_GlcNHglycan	212	215	PF01048	0.356
MOD_GlcNHglycan	226	229	PF01048	0.344
MOD_GlcNHglycan	23	26	PF01048	0.565
MOD_GlcNHglycan	258	261	PF01048	0.385
MOD_GlcNHglycan	305	308	PF01048	0.312
MOD_GlcNHglycan	315	318	PF01048	0.308
MOD_GlcNHglycan	322	325	PF01048	0.268
MOD_GlcNHglycan	516	519	PF01048	0.436
MOD_GSK3_1	103	110	PF00069	0.459
MOD_GSK3_1	252	259	PF00069	0.450
MOD_GSK3_1	297	304	PF00069	0.446
MOD_GSK3_1	397	404	PF00069	0.293
MOD_GSK3_1	498	505	PF00069	0.362
MOD_GSK3_1	584	591	PF00069	0.373
MOD_GSK3_1	601	608	PF00069	0.318
MOD_N-GLC_1	21	26	PF02516	0.430
MOD_NEK2_1	107	112	PF00069	0.300
MOD_NEK2_1	128	133	PF00069	0.375
MOD_NEK2_1	146	151	PF00069	0.282
MOD_NEK2_1	186	191	PF00069	0.351
MOD_NEK2_1	224	229	PF00069	0.324
MOD_NEK2_1	297	302	PF00069	0.279
MOD_NEK2_1	383	388	PF00069	0.364
MOD_NEK2_1	389	394	PF00069	0.348
MOD_NEK2_1	397	402	PF00069	0.327
MOD_NEK2_1	408	413	PF00069	0.319
MOD_NEK2_1	473	478	PF00069	0.348
MOD_NEK2_1	502	507	PF00069	0.360
MOD_NEK2_1	584	589	PF00069	0.352
MOD_NEK2_1	70	75	PF00069	0.410
MOD_NEK2_2	103	108	PF00069	0.190
MOD_NEK2_2	341	346	PF00069	0.319
MOD_NEK2_2	432	437	PF00069	0.422
MOD_NEK2_2	451	456	PF00069	0.336
MOD_PIKK_1	252	258	PF00454	0.200
MOD_PK_1	121	127	PF00069	0.451
MOD_PKA_1	173	179	PF00069	0.341
MOD_PKA_2	301	307	PF00069	0.200
MOD_PKA_2	502	508	PF00069	0.348
MOD_PKA_2	567	573	PF00069	0.333
MOD_PKA_2	79	85	PF00069	0.397
MOD_PKB_1	208	216	PF00069	0.200
MOD_Plk_1	21	27	PF00069	0.434
MOD_Plk_1	547	553	PF00069	0.328
MOD_Plk_4	213	219	PF00069	0.339
MOD_Plk_4	226	232	PF00069	0.329
MOD_Plk_4	384	390	PF00069	0.347
MOD_Plk_4	397	403	PF00069	0.302
MOD_Plk_4	432	438	PF00069	0.437
MOD_Plk_4	451	457	PF00069	0.337
MOD_Plk_4	547	553	PF00069	0.307
MOD_Plk_4	555	561	PF00069	0.306
MOD_Plk_4	569	575	PF00069	0.369
MOD_Plk_4	591	597	PF00069	0.338
MOD_Plk_4	630	636	PF00069	0.367
MOD_Plk_4	95	101	PF00069	0.324
MOD_SUMO_for_1	172	175	PF00179	0.196
MOD_SUMO_for_1	284	287	PF00179	0.391
MOD_SUMO_rev_2	30	39	PF00179	0.689
MOD_SUMO_rev_2	306	314	PF00179	0.405
MOD_SUMO_rev_2	594	602	PF00179	0.200
TRG_ENDOCYTIC_2	102	105	PF00928	0.356
TRG_ENDOCYTIC_2	119	122	PF00928	0.319
TRG_ENDOCYTIC_2	168	171	PF00928	0.335
TRG_ENDOCYTIC_2	203	206	PF00928	0.336
TRG_ENDOCYTIC_2	385	388	PF00928	0.346
TRG_ENDOCYTIC_2	410	413	PF00928	0.357
TRG_ENDOCYTIC_2	441	444	PF00928	0.351
TRG_ENDOCYTIC_2	445	448	PF00928	0.350
TRG_ENDOCYTIC_2	474	477	PF00928	0.350
TRG_ENDOCYTIC_2	530	533	PF00928	0.480
TRG_ENDOCYTIC_2	575	578	PF00928	0.339
TRG_ENDOCYTIC_2	97	100	PF00928	0.365
TRG_ER_diArg_1	18	21	PF00400	0.613
TRG_ER_diArg_1	207	210	PF00400	0.261
TRG_NES_CRM1_1	447	461	PF08389	0.300
TRG_NLS_MonoExtC_3	661	666	PF00514	0.675
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.294
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.277

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	48%	96%
A0A0N1HY49	Leptomonas seymouri	66%	100%
A0A0N1HZ06	Leptomonas seymouri	43%	100%
A0A0N1IHL1	Leptomonas seymouri	42%	95%
A0A0N1PAY4	Leptomonas seymouri	43%	77%
A0A0N1PB77	Leptomonas seymouri	40%	100%
A0A0N1PBZ2	Leptomonas seymouri	47%	100%
A0A0N1PCC1	Leptomonas seymouri	52%	100%
A0A0S4INN8	Bodo saltans	29%	100%
A0A381MBI0	Leishmania infantum	45%	100%
A0A3Q8I8X7	Leishmania donovani	45%	100%
A0A3Q8IAZ0	Leishmania donovani	44%	97%
A0A3Q8IH50	Leishmania donovani	49%	94%
A0A3Q8IVN0	Leishmania donovani	40%	100%
A0A3R7M4J1	Trypanosoma rangeli	44%	100%
A0A3S5H5P4	Leishmania donovani	100%	100%
A0A3S5H5V2	Leishmania donovani	45%	100%
A0A3S5H6F6	Leishmania donovani	44%	97%
A0A3S5H763	Leishmania donovani	49%	100%
A0A3S7WR10	Leishmania donovani	46%	91%
A0A3S7WR14	Leishmania donovani	45%	99%
A0A3S7WR15	Leishmania donovani	43%	80%
A0A3S7WR24	Leishmania donovani	43%	96%
A4H4T8	Leishmania braziliensis	44%	100%
A4H5Y4	Leishmania braziliensis	45%	100%
A4H617	Leishmania braziliensis	44%	100%
A4H618	Leishmania braziliensis	44%	100%
A4H619	Leishmania braziliensis	45%	100%
A4H620	Leishmania braziliensis	50%	100%
A4H6C3	Leishmania braziliensis	45%	100%
A4HNH7	Leishmania braziliensis	39%	98%
A4HUE4	Leishmania infantum	45%	91%
A4HUE5	Leishmania infantum	43%	98%
A4HUE6	Leishmania infantum	45%	99%
A4HUE7	Leishmania infantum	43%	97%
A4HUE8	Leishmania infantum	44%	96%
A4HUF4	Leishmania infantum	43%	97%
A4HUF5	Leishmania infantum	49%	100%
A4HYA9	Leishmania infantum	49%	100%
A4IC33	Leishmania infantum	40%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AG72	Leishmania infantum	45%	100%
E9AI40	Leishmania braziliensis	43%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	98%
Q4QDC4	Leishmania major	50%	100%
Q4QH81	Leishmania major	45%	100%
Q4QHH7	Leishmania major	49%	100%
Q4QHH8	Leishmania major	43%	100%
Q4QHH9	Leishmania major	43%	100%
Q4QHI0	Leishmania major	43%	100%
Q4QHI1	Leishmania major	45%	100%
Q4QHI2	Leishmania major	44%	100%
Q4QIU9	Leishmania major	46%	100%
Q4QJ48	Leishmania major	95%	100%
Q7KIP2	Leishmania major	38%	98%