Leucine zipper transcription factor-like protein 1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HSR6_LEIIN

TriTrypDb:

LINF_060007800

Length:

278

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HSR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSR6

Function

Biological processes
Term	Name	Level	Count
GO:0032879	regulation of localization	3	1
GO:0032880	regulation of protein localization	5	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0060341	regulation of cellular localization	4	1
GO:0065007	biological regulation	1	1
GO:1903564	regulation of protein localization to cilium	6	1
GO:1903565	negative regulation of protein localization to cilium	6	1
GO:1903828	negative regulation of protein localization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.569
CLV_NRD_NRD_1	201	203	PF00675	0.674
CLV_PCSK_KEX2_1	155	157	PF00082	0.488
CLV_PCSK_KEX2_1	201	203	PF00082	0.674
CLV_PCSK_KEX2_1	225	227	PF00082	0.586
CLV_PCSK_KEX2_1	30	32	PF00082	0.430
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.488
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.589
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.455
CLV_PCSK_SKI1_1	104	108	PF00082	0.535
CLV_PCSK_SKI1_1	242	246	PF00082	0.493
CLV_PCSK_SKI1_1	31	35	PF00082	0.513
CLV_PCSK_SKI1_1	86	90	PF00082	0.509
CLV_Separin_Metazoa	83	87	PF03568	0.515
DEG_Nend_UBRbox_2	1	3	PF02207	0.641
DOC_MAPK_gen_1	28	35	PF00069	0.522
DOC_MAPK_gen_1	94	103	PF00069	0.475
DOC_MAPK_MEF2A_6	94	103	PF00069	0.515
DOC_MAPK_NFAT4_5	94	102	PF00069	0.501
LIG_14-3-3_CanoR_1	173	183	PF00244	0.541
LIG_14-3-3_CanoR_1	23	27	PF00244	0.499
LIG_14-3-3_CanoR_1	231	241	PF00244	0.499
LIG_14-3-3_CanoR_1	94	100	PF00244	0.516
LIG_FHA_1	126	132	PF00498	0.664
LIG_FHA_1	177	183	PF00498	0.539
LIG_FHA_1	96	102	PF00498	0.483
LIG_FHA_2	133	139	PF00498	0.572
LIG_FHA_2	211	217	PF00498	0.565
LIG_FHA_2	49	55	PF00498	0.442
LIG_FHA_2	70	76	PF00498	0.544
LIG_GBD_Chelix_1	55	63	PF00786	0.508
LIG_LIR_Gen_1	165	172	PF02991	0.488
LIG_LIR_Gen_1	235	246	PF02991	0.518
LIG_LIR_Nem_3	165	171	PF02991	0.487
LIG_LIR_Nem_3	235	241	PF02991	0.521
LIG_LIR_Nem_3	263	269	PF02991	0.566
LIG_PCNA_TLS_4	12	19	PF02747	0.444
LIG_Pex14_1	46	50	PF04695	0.570
LIG_REV1ctd_RIR_1	16	24	PF16727	0.519
LIG_SH2_CRK	168	172	PF00017	0.500
LIG_SH2_CRK	238	242	PF00017	0.553
LIG_SH2_NCK_1	50	54	PF00017	0.502
LIG_SH2_SRC	262	265	PF00017	0.506
LIG_SH2_STAP1	168	172	PF00017	0.500
LIG_SH2_STAT5	168	171	PF00017	0.558
LIG_SH2_STAT5	50	53	PF00017	0.444
LIG_SUMO_SIM_par_1	132	138	PF11976	0.577
LIG_SUMO_SIM_par_1	97	102	PF11976	0.518
LIG_TRAF2_1	135	138	PF00917	0.624
LIG_TRAF2_1	213	216	PF00917	0.517
LIG_TYR_ITSM	234	241	PF00017	0.555
MOD_CK1_1	125	131	PF00069	0.678
MOD_CK1_1	176	182	PF00069	0.534
MOD_CK1_1	22	28	PF00069	0.507
MOD_CK2_1	132	138	PF00069	0.662
MOD_CK2_1	174	180	PF00069	0.587
MOD_CK2_1	210	216	PF00069	0.516
MOD_CK2_1	48	54	PF00069	0.453
MOD_CK2_1	69	75	PF00069	0.561
MOD_GlcNHglycan	124	127	PF01048	0.601
MOD_GlcNHglycan	137	142	PF01048	0.537
MOD_GlcNHglycan	36	40	PF01048	0.520
MOD_GlcNHglycan	80	83	PF01048	0.444
MOD_GSK3_1	162	169	PF00069	0.529
MOD_GSK3_1	206	213	PF00069	0.675
MOD_GSK3_1	31	38	PF00069	0.556
MOD_GSK3_1	74	81	PF00069	0.514
MOD_NEK2_1	19	24	PF00069	0.468
MOD_NEK2_1	210	215	PF00069	0.568
MOD_NEK2_1	232	237	PF00069	0.494
MOD_NEK2_1	74	79	PF00069	0.517
MOD_PIKK_1	166	172	PF00454	0.590
MOD_PIKK_1	233	239	PF00454	0.505
MOD_PIKK_1	69	75	PF00454	0.481
MOD_PKA_2	174	180	PF00069	0.527
MOD_PKA_2	19	25	PF00069	0.469
MOD_PKA_2	95	101	PF00069	0.442
MOD_Plk_1	31	37	PF00069	0.526
MOD_Plk_4	102	108	PF00069	0.537
MOD_SUMO_for_1	224	227	PF00179	0.586
MOD_SUMO_rev_2	100	106	PF00179	0.532
MOD_SUMO_rev_2	149	157	PF00179	0.491
TRG_ENDOCYTIC_2	168	171	PF00928	0.501
TRG_ENDOCYTIC_2	238	241	PF00928	0.498
TRG_ER_diArg_1	172	175	PF00400	0.529
TRG_ER_diArg_1	94	97	PF00400	0.501
TRG_NES_CRM1_1	57	71	PF08389	0.527
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	31	36	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I805	Leptomonas seymouri	78%	100%
A0A1X0NJT8	Trypanosomatidae	40%	82%
A0A3S7WPD4	Leishmania donovani	100%	100%
A0A422MY50	Trypanosoma rangeli	46%	92%
A4H4J1	Leishmania braziliensis	88%	100%
E9AKQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q3ZBL4	Bos taurus	25%	93%
Q4QJ54	Leishmania major	98%	100%
Q4R6V9	Macaca fascicularis	26%	93%
Q562C6	Rattus norvegicus	25%	93%
Q5RBR4	Pongo abelii	26%	93%
Q9JHQ5	Mus musculus	26%	93%
Q9NQ48	Homo sapiens	26%	93%
V5BAA5	Trypanosoma cruzi	43%	98%