EF-hand domain-containing protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HSR3_LEIIN

TriTrypDb:

LINF_060007500

Length:

286

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HSR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSR3

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.349
CLV_NRD_NRD_1	118	120	PF00675	0.355
CLV_NRD_NRD_1	24	26	PF00675	0.484
CLV_PCSK_KEX2_1	109	111	PF00082	0.357
CLV_PCSK_SKI1_1	17	21	PF00082	0.498
CLV_PCSK_SKI1_1	272	276	PF00082	0.656
CLV_PCSK_SKI1_1	56	60	PF00082	0.340
DEG_APCC_DBOX_1	55	63	PF00400	0.362
DEG_Nend_UBRbox_1	1	4	PF02207	0.658
DEG_SPOP_SBC_1	7	11	PF00917	0.645

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY2	Leptomonas seymouri	57%	97%
A0A0S4KGV5	Bodo saltans	30%	100%
A0A1X0NK20	Trypanosomatidae	31%	90%
A0A3R7M8M9	Trypanosoma rangeli	37%	100%
A0A3S7WPB5	Leishmania donovani	99%	100%
A4H4I8	Leishmania braziliensis	79%	100%
C9ZTB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AKQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QJ57	Leishmania major	91%	100%
V5B5T8	Trypanosoma cruzi	36%	100%

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