LeishMANIAdb
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EF-hand domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
EF-hand domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HSR3_LEIIN
TriTrypDb:
LINF_060007500
Length:
286

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HSR3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSR3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 109 111 PF00675 0.349
CLV_NRD_NRD_1 118 120 PF00675 0.355
CLV_NRD_NRD_1 24 26 PF00675 0.484
CLV_PCSK_KEX2_1 109 111 PF00082 0.357
CLV_PCSK_SKI1_1 17 21 PF00082 0.498
CLV_PCSK_SKI1_1 272 276 PF00082 0.656
CLV_PCSK_SKI1_1 56 60 PF00082 0.340
DEG_APCC_DBOX_1 55 63 PF00400 0.362
DEG_Nend_UBRbox_1 1 4 PF02207 0.658
DEG_SPOP_SBC_1 7 11 PF00917 0.645
DOC_ANK_TNKS_1 231 238 PF00023 0.606
DOC_MAPK_gen_1 109 118 PF00069 0.342
DOC_MAPK_HePTP_8 106 118 PF00069 0.284
DOC_MAPK_MEF2A_6 109 118 PF00069 0.357
DOC_MAPK_MEF2A_6 151 160 PF00069 0.491
DOC_MAPK_MEF2A_6 181 189 PF00069 0.472
DOC_MAPK_RevD_3 96 110 PF00069 0.465
DOC_PP4_FxxP_1 46 49 PF00568 0.338
DOC_USP7_MATH_1 8 12 PF00917 0.630
DOC_USP7_UBL2_3 120 124 PF12436 0.423
DOC_WW_Pin1_4 167 172 PF00397 0.557
DOC_WW_Pin1_4 252 257 PF00397 0.649
DOC_WW_Pin1_4 45 50 PF00397 0.494
LIG_14-3-3_CanoR_1 38 47 PF00244 0.480
LIG_AP2alpha_1 160 164 PF02296 0.474
LIG_BRCT_BRCA1_1 62 66 PF00533 0.197
LIG_CtBP_PxDLS_1 186 192 PF00389 0.415
LIG_deltaCOP1_diTrp_1 198 205 PF00928 0.415
LIG_FHA_1 101 107 PF00498 0.392
LIG_FHA_1 124 130 PF00498 0.457
LIG_FHA_1 168 174 PF00498 0.469
LIG_FHA_1 216 222 PF00498 0.527
LIG_FHA_1 269 275 PF00498 0.623
LIG_FHA_1 92 98 PF00498 0.424
LIG_FHA_2 131 137 PF00498 0.362
LIG_FHA_2 174 180 PF00498 0.356
LIG_FHA_2 193 199 PF00498 0.379
LIG_FHA_2 243 249 PF00498 0.580
LIG_FHA_2 253 259 PF00498 0.574
LIG_LIR_Apic_2 257 262 PF02991 0.639
LIG_LIR_Apic_2 44 49 PF02991 0.546
LIG_LIR_Gen_1 128 138 PF02991 0.390
LIG_LIR_Gen_1 68 79 PF02991 0.307
LIG_LIR_Nem_3 128 134 PF02991 0.393
LIG_LIR_Nem_3 135 141 PF02991 0.376
LIG_MLH1_MIPbox_1 62 66 PF16413 0.197
LIG_NRBOX 229 235 PF00104 0.501
LIG_Pex14_2 160 164 PF04695 0.328
LIG_RPA_C_Fungi 105 117 PF08784 0.287
LIG_SH2_CRK 131 135 PF00017 0.486
LIG_SH2_CRK 138 142 PF00017 0.462
LIG_SH2_CRK 259 263 PF00017 0.633
LIG_SH2_STAT5 183 186 PF00017 0.333
LIG_SH2_STAT5 243 246 PF00017 0.664
LIG_TRAF2_1 246 249 PF00917 0.628
LIG_TYR_ITIM 129 134 PF00017 0.478
MOD_CK1_1 100 106 PF00069 0.455
MOD_CK1_1 130 136 PF00069 0.455
MOD_CK1_1 215 221 PF00069 0.543
MOD_CK1_1 228 234 PF00069 0.446
MOD_CK1_1 254 260 PF00069 0.625
MOD_CK1_1 48 54 PF00069 0.441
MOD_CK2_1 173 179 PF00069 0.334
MOD_CK2_1 192 198 PF00069 0.442
MOD_CK2_1 242 248 PF00069 0.585
MOD_CK2_1 38 44 PF00069 0.453
MOD_CK2_1 7 13 PF00069 0.636
MOD_GlcNHglycan 50 53 PF01048 0.422
MOD_GlcNHglycan 93 97 PF01048 0.424
MOD_GSK3_1 100 107 PF00069 0.431
MOD_GSK3_1 123 130 PF00069 0.409
MOD_GSK3_1 2 9 PF00069 0.633
MOD_GSK3_1 215 222 PF00069 0.499
MOD_GSK3_1 275 282 PF00069 0.629
MOD_GSK3_1 60 67 PF00069 0.422
MOD_N-GLC_2 163 165 PF02516 0.390
MOD_NEK2_1 1 6 PF00069 0.638
MOD_NEK2_1 12 17 PF00069 0.583
MOD_NEK2_1 199 204 PF00069 0.480
MOD_NEK2_1 212 217 PF00069 0.388
MOD_NEK2_1 221 226 PF00069 0.538
MOD_NEK2_1 242 247 PF00069 0.562
MOD_NEK2_1 91 96 PF00069 0.431
MOD_NEK2_1 97 102 PF00069 0.329
MOD_PIKK_1 212 218 PF00454 0.511
MOD_PIKK_1 38 44 PF00454 0.408
MOD_PK_1 60 66 PF00069 0.458
MOD_PKA_2 228 234 PF00069 0.569
MOD_Plk_1 60 66 PF00069 0.395
MOD_Plk_1 92 98 PF00069 0.407
MOD_ProDKin_1 167 173 PF00069 0.558
MOD_ProDKin_1 252 258 PF00069 0.654
MOD_ProDKin_1 45 51 PF00069 0.489
MOD_SUMO_rev_2 253 262 PF00179 0.514
TRG_DiLeu_BaEn_1 153 158 PF01217 0.431
TRG_DiLeu_BaLyEn_6 229 234 PF01217 0.597
TRG_ENDOCYTIC_2 131 134 PF00928 0.426
TRG_ENDOCYTIC_2 138 141 PF00928 0.343
TRG_ENDOCYTIC_2 71 74 PF00928 0.409
TRG_Pf-PMV_PEXEL_1 232 236 PF00026 0.609
TRG_Pf-PMV_PEXEL_1 272 276 PF00026 0.524

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBY2 Leptomonas seymouri 57% 97%
A0A0S4KGV5 Bodo saltans 30% 100%
A0A1X0NK20 Trypanosomatidae 31% 90%
A0A3R7M8M9 Trypanosoma rangeli 37% 100%
A0A3S7WPB5 Leishmania donovani 99% 100%
A4H4I8 Leishmania braziliensis 79% 100%
C9ZTB1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9AKQ0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4QJ57 Leishmania major 91% 100%
V5B5T8 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS