Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FHA domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HSR2_LEIIN

TriTrypDb:

LINF_060007400

Length:

667

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HSR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSR2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.362
CLV_C14_Caspase3-7	357	361	PF00656	0.605
CLV_C14_Caspase3-7	530	534	PF00656	0.416
CLV_NRD_NRD_1	20	22	PF00675	0.401
CLV_NRD_NRD_1	330	332	PF00675	0.678
CLV_NRD_NRD_1	429	431	PF00675	0.796
CLV_NRD_NRD_1	587	589	PF00675	0.598
CLV_PCSK_KEX2_1	20	22	PF00082	0.401
CLV_PCSK_KEX2_1	330	332	PF00082	0.682
CLV_PCSK_KEX2_1	428	430	PF00082	0.722
CLV_PCSK_KEX2_1	442	444	PF00082	0.557
CLV_PCSK_KEX2_1	592	594	PF00082	0.634
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.592
CLV_PCSK_PC1ET2_1	592	594	PF00082	0.622
CLV_PCSK_PC7_1	588	594	PF00082	0.649
CLV_PCSK_SKI1_1	222	226	PF00082	0.495
CLV_PCSK_SKI1_1	230	234	PF00082	0.466
CLV_PCSK_SKI1_1	309	313	PF00082	0.672
DEG_SPOP_SBC_1	70	74	PF00917	0.362
DOC_CKS1_1	115	120	PF01111	0.362
DOC_CKS1_1	248	253	PF01111	0.675
DOC_CKS1_1	362	367	PF01111	0.566
DOC_CKS1_1	616	621	PF01111	0.462
DOC_CYCLIN_yCln2_LP_2	366	372	PF00134	0.660
DOC_MAPK_gen_1	20	26	PF00069	0.402
DOC_MAPK_gen_1	501	510	PF00069	0.513
DOC_MAPK_MEF2A_6	504	512	PF00069	0.466
DOC_MAPK_MEF2A_6	524	531	PF00069	0.244
DOC_PP1_RVXF_1	550	557	PF00149	0.374
DOC_PP2B_LxvP_1	217	220	PF13499	0.473
DOC_PP2B_LxvP_1	658	661	PF13499	0.573
DOC_PP4_FxxP_1	301	304	PF00568	0.613
DOC_USP7_MATH_1	236	240	PF00917	0.511
DOC_USP7_MATH_1	243	247	PF00917	0.696
DOC_USP7_MATH_1	325	329	PF00917	0.727
DOC_USP7_MATH_1	421	425	PF00917	0.731
DOC_USP7_MATH_1	493	497	PF00917	0.693
DOC_USP7_MATH_1	511	515	PF00917	0.258
DOC_USP7_MATH_1	572	576	PF00917	0.601
DOC_USP7_MATH_1	659	663	PF00917	0.520
DOC_USP7_MATH_1	69	73	PF00917	0.346
DOC_USP7_MATH_1	86	90	PF00917	0.222
DOC_USP7_MATH_2	471	477	PF00917	0.496
DOC_USP7_UBL2_3	592	596	PF12436	0.636
DOC_WW_Pin1_4	104	109	PF00397	0.299
DOC_WW_Pin1_4	114	119	PF00397	0.252
DOC_WW_Pin1_4	212	217	PF00397	0.447
DOC_WW_Pin1_4	247	252	PF00397	0.654
DOC_WW_Pin1_4	28	33	PF00397	0.450
DOC_WW_Pin1_4	289	294	PF00397	0.573
DOC_WW_Pin1_4	300	305	PF00397	0.608
DOC_WW_Pin1_4	361	366	PF00397	0.693
DOC_WW_Pin1_4	419	424	PF00397	0.677
DOC_WW_Pin1_4	429	434	PF00397	0.569
DOC_WW_Pin1_4	457	462	PF00397	0.465
DOC_WW_Pin1_4	478	483	PF00397	0.624
DOC_WW_Pin1_4	594	599	PF00397	0.620
DOC_WW_Pin1_4	612	617	PF00397	0.570
DOC_WW_Pin1_4	652	657	PF00397	0.441
DOC_WW_Pin1_4	79	84	PF00397	0.310
DOC_WW_Pin1_4	88	93	PF00397	0.364
LIG_14-3-3_CanoR_1	13	19	PF00244	0.402
LIG_14-3-3_CanoR_1	200	207	PF00244	0.582
LIG_14-3-3_CanoR_1	21	27	PF00244	0.414
LIG_14-3-3_CanoR_1	330	336	PF00244	0.760
LIG_14-3-3_CanoR_1	342	347	PF00244	0.566
LIG_14-3-3_CanoR_1	37	45	PF00244	0.316
LIG_BIR_II_1	1	5	PF00653	0.461
LIG_BIR_III_4	395	399	PF00653	0.458
LIG_BRCT_BRCA1_1	47	51	PF00533	0.461
LIG_deltaCOP1_diTrp_1	550	556	PF00928	0.374
LIG_deltaCOP1_diTrp_1	624	630	PF00928	0.386
LIG_DLG_GKlike_1	331	339	PF00625	0.666
LIG_eIF4E_1	187	193	PF01652	0.429
LIG_eIF4E_1	212	218	PF01652	0.505
LIG_EVH1_2	206	210	PF00568	0.499
LIG_FHA_1	131	137	PF00498	0.365
LIG_FHA_1	213	219	PF00498	0.455
LIG_FHA_1	300	306	PF00498	0.670
LIG_FHA_1	350	356	PF00498	0.765
LIG_FHA_1	515	521	PF00498	0.381
LIG_FHA_1	560	566	PF00498	0.565
LIG_FHA_1	595	601	PF00498	0.689
LIG_FHA_1	607	613	PF00498	0.667
LIG_FHA_2	105	111	PF00498	0.362
LIG_FHA_2	121	127	PF00498	0.216
LIG_FHA_2	281	287	PF00498	0.611
LIG_FHA_2	342	348	PF00498	0.673
LIG_FHA_2	76	82	PF00498	0.333
LIG_LIR_Apic_2	185	190	PF02991	0.443
LIG_LIR_Gen_1	473	482	PF02991	0.524
LIG_LIR_Gen_1	6	15	PF02991	0.368
LIG_LIR_Nem_3	473	478	PF02991	0.517
LIG_LIR_Nem_3	6	12	PF02991	0.366
LIG_PDZ_Class_2	662	667	PF00595	0.535
LIG_Pex14_1	626	630	PF04695	0.370
LIG_PTB_Apo_2	388	395	PF02174	0.394
LIG_PTB_Phospho_1	388	394	PF10480	0.451
LIG_SH2_CRK	384	388	PF00017	0.383
LIG_SH2_PTP2	507	510	PF00017	0.380
LIG_SH2_STAT3	634	637	PF00017	0.409
LIG_SH2_STAT5	137	140	PF00017	0.299
LIG_SH2_STAT5	212	215	PF00017	0.488
LIG_SH2_STAT5	507	510	PF00017	0.380
LIG_SH3_3	21	27	PF00018	0.466
LIG_SH3_3	372	378	PF00018	0.541
LIG_SH3_3	448	454	PF00018	0.538
LIG_SH3_3	505	511	PF00018	0.458
LIG_SH3_3	516	522	PF00018	0.329
LIG_SH3_3	562	568	PF00018	0.514
LIG_SH3_3	613	619	PF00018	0.542
LIG_SH3_3	636	642	PF00018	0.405
LIG_SH3_3	9	15	PF00018	0.359
LIG_SUMO_SIM_anti_2	332	338	PF11976	0.667
LIG_SUMO_SIM_par_1	223	229	PF11976	0.547
LIG_SUMO_SIM_par_1	641	646	PF11976	0.458
LIG_TRAF2_1	315	318	PF00917	0.647
LIG_TRAF2_1	348	351	PF00917	0.677
LIG_TRAF2_1	400	403	PF00917	0.612
LIG_TYR_ITIM	382	387	PF00017	0.397
LIG_UBA3_1	59	65	PF00899	0.299
MOD_CDK_SPK_2	114	119	PF00069	0.266
MOD_CDK_SPK_2	289	294	PF00069	0.567
MOD_CDK_SPxK_1	434	440	PF00069	0.609
MOD_CDK_SPxxK_3	419	426	PF00069	0.675
MOD_CDK_SPxxK_3	478	485	PF00069	0.671
MOD_CDK_SPxxK_3	615	622	PF00069	0.470
MOD_CK1_1	144	150	PF00069	0.333
MOD_CK1_1	247	253	PF00069	0.705
MOD_CK1_1	28	34	PF00069	0.528
MOD_CK1_1	303	309	PF00069	0.690
MOD_CK1_1	361	367	PF00069	0.636
MOD_CK1_1	432	438	PF00069	0.675
MOD_CK1_1	496	502	PF00069	0.762
MOD_CK1_1	514	520	PF00069	0.261
MOD_CK1_1	548	554	PF00069	0.433
MOD_CK1_1	559	565	PF00069	0.516
MOD_CK1_1	580	586	PF00069	0.594
MOD_CK1_1	615	621	PF00069	0.536
MOD_CK1_1	72	78	PF00069	0.336
MOD_CK2_1	341	347	PF00069	0.670
MOD_CK2_1	350	356	PF00069	0.592
MOD_CMANNOS	553	556	PF00535	0.354
MOD_Cter_Amidation	328	331	PF01082	0.667
MOD_GlcNHglycan	154	157	PF01048	0.296
MOD_GlcNHglycan	201	204	PF01048	0.623
MOD_GlcNHglycan	252	255	PF01048	0.719
MOD_GlcNHglycan	276	279	PF01048	0.734
MOD_GlcNHglycan	327	330	PF01048	0.723
MOD_GlcNHglycan	350	355	PF01048	0.675
MOD_GlcNHglycan	419	422	PF01048	0.760
MOD_GlcNHglycan	423	426	PF01048	0.695
MOD_GlcNHglycan	434	437	PF01048	0.548
MOD_GlcNHglycan	495	498	PF01048	0.688
MOD_GlcNHglycan	545	548	PF01048	0.467
MOD_GlcNHglycan	662	665	PF01048	0.603
MOD_GSK3_1	136	143	PF00069	0.339
MOD_GSK3_1	206	213	PF00069	0.624
MOD_GSK3_1	232	239	PF00069	0.480
MOD_GSK3_1	243	250	PF00069	0.641
MOD_GSK3_1	299	306	PF00069	0.744
MOD_GSK3_1	325	332	PF00069	0.640
MOD_GSK3_1	417	424	PF00069	0.693
MOD_GSK3_1	45	52	PF00069	0.531
MOD_GSK3_1	496	503	PF00069	0.678
MOD_GSK3_1	510	517	PF00069	0.306
MOD_GSK3_1	602	609	PF00069	0.565
MOD_GSK3_1	659	666	PF00069	0.541
MOD_GSK3_1	70	77	PF00069	0.331
MOD_GSK3_1	82	89	PF00069	0.221
MOD_LATS_1	307	313	PF00433	0.672
MOD_N-GLC_1	144	149	PF02516	0.299
MOD_N-GLC_1	28	33	PF02516	0.411
MOD_N-GLC_1	390	395	PF02516	0.430
MOD_NEK2_1	141	146	PF00069	0.308
MOD_NEK2_1	210	215	PF00069	0.461
MOD_NEK2_1	22	27	PF00069	0.476
MOD_NEK2_1	232	237	PF00069	0.471
MOD_NEK2_1	49	54	PF00069	0.378
MOD_NEK2_2	572	577	PF00069	0.499
MOD_PIKK_1	335	341	PF00454	0.663
MOD_PIKK_1	452	458	PF00454	0.500
MOD_PIKK_1	50	56	PF00454	0.299
MOD_PIKK_1	556	562	PF00454	0.485
MOD_PK_1	596	602	PF00069	0.655
MOD_PKA_2	131	137	PF00069	0.321
MOD_PKA_2	152	158	PF00069	0.286
MOD_PKA_2	199	205	PF00069	0.571
MOD_PKA_2	22	28	PF00069	0.475
MOD_PKA_2	329	335	PF00069	0.638
MOD_PKA_2	341	347	PF00069	0.590
MOD_PKA_2	36	42	PF00069	0.341
MOD_PKA_2	500	506	PF00069	0.585
MOD_PKA_2	572	578	PF00069	0.666
MOD_Plk_1	390	396	PF00069	0.405
MOD_Plk_2-3	266	272	PF00069	0.609
MOD_Plk_4	144	150	PF00069	0.333
MOD_Plk_4	331	337	PF00069	0.670
MOD_Plk_4	45	51	PF00069	0.420
MOD_Plk_4	514	520	PF00069	0.376
MOD_Plk_4	55	61	PF00069	0.377
MOD_ProDKin_1	104	110	PF00069	0.299
MOD_ProDKin_1	114	120	PF00069	0.252
MOD_ProDKin_1	212	218	PF00069	0.449
MOD_ProDKin_1	247	253	PF00069	0.654
MOD_ProDKin_1	28	34	PF00069	0.443
MOD_ProDKin_1	289	295	PF00069	0.575
MOD_ProDKin_1	300	306	PF00069	0.604
MOD_ProDKin_1	361	367	PF00069	0.691
MOD_ProDKin_1	419	425	PF00069	0.675
MOD_ProDKin_1	429	435	PF00069	0.572
MOD_ProDKin_1	457	463	PF00069	0.462
MOD_ProDKin_1	478	484	PF00069	0.631
MOD_ProDKin_1	594	600	PF00069	0.622
MOD_ProDKin_1	612	618	PF00069	0.557
MOD_ProDKin_1	652	658	PF00069	0.456
MOD_ProDKin_1	79	85	PF00069	0.310
MOD_ProDKin_1	88	94	PF00069	0.364
TRG_DiLeu_BaEn_1	228	233	PF01217	0.472
TRG_DiLeu_BaEn_4	228	234	PF01217	0.533
TRG_ENDOCYTIC_2	384	387	PF00928	0.386
TRG_ENDOCYTIC_2	507	510	PF00928	0.352
TRG_ER_diArg_1	20	23	PF00400	0.420
TRG_ER_diArg_1	428	430	PF00400	0.711
TRG_NLS_Bipartite_1	428	446	PF00514	0.641
TRG_NLS_MonoExtC_3	441	447	PF00514	0.575
TRG_NLS_MonoExtN_4	439	446	PF00514	0.580
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	404	409	PF00026	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4Z7	Leptomonas seymouri	44%	100%
A0A3S7WPD3	Leishmania donovani	99%	100%
E9AKP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QJ58	Leishmania major	91%	100%