ULP_PROTEASE domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HSR1_LEIIN

TriTrypDb:

LINF_060007100

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HSR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.582
CLV_C14_Caspase3-7	278	282	PF00656	0.636
CLV_NRD_NRD_1	140	142	PF00675	0.725
CLV_NRD_NRD_1	160	162	PF00675	0.681
CLV_NRD_NRD_1	194	196	PF00675	0.601
CLV_NRD_NRD_1	203	205	PF00675	0.503
CLV_NRD_NRD_1	218	220	PF00675	0.623
CLV_NRD_NRD_1	252	254	PF00675	0.615
CLV_NRD_NRD_1	268	270	PF00675	0.658
CLV_NRD_NRD_1	50	52	PF00675	0.748
CLV_NRD_NRD_1	55	57	PF00675	0.677
CLV_NRD_NRD_1	77	79	PF00675	0.780
CLV_PCSK_KEX2_1	140	142	PF00082	0.725
CLV_PCSK_KEX2_1	160	162	PF00082	0.682
CLV_PCSK_KEX2_1	193	195	PF00082	0.625
CLV_PCSK_KEX2_1	203	205	PF00082	0.501
CLV_PCSK_KEX2_1	218	220	PF00082	0.623
CLV_PCSK_KEX2_1	252	254	PF00082	0.615
CLV_PCSK_KEX2_1	268	270	PF00082	0.658
CLV_PCSK_KEX2_1	292	294	PF00082	0.608
CLV_PCSK_KEX2_1	495	497	PF00082	0.494
CLV_PCSK_KEX2_1	50	52	PF00082	0.748
CLV_PCSK_KEX2_1	55	57	PF00082	0.677
CLV_PCSK_KEX2_1	77	79	PF00082	0.780
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.604
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.494
CLV_PCSK_PC7_1	46	52	PF00082	0.676
CLV_PCSK_PC7_1	491	497	PF00082	0.440
CLV_PCSK_SKI1_1	203	207	PF00082	0.531
CLV_PCSK_SKI1_1	232	236	PF00082	0.717
CLV_PCSK_SKI1_1	491	495	PF00082	0.417
CLV_PCSK_SKI1_1	78	82	PF00082	0.622
DEG_APCC_DBOX_1	77	85	PF00400	0.638
DEG_SPOP_SBC_1	468	472	PF00917	0.409
DOC_CKS1_1	311	316	PF01111	0.531
DOC_MAPK_DCC_7	253	263	PF00069	0.671
DOC_MAPK_DCC_7	295	305	PF00069	0.524
DOC_MAPK_gen_1	431	441	PF00069	0.472
DOC_MAPK_MEF2A_6	4	11	PF00069	0.614
DOC_MAPK_MEF2A_6	434	441	PF00069	0.458
DOC_PP2B_LxvP_1	255	258	PF13499	0.694
DOC_PP2B_LxvP_1	334	337	PF13499	0.613
DOC_USP7_MATH_1	122	126	PF00917	0.597
DOC_USP7_MATH_1	139	143	PF00917	0.638
DOC_USP7_MATH_1	179	183	PF00917	0.681
DOC_USP7_MATH_1	233	237	PF00917	0.614
DOC_USP7_MATH_1	262	266	PF00917	0.614
DOC_USP7_MATH_1	31	35	PF00917	0.591
DOC_USP7_MATH_1	326	330	PF00917	0.694
DOC_USP7_MATH_1	440	444	PF00917	0.481
DOC_USP7_MATH_1	468	472	PF00917	0.454
DOC_USP7_MATH_1	73	77	PF00917	0.767
DOC_USP7_UBL2_3	434	438	PF12436	0.481
DOC_WW_Pin1_4	10	15	PF00397	0.654
DOC_WW_Pin1_4	104	109	PF00397	0.612
DOC_WW_Pin1_4	310	315	PF00397	0.533
DOC_WW_Pin1_4	35	40	PF00397	0.595
DOC_WW_Pin1_4	97	102	PF00397	0.606
LIG_14-3-3_CanoR_1	140	144	PF00244	0.726
LIG_14-3-3_CanoR_1	23	28	PF00244	0.624
LIG_14-3-3_CanoR_1	268	277	PF00244	0.741
LIG_14-3-3_CanoR_1	293	298	PF00244	0.573
LIG_14-3-3_CanoR_1	333	337	PF00244	0.624
LIG_14-3-3_CanoR_1	397	403	PF00244	0.353
LIG_14-3-3_CanoR_1	424	430	PF00244	0.457
LIG_14-3-3_CanoR_1	462	467	PF00244	0.465
LIG_14-3-3_CanoR_1	469	477	PF00244	0.386
LIG_14-3-3_CanoR_1	77	84	PF00244	0.701
LIG_Actin_WH2_2	409	426	PF00022	0.422
LIG_BIR_II_1	1	5	PF00653	0.602
LIG_BIR_III_2	136	140	PF00653	0.643
LIG_Clathr_ClatBox_1	413	417	PF01394	0.340
LIG_FHA_1	204	210	PF00498	0.616
LIG_FHA_1	233	239	PF00498	0.663
LIG_FHA_1	240	246	PF00498	0.593
LIG_FHA_1	258	264	PF00498	0.694
LIG_FHA_1	366	372	PF00498	0.644
LIG_FHA_1	413	419	PF00498	0.423
LIG_FHA_1	434	440	PF00498	0.519
LIG_FHA_1	447	453	PF00498	0.335
LIG_FHA_2	481	487	PF00498	0.402
LIG_FHA_2	86	92	PF00498	0.610
LIG_LIR_Apic_2	296	300	PF02991	0.635
LIG_LIR_Gen_1	461	468	PF02991	0.435
LIG_LIR_Nem_3	272	277	PF02991	0.643
LIG_LIR_Nem_3	461	467	PF02991	0.443
LIG_NRP_CendR_1	495	497	PF00754	0.482
LIG_SH2_CRK	464	468	PF00017	0.376
LIG_SH2_NCK_1	464	468	PF00017	0.434
LIG_SH2_STAP1	464	468	PF00017	0.376
LIG_SH2_STAT3	321	324	PF00017	0.691
LIG_SH2_STAT5	321	324	PF00017	0.583
LIG_SH2_STAT5	394	397	PF00017	0.385
LIG_SH2_STAT5	464	467	PF00017	0.380
LIG_SH3_3	16	22	PF00018	0.646
LIG_SH3_3	244	250	PF00018	0.615
LIG_SH3_3	256	262	PF00018	0.751
LIG_SH3_3	298	304	PF00018	0.619
LIG_SH3_3	319	325	PF00018	0.650
LIG_SH3_3	8	14	PF00018	0.651
LIG_SUMO_SIM_par_1	411	417	PF11976	0.363
LIG_SUMO_SIM_par_1	443	450	PF11976	0.471
LIG_WRC_WIRS_1	403	408	PF05994	0.403
LIG_WW_2	301	304	PF00397	0.517
MOD_CDK_SPxxK_3	310	317	PF00069	0.537
MOD_CK1_1	13	19	PF00069	0.636
MOD_CK1_1	153	159	PF00069	0.733
MOD_CK1_1	172	178	PF00069	0.685
MOD_CK1_1	26	32	PF00069	0.636
MOD_CK1_1	272	278	PF00069	0.777
MOD_CK1_1	283	289	PF00069	0.696
MOD_CK1_1	316	322	PF00069	0.587
MOD_CK1_1	76	82	PF00069	0.788
MOD_CK2_1	153	159	PF00069	0.712
MOD_CK2_1	293	299	PF00069	0.627
MOD_CK2_1	480	486	PF00069	0.404
MOD_CK2_1	85	91	PF00069	0.610
MOD_GlcNHglycan	124	127	PF01048	0.596
MOD_GlcNHglycan	128	131	PF01048	0.628
MOD_GlcNHglycan	155	158	PF01048	0.779
MOD_GlcNHglycan	181	184	PF01048	0.759
MOD_GlcNHglycan	221	224	PF01048	0.640
MOD_GlcNHglycan	235	238	PF01048	0.732
MOD_GlcNHglycan	276	280	PF01048	0.703
MOD_GlcNHglycan	29	32	PF01048	0.755
MOD_GlcNHglycan	328	331	PF01048	0.574
MOD_GlcNHglycan	33	36	PF01048	0.755
MOD_GlcNHglycan	347	350	PF01048	0.650
MOD_GlcNHglycan	382	385	PF01048	0.619
MOD_GlcNHglycan	410	413	PF01048	0.400
MOD_GSK3_1	104	111	PF00069	0.620
MOD_GSK3_1	112	119	PF00069	0.615
MOD_GSK3_1	120	127	PF00069	0.604
MOD_GSK3_1	13	20	PF00069	0.620
MOD_GSK3_1	165	172	PF00069	0.665
MOD_GSK3_1	23	30	PF00069	0.671
MOD_GSK3_1	257	264	PF00069	0.717
MOD_GSK3_1	275	282	PF00069	0.756
MOD_GSK3_1	283	290	PF00069	0.560
MOD_GSK3_1	306	313	PF00069	0.638
MOD_GSK3_1	31	38	PF00069	0.551
MOD_GSK3_1	398	405	PF00069	0.386
MOD_GSK3_1	408	415	PF00069	0.395
MOD_GSK3_1	468	475	PF00069	0.419
MOD_GSK3_1	85	92	PF00069	0.665
MOD_N-GLC_1	153	158	PF02516	0.713
MOD_N-GLC_1	179	184	PF02516	0.585
MOD_N-GLC_1	240	245	PF02516	0.680
MOD_N-GLC_1	279	284	PF02516	0.707
MOD_N-GLC_1	365	370	PF02516	0.538
MOD_NEK2_1	165	170	PF00069	0.674
MOD_NEK2_1	284	289	PF00069	0.674
MOD_NEK2_1	402	407	PF00069	0.423
MOD_NEK2_1	423	428	PF00069	0.522
MOD_NEK2_1	89	94	PF00069	0.711
MOD_NEK2_2	433	438	PF00069	0.536
MOD_PIKK_1	306	312	PF00454	0.688
MOD_PIKK_1	423	429	PF00454	0.506
MOD_PIKK_1	472	478	PF00454	0.417
MOD_PK_1	23	29	PF00069	0.624
MOD_PKA_1	203	209	PF00069	0.614
MOD_PKA_2	113	119	PF00069	0.700
MOD_PKA_2	139	145	PF00069	0.726
MOD_PKA_2	203	209	PF00069	0.614
MOD_PKA_2	316	322	PF00069	0.691
MOD_PKA_2	332	338	PF00069	0.469
MOD_PKA_2	423	429	PF00069	0.439
MOD_PKA_2	468	474	PF00069	0.417
MOD_PKA_2	76	82	PF00069	0.720
MOD_Plk_1	179	185	PF00069	0.686
MOD_Plk_1	240	246	PF00069	0.676
MOD_Plk_1	279	285	PF00069	0.616
MOD_Plk_2-3	85	91	PF00069	0.529
MOD_Plk_4	316	322	PF00069	0.691
MOD_Plk_4	40	46	PF00069	0.676
MOD_Plk_4	440	446	PF00069	0.488
MOD_Plk_4	462	468	PF00069	0.399
MOD_ProDKin_1	10	16	PF00069	0.652
MOD_ProDKin_1	104	110	PF00069	0.612
MOD_ProDKin_1	310	316	PF00069	0.532
MOD_ProDKin_1	35	41	PF00069	0.596
MOD_ProDKin_1	97	103	PF00069	0.606
MOD_SUMO_for_1	418	421	PF00179	0.438
TRG_ENDOCYTIC_2	464	467	PF00928	0.380
TRG_ER_diArg_1	139	141	PF00400	0.685
TRG_ER_diArg_1	193	195	PF00400	0.620
TRG_ER_diArg_1	202	204	PF00400	0.502
TRG_ER_diArg_1	217	219	PF00400	0.626
TRG_ER_diArg_1	268	271	PF00400	0.660
TRG_ER_diArg_1	49	51	PF00400	0.680
TRG_ER_diArg_1	54	56	PF00400	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6H1	Leptomonas seymouri	39%	87%
A0A3S5H5N7	Leishmania donovani	99%	100%
A4H4I6	Leishmania braziliensis	70%	98%
E9AKP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QJ59	Leishmania major	92%	100%