Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin-like protein

Species:

Leishmania infantum

UniProt:

A4HSQ9_LEIIN

TriTrypDb:

LINF_060006900

Length:

662

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	9
GO:0099080	supramolecular complex	2	9
GO:0099081	supramolecular polymer	3	9
GO:0099512	supramolecular fiber	4	9
GO:0099513	polymeric cytoskeletal fiber	5	9
GO:0110165	cellular anatomical entity	1	9
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

A4HSQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSQ9

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003774	cytoskeletal motor activity	1	11
GO:0003777	microtubule motor activity	2	11
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0005524	ATP binding	5	11
GO:0008017	microtubule binding	5	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0015631	tubulin binding	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	2
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.457
CLV_C14_Caspase3-7	340	344	PF00656	0.379
CLV_NRD_NRD_1	191	193	PF00675	0.392
CLV_NRD_NRD_1	197	199	PF00675	0.380
CLV_NRD_NRD_1	200	202	PF00675	0.337
CLV_NRD_NRD_1	207	209	PF00675	0.247
CLV_NRD_NRD_1	506	508	PF00675	0.513
CLV_NRD_NRD_1	514	516	PF00675	0.549
CLV_NRD_NRD_1	568	570	PF00675	0.800
CLV_NRD_NRD_1	577	579	PF00675	0.688
CLV_PCSK_KEX2_1	191	193	PF00082	0.392
CLV_PCSK_KEX2_1	197	199	PF00082	0.380
CLV_PCSK_KEX2_1	206	208	PF00082	0.273
CLV_PCSK_KEX2_1	514	516	PF00082	0.566
CLV_PCSK_KEX2_1	577	579	PF00082	0.735
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.413
CLV_PCSK_SKI1_1	191	195	PF00082	0.424
CLV_PCSK_SKI1_1	201	205	PF00082	0.424
CLV_PCSK_SKI1_1	367	371	PF00082	0.424
CLV_PCSK_SKI1_1	38	42	PF00082	0.589
CLV_PCSK_SKI1_1	395	399	PF00082	0.369
CLV_PCSK_SKI1_1	496	500	PF00082	0.573
CLV_PCSK_SKI1_1	514	518	PF00082	0.356
CLV_PCSK_SKI1_1	577	581	PF00082	0.738
CLV_Separin_Metazoa	57	61	PF03568	0.643
DEG_APCC_KENBOX_2	507	511	PF00400	0.502
DEG_Nend_UBRbox_2	1	3	PF02207	0.772
DEG_SPOP_SBC_1	347	351	PF00917	0.379
DEG_SPOP_SBC_1	614	618	PF00917	0.780
DOC_CKS1_1	546	551	PF01111	0.591
DOC_CYCLIN_RxL_1	392	399	PF00134	0.422
DOC_CYCLIN_yCln2_LP_2	159	165	PF00134	0.457
DOC_MAPK_gen_1	289	298	PF00069	0.413
DOC_MAPK_gen_1	305	314	PF00069	0.269
DOC_MAPK_gen_1	364	373	PF00069	0.392
DOC_MAPK_gen_1	479	489	PF00069	0.536
DOC_MAPK_MEF2A_6	364	373	PF00069	0.388
DOC_MAPK_MEF2A_6	482	489	PF00069	0.566
DOC_PP1_RVXF_1	365	371	PF00149	0.385
DOC_PP2B_LxvP_1	123	126	PF13499	0.457
DOC_PP2B_LxvP_1	159	162	PF13499	0.418
DOC_PP2B_LxvP_1	517	520	PF13499	0.494
DOC_PP2B_LxvP_1	59	62	PF13499	0.641
DOC_PP4_FxxP_1	546	549	PF00568	0.520
DOC_USP7_MATH_1	110	114	PF00917	0.457
DOC_USP7_MATH_1	233	237	PF00917	0.448
DOC_USP7_MATH_1	243	247	PF00917	0.385
DOC_USP7_MATH_1	273	277	PF00917	0.403
DOC_USP7_MATH_1	335	339	PF00917	0.360
DOC_USP7_MATH_1	354	358	PF00917	0.369
DOC_USP7_MATH_1	359	363	PF00917	0.326
DOC_USP7_MATH_1	412	416	PF00917	0.445
DOC_USP7_MATH_1	421	425	PF00917	0.422
DOC_USP7_MATH_1	432	436	PF00917	0.344
DOC_USP7_MATH_1	590	594	PF00917	0.691
DOC_USP7_MATH_1	643	647	PF00917	0.614
DOC_USP7_MATH_1	7	11	PF00917	0.778
DOC_USP7_UBL2_3	202	206	PF12436	0.282
DOC_WW_Pin1_4	170	175	PF00397	0.438
DOC_WW_Pin1_4	348	353	PF00397	0.423
DOC_WW_Pin1_4	407	412	PF00397	0.348
DOC_WW_Pin1_4	456	461	PF00397	0.312
DOC_WW_Pin1_4	481	486	PF00397	0.511
DOC_WW_Pin1_4	49	54	PF00397	0.691
DOC_WW_Pin1_4	545	550	PF00397	0.645
DOC_WW_Pin1_4	564	569	PF00397	0.641
DOC_WW_Pin1_4	580	585	PF00397	0.723
DOC_WW_Pin1_4	606	611	PF00397	0.700
DOC_WW_Pin1_4	79	84	PF00397	0.663
DOC_WW_Pin1_4	9	14	PF00397	0.775
LIG_14-3-3_CanoR_1	197	203	PF00244	0.428
LIG_14-3-3_CanoR_1	268	278	PF00244	0.408
LIG_14-3-3_CanoR_1	378	384	PF00244	0.409
LIG_14-3-3_CanoR_1	38	46	PF00244	0.634
LIG_14-3-3_CanoR_1	434	438	PF00244	0.385
LIG_14-3-3_CanoR_1	48	53	PF00244	0.676
LIG_14-3-3_CanoR_1	563	568	PF00244	0.649
LIG_14-3-3_CanoR_1	606	610	PF00244	0.768
LIG_14-3-3_CterR_2	658	662	PF00244	0.783
LIG_Actin_WH2_2	182	199	PF00022	0.461
LIG_Actin_WH2_2	366	382	PF00022	0.424
LIG_Actin_WH2_2	499	516	PF00022	0.569
LIG_APCC_ABBA_1	248	253	PF00400	0.332
LIG_APCC_ABBA_1	323	328	PF00400	0.385
LIG_BIR_III_2	416	420	PF00653	0.340
LIG_BRCT_BRCA1_1	275	279	PF00533	0.457
LIG_Clathr_ClatBox_1	368	372	PF01394	0.424
LIG_FHA_1	149	155	PF00498	0.336
LIG_FHA_1	171	177	PF00498	0.443
LIG_FHA_1	437	443	PF00498	0.312
LIG_FHA_1	450	456	PF00498	0.312
LIG_FHA_1	482	488	PF00498	0.506
LIG_FHA_1	98	104	PF00498	0.381
LIG_FHA_2	112	118	PF00498	0.361
LIG_FHA_2	335	341	PF00498	0.437
LIG_FHA_2	616	622	PF00498	0.782
LIG_Integrin_RGD_1	220	222	PF01839	0.267
LIG_LIR_Gen_1	117	128	PF02991	0.387
LIG_LIR_Gen_1	246	255	PF02991	0.356
LIG_LIR_Gen_1	292	298	PF02991	0.385
LIG_LIR_Gen_1	31	40	PF02991	0.488
LIG_LIR_Nem_3	117	123	PF02991	0.351
LIG_LIR_Nem_3	246	250	PF02991	0.335
LIG_LIR_Nem_3	253	259	PF02991	0.306
LIG_LIR_Nem_3	292	297	PF02991	0.385
LIG_LIR_Nem_3	31	36	PF02991	0.640
LIG_LIR_Nem_3	324	329	PF02991	0.302
LIG_LIR_Nem_3	362	368	PF02991	0.391
LIG_MLH1_MIPbox_1	275	279	PF16413	0.457
LIG_NRBOX	254	260	PF00104	0.424
LIG_NRBOX	437	443	PF00104	0.332
LIG_Pex14_2	323	327	PF04695	0.424
LIG_REV1ctd_RIR_1	324	334	PF16727	0.457
LIG_SH2_CRK	183	187	PF00017	0.457
LIG_SH2_CRK	256	260	PF00017	0.355
LIG_SH2_CRK	365	369	PF00017	0.418
LIG_SH2_PTP2	247	250	PF00017	0.418
LIG_SH2_SRC	251	254	PF00017	0.457
LIG_SH2_STAP1	104	108	PF00017	0.418
LIG_SH2_STAP1	33	37	PF00017	0.614
LIG_SH2_STAP1	474	478	PF00017	0.355
LIG_SH2_STAT5	108	111	PF00017	0.406
LIG_SH2_STAT5	188	191	PF00017	0.424
LIG_SH2_STAT5	247	250	PF00017	0.346
LIG_SH3_1	581	587	PF00018	0.677
LIG_SH3_2	429	434	PF14604	0.424
LIG_SH3_2	75	80	PF14604	0.701
LIG_SH3_3	408	414	PF00018	0.400
LIG_SH3_3	426	432	PF00018	0.422
LIG_SH3_3	55	61	PF00018	0.570
LIG_SH3_3	581	587	PF00018	0.707
LIG_SH3_3	72	78	PF00018	0.697
LIG_SUMO_SIM_anti_2	136	142	PF11976	0.418
LIG_SUMO_SIM_anti_2	292	300	PF11976	0.355
LIG_SUMO_SIM_anti_2	646	652	PF11976	0.617
LIG_SUMO_SIM_par_1	292	300	PF11976	0.417
LIG_SUMO_SIM_par_1	402	408	PF11976	0.424
LIG_SUMO_SIM_par_1	646	652	PF11976	0.693
LIG_TRAF2_1	114	117	PF00917	0.457
LIG_TRAF2_1	498	501	PF00917	0.551
LIG_TYR_ITIM	181	186	PF00017	0.457
LIG_TYR_ITIM	363	368	PF00017	0.243
LIG_WW_3	553	557	PF00397	0.590
LIG_WW_3	560	564	PF00397	0.522
MOD_CDC14_SPxK_1	583	586	PF00782	0.652
MOD_CDK_SPK_2	564	569	PF00069	0.622
MOD_CDK_SPxK_1	564	570	PF00069	0.606
MOD_CDK_SPxK_1	580	586	PF00069	0.659
MOD_CK1_1	12	18	PF00069	0.793
MOD_CK1_1	148	154	PF00069	0.312
MOD_CK1_1	155	161	PF00069	0.312
MOD_CK1_1	227	233	PF00069	0.430
MOD_CK1_1	236	242	PF00069	0.335
MOD_CK1_1	31	37	PF00069	0.502
MOD_CK1_1	316	322	PF00069	0.312
MOD_CK1_1	396	402	PF00069	0.378
MOD_CK1_1	436	442	PF00069	0.330
MOD_CK1_1	468	474	PF00069	0.382
MOD_CK1_1	609	615	PF00069	0.738
MOD_CK1_1	617	623	PF00069	0.748
MOD_CK1_1	76	82	PF00069	0.779
MOD_CK1_1	97	103	PF00069	0.452
MOD_CK2_1	111	117	PF00069	0.388
MOD_CK2_1	243	249	PF00069	0.354
MOD_CK2_1	29	35	PF00069	0.649
MOD_CK2_1	334	340	PF00069	0.437
MOD_CK2_1	383	389	PF00069	0.388
MOD_CK2_1	613	619	PF00069	0.783
MOD_GlcNHglycan	147	150	PF01048	0.325
MOD_GlcNHglycan	154	157	PF01048	0.315
MOD_GlcNHglycan	216	219	PF01048	0.371
MOD_GlcNHglycan	226	229	PF01048	0.418
MOD_GlcNHglycan	233	236	PF01048	0.371
MOD_GlcNHglycan	271	274	PF01048	0.380
MOD_GlcNHglycan	337	340	PF01048	0.457
MOD_GlcNHglycan	356	359	PF01048	0.418
MOD_GlcNHglycan	383	386	PF01048	0.243
MOD_GlcNHglycan	407	410	PF01048	0.417
MOD_GlcNHglycan	460	463	PF01048	0.424
MOD_GlcNHglycan	556	559	PF01048	0.730
MOD_GlcNHglycan	599	602	PF01048	0.708
MOD_GlcNHglycan	627	630	PF01048	0.762
MOD_GlcNHglycan	70	73	PF01048	0.785
MOD_GlcNHglycan	9	12	PF01048	0.779
MOD_GSK3_1	148	155	PF00069	0.385
MOD_GSK3_1	166	173	PF00069	0.343
MOD_GSK3_1	227	234	PF00069	0.405
MOD_GSK3_1	239	246	PF00069	0.396
MOD_GSK3_1	269	276	PF00069	0.383
MOD_GSK3_1	354	361	PF00069	0.420
MOD_GSK3_1	379	386	PF00069	0.388
MOD_GSK3_1	389	396	PF00069	0.415
MOD_GSK3_1	432	439	PF00069	0.358
MOD_GSK3_1	44	51	PF00069	0.720
MOD_GSK3_1	590	597	PF00069	0.643
MOD_GSK3_1	605	612	PF00069	0.636
MOD_GSK3_1	613	620	PF00069	0.757
MOD_GSK3_1	79	86	PF00069	0.724
MOD_N-GLC_1	393	398	PF02516	0.312
MOD_NEK2_1	143	148	PF00069	0.359
MOD_NEK2_1	196	201	PF00069	0.431
MOD_NEK2_1	23	28	PF00069	0.558
MOD_NEK2_1	314	319	PF00069	0.398
MOD_NEK2_1	379	384	PF00069	0.301
MOD_NEK2_1	465	470	PF00069	0.388
MOD_NEK2_1	605	610	PF00069	0.671
MOD_NEK2_2	251	256	PF00069	0.424
MOD_NEK2_2	274	279	PF00069	0.403
MOD_NEK2_2	359	364	PF00069	0.243
MOD_PIKK_1	112	118	PF00454	0.382
MOD_PIKK_1	12	18	PF00454	0.667
MOD_PIKK_1	422	428	PF00454	0.383
MOD_PIKK_1	436	442	PF00454	0.329
MOD_PIKK_1	490	496	PF00454	0.532
MOD_PKA_1	197	203	PF00069	0.451
MOD_PKA_1	207	213	PF00069	0.388
MOD_PKA_1	577	583	PF00069	0.572
MOD_PKA_2	196	202	PF00069	0.431
MOD_PKA_2	207	213	PF00069	0.314
MOD_PKA_2	23	29	PF00069	0.693
MOD_PKA_2	269	275	PF00069	0.385
MOD_PKA_2	306	312	PF00069	0.388
MOD_PKA_2	433	439	PF00069	0.312
MOD_PKA_2	44	50	PF00069	0.698
MOD_PKA_2	562	568	PF00069	0.715
MOD_PKA_2	577	583	PF00069	0.747
MOD_PKA_2	605	611	PF00069	0.771
MOD_PKA_2	73	79	PF00069	0.741
MOD_Plk_1	393	399	PF00069	0.312
MOD_Plk_1	465	471	PF00069	0.385
MOD_Plk_4	136	142	PF00069	0.333
MOD_Plk_4	236	242	PF00069	0.369
MOD_Plk_4	243	249	PF00069	0.296
MOD_Plk_4	251	257	PF00069	0.253
MOD_Plk_4	274	280	PF00069	0.356
MOD_Plk_4	393	399	PF00069	0.388
MOD_Plk_4	433	439	PF00069	0.354
MOD_Plk_4	609	615	PF00069	0.778
MOD_Plk_4	643	649	PF00069	0.656
MOD_ProDKin_1	170	176	PF00069	0.438
MOD_ProDKin_1	348	354	PF00069	0.423
MOD_ProDKin_1	407	413	PF00069	0.348
MOD_ProDKin_1	456	462	PF00069	0.312
MOD_ProDKin_1	481	487	PF00069	0.510
MOD_ProDKin_1	49	55	PF00069	0.684
MOD_ProDKin_1	545	551	PF00069	0.652
MOD_ProDKin_1	564	570	PF00069	0.664
MOD_ProDKin_1	580	586	PF00069	0.723
MOD_ProDKin_1	606	612	PF00069	0.701
MOD_ProDKin_1	79	85	PF00069	0.663
MOD_ProDKin_1	9	15	PF00069	0.775
TRG_DiLeu_BaEn_1	292	297	PF01217	0.457
TRG_DiLeu_BaEn_3	117	123	PF01217	0.457
TRG_ENDOCYTIC_2	183	186	PF00928	0.457
TRG_ENDOCYTIC_2	247	250	PF00928	0.327
TRG_ENDOCYTIC_2	256	259	PF00928	0.298
TRG_ENDOCYTIC_2	33	36	PF00928	0.629
TRG_ENDOCYTIC_2	365	368	PF00928	0.418
TRG_ER_diArg_1	191	193	PF00400	0.394
TRG_ER_diArg_1	196	198	PF00400	0.385
TRG_ER_diArg_1	267	270	PF00400	0.411
TRG_ER_diArg_1	513	515	PF00400	0.557
TRG_NLS_Bipartite_1	191	205	PF00514	0.406
TRG_NLS_MonoExtN_4	198	205	PF00514	0.360
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY56	Leptomonas seymouri	52%	97%
A0A0S4ILK1	Bodo saltans	29%	77%
A0A0S4IP49	Bodo saltans	28%	82%
A0A0S4JN49	Bodo saltans	24%	91%
A0A0S4JQF7	Bodo saltans	28%	72%
A0A0S4KL43	Bodo saltans	30%	100%
A0A1X0NPH9	Trypanosomatidae	25%	72%
A0A1X0NQ03	Trypanosomatidae	26%	80%
A0A1X0P2B6	Trypanosomatidae	27%	100%
A0A1X0P9E3	Trypanosomatidae	30%	100%
A0A3R7LER1	Trypanosoma rangeli	25%	72%
A0A3R7MC35	Trypanosoma rangeli	38%	100%
A0A3S5H5N6	Leishmania donovani	100%	100%
A0A3S5IRH3	Trypanosoma rangeli	26%	100%
A0A3S7WU64	Leishmania donovani	25%	77%
A0A422NE49	Trypanosoma rangeli	25%	74%
A0A422NEQ8	Trypanosoma rangeli	27%	88%
A4H4I4	Leishmania braziliensis	75%	99%
A4HAQ7	Leishmania braziliensis	26%	100%
A4HX45	Leishmania infantum	25%	83%
C9ZU98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	82%
D0A992	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	72%
E9AKP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AVN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	74%
E9B004	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	69%
F4IL57	Arabidopsis thaliana	28%	67%
O14343	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	75%
O95235	Homo sapiens	23%	74%
P46864	Arabidopsis thaliana	27%	89%
P46865	Leishmania chagasi	28%	69%
P46870	Chlamydomonas reinhardtii	29%	85%
P53086	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	82%
P97329	Mus musculus	24%	75%
Q29RT6	Bos taurus	25%	75%
Q4Q348	Leishmania major	29%	70%
Q4QEL8	Leishmania major	25%	82%
Q4QJ61	Leishmania major	92%	100%
Q6H638	Oryza sativa subsp. japonica	28%	75%
Q75HV1	Oryza sativa subsp. japonica	27%	79%
Q9LPC6	Arabidopsis thaliana	26%	74%
V5BAR9	Trypanosoma cruzi	24%	100%
V5BK25	Trypanosoma cruzi	29%	92%
V5BLH7	Trypanosoma cruzi	26%	77%