Putative pumillio protein 5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio/PUF RNA binding protein 5 - putative

Species:

Leishmania infantum

UniProt:

A4HSP8_LEIIN

TriTrypDb:

LINF_060005400

Length:

481

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HSP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSP8

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	14
GO:0003723	RNA binding	4	14
GO:0005488	binding	1	14
GO:0097159	organic cyclic compound binding	2	14
GO:1901363	heterocyclic compound binding	2	14
GO:0003729	mRNA binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	269	271	PF00675	0.366
CLV_PCSK_KEX2_1	269	271	PF00082	0.366
CLV_PCSK_KEX2_1	320	322	PF00082	0.360
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.424
CLV_PCSK_SKI1_1	195	199	PF00082	0.365
CLV_PCSK_SKI1_1	269	273	PF00082	0.383
DEG_APCC_DBOX_1	194	202	PF00400	0.343
DEG_APCC_DBOX_1	268	276	PF00400	0.393
DEG_MDM2_SWIB_1	364	371	PF02201	0.316
DEG_SCF_FBW7_1	143	148	PF00400	0.644
DEG_SCF_FBW7_2	241	247	PF00400	0.393
DOC_CKS1_1	241	246	PF01111	0.393
DOC_CYCLIN_yCln2_LP_2	56	62	PF00134	0.675
DOC_MAPK_gen_1	193	201	PF00069	0.440
DOC_MAPK_gen_1	393	402	PF00069	0.424
DOC_MAPK_MEF2A_6	193	201	PF00069	0.440
DOC_MAPK_MEF2A_6	78	85	PF00069	0.623
DOC_PP4_FxxP_1	128	131	PF00568	0.625
DOC_PP4_FxxP_1	60	63	PF00568	0.720
DOC_PP4_MxPP_1	143	146	PF00568	0.591
DOC_USP7_MATH_1	105	109	PF00917	0.542
DOC_USP7_MATH_1	146	150	PF00917	0.682
DOC_USP7_MATH_1	189	193	PF00917	0.422
DOC_USP7_UBL2_3	316	320	PF12436	0.393
DOC_USP7_UBL2_3	95	99	PF12436	0.721
DOC_WW_Pin1_4	109	114	PF00397	0.580
DOC_WW_Pin1_4	127	132	PF00397	0.518
DOC_WW_Pin1_4	141	146	PF00397	0.571
DOC_WW_Pin1_4	240	245	PF00397	0.392
DOC_WW_Pin1_4	37	42	PF00397	0.739
DOC_WW_Pin1_4	438	443	PF00397	0.403
DOC_WW_Pin1_4	444	449	PF00397	0.320
DOC_WW_Pin1_4	471	476	PF00397	0.649
DOC_WW_Pin1_4	65	70	PF00397	0.710
LIG_14-3-3_CanoR_1	139	146	PF00244	0.629
LIG_14-3-3_CanoR_1	321	331	PF00244	0.362
LIG_APCC_ABBA_1	249	254	PF00400	0.448
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_BIR_III_2	20	24	PF00653	0.695
LIG_BRCT_BRCA1_1	124	128	PF00533	0.698
LIG_BRCT_BRCA1_1	4	8	PF00533	0.687
LIG_EH1_1	341	349	PF00400	0.316
LIG_FHA_1	151	157	PF00498	0.614
LIG_FHA_1	266	272	PF00498	0.378
LIG_FHA_1	439	445	PF00498	0.507
LIG_FHA_1	471	477	PF00498	0.544
LIG_FHA_1	78	84	PF00498	0.739
LIG_FHA_2	119	125	PF00498	0.693
LIG_FHA_2	234	240	PF00498	0.374
LIG_FHA_2	472	478	PF00498	0.641
LIG_GBD_Chelix_1	343	351	PF00786	0.312
LIG_GBD_Chelix_1	384	392	PF00786	0.393
LIG_IBAR_NPY_1	104	106	PF08397	0.516
LIG_LIR_Apic_2	125	131	PF02991	0.622
LIG_LIR_Apic_2	313	317	PF02991	0.424
LIG_LIR_Apic_2	57	63	PF02991	0.706
LIG_LIR_Gen_1	175	186	PF02991	0.471
LIG_LIR_Gen_1	352	362	PF02991	0.487
LIG_LIR_Nem_3	152	157	PF02991	0.676
LIG_LIR_Nem_3	175	181	PF02991	0.400
LIG_LIR_Nem_3	352	357	PF02991	0.506
LIG_LIR_Nem_3	414	418	PF02991	0.322
LIG_LIR_Nem_3	432	436	PF02991	0.239
LIG_PCNA_yPIPBox_3	393	401	PF02747	0.435
LIG_Pex14_2	364	368	PF04695	0.385
LIG_SH2_CRK	314	318	PF00017	0.424
LIG_SH2_CRK	38	42	PF00017	0.708
LIG_SH2_CRK	433	437	PF00017	0.469
LIG_SH2_NCK_1	314	318	PF00017	0.424
LIG_SH2_NCK_1	43	47	PF00017	0.676
LIG_SH2_NCK_1	437	441	PF00017	0.445
LIG_SH2_PTP2	252	255	PF00017	0.462
LIG_SH2_PTP2	354	357	PF00017	0.484
LIG_SH2_SRC	252	255	PF00017	0.414
LIG_SH2_SRC	431	434	PF00017	0.431
LIG_SH2_STAP1	214	218	PF00017	0.428
LIG_SH2_STAP1	376	380	PF00017	0.424
LIG_SH2_STAP1	465	469	PF00017	0.562
LIG_SH2_STAP1	9	13	PF00017	0.564
LIG_SH2_STAT3	342	345	PF00017	0.305
LIG_SH2_STAT3	418	421	PF00017	0.387
LIG_SH2_STAT5	101	104	PF00017	0.554
LIG_SH2_STAT5	132	135	PF00017	0.676
LIG_SH2_STAT5	240	243	PF00017	0.369
LIG_SH2_STAT5	252	255	PF00017	0.446
LIG_SH2_STAT5	342	345	PF00017	0.276
LIG_SH2_STAT5	354	357	PF00017	0.337
LIG_SH2_STAT5	418	421	PF00017	0.387
LIG_SH3_3	73	79	PF00018	0.738
LIG_SH3_4	316	323	PF00018	0.393
LIG_SUMO_SIM_par_1	286	294	PF11976	0.444
LIG_TYR_ITIM	435	440	PF00017	0.441
LIG_UBA3_1	308	316	PF00899	0.393
LIG_UBA3_1	330	336	PF00899	0.393
LIG_WRC_WIRS_1	361	366	PF05994	0.496
MOD_CK1_1	108	114	PF00069	0.489
MOD_CK1_1	118	124	PF00069	0.561
MOD_CK1_1	126	132	PF00069	0.506
MOD_CK1_1	149	155	PF00069	0.697
MOD_CK1_1	160	166	PF00069	0.543
MOD_CK1_1	2	8	PF00069	0.643
MOD_CK1_1	54	60	PF00069	0.626
MOD_CK1_1	61	67	PF00069	0.658
MOD_CK1_1	94	100	PF00069	0.662
MOD_CK2_1	118	124	PF00069	0.710
MOD_CK2_1	160	166	PF00069	0.531
MOD_CK2_1	233	239	PF00069	0.374
MOD_GlcNHglycan	1	4	PF01048	0.657
MOD_GlcNHglycan	113	116	PF01048	0.476
MOD_GlcNHglycan	324	327	PF01048	0.424
MOD_GlcNHglycan	425	428	PF01048	0.407
MOD_GlcNHglycan	44	47	PF01048	0.620
MOD_GlcNHglycan	467	470	PF01048	0.569
MOD_GlcNHglycan	96	99	PF01048	0.641
MOD_GSK3_1	105	112	PF00069	0.541
MOD_GSK3_1	115	122	PF00069	0.594
MOD_GSK3_1	123	130	PF00069	0.495
MOD_GSK3_1	137	144	PF00069	0.557
MOD_GSK3_1	145	152	PF00069	0.652
MOD_GSK3_1	184	191	PF00069	0.473
MOD_GSK3_1	261	268	PF00069	0.405
MOD_GSK3_1	44	51	PF00069	0.599
MOD_GSK3_1	54	61	PF00069	0.568
MOD_GSK3_1	87	94	PF00069	0.665
MOD_NEK2_1	117	122	PF00069	0.612
MOD_NEK2_1	123	128	PF00069	0.555
MOD_NEK2_1	261	266	PF00069	0.470
MOD_NEK2_1	298	303	PF00069	0.334
MOD_NEK2_1	330	335	PF00069	0.439
MOD_NEK2_1	360	365	PF00069	0.449
MOD_NEK2_1	388	393	PF00069	0.399
MOD_NEK2_1	411	416	PF00069	0.387
MOD_NEK2_1	443	448	PF00069	0.402
MOD_NEK2_1	8	13	PF00069	0.572
MOD_PIKK_1	115	121	PF00454	0.681
MOD_PIKK_1	262	268	PF00454	0.396
MOD_PIKK_1	298	304	PF00454	0.353
MOD_PIKK_1	54	60	PF00454	0.682
MOD_PKA_2	138	144	PF00069	0.691
MOD_PKA_2	77	83	PF00069	0.756
MOD_Plk_1	123	129	PF00069	0.656
MOD_Plk_4	177	183	PF00069	0.514
MOD_Plk_4	77	83	PF00069	0.684
MOD_Plk_4	8	14	PF00069	0.532
MOD_ProDKin_1	109	115	PF00069	0.581
MOD_ProDKin_1	127	133	PF00069	0.518
MOD_ProDKin_1	141	147	PF00069	0.572
MOD_ProDKin_1	240	246	PF00069	0.392
MOD_ProDKin_1	37	43	PF00069	0.736
MOD_ProDKin_1	438	444	PF00069	0.401
MOD_ProDKin_1	471	477	PF00069	0.684
MOD_ProDKin_1	65	71	PF00069	0.710
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.478
TRG_DiLeu_BaLyEn_6	439	444	PF01217	0.379
TRG_ENDOCYTIC_2	214	217	PF00928	0.429
TRG_ENDOCYTIC_2	354	357	PF00928	0.470
TRG_ENDOCYTIC_2	433	436	PF00928	0.460
TRG_ENDOCYTIC_2	437	440	PF00928	0.469
TRG_ENDOCYTIC_2	9	12	PF00928	0.533
TRG_ER_diArg_1	269	271	PF00400	0.368
TRG_ER_diArg_1	392	395	PF00400	0.432
TRG_ER_FFAT_2	122	134	PF00635	0.561
TRG_NES_CRM1_1	345	359	PF08389	0.451
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.319

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P473	Leptomonas seymouri	28%	86%
A0A0N1HSE0	Leptomonas seymouri	63%	100%
A0A0S4J2F9	Bodo saltans	48%	100%
A0A1X0NJM4	Trypanosomatidae	48%	100%
A0A3S5IQY1	Trypanosoma rangeli	47%	100%
A0A3S7WPA1	Leishmania donovani	100%	100%
A4H4H3	Leishmania braziliensis	86%	100%
C9ZT94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AKN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QCQ8	Leishmania major	34%	100%
Q4QJ74	Leishmania major	95%	100%
Q9FMH4	Arabidopsis thaliana	23%	91%
V5B968	Trypanosoma cruzi	45%	100%