LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
39S mitochondrial ribosomal protein L46 - putative
Species:
Leishmania infantum
UniProt:
A4HSP7_LEIIN
TriTrypDb:
LINF_060005300
Length:
291

Annotations

Annotations by Jardim et al.

Ribosomal Protein, mitochondrial ribosomal L46

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 11
GO:0005840 ribosome 5 11
GO:0032991 protein-containing complex 1 12
GO:0043226 organelle 2 11
GO:0043227 membrane-bounded organelle 3 11
GO:0043228 non-membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 11
GO:0043231 intracellular membrane-bounded organelle 4 11
GO:0043232 intracellular non-membrane-bounded organelle 4 11
GO:0110165 cellular anatomical entity 1 12
GO:1990904 ribonucleoprotein complex 2 12
GO:0000315 organellar large ribosomal subunit 5 1
GO:0005737 cytoplasm 2 1
GO:0005762 mitochondrial large ribosomal subunit 3 1
GO:0015934 large ribosomal subunit 4 1
GO:0044391 ribosomal subunit 3 1
GO:0098798 mitochondrial protein-containing complex 2 1

Expansion

Sequence features

A4HSP7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSP7

PDB structure(s): 7aih_Ac , 7ane_Ac

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003735 structural constituent of ribosome 2 12
GO:0005198 structural molecule activity 1 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 162 164 PF00675 0.363
CLV_NRD_NRD_1 187 189 PF00675 0.484
CLV_PCSK_KEX2_1 138 140 PF00082 0.285
CLV_PCSK_PC1ET2_1 138 140 PF00082 0.340
CLV_PCSK_SKI1_1 138 142 PF00082 0.333
CLV_PCSK_SKI1_1 278 282 PF00082 0.470
DEG_Nend_UBRbox_1 1 4 PF02207 0.621
DEG_SPOP_SBC_1 18 22 PF00917 0.534
DOC_CYCLIN_RxL_1 2 16 PF00134 0.539
DOC_CYCLIN_RxL_1 272 284 PF00134 0.460
DOC_MAPK_DCC_7 30 39 PF00069 0.448
DOC_MAPK_gen_1 163 171 PF00069 0.334
DOC_MAPK_gen_1 2 12 PF00069 0.634
DOC_MAPK_HePTP_8 161 173 PF00069 0.351
DOC_MAPK_MEF2A_6 164 173 PF00069 0.339
DOC_MAPK_MEF2A_6 30 39 PF00069 0.423
DOC_USP7_MATH_1 13 17 PF00917 0.638
DOC_USP7_MATH_1 201 205 PF00917 0.420
DOC_WW_Pin1_4 132 137 PF00397 0.306
DOC_WW_Pin1_4 28 33 PF00397 0.430
DOC_WW_Pin1_4 60 65 PF00397 0.260
LIG_14-3-3_CanoR_1 139 148 PF00244 0.345
LIG_14-3-3_CanoR_1 14 19 PF00244 0.566
LIG_14-3-3_CanoR_1 158 162 PF00244 0.419
LIG_14-3-3_CanoR_1 195 202 PF00244 0.447
LIG_14-3-3_CanoR_1 23 33 PF00244 0.428
LIG_APCC_ABBA_1 120 125 PF00400 0.228
LIG_BIR_III_2 153 157 PF00653 0.493
LIG_BRCT_BRCA1_1 21 25 PF00533 0.505
LIG_BRCT_BRCA1_1 267 271 PF00533 0.467
LIG_FHA_1 220 226 PF00498 0.421
LIG_FHA_1 29 35 PF00498 0.413
LIG_FHA_1 99 105 PF00498 0.464
LIG_FHA_2 139 145 PF00498 0.249
LIG_FHA_2 258 264 PF00498 0.340
LIG_IRF3_LxIS_1 277 284 PF10401 0.321
LIG_LIR_Apic_2 178 184 PF02991 0.310
LIG_LIR_Gen_1 166 173 PF02991 0.324
LIG_LIR_Nem_3 166 171 PF02991 0.329
LIG_MAD2 128 136 PF02301 0.228
LIG_NRBOX 276 282 PF00104 0.364
LIG_PDZ_Class_2 286 291 PF00595 0.433
LIG_REV1ctd_RIR_1 92 102 PF16727 0.392
LIG_SH2_CRK 3 7 PF00017 0.505
LIG_SH2_NCK_1 3 7 PF00017 0.444
LIG_SH2_SRC 123 126 PF00017 0.249
LIG_SH2_SRC 170 173 PF00017 0.309
LIG_SH2_STAP1 235 239 PF00017 0.292
LIG_SH2_STAP1 267 271 PF00017 0.417
LIG_SH2_STAT5 170 173 PF00017 0.280
LIG_SH2_STAT5 213 216 PF00017 0.345
LIG_SH2_STAT5 239 242 PF00017 0.325
LIG_SH2_STAT5 53 56 PF00017 0.282
LIG_SH2_STAT5 73 76 PF00017 0.281
LIG_SH3_1 3 9 PF00018 0.656
LIG_SH3_3 29 35 PF00018 0.432
LIG_SH3_3 3 9 PF00018 0.659
LIG_SUMO_SIM_anti_2 101 106 PF11976 0.271
LIG_SUMO_SIM_par_1 279 284 PF11976 0.327
LIG_WRC_WIRS_1 246 251 PF05994 0.399
LIG_WW_3 155 159 PF00397 0.476
MOD_CDC14_SPxK_1 135 138 PF00782 0.313
MOD_CDK_SPxK_1 132 138 PF00069 0.392
MOD_CDK_SPxxK_3 132 139 PF00069 0.392
MOD_CK1_1 17 23 PF00069 0.539
MOD_CK1_1 204 210 PF00069 0.475
MOD_CK1_1 4 10 PF00069 0.678
MOD_CK1_1 87 93 PF00069 0.332
MOD_CK2_1 257 263 PF00069 0.322
MOD_CK2_1 80 86 PF00069 0.305
MOD_GlcNHglycan 141 144 PF01048 0.423
MOD_GlcNHglycan 282 286 PF01048 0.340
MOD_GlcNHglycan 86 89 PF01048 0.288
MOD_GSK3_1 13 20 PF00069 0.584
MOD_GSK3_1 175 182 PF00069 0.352
MOD_GSK3_1 190 197 PF00069 0.369
MOD_GSK3_1 200 207 PF00069 0.379
MOD_GSK3_1 24 31 PF00069 0.418
MOD_GSK3_1 267 274 PF00069 0.292
MOD_GSK3_1 281 288 PF00069 0.352
MOD_GSK3_1 80 87 PF00069 0.269
MOD_GSK3_1 94 101 PF00069 0.388
MOD_NEK2_1 1 6 PF00069 0.600
MOD_NEK2_1 19 24 PF00069 0.573
MOD_NEK2_1 94 99 PF00069 0.343
MOD_NEK2_2 157 162 PF00069 0.511
MOD_NEK2_2 219 224 PF00069 0.389
MOD_NEK2_2 267 272 PF00069 0.468
MOD_PIKK_1 201 207 PF00454 0.407
MOD_PIKK_1 24 30 PF00454 0.429
MOD_PK_1 14 20 PF00069 0.662
MOD_PKA_1 138 144 PF00069 0.308
MOD_PKA_2 1 7 PF00069 0.624
MOD_PKA_2 13 19 PF00069 0.558
MOD_PKA_2 138 144 PF00069 0.316
MOD_PKA_2 157 163 PF00069 0.358
MOD_PKA_2 194 200 PF00069 0.379
MOD_PKA_2 80 86 PF00069 0.347
MOD_Plk_1 190 196 PF00069 0.484
MOD_Plk_1 227 233 PF00069 0.352
MOD_Plk_4 14 20 PF00069 0.587
MOD_Plk_4 219 225 PF00069 0.378
MOD_Plk_4 235 241 PF00069 0.278
MOD_ProDKin_1 132 138 PF00069 0.306
MOD_ProDKin_1 28 34 PF00069 0.433
MOD_ProDKin_1 60 66 PF00069 0.260
MOD_SUMO_rev_2 248 253 PF00179 0.466
TRG_DiLeu_BaEn_1 70 75 PF01217 0.303
TRG_ENDOCYTIC_2 170 173 PF00928 0.280
TRG_NES_CRM1_1 112 125 PF08389 0.260
TRG_Pf-PMV_PEXEL_1 163 167 PF00026 0.329

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IH67 Leptomonas seymouri 74% 100%
A0A0S4J242 Bodo saltans 51% 100%
A0A1X0NJC0 Trypanosomatidae 65% 100%
A0A3S7WPC6 Leishmania donovani 99% 100%
A0A422NCS2 Trypanosoma rangeli 65% 100%
A4H4H2 Leishmania braziliensis 86% 100%
C9ZT91 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 98%
E9AKN2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q3SZ22 Bos taurus 25% 100%
Q4QJ75 Leishmania major 98% 100%
Q5RBU2 Pongo abelii 26% 100%
Q5RK00 Rattus norvegicus 26% 100%
Q9EQI8 Mus musculus 27% 100%
Q9H2W6 Homo sapiens 28% 100%
V5AP90 Trypanosoma cruzi 66% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS