LeishMANIAdb
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Guanine nucleotide-binding protein subunit beta-like protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Guanine nucleotide-binding protein subunit beta-like protein
Gene product:
WD domain - G-beta repeat - putative
Species:
Leishmania infantum
UniProt:
A4HSP6_LEIIN
TriTrypDb:
LINF_060005200
Length:
675

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 17
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 18
GO:0032991 protein-containing complex 1 18
GO:0043226 organelle 2 18
GO:0043228 non-membrane-bounded organelle 3 18
GO:0043229 intracellular organelle 3 18
GO:0043232 intracellular non-membrane-bounded organelle 4 18
GO:0110165 cellular anatomical entity 1 18
GO:1990904 ribonucleoprotein complex 2 18
GO:0000974 Prp19 complex 2 1
GO:0005654 nucleoplasm 2 1
GO:0005681 spliceosomal complex 3 1
GO:0071013 catalytic step 2 spliceosome 3 1
GO:0140513 nuclear protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:0005730 nucleolus 5 1
GO:0097361 CIA complex 3 1
GO:0140535 intracellular protein-containing complex 2 1

Phosphorylation

Amastigote: 206, 211, 256, 356
Promastigote: 98
Promastigote/Amastigote: 273

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HSP6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSP6

Function

Biological processes
Term Name Level Count
GO:0000375 RNA splicing, via transesterification reactions 8 4
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 9 4
GO:0000398 mRNA splicing, via spliceosome 8 4
GO:0006139 nucleobase-containing compound metabolic process 3 4
GO:0006396 RNA processing 6 4
GO:0006397 mRNA processing 7 4
GO:0006725 cellular aromatic compound metabolic process 3 4
GO:0006807 nitrogen compound metabolic process 2 4
GO:0008152 metabolic process 1 5
GO:0008380 RNA splicing 7 4
GO:0009987 cellular process 1 5
GO:0016070 RNA metabolic process 5 4
GO:0016071 mRNA metabolic process 6 4
GO:0034641 cellular nitrogen compound metabolic process 3 4
GO:0043170 macromolecule metabolic process 3 4
GO:0044237 cellular metabolic process 2 5
GO:0044238 primary metabolic process 2 4
GO:0046483 heterocycle metabolic process 3 4
GO:0071704 organic substance metabolic process 2 4
GO:0090304 nucleic acid metabolic process 4 4
GO:1901360 organic cyclic compound metabolic process 3 4
GO:0006790 sulfur compound metabolic process 3 1
GO:0016043 cellular component organization 3 1
GO:0016226 iron-sulfur cluster assembly 4 1
GO:0022607 cellular component assembly 4 1
GO:0031163 metallo-sulfur cluster assembly 5 1
GO:0071840 cellular component organization or biogenesis 2 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 202 206 PF00656 0.571
CLV_C14_Caspase3-7 48 52 PF00656 0.423
CLV_C14_Caspase3-7 526 530 PF00656 0.441
CLV_NRD_NRD_1 172 174 PF00675 0.441
CLV_NRD_NRD_1 175 177 PF00675 0.467
CLV_NRD_NRD_1 23 25 PF00675 0.439
CLV_NRD_NRD_1 298 300 PF00675 0.394
CLV_PCSK_KEX2_1 126 128 PF00082 0.514
CLV_PCSK_KEX2_1 23 25 PF00082 0.498
CLV_PCSK_KEX2_1 242 244 PF00082 0.706
CLV_PCSK_KEX2_1 673 675 PF00082 0.493
CLV_PCSK_PC1ET2_1 126 128 PF00082 0.514
CLV_PCSK_PC1ET2_1 242 244 PF00082 0.568
CLV_PCSK_PC7_1 238 244 PF00082 0.569
CLV_PCSK_SKI1_1 107 111 PF00082 0.379
CLV_PCSK_SKI1_1 300 304 PF00082 0.326
CLV_PCSK_SKI1_1 455 459 PF00082 0.243
CLV_PCSK_SKI1_1 467 471 PF00082 0.297
CLV_PCSK_SKI1_1 509 513 PF00082 0.237
CLV_PCSK_SKI1_1 541 545 PF00082 0.235
CLV_PCSK_SKI1_1 574 578 PF00082 0.270
CLV_PCSK_SKI1_1 657 661 PF00082 0.380
DEG_SCF_FBW7_1 278 285 PF00400 0.317
DEG_SPOP_SBC_1 448 452 PF00917 0.481
DOC_ANK_TNKS_1 356 363 PF00023 0.495
DOC_CKS1_1 279 284 PF01111 0.324
DOC_CYCLIN_RxL_1 136 148 PF00134 0.343
DOC_MAPK_gen_1 113 122 PF00069 0.415
DOC_MAPK_gen_1 126 133 PF00069 0.513
DOC_MAPK_gen_1 23 33 PF00069 0.338
DOC_MAPK_gen_1 295 305 PF00069 0.376
DOC_MAPK_HePTP_8 255 267 PF00069 0.532
DOC_MAPK_HePTP_8 293 305 PF00069 0.437
DOC_MAPK_MEF2A_6 24 33 PF00069 0.361
DOC_MAPK_MEF2A_6 258 267 PF00069 0.548
DOC_MAPK_MEF2A_6 296 305 PF00069 0.436
DOC_PP1_RVXF_1 3 9 PF00149 0.363
DOC_USP7_MATH_1 154 158 PF00917 0.376
DOC_USP7_MATH_1 185 189 PF00917 0.545
DOC_USP7_MATH_1 193 197 PF00917 0.713
DOC_USP7_MATH_1 198 202 PF00917 0.671
DOC_USP7_MATH_1 203 207 PF00917 0.647
DOC_USP7_MATH_1 257 261 PF00917 0.635
DOC_USP7_MATH_1 282 286 PF00917 0.517
DOC_USP7_MATH_1 449 453 PF00917 0.439
DOC_USP7_MATH_1 84 88 PF00917 0.806
DOC_USP7_UBL2_3 177 181 PF12436 0.520
DOC_USP7_UBL2_3 296 300 PF12436 0.306
DOC_USP7_UBL2_3 5 9 PF12436 0.390
DOC_USP7_UBL2_3 75 79 PF12436 0.501
DOC_WW_Pin1_4 278 283 PF00397 0.417
DOC_WW_Pin1_4 397 402 PF00397 0.491
DOC_WW_Pin1_4 439 444 PF00397 0.452
LIG_14-3-3_CanoR_1 447 457 PF00244 0.447
LIG_14-3-3_CanoR_1 514 519 PF00244 0.435
LIG_14-3-3_CanoR_1 595 600 PF00244 0.516
LIG_14-3-3_CanoR_1 631 638 PF00244 0.294
LIG_APCC_ABBA_1 320 325 PF00400 0.331
LIG_APCC_ABBA_1 62 67 PF00400 0.508
LIG_BIR_II_1 1 5 PF00653 0.416
LIG_BIR_III_4 184 188 PF00653 0.515
LIG_BRCT_BRCA1_1 521 525 PF00533 0.430
LIG_deltaCOP1_diTrp_1 624 630 PF00928 0.422
LIG_FHA_1 139 145 PF00498 0.541
LIG_FHA_1 273 279 PF00498 0.509
LIG_FHA_1 367 373 PF00498 0.539
LIG_FHA_1 38 44 PF00498 0.563
LIG_FHA_1 412 418 PF00498 0.583
LIG_FHA_1 454 460 PF00498 0.426
LIG_FHA_1 484 490 PF00498 0.520
LIG_FHA_1 496 502 PF00498 0.470
LIG_FHA_1 506 512 PF00498 0.320
LIG_FHA_1 658 664 PF00498 0.294
LIG_FHA_2 157 163 PF00498 0.422
LIG_FHA_2 289 295 PF00498 0.357
LIG_FHA_2 43 49 PF00498 0.410
LIG_FHA_2 96 102 PF00498 0.532
LIG_GBD_Chelix_1 320 328 PF00786 0.292
LIG_LIR_Gen_1 161 170 PF02991 0.388
LIG_LIR_Gen_1 285 293 PF02991 0.375
LIG_LIR_Gen_1 563 569 PF02991 0.555
LIG_LIR_Gen_1 580 591 PF02991 0.417
LIG_LIR_Gen_1 624 629 PF02991 0.411
LIG_LIR_Nem_3 118 122 PF02991 0.389
LIG_LIR_Nem_3 16 20 PF02991 0.492
LIG_LIR_Nem_3 161 167 PF02991 0.404
LIG_LIR_Nem_3 285 289 PF02991 0.380
LIG_LIR_Nem_3 563 568 PF02991 0.569
LIG_LIR_Nem_3 580 586 PF02991 0.378
LIG_NRP_CendR_1 673 675 PF00754 0.353
LIG_Pex14_1 565 569 PF04695 0.422
LIG_Pex14_2 521 525 PF04695 0.422
LIG_SH2_CRK 279 283 PF00017 0.331
LIG_SH2_GRB2like 374 377 PF00017 0.465
LIG_SH2_PTP2 119 122 PF00017 0.347
LIG_SH2_STAP1 583 587 PF00017 0.524
LIG_SH2_STAT5 119 122 PF00017 0.553
LIG_SH2_STAT5 266 269 PF00017 0.343
LIG_SH2_STAT5 395 398 PF00017 0.425
LIG_SH2_STAT5 479 482 PF00017 0.462
LIG_SH2_STAT5 575 578 PF00017 0.524
LIG_SH2_STAT5 617 620 PF00017 0.422
LIG_SH3_1 238 244 PF00018 0.511
LIG_SH3_2 342 347 PF14604 0.452
LIG_SH3_3 117 123 PF00018 0.336
LIG_SH3_3 238 244 PF00018 0.591
LIG_SH3_3 339 345 PF00018 0.396
LIG_SUMO_SIM_par_1 38 45 PF11976 0.302
LIG_TRAF2_1 135 138 PF00917 0.376
LIG_TRAF2_1 158 161 PF00917 0.457
LIG_TYR_ITIM 117 122 PF00017 0.519
LIG_UBA3_1 28 34 PF00899 0.334
LIG_WRC_WIRS_1 146 151 PF05994 0.414
LIG_WRC_WIRS_1 43 48 PF05994 0.485
MOD_CDK_SPK_2 397 402 PF00069 0.481
MOD_CDK_SPK_2 439 444 PF00069 0.430
MOD_CK1_1 388 394 PF00069 0.482
MOD_CK1_1 461 467 PF00069 0.479
MOD_CK1_1 494 500 PF00069 0.426
MOD_CK2_1 132 138 PF00069 0.492
MOD_CK2_1 154 160 PF00069 0.420
MOD_CK2_1 208 214 PF00069 0.464
MOD_CK2_1 288 294 PF00069 0.359
MOD_CK2_1 337 343 PF00069 0.432
MOD_CK2_1 372 378 PF00069 0.459
MOD_CK2_1 42 48 PF00069 0.422
MOD_CK2_1 482 488 PF00069 0.392
MOD_CK2_1 630 636 PF00069 0.412
MOD_CK2_1 67 73 PF00069 0.530
MOD_CK2_1 95 101 PF00069 0.677
MOD_Cter_Amidation 124 127 PF01082 0.390
MOD_Cter_Amidation 297 300 PF01082 0.360
MOD_GlcNHglycan 123 126 PF01048 0.426
MOD_GlcNHglycan 201 204 PF01048 0.566
MOD_GlcNHglycan 259 262 PF01048 0.559
MOD_GlcNHglycan 272 275 PF01048 0.521
MOD_GlcNHglycan 387 390 PF01048 0.232
MOD_GlcNHglycan 491 494 PF01048 0.246
MOD_GlcNHglycan 535 538 PF01048 0.258
MOD_GlcNHglycan 577 580 PF01048 0.299
MOD_GlcNHglycan 69 72 PF01048 0.574
MOD_GlcNHglycan 85 89 PF01048 0.670
MOD_GSK3_1 199 206 PF00069 0.620
MOD_GSK3_1 253 260 PF00069 0.529
MOD_GSK3_1 278 285 PF00069 0.400
MOD_GSK3_1 37 44 PF00069 0.307
MOD_GSK3_1 379 386 PF00069 0.387
MOD_GSK3_1 407 414 PF00069 0.422
MOD_GSK3_1 419 426 PF00069 0.383
MOD_GSK3_1 435 442 PF00069 0.559
MOD_GSK3_1 449 456 PF00069 0.472
MOD_GSK3_1 459 466 PF00069 0.487
MOD_GSK3_1 491 498 PF00069 0.473
MOD_GSK3_1 505 512 PF00069 0.398
MOD_GSK3_1 519 526 PF00069 0.477
MOD_GSK3_1 563 570 PF00069 0.445
MOD_GSK3_1 587 594 PF00069 0.548
MOD_GSK3_1 609 616 PF00069 0.439
MOD_N-GLC_1 13 18 PF02516 0.551
MOD_N-GLC_1 177 182 PF02516 0.495
MOD_N-GLC_1 270 275 PF02516 0.408
MOD_N-GLC_1 379 384 PF02516 0.328
MOD_N-GLC_1 483 488 PF02516 0.228
MOD_NEK2_1 253 258 PF00069 0.543
MOD_NEK2_1 301 306 PF00069 0.336
MOD_NEK2_1 324 329 PF00069 0.358
MOD_NEK2_1 337 342 PF00069 0.408
MOD_NEK2_1 353 358 PF00069 0.654
MOD_NEK2_1 364 369 PF00069 0.647
MOD_NEK2_1 372 377 PF00069 0.520
MOD_NEK2_1 405 410 PF00069 0.491
MOD_NEK2_1 459 464 PF00069 0.590
MOD_NEK2_1 489 494 PF00069 0.421
MOD_NEK2_1 533 538 PF00069 0.508
MOD_NEK2_1 587 592 PF00069 0.585
MOD_NEK2_1 658 663 PF00069 0.263
MOD_NEK2_2 145 150 PF00069 0.456
MOD_NEK2_2 495 500 PF00069 0.422
MOD_PIKK_1 503 509 PF00454 0.499
MOD_PIKK_1 56 62 PF00454 0.511
MOD_PK_1 623 629 PF00069 0.481
MOD_PKA_2 172 178 PF00069 0.586
MOD_PKA_2 257 263 PF00069 0.523
MOD_PKA_2 351 357 PF00069 0.628
MOD_PKA_2 630 636 PF00069 0.294
MOD_Plk_1 13 19 PF00069 0.375
MOD_Plk_1 324 330 PF00069 0.381
MOD_Plk_1 37 43 PF00069 0.393
MOD_Plk_1 411 417 PF00069 0.422
MOD_Plk_1 453 459 PF00069 0.476
MOD_Plk_1 495 501 PF00069 0.476
MOD_Plk_1 613 619 PF00069 0.508
MOD_Plk_1 623 629 PF00069 0.473
MOD_Plk_2-3 156 162 PF00069 0.533
MOD_Plk_2-3 288 294 PF00069 0.403
MOD_Plk_4 115 121 PF00069 0.347
MOD_Plk_4 288 294 PF00069 0.469
MOD_Plk_4 301 307 PF00069 0.330
MOD_Plk_4 37 43 PF00069 0.309
MOD_Plk_4 423 429 PF00069 0.374
MOD_Plk_4 553 559 PF00069 0.447
MOD_Plk_4 560 566 PF00069 0.424
MOD_Plk_4 613 619 PF00069 0.375
MOD_Plk_4 637 643 PF00069 0.369
MOD_Plk_4 644 650 PF00069 0.238
MOD_ProDKin_1 278 284 PF00069 0.412
MOD_ProDKin_1 397 403 PF00069 0.491
MOD_ProDKin_1 439 445 PF00069 0.452
MOD_SUMO_rev_2 239 244 PF00179 0.513
MOD_SUMO_rev_2 288 297 PF00179 0.358
MOD_SUMO_rev_2 325 335 PF00179 0.433
MOD_SUMO_rev_2 652 659 PF00179 0.476
MOD_SUMO_rev_2 661 667 PF00179 0.396
MOD_SUMO_rev_2 67 76 PF00179 0.451
TRG_DiLeu_BaEn_1 161 166 PF01217 0.401
TRG_DiLeu_BaEn_1 553 558 PF01217 0.508
TRG_DiLeu_BaLyEn_6 333 338 PF01217 0.462
TRG_ENDOCYTIC_2 119 122 PF00928 0.377
TRG_ENDOCYTIC_2 583 586 PF00928 0.524
TRG_ER_diArg_1 23 25 PF00400 0.377
TRG_ER_diArg_1 672 675 PF00400 0.450
TRG_NES_CRM1_1 27 39 PF08389 0.370
TRG_NES_CRM1_1 318 331 PF08389 0.395
TRG_NLS_MonoExtN_4 332 337 PF00514 0.427

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBF5 Leptomonas seymouri 67% 98%
A0A0S4JTE0 Bodo saltans 42% 89%
A0A1X0NK47 Trypanosomatidae 50% 96%
A0A3R7K7N9 Trypanosoma rangeli 49% 97%
A0A3S5H5M7 Leishmania donovani 99% 100%
A0A3S7XBP3 Leishmania donovani 26% 100%
A4H4H1 Leishmania braziliensis 67% 99%
A4HPZ9 Leishmania braziliensis 25% 100%
A4IDR0 Leishmania infantum 26% 100%
C9ZT89 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 97%
E9AKN1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
E9ATR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9AX72 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
Q4Q0T1 Leishmania major 26% 100%
Q4QJ76 Leishmania major 89% 100%
V5BDR9 Trypanosoma cruzi 51% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS