Putative prefoldin subunit

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prefoldin subunit - putative

Species:

Leishmania infantum

UniProt:

A4HSP1_LEIIN

TriTrypDb:

LINF_050017300

Length:

135

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, prefoldin subunit

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016272	prefoldin complex	2	12
GO:0032991	protein-containing complex	1	12
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HSP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSP1

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0051131	chaperone-mediated protein complex assembly	6	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0051082	unfolded protein binding	3	12
GO:0051087	protein-folding chaperone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.421
CLV_NRD_NRD_1	104	106	PF00675	0.238
CLV_NRD_NRD_1	118	120	PF00675	0.187
CLV_NRD_NRD_1	36	38	PF00675	0.234
CLV_PCSK_KEX2_1	36	38	PF00082	0.233
CLV_PCSK_KEX2_1	94	96	PF00082	0.227
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.227
CLV_PCSK_SKI1_1	16	20	PF00082	0.468
CLV_Separin_Metazoa	47	51	PF03568	0.432
DEG_APCC_DBOX_1	15	23	PF00400	0.365
DEG_APCC_DBOX_1	49	57	PF00400	0.472
DEG_Nend_UBRbox_3	1	3	PF02207	0.544
DOC_CYCLIN_yCln2_LP_2	65	71	PF00134	0.432
LIG_LIR_Nem_3	61	66	PF02991	0.430
LIG_MYND_1	68	72	PF01753	0.482
LIG_NRBOX	10	16	PF00104	0.512
LIG_SH2_CRK	63	67	PF00017	0.432
LIG_SH2_GRB2like	88	91	PF00017	0.446
LIG_SH2_SRC	88	91	PF00017	0.446
LIG_SH2_STAT5	88	91	PF00017	0.421
LIG_TYR_ITSM	59	66	PF00017	0.507
LIG_UBA3_1	14	20	PF00899	0.530
MOD_CK1_1	96	102	PF00069	0.507
MOD_CK2_1	96	102	PF00069	0.462
MOD_GSK3_1	73	80	PF00069	0.507
MOD_NEK2_2	58	63	PF00069	0.507
MOD_Plk_1	58	64	PF00069	0.507
MOD_Plk_1	96	102	PF00069	0.432
MOD_Plk_4	58	64	PF00069	0.507
MOD_Plk_4	77	83	PF00069	0.507
MOD_SUMO_rev_2	74	81	PF00179	0.428
MOD_SUMO_rev_2	87	96	PF00179	0.404
MOD_SUMO_rev_2	99	108	PF00179	0.421
TRG_ENDOCYTIC_2	118	121	PF00928	0.595
TRG_ENDOCYTIC_2	63	66	PF00928	0.432
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.285
TRG_Pf-PMV_PEXEL_1	37	42	PF00026	0.238

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Y5	Leptomonas seymouri	89%	97%
A0A0S4INB7	Bodo saltans	50%	99%
A0A1X0NLX1	Trypanosomatidae	66%	96%
A0A3R7LL27	Trypanosoma rangeli	67%	99%
A0A3S5H5M5	Leishmania donovani	100%	100%
A4H4G4	Leishmania braziliensis	94%	100%
C9ZNE5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AKM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
P52553	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	100%
Q03958	Mus musculus	36%	100%
Q2HIK4	Arabidopsis thaliana	40%	100%
Q4QJ82	Leishmania major	100%	100%
Q54M71	Dictyostelium discoideum	38%	96%
V5B7F5	Trypanosoma cruzi	68%	98%