Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid elongase - putative

Species:

Leishmania infantum

UniProt:

A4HSN8_LEIIN

TriTrypDb:

LINF_050017000

Length:

249

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Annotations by Jardim et al.

Fatty acid metabolism, Elongation of fatty acids

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HSN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSN8

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	13
GO:0006629	lipid metabolic process	3	13
GO:0006631	fatty acid metabolic process	4	13
GO:0006633	fatty acid biosynthetic process	5	13
GO:0008152	metabolic process	1	13
GO:0008610	lipid biosynthetic process	4	13
GO:0009058	biosynthetic process	2	13
GO:0009987	cellular process	1	13
GO:0016053	organic acid biosynthetic process	4	13
GO:0019752	carboxylic acid metabolic process	5	13
GO:0032787	monocarboxylic acid metabolic process	6	13
GO:0043436	oxoacid metabolic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044249	cellular biosynthetic process	3	13
GO:0044255	cellular lipid metabolic process	3	13
GO:0044281	small molecule metabolic process	2	13
GO:0044283	small molecule biosynthetic process	3	13
GO:0046394	carboxylic acid biosynthetic process	5	13
GO:0071704	organic substance metabolic process	2	13
GO:0072330	monocarboxylic acid biosynthetic process	6	13
GO:1901576	organic substance biosynthetic process	3	13
GO:0000038	very long-chain fatty acid metabolic process	5	1
GO:0001676	long-chain fatty acid metabolic process	5	1
GO:0006643	membrane lipid metabolic process	4	1
GO:0006665	sphingolipid metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0019367	fatty acid elongation, saturated fatty acid	7	1
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	1
GO:0030148	sphingolipid biosynthetic process	5	1
GO:0030497	fatty acid elongation	6	1
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	1
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	1
GO:0042759	long-chain fatty acid biosynthetic process	6	1
GO:0042761	very long-chain fatty acid biosynthetic process	6	1
GO:0046467	membrane lipid biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004312	fatty acid synthase activity	5	13
GO:0009922	fatty acid elongase activity	6	13
GO:0016740	transferase activity	2	13
GO:0016746	acyltransferase activity	3	13
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	13
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.223
CLV_NRD_NRD_1	236	238	PF00675	0.237
CLV_NRD_NRD_1	240	242	PF00675	0.225
CLV_NRD_NRD_1	244	246	PF00675	0.212
CLV_PCSK_KEX2_1	244	246	PF00082	0.230
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.241
CLV_PCSK_SKI1_1	186	190	PF00082	0.194
CLV_PCSK_SKI1_1	241	245	PF00082	0.258
DEG_Nend_UBRbox_1	1	4	PF02207	0.337
DOC_CDC14_PxL_1	24	32	PF14671	0.392
DOC_CYCLIN_yCln2_LP_2	56	62	PF00134	0.478
DOC_MAPK_gen_1	121	129	PF00069	0.402
DOC_MAPK_gen_1	215	222	PF00069	0.233
DOC_USP7_UBL2_3	238	242	PF12436	0.431
DOC_USP7_UBL2_3	244	248	PF12436	0.412
DOC_WW_Pin1_4	208	213	PF00397	0.217
LIG_14-3-3_CanoR_1	92	100	PF00244	0.246
LIG_AP2alpha_1	109	113	PF02296	0.392
LIG_BRCT_BRCA1_1	13	17	PF00533	0.275
LIG_deltaCOP1_diTrp_1	98	102	PF00928	0.222
LIG_EH1_1	36	44	PF00400	0.310
LIG_FHA_1	105	111	PF00498	0.232
LIG_FHA_1	113	119	PF00498	0.245
LIG_FHA_1	179	185	PF00498	0.528
LIG_FHA_1	50	56	PF00498	0.473
LIG_FHA_1	63	69	PF00498	0.314
LIG_FHA_1	92	98	PF00498	0.267
LIG_Integrin_isoDGR_2	90	92	PF01839	0.432
LIG_LIR_Apic_2	177	183	PF02991	0.422
LIG_LIR_Gen_1	107	117	PF02991	0.238
LIG_LIR_Gen_1	128	136	PF02991	0.237
LIG_LIR_Gen_1	227	236	PF02991	0.294
LIG_LIR_Gen_1	98	106	PF02991	0.203
LIG_LIR_Nem_3	111	116	PF02991	0.230
LIG_LIR_Nem_3	128	132	PF02991	0.143
LIG_LIR_Nem_3	96	102	PF02991	0.204
LIG_LYPXL_yS_3	27	30	PF13949	0.392
LIG_LYPXL_yS_3	58	61	PF13949	0.449
LIG_OCRL_FandH_1	197	209	PF00620	0.181
LIG_PCNA_yPIPBox_3	80	92	PF02747	0.178
LIG_Pex14_2	109	113	PF04695	0.351
LIG_Pex14_2	156	160	PF04695	0.263
LIG_SH2_CRK	175	179	PF00017	0.494
LIG_SH2_CRK	180	184	PF00017	0.461
LIG_SH2_GRB2like	180	183	PF00017	0.501
LIG_SH2_NCK_1	63	67	PF00017	0.261
LIG_SH2_STAP1	105	109	PF00017	0.307
LIG_SH2_STAT3	187	190	PF00017	0.517
LIG_SH2_STAT5	116	119	PF00017	0.316
LIG_SH2_STAT5	170	173	PF00017	0.293
LIG_SH2_STAT5	175	178	PF00017	0.430
LIG_SH2_STAT5	180	183	PF00017	0.427
LIG_SH2_STAT5	187	190	PF00017	0.409
LIG_SH2_STAT5	230	233	PF00017	0.319
LIG_SH2_STAT5	37	40	PF00017	0.250
LIG_SH2_STAT5	54	57	PF00017	0.402
LIG_SH3_3	22	28	PF00018	0.293
LIG_SxIP_EBH_1	206	216	PF03271	0.258
LIG_TYR_ITIM	25	30	PF00017	0.370
LIG_TYR_ITIM	35	40	PF00017	0.204
LIG_UBA3_1	41	46	PF00899	0.288
MOD_CDK_SPxxK_3	208	215	PF00069	0.217
MOD_GlcNHglycan	162	165	PF01048	0.326
MOD_GSK3_1	174	181	PF00069	0.368
MOD_N-GLC_1	151	156	PF02516	0.436
MOD_NEK2_1	112	117	PF00069	0.250
MOD_NEK2_1	174	179	PF00069	0.274
MOD_NEK2_1	62	67	PF00069	0.308
MOD_PIKK_1	186	192	PF00454	0.513
MOD_PKA_2	91	97	PF00069	0.224
MOD_Plk_4	112	118	PF00069	0.263
MOD_Plk_4	125	131	PF00069	0.462
MOD_Plk_4	224	230	PF00069	0.284
MOD_ProDKin_1	208	214	PF00069	0.217
TRG_DiLeu_BaEn_2	19	25	PF01217	0.323
TRG_DiLeu_BaEn_2	97	103	PF01217	0.222
TRG_ENDOCYTIC_2	116	119	PF00928	0.221
TRG_ENDOCYTIC_2	133	136	PF00928	0.363
TRG_ENDOCYTIC_2	175	178	PF00928	0.506
TRG_ENDOCYTIC_2	230	233	PF00928	0.317
TRG_ENDOCYTIC_2	27	30	PF00928	0.357
TRG_ENDOCYTIC_2	37	40	PF00928	0.184
TRG_ENDOCYTIC_2	45	48	PF00928	0.402
TRG_ENDOCYTIC_2	58	61	PF00928	0.373
TRG_ENDOCYTIC_2	84	87	PF00928	0.315
TRG_ENDOCYTIC_2	99	102	PF00928	0.355
TRG_ER_diLys_1	244	249	PF00400	0.630
TRG_NLS_MonoExtC_3	240	245	PF00514	0.508
TRG_NLS_MonoExtN_4	238	245	PF00514	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0C5PHQ7	Tachysurus fulvidraco	33%	85%
A0A0N0P5E5	Leptomonas seymouri	30%	83%
A0A0N1HZJ8	Leptomonas seymouri	28%	77%
A0A0N1PBS4	Leptomonas seymouri	76%	100%
A0A0N1PDR8	Leptomonas seymouri	30%	92%
A0A0S4IVS6	Bodo saltans	26%	88%
A0A0S4J4C4	Bodo saltans	61%	95%
A0A0S4JCZ3	Bodo saltans	32%	77%
A0A0S4JH58	Bodo saltans	36%	83%
A0A1X0NNK7	Trypanosomatidae	28%	87%
A0A1X0NNL0	Trypanosomatidae	28%	82%
A0A1X0NUJ4	Trypanosomatidae	29%	69%
A0A1X0P2P0	Trypanosomatidae	54%	100%
A0A3Q8IC05	Leishmania donovani	33%	82%
A0A3R7NSQ3	Trypanosoma rangeli	29%	86%
A0A3S5H5M3	Leishmania donovani	99%	100%
A0A422NYI1	Trypanosoma rangeli	55%	98%
A0JNC4	Bos taurus	30%	89%
A1L3X0	Homo sapiens	34%	89%
A4H4G1	Leishmania braziliensis	84%	100%
A4H7N0	Leishmania braziliensis	32%	84%
A4HKA3	Leishmania braziliensis	33%	76%
A4HW13	Leishmania infantum	28%	76%
A4HW18	Leishmania infantum	33%	82%
B4QVX4	Drosophila simulans	27%	95%
C9ZPY9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	99%
C9ZT15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	92%
C9ZT16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	81%
D4A612	Rattus norvegicus	36%	89%
D4ADY9	Rattus norvegicus	33%	89%
E9AKM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9APR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	77%
E9APR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	83%
G5EEE5	Caenorhabditis elegans	30%	86%
O35949	Mus musculus	25%	92%
P49191	Caenorhabditis elegans	28%	78%
Q1HRV8	Aedes aegypti	31%	70%
Q20300	Caenorhabditis elegans	29%	91%
Q20303	Caenorhabditis elegans	29%	91%
Q2KJD9	Bos taurus	31%	83%
Q32NI8	Xenopus laevis	30%	84%
Q3S8M4	Macaca mulatta	33%	79%
Q4QFQ9	Leishmania major	33%	83%
Q4QFR4	Leishmania major	29%	77%
Q4QFR7	Leishmania major	25%	100%
Q4QJ85	Leishmania major	94%	100%
Q4R516	Macaca fascicularis	30%	83%
Q54CJ4	Dictyostelium discoideum	30%	92%
Q54TC9	Dictyostelium discoideum	28%	93%
Q5M8U1	Xenopus tropicalis	31%	84%
Q5RFL5	Pongo abelii	30%	83%
Q6PC64	Danio rerio	27%	94%
Q7LKX0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	68%
Q86JM5	Dictyostelium discoideum	31%	84%
Q8BHI7	Mus musculus	32%	83%
Q920L7	Rattus norvegicus	31%	83%
Q95K73	Macaca fascicularis	33%	79%
Q9BW60	Homo sapiens	32%	89%
Q9D2Y9	Mus musculus	32%	89%
Q9EQC4	Mus musculus	33%	80%
Q9GZR5	Homo sapiens	32%	79%
Q9HB03	Homo sapiens	28%	92%
Q9JLJ4	Mus musculus	36%	85%
Q9JLJ5	Mus musculus	31%	89%
Q9NXB9	Homo sapiens	35%	84%
Q9NYP7	Homo sapiens	30%	83%
Q9VH58	Drosophila melanogaster	29%	97%
Q9VHX7	Drosophila melanogaster	30%	76%
Q9VV87	Drosophila melanogaster	29%	79%
Q9XVQ9	Caenorhabditis elegans	27%	91%
V5AUX1	Trypanosoma cruzi	58%	98%
V5BE99	Trypanosoma cruzi	25%	87%
V5DF68	Trypanosoma cruzi	28%	86%