Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - unknown function

Species:

Leishmania infantum

UniProt:

A4HSN7_LEIIN

TriTrypDb:

LINF_050016800

Length:

916

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

A4HSN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSN7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.512
CLV_C14_Caspase3-7	223	227	PF00656	0.818
CLV_C14_Caspase3-7	384	388	PF00656	0.594
CLV_NRD_NRD_1	138	140	PF00675	0.622
CLV_NRD_NRD_1	429	431	PF00675	0.556
CLV_NRD_NRD_1	483	485	PF00675	0.702
CLV_NRD_NRD_1	7	9	PF00675	0.658
CLV_NRD_NRD_1	832	834	PF00675	0.656
CLV_PCSK_KEX2_1	138	140	PF00082	0.600
CLV_PCSK_KEX2_1	429	431	PF00082	0.556
CLV_PCSK_KEX2_1	483	485	PF00082	0.702
CLV_PCSK_KEX2_1	642	644	PF00082	0.814
CLV_PCSK_KEX2_1	7	9	PF00082	0.658
CLV_PCSK_KEX2_1	831	833	PF00082	0.670
CLV_PCSK_PC1ET2_1	642	644	PF00082	0.814
CLV_PCSK_SKI1_1	429	433	PF00082	0.570
CLV_PCSK_SKI1_1	514	518	PF00082	0.712
CLV_PCSK_SKI1_1	685	689	PF00082	0.694
CLV_PCSK_SKI1_1	725	729	PF00082	0.679
CLV_PCSK_SKI1_1	856	860	PF00082	0.548
CLV_PCSK_SKI1_1	90	94	PF00082	0.539
DEG_APCC_DBOX_1	513	521	PF00400	0.583
DEG_SPOP_SBC_1	397	401	PF00917	0.632
DEG_SPOP_SBC_1	572	576	PF00917	0.790
DEG_SPOP_SBC_1	65	69	PF00917	0.664
DEG_SPOP_SBC_1	747	751	PF00917	0.809
DEG_SPOP_SBC_1	757	761	PF00917	0.713
DOC_ANK_TNKS_1	255	262	PF00023	0.668
DOC_CKS1_1	431	436	PF01111	0.704
DOC_CKS1_1	688	693	PF01111	0.704
DOC_CKS1_1	732	737	PF01111	0.702
DOC_CYCLIN_yCln2_LP_2	44	50	PF00134	0.603
DOC_CYCLIN_yCln2_LP_2	586	592	PF00134	0.672
DOC_CYCLIN_yCln2_LP_2	630	636	PF00134	0.709
DOC_CYCLIN_yCln2_LP_2	904	910	PF00134	0.681
DOC_MAPK_gen_1	138	145	PF00069	0.562
DOC_MAPK_gen_1	622	632	PF00069	0.752
DOC_MAPK_gen_1	694	703	PF00069	0.806
DOC_MAPK_MEF2A_6	360	367	PF00069	0.533
DOC_MAPK_RevD_3	818	832	PF00069	0.543
DOC_PP2B_LxvP_1	160	163	PF13499	0.722
DOC_PP2B_LxvP_1	630	633	PF13499	0.699
DOC_PP2B_LxvP_1	689	692	PF13499	0.704
DOC_PP2B_LxvP_1	904	907	PF13499	0.765
DOC_PP2B_LxvP_1	908	911	PF13499	0.741
DOC_PP4_FxxP_1	535	538	PF00568	0.571
DOC_PP4_FxxP_1	688	691	PF00568	0.708
DOC_USP7_MATH_1	127	131	PF00917	0.517
DOC_USP7_MATH_1	161	165	PF00917	0.736
DOC_USP7_MATH_1	183	187	PF00917	0.650
DOC_USP7_MATH_1	188	192	PF00917	0.667
DOC_USP7_MATH_1	298	302	PF00917	0.695
DOC_USP7_MATH_1	319	323	PF00917	0.696
DOC_USP7_MATH_1	441	445	PF00917	0.702
DOC_USP7_MATH_1	49	53	PF00917	0.739
DOC_USP7_MATH_1	540	544	PF00917	0.693
DOC_USP7_MATH_1	546	550	PF00917	0.677
DOC_USP7_MATH_1	573	577	PF00917	0.727
DOC_USP7_MATH_1	65	69	PF00917	0.601
DOC_USP7_MATH_1	681	685	PF00917	0.739
DOC_USP7_MATH_1	727	731	PF00917	0.664
DOC_USP7_MATH_1	75	79	PF00917	0.764
DOC_USP7_MATH_1	757	761	PF00917	0.652
DOC_USP7_MATH_1	780	784	PF00917	0.736
DOC_USP7_MATH_1	803	807	PF00917	0.690
DOC_USP7_MATH_1	809	813	PF00917	0.662
DOC_USP7_MATH_1	91	95	PF00917	0.629
DOC_WW_Pin1_4	169	174	PF00397	0.735
DOC_WW_Pin1_4	231	236	PF00397	0.702
DOC_WW_Pin1_4	340	345	PF00397	0.721
DOC_WW_Pin1_4	430	435	PF00397	0.664
DOC_WW_Pin1_4	437	442	PF00397	0.681
DOC_WW_Pin1_4	536	541	PF00397	0.750
DOC_WW_Pin1_4	585	590	PF00397	0.726
DOC_WW_Pin1_4	644	649	PF00397	0.755
DOC_WW_Pin1_4	655	660	PF00397	0.661
DOC_WW_Pin1_4	687	692	PF00397	0.705
DOC_WW_Pin1_4	712	717	PF00397	0.696
DOC_WW_Pin1_4	731	736	PF00397	0.711
LIG_14-3-3_CanoR_1	297	306	PF00244	0.690
LIG_14-3-3_CanoR_1	373	378	PF00244	0.592
LIG_14-3-3_CanoR_1	406	415	PF00244	0.639
LIG_14-3-3_CanoR_1	506	510	PF00244	0.811
LIG_14-3-3_CanoR_1	514	524	PF00244	0.607
LIG_14-3-3_CanoR_1	529	538	PF00244	0.501
LIG_14-3-3_CanoR_1	567	573	PF00244	0.645
LIG_14-3-3_CanoR_1	725	735	PF00244	0.759
LIG_14-3-3_CanoR_1	839	847	PF00244	0.537
LIG_14-3-3_CanoR_1	90	96	PF00244	0.619
LIG_Actin_WH2_2	9	26	PF00022	0.663
LIG_BIR_III_2	341	345	PF00653	0.696
LIG_BRCT_BRCA1_1	518	522	PF00533	0.581
LIG_BRCT_BRCA1_1	531	535	PF00533	0.451
LIG_FHA_1	115	121	PF00498	0.491
LIG_FHA_1	236	242	PF00498	0.734
LIG_FHA_1	29	35	PF00498	0.572
LIG_FHA_1	312	318	PF00498	0.639
LIG_FHA_1	399	405	PF00498	0.678
LIG_FHA_1	602	608	PF00498	0.677
LIG_FHA_1	757	763	PF00498	0.708
LIG_FHA_1	800	806	PF00498	0.627
LIG_FHA_1	808	814	PF00498	0.678
LIG_FHA_1	843	849	PF00498	0.600
LIG_FHA_1	859	865	PF00498	0.439
LIG_FHA_1	901	907	PF00498	0.659
LIG_FHA_1	94	100	PF00498	0.481
LIG_FHA_2	127	133	PF00498	0.506
LIG_FHA_2	172	178	PF00498	0.573
LIG_FHA_2	411	417	PF00498	0.500
LIG_FHA_2	506	512	PF00498	0.660
LIG_FHA_2	852	858	PF00498	0.636
LIG_LIR_Apic_2	532	538	PF02991	0.563
LIG_LIR_Gen_1	144	153	PF02991	0.492
LIG_LIR_Gen_1	174	183	PF02991	0.626
LIG_LIR_Gen_1	219	229	PF02991	0.708
LIG_LIR_Gen_1	582	592	PF02991	0.690
LIG_LIR_Nem_3	144	150	PF02991	0.479
LIG_LIR_Nem_3	174	179	PF02991	0.616
LIG_LIR_Nem_3	219	225	PF02991	0.714
LIG_LIR_Nem_3	582	587	PF02991	0.695
LIG_LIR_Nem_3	761	767	PF02991	0.707
LIG_MYND_1	403	407	PF01753	0.522
LIG_NRBOX	94	100	PF00104	0.575
LIG_PCNA_yPIPBox_3	554	567	PF02747	0.677
LIG_SH2_CRK	176	180	PF00017	0.632
LIG_SH2_CRK	330	334	PF00017	0.632
LIG_SH2_NCK_1	147	151	PF00017	0.583
LIG_SH2_PTP2	142	145	PF00017	0.460
LIG_SH2_STAP1	640	644	PF00017	0.703
LIG_SH2_STAT5	142	145	PF00017	0.460
LIG_SH2_STAT5	421	424	PF00017	0.495
LIG_SH3_2	732	737	PF14604	0.702
LIG_SH3_3	331	337	PF00018	0.800
LIG_SH3_3	341	347	PF00018	0.685
LIG_SH3_3	435	441	PF00018	0.654
LIG_SH3_3	711	717	PF00018	0.699
LIG_SH3_3	729	735	PF00018	0.762
LIG_SH3_3	896	902	PF00018	0.631
LIG_SUMO_SIM_anti_2	116	122	PF11976	0.549
LIG_SUMO_SIM_anti_2	611	616	PF11976	0.597
LIG_SUMO_SIM_par_1	116	124	PF11976	0.575
LIG_SUMO_SIM_par_1	240	248	PF11976	0.770
LIG_SUMO_SIM_par_1	312	318	PF11976	0.639
LIG_SUMO_SIM_par_1	362	368	PF11976	0.591
LIG_TRAF2_1	81	84	PF00917	0.631
LIG_TRAF2_1	865	868	PF00917	0.534
LIG_TYR_ITIM	140	145	PF00017	0.466
LIG_WW_3	691	695	PF00397	0.799
LIG_WW_3	734	738	PF00397	0.707
MOD_CDK_SPxK_1	430	436	PF00069	0.647
MOD_CDK_SPxK_1	646	652	PF00069	0.763
MOD_CDK_SPxK_1	731	737	PF00069	0.704
MOD_CDK_SPxxK_3	687	694	PF00069	0.705
MOD_CK1_1	146	152	PF00069	0.602
MOD_CK1_1	169	175	PF00069	0.757
MOD_CK1_1	184	190	PF00069	0.538
MOD_CK1_1	237	243	PF00069	0.727
MOD_CK1_1	244	250	PF00069	0.695
MOD_CK1_1	284	290	PF00069	0.721
MOD_CK1_1	293	299	PF00069	0.512
MOD_CK1_1	301	307	PF00069	0.596
MOD_CK1_1	322	328	PF00069	0.690
MOD_CK1_1	439	445	PF00069	0.721
MOD_CK1_1	515	521	PF00069	0.621
MOD_CK1_1	585	591	PF00069	0.772
MOD_CK1_1	655	661	PF00069	0.772
MOD_CK1_1	662	668	PF00069	0.803
MOD_CK1_1	69	75	PF00069	0.709
MOD_CK1_1	706	712	PF00069	0.747
MOD_CK1_1	749	755	PF00069	0.776
MOD_CK1_1	78	84	PF00069	0.739
MOD_CK2_1	183	189	PF00069	0.714
MOD_CK2_1	78	84	PF00069	0.654
MOD_CK2_1	851	857	PF00069	0.635
MOD_GlcNHglycan	300	303	PF01048	0.663
MOD_GlcNHglycan	317	320	PF01048	0.559
MOD_GlcNHglycan	321	324	PF01048	0.647
MOD_GlcNHglycan	350	353	PF01048	0.728
MOD_GlcNHglycan	384	387	PF01048	0.638
MOD_GlcNHglycan	444	447	PF01048	0.761
MOD_GlcNHglycan	462	466	PF01048	0.614
MOD_GlcNHglycan	480	483	PF01048	0.519
MOD_GlcNHglycan	531	534	PF01048	0.598
MOD_GlcNHglycan	542	545	PF01048	0.645
MOD_GlcNHglycan	575	578	PF01048	0.791
MOD_GlcNHglycan	634	637	PF01048	0.707
MOD_GlcNHglycan	654	657	PF01048	0.727
MOD_GlcNHglycan	709	712	PF01048	0.817
MOD_GlcNHglycan	729	732	PF01048	0.595
MOD_GlcNHglycan	73	76	PF01048	0.734
MOD_GlcNHglycan	781	785	PF01048	0.764
MOD_GlcNHglycan	786	789	PF01048	0.769
MOD_GlcNHglycan	799	802	PF01048	0.596
MOD_GlcNHglycan	813	816	PF01048	0.597
MOD_GlcNHglycan	83	89	PF01048	0.514
MOD_GSK3_1	184	191	PF00069	0.717
MOD_GSK3_1	231	238	PF00069	0.735
MOD_GSK3_1	241	248	PF00069	0.680
MOD_GSK3_1	250	257	PF00069	0.641
MOD_GSK3_1	298	305	PF00069	0.707
MOD_GSK3_1	311	318	PF00069	0.551
MOD_GSK3_1	348	355	PF00069	0.652
MOD_GSK3_1	437	444	PF00069	0.696
MOD_GSK3_1	488	495	PF00069	0.698
MOD_GSK3_1	512	519	PF00069	0.721
MOD_GSK3_1	525	532	PF00069	0.514
MOD_GSK3_1	536	543	PF00069	0.673
MOD_GSK3_1	568	575	PF00069	0.741
MOD_GSK3_1	61	68	PF00069	0.760
MOD_GSK3_1	655	662	PF00069	0.790
MOD_GSK3_1	693	700	PF00069	0.718
MOD_GSK3_1	703	710	PF00069	0.702
MOD_GSK3_1	71	78	PF00069	0.663
MOD_GSK3_1	727	734	PF00069	0.717
MOD_GSK3_1	746	753	PF00069	0.766
MOD_GSK3_1	780	787	PF00069	0.813
MOD_GSK3_1	799	806	PF00069	0.639
MOD_GSK3_1	807	814	PF00069	0.770
MOD_GSK3_1	838	845	PF00069	0.648
MOD_N-GLC_1	34	39	PF02516	0.479
MOD_N-GLC_1	470	475	PF02516	0.581
MOD_NEK2_1	121	126	PF00069	0.475
MOD_NEK2_1	245	250	PF00069	0.702
MOD_NEK2_1	34	39	PF00069	0.587
MOD_NEK2_1	365	370	PF00069	0.586
MOD_NEK2_1	415	420	PF00069	0.501
MOD_NEK2_1	461	466	PF00069	0.580
MOD_NEK2_1	478	483	PF00069	0.521
MOD_NEK2_1	48	53	PF00069	0.553
MOD_NEK2_1	560	565	PF00069	0.621
MOD_NEK2_1	726	731	PF00069	0.778
MOD_NEK2_1	748	753	PF00069	0.694
MOD_NEK2_1	794	799	PF00069	0.677
MOD_NEK2_1	858	863	PF00069	0.522
MOD_NEK2_2	579	584	PF00069	0.791
MOD_PIKK_1	328	334	PF00454	0.783
MOD_PIKK_1	49	55	PF00454	0.777
MOD_PIKK_1	741	747	PF00454	0.645
MOD_PK_1	697	703	PF00069	0.811
MOD_PKA_1	483	489	PF00069	0.711
MOD_PKA_2	296	302	PF00069	0.703
MOD_PKA_2	483	489	PF00069	0.711
MOD_PKA_2	492	498	PF00069	0.715
MOD_PKA_2	505	511	PF00069	0.602
MOD_PKA_2	693	699	PF00069	0.800
MOD_PKA_2	838	844	PF00069	0.553
MOD_PKB_1	371	379	PF00069	0.506
MOD_Plk_1	143	149	PF00069	0.565
MOD_Plk_1	284	290	PF00069	0.667
MOD_Plk_1	302	308	PF00069	0.664
MOD_Plk_1	311	317	PF00069	0.565
MOD_Plk_1	512	518	PF00069	0.669
MOD_Plk_1	610	616	PF00069	0.603
MOD_Plk_1	697	703	PF00069	0.779
MOD_Plk_1	757	763	PF00069	0.686
MOD_Plk_1	84	90	PF00069	0.583
MOD_Plk_1	842	848	PF00069	0.647
MOD_Plk_1	851	857	PF00069	0.489
MOD_Plk_2-3	492	498	PF00069	0.664
MOD_Plk_4	104	110	PF00069	0.548
MOD_Plk_4	116	122	PF00069	0.443
MOD_Plk_4	579	585	PF00069	0.791
MOD_Plk_4	610	616	PF00069	0.603
MOD_Plk_4	703	709	PF00069	0.736
MOD_ProDKin_1	169	175	PF00069	0.729
MOD_ProDKin_1	231	237	PF00069	0.703
MOD_ProDKin_1	340	346	PF00069	0.722
MOD_ProDKin_1	430	436	PF00069	0.679
MOD_ProDKin_1	437	443	PF00069	0.684
MOD_ProDKin_1	536	542	PF00069	0.742
MOD_ProDKin_1	585	591	PF00069	0.727
MOD_ProDKin_1	644	650	PF00069	0.756
MOD_ProDKin_1	655	661	PF00069	0.658
MOD_ProDKin_1	687	693	PF00069	0.704
MOD_ProDKin_1	712	718	PF00069	0.699
MOD_ProDKin_1	731	737	PF00069	0.716
MOD_SUMO_rev_2	852	861	PF00179	0.639
TRG_DiLeu_BaEn_4	84	90	PF01217	0.556
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.697
TRG_DiLeu_BaLyEn_6	400	405	PF01217	0.578
TRG_ENDOCYTIC_2	142	145	PF00928	0.460
TRG_ENDOCYTIC_2	147	150	PF00928	0.475
TRG_ENDOCYTIC_2	176	179	PF00928	0.626
TRG_ENDOCYTIC_2	764	767	PF00928	0.657
TRG_ENDOCYTIC_2	834	837	PF00928	0.596
TRG_ER_diArg_1	138	140	PF00400	0.622
TRG_ER_diArg_1	372	375	PF00400	0.536
TRG_ER_diArg_1	428	430	PF00400	0.553
TRG_ER_diArg_1	483	485	PF00400	0.759
TRG_ER_diArg_1	830	833	PF00400	0.554
TRG_NES_CRM1_1	879	892	PF08389	0.522
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	835	840	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	881	886	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I133	Leptomonas seymouri	38%	100%
A0A3S7WPA4	Leishmania donovani	99%	100%
A4H4G0	Leishmania braziliensis	67%	100%
E9AKM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	93%