LeishMANIAdb
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V-type proton ATPase subunit

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
V-type proton ATPase subunit
Gene product:
V-type proton ATPase subunit D - putative
Species:
Leishmania infantum
UniProt:
A4HSN6_LEIIN
TriTrypDb:
LINF_050016700
Length:
357

Annotations

Annotations by Jardim et al.

Acidocalcisome, Vacuolar ATPase subunit-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0032991 protein-containing complex 1 12
GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain 3 12
GO:0033179 proton-transporting V-type ATPase, V0 domain 4 12
GO:0098796 membrane protein complex 2 12
GO:0000323 lytic vacuole 6 1
GO:0005764 lysosome 7 1
GO:0005773 vacuole 5 1
GO:0005794 Golgi apparatus 5 1
GO:0016469 proton-transporting two-sector ATPase complex 3 1
GO:0016471 vacuolar proton-transporting V-type ATPase complex 5 1
GO:0020022 acidocalcisome 5 1
GO:0033176 proton-transporting V-type ATPase complex 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HSN6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSN6

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006873 intracellular monoatomic ion homeostasis 4 1
GO:0006885 regulation of pH 8 1
GO:0007034 vacuolar transport 4 1
GO:0007035 vacuolar acidification 10 1
GO:0009987 cellular process 1 1
GO:0019725 cellular homeostasis 2 1
GO:0030003 intracellular monoatomic cation homeostasis 5 1
GO:0030004 obsolete cellular monovalent inorganic cation homeostasis 6 1
GO:0030641 regulation of cellular pH 7 1
GO:0042592 homeostatic process 3 1
GO:0046907 intracellular transport 3 1
GO:0048878 chemical homeostasis 4 1
GO:0050801 monoatomic ion homeostasis 5 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051452 intracellular pH reduction 9 1
GO:0051453 regulation of intracellular pH 8 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0055067 obsolete monovalent inorganic cation homeostasis 7 1
GO:0055080 monoatomic cation homeostasis 6 1
GO:0055082 intracellular chemical homeostasis 3 1
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0098771 inorganic ion homeostasis 6 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 12
GO:0008324 monoatomic cation transmembrane transporter activity 4 12
GO:0009678 pyrophosphate hydrolysis-driven proton transmembrane transporter activity 5 12
GO:0015075 monoatomic ion transmembrane transporter activity 3 12
GO:0015078 proton transmembrane transporter activity 5 12
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 12
GO:0015399 primary active transmembrane transporter activity 4 12
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3 12
GO:0022804 active transmembrane transporter activity 3 12
GO:0022853 active monoatomic ion transmembrane transporter activity 4 12
GO:0022857 transmembrane transporter activity 2 12
GO:0022890 inorganic cation transmembrane transporter activity 4 12
GO:0042625 ATPase-coupled ion transmembrane transporter activity 3 12
GO:0042626 ATPase-coupled transmembrane transporter activity 2 12
GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 4 12
GO:0046961 proton-transporting ATPase activity, rotational mechanism 4 12
GO:0140657 ATP-dependent activity 1 12
GO:0003824 catalytic activity 1 2
GO:0016787 hydrolase activity 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 237 239 PF00675 0.311
CLV_NRD_NRD_1 268 270 PF00675 0.310
CLV_NRD_NRD_1 294 296 PF00675 0.379
CLV_PCSK_FUR_1 266 270 PF00082 0.294
CLV_PCSK_KEX2_1 114 116 PF00082 0.288
CLV_PCSK_KEX2_1 237 239 PF00082 0.310
CLV_PCSK_KEX2_1 268 270 PF00082 0.294
CLV_PCSK_KEX2_1 294 296 PF00082 0.294
CLV_PCSK_PC1ET2_1 114 116 PF00082 0.294
CLV_PCSK_PC7_1 264 270 PF00082 0.310
CLV_PCSK_SKI1_1 181 185 PF00082 0.310
CLV_PCSK_SKI1_1 217 221 PF00082 0.329
CLV_PCSK_SKI1_1 23 27 PF00082 0.414
CLV_PCSK_SKI1_1 230 234 PF00082 0.298
CLV_PCSK_SKI1_1 238 242 PF00082 0.294
CLV_PCSK_SKI1_1 78 82 PF00082 0.378
DEG_APCC_DBOX_1 117 125 PF00400 0.286
DEG_APCC_DBOX_1 22 30 PF00400 0.375
DOC_AGCK_PIF_2 97 102 PF00069 0.356
DOC_MAPK_gen_1 114 123 PF00069 0.270
DOC_MAPK_gen_1 294 301 PF00069 0.379
DOC_MAPK_MEF2A_6 294 303 PF00069 0.361
DOC_USP7_MATH_1 113 117 PF00917 0.294
DOC_USP7_MATH_1 283 287 PF00917 0.384
DOC_WW_Pin1_4 153 158 PF00397 0.294
DOC_WW_Pin1_4 230 235 PF00397 0.384
LIG_14-3-3_CanoR_1 160 168 PF00244 0.329
LIG_14-3-3_CanoR_1 217 223 PF00244 0.297
LIG_APCC_ABBA_1 130 135 PF00400 0.414
LIG_APCC_ABBA_1 248 253 PF00400 0.294
LIG_APCC_ABBA_1 301 306 PF00400 0.310
LIG_Clathr_ClatBox_1 26 30 PF01394 0.375
LIG_eIF4E_1 179 185 PF01652 0.310
LIG_FHA_1 201 207 PF00498 0.294
LIG_FHA_1 219 225 PF00498 0.294
LIG_FHA_1 62 68 PF00498 0.279
LIG_FHA_2 2 8 PF00498 0.495
LIG_FHA_2 231 237 PF00498 0.367
LIG_LIR_Apic_2 85 89 PF02991 0.329
LIG_LIR_Gen_1 147 157 PF02991 0.295
LIG_LIR_Gen_1 293 304 PF02991 0.361
LIG_LIR_Gen_1 30 39 PF02991 0.294
LIG_LIR_Gen_1 99 108 PF02991 0.227
LIG_LIR_Nem_3 147 152 PF02991 0.305
LIG_LIR_Nem_3 190 195 PF02991 0.295
LIG_LIR_Nem_3 30 35 PF02991 0.294
LIG_LIR_Nem_3 51 56 PF02991 0.294
LIG_LIR_Nem_3 96 100 PF02991 0.227
LIG_Pex14_2 270 274 PF04695 0.414
LIG_SH2_CRK 318 322 PF00017 0.379
LIG_SH2_CRK 32 36 PF00017 0.270
LIG_SH2_PTP2 320 323 PF00017 0.379
LIG_SH2_SRC 318 321 PF00017 0.379
LIG_SH2_STAP1 100 104 PF00017 0.222
LIG_SH2_STAP1 189 193 PF00017 0.333
LIG_SH2_STAT3 188 191 PF00017 0.310
LIG_SH2_STAT5 179 182 PF00017 0.294
LIG_SH2_STAT5 273 276 PF00017 0.441
LIG_SH2_STAT5 320 323 PF00017 0.379
LIG_SH2_STAT5 349 352 PF00017 0.370
LIG_SH3_3 131 137 PF00018 0.414
LIG_SH3_3 203 209 PF00018 0.286
LIG_SUMO_SIM_anti_2 150 156 PF11976 0.329
LIG_SUMO_SIM_par_1 150 156 PF11976 0.305
LIG_SUMO_SIM_par_1 246 253 PF11976 0.310
LIG_TYR_ITIM 316 321 PF00017 0.310
LIG_WRC_WIRS_1 219 224 PF05994 0.329
MOD_CDK_SPxxK_3 153 160 PF00069 0.294
MOD_CDK_SPxxK_3 230 237 PF00069 0.414
MOD_CK1_1 243 249 PF00069 0.402
MOD_CK2_1 254 260 PF00069 0.414
MOD_CK2_1 82 88 PF00069 0.441
MOD_GlcNHglycan 115 118 PF01048 0.306
MOD_GlcNHglycan 162 165 PF01048 0.329
MOD_GlcNHglycan 285 288 PF01048 0.438
MOD_N-GLC_2 34 36 PF02516 0.342
MOD_NEK2_1 1 6 PF00069 0.604
MOD_NEK2_1 218 223 PF00069 0.333
MOD_PIKK_1 43 49 PF00454 0.310
MOD_Plk_1 173 179 PF00069 0.310
MOD_Plk_1 297 303 PF00069 0.270
MOD_Plk_2-3 173 179 PF00069 0.310
MOD_Plk_2-3 82 88 PF00069 0.441
MOD_Plk_2-3 96 102 PF00069 0.299
MOD_Plk_4 135 141 PF00069 0.379
MOD_Plk_4 243 249 PF00069 0.294
MOD_Plk_4 297 303 PF00069 0.361
MOD_ProDKin_1 153 159 PF00069 0.294
MOD_ProDKin_1 230 236 PF00069 0.384
MOD_SUMO_rev_2 39 46 PF00179 0.294
TRG_DiLeu_BaEn_1 135 140 PF01217 0.367
TRG_DiLeu_BaLyEn_6 206 211 PF01217 0.329
TRG_ENDOCYTIC_2 100 103 PF00928 0.208
TRG_ENDOCYTIC_2 189 192 PF00928 0.339
TRG_ENDOCYTIC_2 273 276 PF00928 0.414
TRG_ENDOCYTIC_2 314 317 PF00928 0.294
TRG_ENDOCYTIC_2 318 321 PF00928 0.294
TRG_ENDOCYTIC_2 32 35 PF00928 0.278
TRG_ENDOCYTIC_2 53 56 PF00928 0.294
TRG_ER_diArg_1 266 269 PF00400 0.310
TRG_ER_diArg_1 294 296 PF00400 0.379
TRG_ER_diArg_1 342 345 PF00400 0.414
TRG_NES_CRM1_1 265 279 PF08389 0.385
TRG_NES_CRM1_1 39 52 PF08389 0.294
TRG_Pf-PMV_PEXEL_1 170 174 PF00026 0.319
TRG_Pf-PMV_PEXEL_1 66 70 PF00026 0.334

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHC7 Leptomonas seymouri 91% 100%
A0A0S4INJ3 Bodo saltans 64% 100%
A0A1X0NK55 Trypanosomatidae 71% 98%
A0A3S7WP99 Leishmania donovani 100% 100%
A0A422N530 Trypanosoma rangeli 70% 100%
A4H4F9 Leishmania braziliensis 94% 100%
C9ZNE1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 93%
E9AKM1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
O13753 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 40% 100%
P32366 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 35% 100%
P51863 Mus musculus 41% 100%
P53659 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 34% 98%
P54641 Dictyostelium discoideum 40% 100%
P61420 Bos taurus 41% 100%
P61421 Homo sapiens 41% 100%
Q25531 Manduca sexta 40% 100%
Q2KJB6 Bos taurus 39% 100%
Q4QJ88 Leishmania major 98% 100%
Q5FVL0 Rattus norvegicus 39% 100%
Q5R6I1 Pongo abelii 41% 100%
Q5R7B7 Pongo abelii 40% 100%
Q5ZHL0 Gallus gallus 40% 100%
Q6P335 Xenopus tropicalis 40% 100%
Q6PGV1 Danio rerio 41% 100%
Q80SY3 Mus musculus 39% 100%
Q8N8Y2 Homo sapiens 40% 100%
Q8RU33 Oryza sativa subsp. japonica 39% 100%
Q9LHA4 Arabidopsis thaliana 38% 100%
Q9LJI5 Arabidopsis thaliana 38% 100%
Q9VCQ3 Drosophila melanogaster 35% 100%
Q9W4P5 Drosophila melanogaster 40% 100%
V5ARU6 Trypanosoma cruzi 68% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS