LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Protein of unknown function (DUF2946), putative
Species:
Leishmania infantum
UniProt:
A4HSN5_LEIIN
TriTrypDb:
Length:
508

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HSN5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSN5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 170 174 PF00656 0.558
CLV_C14_Caspase3-7 184 188 PF00656 0.628
CLV_C14_Caspase3-7 489 493 PF00656 0.769
CLV_NRD_NRD_1 15 17 PF00675 0.689
CLV_NRD_NRD_1 221 223 PF00675 0.467
CLV_NRD_NRD_1 63 65 PF00675 0.490
CLV_PCSK_KEX2_1 15 17 PF00082 0.557
CLV_PCSK_KEX2_1 221 223 PF00082 0.467
CLV_PCSK_KEX2_1 356 358 PF00082 0.455
CLV_PCSK_KEX2_1 63 65 PF00082 0.490
CLV_PCSK_PC1ET2_1 356 358 PF00082 0.381
CLV_PCSK_SKI1_1 102 106 PF00082 0.409
CLV_PCSK_SKI1_1 2 6 PF00082 0.495
CLV_PCSK_SKI1_1 213 217 PF00082 0.308
CLV_PCSK_SKI1_1 283 287 PF00082 0.412
CLV_PCSK_SKI1_1 311 315 PF00082 0.352
CLV_PCSK_SKI1_1 427 431 PF00082 0.546
CLV_PCSK_SKI1_1 458 462 PF00082 0.389
DEG_Nend_UBRbox_1 1 4 PF02207 0.486
DEG_SPOP_SBC_1 444 448 PF00917 0.508
DOC_CKS1_1 179 184 PF01111 0.587
DOC_CKS1_1 369 374 PF01111 0.560
DOC_CYCLIN_RxL_1 332 342 PF00134 0.503
DOC_CYCLIN_yCln2_LP_2 337 343 PF00134 0.336
DOC_MAPK_gen_1 425 434 PF00069 0.457
DOC_MAPK_gen_1 456 464 PF00069 0.366
DOC_MAPK_MEF2A_6 213 220 PF00069 0.347
DOC_MAPK_MEF2A_6 335 343 PF00069 0.406
DOC_MAPK_MEF2A_6 456 464 PF00069 0.420
DOC_PP2B_LxvP_1 337 340 PF13499 0.355
DOC_PP2B_LxvP_1 341 344 PF13499 0.314
DOC_PP2B_LxvP_1 362 365 PF13499 0.337
DOC_SPAK_OSR1_1 166 170 PF12202 0.476
DOC_SPAK_OSR1_1 347 351 PF12202 0.310
DOC_USP7_MATH_1 226 230 PF00917 0.307
DOC_USP7_MATH_1 33 37 PF00917 0.452
DOC_USP7_MATH_1 333 337 PF00917 0.501
DOC_USP7_MATH_1 436 440 PF00917 0.471
DOC_USP7_MATH_1 487 491 PF00917 0.701
DOC_USP7_MATH_1 494 498 PF00917 0.575
DOC_WW_Pin1_4 14 19 PF00397 0.563
DOC_WW_Pin1_4 175 180 PF00397 0.535
DOC_WW_Pin1_4 368 373 PF00397 0.527
DOC_WW_Pin1_4 386 391 PF00397 0.385
DOC_WW_Pin1_4 501 506 PF00397 0.624
LIG_14-3-3_CanoR_1 486 494 PF00244 0.481
LIG_14-3-3_CanoR_1 69 73 PF00244 0.358
LIG_14-3-3_CanoR_1 84 91 PF00244 0.412
LIG_Actin_WH2_2 139 157 PF00022 0.505
LIG_BIR_III_4 395 399 PF00653 0.316
LIG_BRCT_BRCA1_1 69 73 PF00533 0.377
LIG_deltaCOP1_diTrp_1 351 358 PF00928 0.329
LIG_FHA_1 184 190 PF00498 0.555
LIG_FHA_1 303 309 PF00498 0.368
LIG_FHA_1 312 318 PF00498 0.376
LIG_FHA_1 417 423 PF00498 0.442
LIG_FHA_1 7 13 PF00498 0.570
LIG_FHA_2 182 188 PF00498 0.630
LIG_FHA_2 292 298 PF00498 0.492
LIG_FHA_2 369 375 PF00498 0.479
LIG_FHA_2 406 412 PF00498 0.521
LIG_FHA_2 444 450 PF00498 0.429
LIG_FHA_2 69 75 PF00498 0.357
LIG_GSK3_LRP6_1 368 373 PF00069 0.441
LIG_Integrin_RGD_1 295 297 PF01839 0.432
LIG_LIR_Gen_1 3 12 PF02991 0.512
LIG_LIR_Gen_1 408 417 PF02991 0.542
LIG_LIR_LC3C_4 459 463 PF02991 0.424
LIG_LIR_Nem_3 3 8 PF02991 0.506
LIG_LIR_Nem_3 342 348 PF02991 0.376
LIG_LIR_Nem_3 352 358 PF02991 0.300
LIG_LIR_Nem_3 408 412 PF02991 0.420
LIG_LIR_Nem_3 439 444 PF02991 0.404
LIG_PCNA_PIPBox_1 147 156 PF02747 0.401
LIG_Pex14_1 355 359 PF04695 0.361
LIG_Pex14_2 354 358 PF04695 0.321
LIG_Pex14_2 95 99 PF04695 0.451
LIG_PTB_Apo_2 229 236 PF02174 0.419
LIG_REV1ctd_RIR_1 2 11 PF16727 0.501
LIG_SH2_CRK 263 267 PF00017 0.342
LIG_SH2_CRK 359 363 PF00017 0.453
LIG_SH2_CRK 441 445 PF00017 0.509
LIG_SH2_SRC 441 444 PF00017 0.372
LIG_SH2_STAT5 210 213 PF00017 0.295
LIG_SH2_STAT5 303 306 PF00017 0.353
LIG_SH2_STAT5 392 395 PF00017 0.403
LIG_SH3_1 15 21 PF00018 0.591
LIG_SH3_3 15 21 PF00018 0.568
LIG_SH3_3 176 182 PF00018 0.643
LIG_SH3_3 29 35 PF00018 0.324
LIG_SH3_3 362 368 PF00018 0.363
LIG_SH3_3 497 503 PF00018 0.787
LIG_SH3_4 271 278 PF00018 0.437
LIG_Sin3_3 251 258 PF02671 0.361
LIG_SUMO_SIM_anti_2 459 466 PF11976 0.459
LIG_SUMO_SIM_par_1 459 466 PF11976 0.404
LIG_TRAF2_1 134 137 PF00917 0.420
LIG_TRAF2_1 371 374 PF00917 0.491
LIG_TYR_ITIM 261 266 PF00017 0.339
LIG_WRC_WIRS_1 1 6 PF05994 0.504
LIG_WRC_WIRS_1 406 411 PF05994 0.406
LIG_WRC_WIRS_1 464 469 PF05994 0.532
MOD_CDK_SPK_2 178 183 PF00069 0.581
MOD_CDK_SPxxK_3 501 508 PF00069 0.627
MOD_CK1_1 3 9 PF00069 0.528
MOD_CK2_1 368 374 PF00069 0.475
MOD_CK2_1 443 449 PF00069 0.419
MOD_CK2_1 501 507 PF00069 0.625
MOD_CK2_1 54 60 PF00069 0.479
MOD_GlcNHglycan 475 478 PF01048 0.499
MOD_GlcNHglycan 496 499 PF01048 0.661
MOD_GSK3_1 181 188 PF00069 0.654
MOD_GSK3_1 262 269 PF00069 0.483
MOD_GSK3_1 298 305 PF00069 0.383
MOD_GSK3_1 3 10 PF00069 0.605
MOD_GSK3_1 307 314 PF00069 0.297
MOD_GSK3_1 315 322 PF00069 0.285
MOD_NEK2_1 11 16 PF00069 0.580
MOD_NEK2_1 266 271 PF00069 0.564
MOD_NEK2_1 291 296 PF00069 0.472
MOD_NEK2_2 185 190 PF00069 0.558
MOD_OFUCOSY 87 93 PF10250 0.372
MOD_PKA_2 473 479 PF00069 0.536
MOD_PKA_2 68 74 PF00069 0.362
MOD_PKA_2 83 89 PF00069 0.404
MOD_Plk_1 204 210 PF00069 0.427
MOD_Plk_1 240 246 PF00069 0.397
MOD_Plk_4 205 211 PF00069 0.404
MOD_Plk_4 226 232 PF00069 0.325
MOD_Plk_4 68 74 PF00069 0.343
MOD_Plk_4 7 13 PF00069 0.472
MOD_ProDKin_1 14 20 PF00069 0.552
MOD_ProDKin_1 175 181 PF00069 0.533
MOD_ProDKin_1 368 374 PF00069 0.529
MOD_ProDKin_1 386 392 PF00069 0.373
MOD_ProDKin_1 501 507 PF00069 0.625
MOD_SUMO_rev_2 373 377 PF00179 0.539
MOD_SUMO_rev_2 424 432 PF00179 0.413
TRG_DiLeu_BaEn_1 126 131 PF01217 0.511
TRG_DiLeu_BaEn_1 282 287 PF01217 0.397
TRG_DiLeu_BaEn_4 204 210 PF01217 0.414
TRG_DiLeu_BaLyEn_6 281 286 PF01217 0.357
TRG_ENDOCYTIC_2 263 266 PF00928 0.333
TRG_ENDOCYTIC_2 345 348 PF00928 0.325
TRG_ENDOCYTIC_2 359 362 PF00928 0.453
TRG_ENDOCYTIC_2 441 444 PF00928 0.388
TRG_ER_diArg_1 220 222 PF00400 0.479
TRG_ER_diArg_1 242 245 PF00400 0.381
TRG_Pf-PMV_PEXEL_1 166 170 PF00026 0.476

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2F7 Leptomonas seymouri 80% 100%
A0A0S4IPB6 Bodo saltans 43% 97%
A0A1X0NKA7 Trypanosomatidae 51% 87%
A0A3R7NCC1 Trypanosoma rangeli 55% 96%
A0A3S7WPA3 Leishmania donovani 100% 100%
A4H4F8 Leishmania braziliensis 92% 100%
C9ZND9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 77%
E9AKM0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4QJ89 Leishmania major 97% 100%
V5D7S2 Trypanosoma cruzi 55% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS