Putative double-strand-break repair protein rad21 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

double-strand-break repair protein rad21 homolog - putative

Species:

Leishmania infantum

UniProt:

A4HSN1_LEIIN

TriTrypDb:

LINF_050016200

Length:

574

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0008278	cohesin complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0044815	DNA packaging complex	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005654	nucleoplasm	2	1

Expansion

Sequence features

A4HSN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSN1

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	12
GO:0007062	sister chromatid cohesion	3	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022402	cell cycle process	2	12
GO:0051276	chromosome organization	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1990414	replication-born double-strand break repair via sister chromatid exchange	8	1

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.643
CLV_NRD_NRD_1	309	311	PF00675	0.568
CLV_NRD_NRD_1	346	348	PF00675	0.524
CLV_NRD_NRD_1	419	421	PF00675	0.717
CLV_NRD_NRD_1	459	461	PF00675	0.600
CLV_NRD_NRD_1	501	503	PF00675	0.564
CLV_NRD_NRD_1	529	531	PF00675	0.266
CLV_PCSK_FUR_1	459	463	PF00082	0.719
CLV_PCSK_KEX2_1	25	27	PF00082	0.264
CLV_PCSK_KEX2_1	346	348	PF00082	0.524
CLV_PCSK_KEX2_1	419	421	PF00082	0.655
CLV_PCSK_KEX2_1	459	461	PF00082	0.594
CLV_PCSK_KEX2_1	528	530	PF00082	0.265
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.315
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.578
CLV_PCSK_PC7_1	525	531	PF00082	0.257
CLV_PCSK_SKI1_1	25	29	PF00082	0.231
CLV_PCSK_SKI1_1	327	331	PF00082	0.556
CLV_PCSK_SKI1_1	72	76	PF00082	0.242
DEG_Nend_Nbox_1	1	3	PF02207	0.431
DOC_CYCLIN_RxL_1	69	79	PF00134	0.442
DOC_MAPK_gen_1	205	213	PF00069	0.483
DOC_MAPK_gen_1	235	244	PF00069	0.566
DOC_MAPK_gen_1	25	34	PF00069	0.442
DOC_MAPK_gen_1	307	317	PF00069	0.587
DOC_MAPK_gen_1	489	496	PF00069	0.459
DOC_MAPK_HePTP_8	51	63	PF00069	0.431
DOC_MAPK_MEF2A_6	235	244	PF00069	0.665
DOC_MAPK_MEF2A_6	46	53	PF00069	0.456
DOC_MAPK_MEF2A_6	489	496	PF00069	0.502
DOC_MAPK_MEF2A_6	54	63	PF00069	0.408
DOC_MAPK_NFAT4_5	489	497	PF00069	0.512
DOC_PP4_FxxP_1	287	290	PF00568	0.624
DOC_USP7_MATH_1	217	221	PF00917	0.705
DOC_USP7_MATH_1	303	307	PF00917	0.551
DOC_USP7_MATH_1	335	339	PF00917	0.506
DOC_USP7_MATH_1	418	422	PF00917	0.638
DOC_USP7_MATH_1	541	545	PF00917	0.452
DOC_USP7_UBL2_3	72	76	PF12436	0.456
LIG_14-3-3_CanoR_1	104	112	PF00244	0.748
LIG_14-3-3_CanoR_1	358	362	PF00244	0.585
LIG_14-3-3_CanoR_1	399	406	PF00244	0.482
LIG_14-3-3_CanoR_1	419	427	PF00244	0.718
LIG_14-3-3_CanoR_1	506	511	PF00244	0.479
LIG_14-3-3_CanoR_1	86	91	PF00244	0.498
LIG_Actin_WH2_2	378	393	PF00022	0.611
LIG_Actin_WH2_2	38	56	PF00022	0.498
LIG_Actin_WH2_2	483	499	PF00022	0.536
LIG_Actin_WH2_2	507	523	PF00022	0.327
LIG_Actin_WH2_2	62	78	PF00022	0.456
LIG_AP2alpha_2	285	287	PF02296	0.567
LIG_BIR_III_2	378	382	PF00653	0.586
LIG_FHA_1	103	109	PF00498	0.596
LIG_FHA_1	3	9	PF00498	0.431
LIG_FHA_1	505	511	PF00498	0.441
LIG_FHA_1	80	86	PF00498	0.442
LIG_FHA_2	104	110	PF00498	0.672
LIG_FHA_2	166	172	PF00498	0.573
LIG_FHA_2	26	32	PF00498	0.440
LIG_FHA_2	53	59	PF00498	0.433
LIG_FHA_2	533	539	PF00498	0.569
LIG_FHA_2	560	566	PF00498	0.430
LIG_LIR_Apic_2	284	290	PF02991	0.600
LIG_LIR_Gen_1	147	157	PF02991	0.455
LIG_LIR_Gen_1	199	208	PF02991	0.428
LIG_LIR_Gen_1	535	543	PF02991	0.454
LIG_LIR_Gen_1	82	91	PF02991	0.544
LIG_LIR_Nem_3	147	153	PF02991	0.435
LIG_LIR_Nem_3	177	182	PF02991	0.545
LIG_LIR_Nem_3	199	203	PF02991	0.431
LIG_LIR_Nem_3	535	539	PF02991	0.454
LIG_LIR_Nem_3	82	87	PF02991	0.535
LIG_MYND_1	286	290	PF01753	0.636
LIG_SH2_NCK_1	200	204	PF00017	0.446
LIG_SH2_SRC	200	203	PF00017	0.448
LIG_SH2_STAP1	200	204	PF00017	0.446
LIG_SH2_STAP1	394	398	PF00017	0.473
LIG_SH2_STAP1	67	71	PF00017	0.466
LIG_SH2_STAT3	180	183	PF00017	0.636
LIG_SH2_STAT3	350	353	PF00017	0.514
LIG_SH2_STAT5	180	183	PF00017	0.617
LIG_SH2_STAT5	359	362	PF00017	0.638
LIG_SH2_STAT5	547	550	PF00017	0.535
LIG_SH2_STAT5	6	9	PF00017	0.433
LIG_SH3_3	108	114	PF00018	0.645
LIG_SH3_3	257	263	PF00018	0.620
LIG_SH3_3	265	271	PF00018	0.643
LIG_SH3_3	280	286	PF00018	0.667
LIG_SH3_3	382	388	PF00018	0.623
LIG_SH3_3	44	50	PF00018	0.431
LIG_SH3_4	504	511	PF00018	0.433
LIG_SUMO_SIM_anti_2	535	541	PF11976	0.456
LIG_SUMO_SIM_par_1	33	38	PF11976	0.498
LIG_SUMO_SIM_par_1	49	56	PF11976	0.372
LIG_SUMO_SIM_par_1	538	544	PF11976	0.431
LIG_TRAF2_1	352	355	PF00917	0.582
LIG_TRAF2_1	401	404	PF00917	0.470
LIG_TRAF2_1	451	454	PF00917	0.550
MOD_CK1_1	220	226	PF00069	0.600
MOD_CK1_1	228	234	PF00069	0.518
MOD_CK1_1	509	515	PF00069	0.565
MOD_CK2_1	115	121	PF00069	0.568
MOD_CK2_1	165	171	PF00069	0.577
MOD_CK2_1	228	234	PF00069	0.685
MOD_CK2_1	25	31	PF00069	0.464
MOD_CK2_1	398	404	PF00069	0.559
MOD_CK2_1	52	58	PF00069	0.431
MOD_CK2_1	559	565	PF00069	0.430
MOD_Cter_Amidation	308	311	PF01082	0.618
MOD_GlcNHglycan	176	179	PF01048	0.528
MOD_GlcNHglycan	217	220	PF01048	0.611
MOD_GlcNHglycan	363	366	PF01048	0.610
MOD_GlcNHglycan	382	385	PF01048	0.559
MOD_GlcNHglycan	400	403	PF01048	0.365
MOD_GlcNHglycan	479	482	PF01048	0.448
MOD_GlcNHglycan	548	551	PF01048	0.309
MOD_GlcNHglycan	55	58	PF01048	0.266
MOD_GlcNHglycan	565	568	PF01048	0.392
MOD_GSK3_1	174	181	PF00069	0.580
MOD_GSK3_1	2	9	PF00069	0.431
MOD_GSK3_1	215	222	PF00069	0.551
MOD_GSK3_1	225	232	PF00069	0.610
MOD_GSK3_1	319	326	PF00069	0.633
MOD_GSK3_1	357	364	PF00069	0.642
MOD_GSK3_1	470	477	PF00069	0.500
MOD_GSK3_1	479	486	PF00069	0.411
MOD_GSK3_1	559	566	PF00069	0.418
MOD_GSK3_1	85	92	PF00069	0.498
MOD_N-GLC_1	563	568	PF02516	0.380
MOD_N-GLC_2	316	318	PF02516	0.577
MOD_NEK2_1	1	6	PF00069	0.431
MOD_NEK2_1	157	162	PF00069	0.591
MOD_NEK2_1	174	179	PF00069	0.520
MOD_NEK2_1	320	325	PF00069	0.531
MOD_NEK2_1	37	42	PF00069	0.451
MOD_NEK2_1	413	418	PF00069	0.652
MOD_NEK2_1	443	448	PF00069	0.753
MOD_NEK2_1	492	497	PF00069	0.476
MOD_NEK2_1	563	568	PF00069	0.493
MOD_NEK2_1	85	90	PF00069	0.480
MOD_PIKK_1	183	189	PF00454	0.520
MOD_PIKK_1	35	41	PF00454	0.535
MOD_PIKK_1	504	510	PF00454	0.602
MOD_PK_1	104	110	PF00069	0.673
MOD_PK_1	506	512	PF00069	0.392
MOD_PKA_1	25	31	PF00069	0.431
MOD_PKA_2	103	109	PF00069	0.756
MOD_PKA_2	215	221	PF00069	0.567
MOD_PKA_2	236	242	PF00069	0.539
MOD_PKA_2	25	31	PF00069	0.442
MOD_PKA_2	357	363	PF00069	0.577
MOD_PKA_2	398	404	PF00069	0.540
MOD_PKA_2	413	419	PF00069	0.513
MOD_PKA_2	53	59	PF00069	0.462
MOD_PKA_2	85	91	PF00069	0.474
MOD_PKB_1	462	470	PF00069	0.499
MOD_Plk_1	320	326	PF00069	0.589
MOD_Plk_1	464	470	PF00069	0.764
MOD_Plk_1	471	477	PF00069	0.569
MOD_Plk_1	492	498	PF00069	0.452
MOD_Plk_1	563	569	PF00069	0.389
MOD_Plk_1	79	85	PF00069	0.448
MOD_Plk_2-3	121	127	PF00069	0.525
MOD_Plk_4	2	8	PF00069	0.431
MOD_Plk_4	37	43	PF00069	0.442
MOD_Plk_4	445	451	PF00069	0.511
MOD_Plk_4	509	515	PF00069	0.549
MOD_Plk_4	79	85	PF00069	0.442
MOD_SUMO_rev_2	495	505	PF00179	0.470
TRG_DiLeu_BaEn_2	79	85	PF01217	0.535
TRG_DiLeu_BaLyEn_6	566	571	PF01217	0.400
TRG_ENDOCYTIC_2	200	203	PF00928	0.479
TRG_ER_diArg_1	305	308	PF00400	0.694
TRG_ER_diArg_1	345	347	PF00400	0.536
TRG_ER_diArg_1	459	462	PF00400	0.649
TRG_ER_diArg_1	489	492	PF00400	0.467
TRG_ER_diArg_1	527	530	PF00400	0.456
TRG_NLS_MonoCore_2	502	507	PF00514	0.465
TRG_NLS_MonoExtC_3	309	314	PF00514	0.667
TRG_NLS_MonoExtC_3	459	464	PF00514	0.611
TRG_NLS_MonoExtN_4	307	314	PF00514	0.624
TRG_NLS_MonoExtN_4	459	464	PF00514	0.726
TRG_NLS_MonoExtN_4	500	507	PF00514	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBV6	Leptomonas seymouri	66%	100%
A0A0S4ISR7	Bodo saltans	39%	100%
A0A1X0NLU9	Trypanosomatidae	45%	92%
A0A3S5H5L9	Leishmania donovani	100%	100%
A0A422NBQ8	Trypanosoma rangeli	47%	99%
A4H4F4	Leishmania braziliensis	86%	100%
C9ZU64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	98%
E9AKL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QJ93	Leishmania major	95%	100%
V5D7E1	Trypanosoma cruzi	45%	97%