LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Legume-like lectin family - putative
Species:
Leishmania infantum
UniProt:
A4HSM9_LEIIN
TriTrypDb:
LINF_050016000
Length:
517

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 5, no: 6
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0000139 Golgi membrane 5 1
GO:0005737 cytoplasm 2 1
GO:0005789 endoplasmic reticulum membrane 4 1
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 5 1
GO:0030134 COPII-coated ER to Golgi transport vesicle 8 1
GO:0030135 coated vesicle 7 1
GO:0031090 organelle membrane 3 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1
GO:0098588 bounding membrane of organelle 4 1

Expansion

Sequence features

A4HSM9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSM9

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 4 1
GO:0006996 organelle organization 4 1
GO:0007029 endoplasmic reticulum organization 5 1
GO:0007030 Golgi organization 5 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0016192 vesicle-mediated transport 4 1
GO:0046907 intracellular transport 3 1
GO:0048193 Golgi vesicle transport 5 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 2
GO:0005537 mannose binding 4 1
GO:0030246 carbohydrate binding 2 2
GO:0036094 small molecule binding 2 1
GO:0048029 monosaccharide binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 171 175 PF00656 0.514
CLV_NRD_NRD_1 217 219 PF00675 0.641
CLV_NRD_NRD_1 222 224 PF00675 0.623
CLV_NRD_NRD_1 379 381 PF00675 0.523
CLV_NRD_NRD_1 440 442 PF00675 0.654
CLV_NRD_NRD_1 443 445 PF00675 0.672
CLV_NRD_NRD_1 498 500 PF00675 0.608
CLV_PCSK_FUR_1 441 445 PF00082 0.678
CLV_PCSK_KEX2_1 217 219 PF00082 0.632
CLV_PCSK_KEX2_1 222 224 PF00082 0.616
CLV_PCSK_KEX2_1 230 232 PF00082 0.649
CLV_PCSK_KEX2_1 234 236 PF00082 0.576
CLV_PCSK_KEX2_1 379 381 PF00082 0.525
CLV_PCSK_KEX2_1 385 387 PF00082 0.565
CLV_PCSK_KEX2_1 442 444 PF00082 0.687
CLV_PCSK_KEX2_1 498 500 PF00082 0.605
CLV_PCSK_PC1ET2_1 222 224 PF00082 0.632
CLV_PCSK_PC1ET2_1 230 232 PF00082 0.643
CLV_PCSK_PC1ET2_1 234 236 PF00082 0.590
CLV_PCSK_PC1ET2_1 385 387 PF00082 0.607
CLV_PCSK_PC1ET2_1 442 444 PF00082 0.704
CLV_PCSK_PC7_1 218 224 PF00082 0.654
CLV_PCSK_SKI1_1 217 221 PF00082 0.643
CLV_PCSK_SKI1_1 225 229 PF00082 0.566
CLV_PCSK_SKI1_1 230 234 PF00082 0.573
CLV_PCSK_SKI1_1 354 358 PF00082 0.662
CLV_PCSK_SKI1_1 436 440 PF00082 0.740
CLV_PCSK_SKI1_1 447 451 PF00082 0.720
CLV_PCSK_SKI1_1 456 460 PF00082 0.659
CLV_Separin_Metazoa 403 407 PF03568 0.410
DEG_APCC_DBOX_1 442 450 PF00400 0.551
DOC_CYCLIN_RxL_1 224 237 PF00134 0.488
DOC_MAPK_gen_1 244 253 PF00069 0.408
DOC_MAPK_gen_1 368 378 PF00069 0.313
DOC_MAPK_gen_1 455 463 PF00069 0.528
DOC_MAPK_gen_1 498 504 PF00069 0.496
DOC_MAPK_MEF2A_6 244 253 PF00069 0.408
DOC_MAPK_MEF2A_6 371 378 PF00069 0.309
DOC_PP1_RVXF_1 113 119 PF00149 0.256
DOC_PP1_RVXF_1 384 391 PF00149 0.386
DOC_PP1_RVXF_1 499 505 PF00149 0.448
DOC_PP2B_LxvP_1 297 300 PF13499 0.367
DOC_PP4_FxxP_1 59 62 PF00568 0.269
DOC_SPAK_OSR1_1 117 121 PF12202 0.269
DOC_USP7_MATH_1 30 34 PF00917 0.459
DOC_USP7_MATH_1 445 449 PF00917 0.572
DOC_USP7_MATH_1 62 66 PF00917 0.423
DOC_USP7_UBL2_3 230 234 PF12436 0.563
DOC_WW_Pin1_4 162 167 PF00397 0.528
DOC_WW_Pin1_4 321 326 PF00397 0.342
LIG_14-3-3_CanoR_1 16 22 PF00244 0.335
LIG_14-3-3_CanoR_1 235 240 PF00244 0.428
LIG_14-3-3_CanoR_1 329 333 PF00244 0.457
LIG_14-3-3_CanoR_1 444 450 PF00244 0.505
LIG_14-3-3_CanoR_1 6 12 PF00244 0.557
LIG_14-3-3_CanoR_1 89 95 PF00244 0.282
LIG_BIR_II_1 1 5 PF00653 0.606
LIG_BIR_III_3 1 5 PF00653 0.606
LIG_deltaCOP1_diTrp_1 110 118 PF00928 0.363
LIG_deltaCOP1_diTrp_1 176 184 PF00928 0.489
LIG_FHA_1 102 108 PF00498 0.300
LIG_FHA_1 12 18 PF00498 0.367
LIG_FHA_1 21 27 PF00498 0.315
LIG_FHA_1 288 294 PF00498 0.410
LIG_FHA_1 373 379 PF00498 0.360
LIG_FHA_1 397 403 PF00498 0.435
LIG_FHA_1 484 490 PF00498 0.528
LIG_FHA_1 90 96 PF00498 0.300
LIG_FHA_2 202 208 PF00498 0.537
LIG_FHA_2 235 241 PF00498 0.419
LIG_FHA_2 355 361 PF00498 0.361
LIG_FHA_2 405 411 PF00498 0.395
LIG_FHA_2 457 463 PF00498 0.399
LIG_FHA_2 89 95 PF00498 0.370
LIG_LIR_Apic_2 56 62 PF02991 0.269
LIG_LIR_Gen_1 291 300 PF02991 0.424
LIG_LIR_Gen_1 457 466 PF02991 0.435
LIG_LIR_Gen_1 85 95 PF02991 0.294
LIG_LIR_Nem_3 226 232 PF02991 0.387
LIG_LIR_Nem_3 291 297 PF02991 0.419
LIG_LIR_Nem_3 457 461 PF02991 0.446
LIG_LIR_Nem_3 85 90 PF02991 0.294
LIG_PDZ_Class_3 512 517 PF00595 0.525
LIG_Pex14_2 229 233 PF04695 0.490
LIG_Pex14_2 256 260 PF04695 0.359
LIG_PTB_Apo_2 81 88 PF02174 0.282
LIG_SH2_STAP1 160 164 PF00017 0.512
LIG_SH2_STAP1 408 412 PF00017 0.414
LIG_SH2_STAP1 483 487 PF00017 0.435
LIG_SH2_STAT3 145 148 PF00017 0.282
LIG_SH2_STAT3 369 372 PF00017 0.303
LIG_SH2_STAT5 145 148 PF00017 0.269
LIG_SH2_STAT5 294 297 PF00017 0.416
LIG_SH2_STAT5 408 411 PF00017 0.354
LIG_SH3_1 506 512 PF00018 0.458
LIG_SH3_3 338 344 PF00018 0.507
LIG_SH3_3 506 512 PF00018 0.460
LIG_SUMO_SIM_anti_2 360 367 PF11976 0.311
LIG_SUMO_SIM_anti_2 399 407 PF11976 0.411
LIG_SxIP_EBH_1 3 16 PF03271 0.423
LIG_TRAF2_1 204 207 PF00917 0.474
LIG_TRAF2_1 358 361 PF00917 0.389
LIG_TRAF2_1 58 61 PF00917 0.425
LIG_UBA3_1 228 234 PF00899 0.614
MOD_CDK_SPxxK_3 162 169 PF00069 0.663
MOD_CK1_1 20 26 PF00069 0.353
MOD_CK1_1 306 312 PF00069 0.575
MOD_CK1_1 430 436 PF00069 0.423
MOD_CK2_1 201 207 PF00069 0.655
MOD_CK2_1 235 241 PF00069 0.503
MOD_CK2_1 354 360 PF00069 0.501
MOD_CK2_1 404 410 PF00069 0.488
MOD_CK2_1 55 61 PF00069 0.437
MOD_GlcNHglycan 305 308 PF01048 0.657
MOD_GlcNHglycan 429 432 PF01048 0.384
MOD_GlcNHglycan 79 82 PF01048 0.325
MOD_GSK3_1 158 165 PF00069 0.680
MOD_GSK3_1 235 242 PF00069 0.498
MOD_GSK3_1 302 309 PF00069 0.584
MOD_GSK3_1 350 357 PF00069 0.595
MOD_GSK3_1 404 411 PF00069 0.423
MOD_N-GLC_1 129 134 PF02516 0.420
MOD_N-GLC_1 300 305 PF02516 0.547
MOD_NEK2_1 12 17 PF00069 0.436
MOD_NEK2_1 129 134 PF00069 0.394
MOD_NEK2_1 427 432 PF00069 0.366
MOD_NEK2_1 481 486 PF00069 0.503
MOD_NEK2_1 502 507 PF00069 0.643
MOD_NEK2_1 88 93 PF00069 0.450
MOD_NEK2_2 445 450 PF00069 0.610
MOD_PK_1 235 241 PF00069 0.539
MOD_PKA_1 217 223 PF00069 0.644
MOD_PKA_1 234 240 PF00069 0.444
MOD_PKA_2 116 122 PF00069 0.304
MOD_PKA_2 217 223 PF00069 0.620
MOD_PKA_2 234 240 PF00069 0.404
MOD_PKA_2 328 334 PF00069 0.499
MOD_PKA_2 5 11 PF00069 0.264
MOD_PKA_2 88 94 PF00069 0.323
MOD_Plk_1 386 392 PF00069 0.523
MOD_Plk_1 55 61 PF00069 0.323
MOD_Plk_2-3 201 207 PF00069 0.665
MOD_Plk_4 17 23 PF00069 0.375
MOD_Plk_4 289 295 PF00069 0.478
MOD_Plk_4 306 312 PF00069 0.550
MOD_Plk_4 372 378 PF00069 0.373
MOD_Plk_4 386 392 PF00069 0.452
MOD_ProDKin_1 162 168 PF00069 0.664
MOD_ProDKin_1 321 327 PF00069 0.408
MOD_SUMO_for_1 384 387 PF00179 0.496
MOD_SUMO_rev_2 448 458 PF00179 0.580
MOD_SUMO_rev_2 473 481 PF00179 0.407
TRG_DiLeu_BaEn_1 361 366 PF01217 0.442
TRG_DiLeu_BaLyEn_6 49 54 PF01217 0.453
TRG_ENDOCYTIC_2 294 297 PF00928 0.511
TRG_ER_diArg_1 115 118 PF00400 0.307
TRG_ER_diArg_1 378 380 PF00400 0.385
TRG_ER_diArg_1 441 444 PF00400 0.647
TRG_NES_CRM1_1 465 477 PF08389 0.563
TRG_NLS_MonoCore_2 220 225 PF00514 0.612
TRG_NLS_MonoCore_2 440 445 PF00514 0.594
TRG_NLS_MonoExtC_3 220 225 PF00514 0.612
TRG_NLS_MonoExtC_3 440 445 PF00514 0.594
TRG_NLS_MonoExtN_4 218 225 PF00514 0.621
TRG_NLS_MonoExtN_4 439 446 PF00514 0.600
TRG_Pf-PMV_PEXEL_1 472 477 PF00026 0.346

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IIA0 Leptomonas seymouri 78% 100%
A0A1X0NKB0 Trypanosomatidae 42% 80%
A0A3R7LT82 Trypanosoma rangeli 47% 95%
A0A3S5H5L7 Leishmania donovani 100% 86%
A4H4F2 Leishmania braziliensis 87% 100%
C9ZU67 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 83%
E8NHN5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9AKL4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QJ95 Leishmania major 96% 100%
V5ARI9 Trypanosoma cruzi 46% 88%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS