LeishMANIAdb
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Stomatin-like protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Stomatin-like protein
Gene product:
stomatin-like protein
Species:
Leishmania infantum
UniProt:
A4HSM6_LEIIN
TriTrypDb:
LINF_050015800
Length:
357

Annotations

Annotations by Jardim et al.

Structural Proteins, Stomatin-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005739 mitochondrion 5 1
GO:0005886 plasma membrane 3 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HSM6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSM6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 186 188 PF00675 0.257
CLV_NRD_NRD_1 211 213 PF00675 0.228
CLV_NRD_NRD_1 221 223 PF00675 0.200
CLV_NRD_NRD_1 224 226 PF00675 0.194
CLV_NRD_NRD_1 3 5 PF00675 0.455
CLV_PCSK_FUR_1 222 226 PF00082 0.211
CLV_PCSK_KEX2_1 186 188 PF00082 0.239
CLV_PCSK_KEX2_1 197 199 PF00082 0.144
CLV_PCSK_KEX2_1 211 213 PF00082 0.211
CLV_PCSK_KEX2_1 224 226 PF00082 0.194
CLV_PCSK_KEX2_1 3 5 PF00082 0.454
CLV_PCSK_PC1ET2_1 197 199 PF00082 0.211
CLV_PCSK_PC1ET2_1 224 226 PF00082 0.211
CLV_PCSK_SKI1_1 226 230 PF00082 0.305
CLV_PCSK_SKI1_1 44 48 PF00082 0.604
CLV_Separin_Metazoa 183 187 PF03568 0.226
CLV_Separin_Metazoa 208 212 PF03568 0.226
DEG_APCC_DBOX_1 163 171 PF00400 0.226
DEG_Nend_Nbox_1 1 3 PF02207 0.476
DOC_CYCLIN_RxL_1 222 232 PF00134 0.211
DOC_CYCLIN_yCln2_LP_2 46 52 PF00134 0.536
DOC_MAPK_gen_1 222 229 PF00069 0.211
DOC_MAPK_gen_1 3 9 PF00069 0.584
DOC_USP7_MATH_1 111 115 PF00917 0.217
DOC_USP7_MATH_1 19 23 PF00917 0.707
DOC_USP7_MATH_1 276 280 PF00917 0.443
DOC_USP7_MATH_1 292 296 PF00917 0.171
DOC_USP7_MATH_1 315 319 PF00917 0.305
DOC_USP7_MATH_2 24 30 PF00917 0.504
DOC_WW_Pin1_4 349 354 PF00397 0.596
LIG_14-3-3_CanoR_1 164 168 PF00244 0.328
LIG_14-3-3_CanoR_1 174 178 PF00244 0.270
LIG_14-3-3_CanoR_1 211 215 PF00244 0.211
LIG_14-3-3_CanoR_1 58 62 PF00244 0.496
LIG_14-3-3_CanoR_1 78 84 PF00244 0.097
LIG_Actin_WH2_2 118 134 PF00022 0.211
LIG_APCC_ABBA_1 90 95 PF00400 0.305
LIG_deltaCOP1_diTrp_1 84 93 PF00928 0.245
LIG_EH1_1 198 206 PF00400 0.357
LIG_FHA_1 179 185 PF00498 0.292
LIG_FHA_1 234 240 PF00498 0.427
LIG_FHA_1 333 339 PF00498 0.305
LIG_FHA_1 4 10 PF00498 0.628
LIG_LIR_Gen_1 339 349 PF02991 0.245
LIG_LIR_Gen_1 60 66 PF02991 0.381
LIG_LIR_Gen_1 85 94 PF02991 0.357
LIG_LIR_Nem_3 309 314 PF02991 0.211
LIG_LIR_Nem_3 339 344 PF02991 0.226
LIG_LIR_Nem_3 60 65 PF02991 0.381
LIG_LIR_Nem_3 84 90 PF02991 0.211
LIG_PTB_Apo_2 142 149 PF02174 0.211
LIG_SH2_STAT3 11 14 PF00017 0.516
LIG_SH2_STAT5 258 261 PF00017 0.374
LIG_SH2_STAT5 307 310 PF00017 0.211
LIG_SH2_STAT5 71 74 PF00017 0.211
LIG_SH3_3 324 330 PF00018 0.215
LIG_SH3_3 86 92 PF00018 0.338
LIG_SUMO_SIM_anti_2 180 186 PF11976 0.276
LIG_SUMO_SIM_anti_2 279 287 PF11976 0.381
LIG_SUMO_SIM_par_1 121 126 PF11976 0.211
LIG_TRAF2_1 23 26 PF00917 0.571
LIG_UBA3_1 129 138 PF00899 0.211
LIG_WW_3 55 59 PF00397 0.496
MOD_CK1_1 114 120 PF00069 0.211
MOD_CK1_1 166 172 PF00069 0.357
MOD_CK1_1 235 241 PF00069 0.480
MOD_CK1_1 283 289 PF00069 0.291
MOD_CK1_1 29 35 PF00069 0.573
MOD_CK2_1 177 183 PF00069 0.276
MOD_CK2_1 228 234 PF00069 0.214
MOD_CK2_1 303 309 PF00069 0.370
MOD_CK2_1 48 54 PF00069 0.439
MOD_GlcNHglycan 113 116 PF01048 0.238
MOD_GlcNHglycan 21 24 PF01048 0.584
MOD_GlcNHglycan 28 31 PF01048 0.544
MOD_GlcNHglycan 346 349 PF01048 0.508
MOD_GlcNHglycan 84 87 PF01048 0.305
MOD_GSK3_1 111 118 PF00069 0.245
MOD_GSK3_1 133 140 PF00069 0.305
MOD_GSK3_1 153 160 PF00069 0.090
MOD_GSK3_1 173 180 PF00069 0.090
MOD_GSK3_1 228 235 PF00069 0.305
MOD_GSK3_1 276 283 PF00069 0.348
MOD_GSK3_1 317 324 PF00069 0.305
MOD_GSK3_1 325 332 PF00069 0.261
MOD_GSK3_1 336 343 PF00069 0.214
MOD_N-GLC_1 111 116 PF02516 0.211
MOD_N-GLC_1 177 182 PF02516 0.276
MOD_N-GLC_1 280 285 PF02516 0.432
MOD_NEK2_1 153 158 PF00069 0.211
MOD_NEK2_1 177 182 PF00069 0.296
MOD_NEK2_1 39 44 PF00069 0.571
MOD_NEK2_2 154 159 PF00069 0.211
MOD_NEK2_2 57 62 PF00069 0.404
MOD_PIKK_1 321 327 PF00454 0.329
MOD_PIKK_1 332 338 PF00454 0.268
MOD_PIKK_1 39 45 PF00454 0.623
MOD_PKA_1 3 9 PF00069 0.518
MOD_PKA_2 163 169 PF00069 0.328
MOD_PKA_2 173 179 PF00069 0.270
MOD_PKA_2 210 216 PF00069 0.211
MOD_PKA_2 261 267 PF00069 0.504
MOD_PKA_2 3 9 PF00069 0.402
MOD_PKA_2 57 63 PF00069 0.385
MOD_Plk_1 111 117 PF00069 0.211
MOD_Plk_1 177 183 PF00069 0.328
MOD_Plk_1 280 286 PF00069 0.443
MOD_Plk_2-3 48 54 PF00069 0.525
MOD_Plk_4 166 172 PF00069 0.211
MOD_Plk_4 3 9 PF00069 0.384
MOD_Plk_4 303 309 PF00069 0.314
MOD_Plk_4 317 323 PF00069 0.138
MOD_Plk_4 336 342 PF00069 0.226
MOD_Plk_4 48 54 PF00069 0.450
MOD_Plk_4 57 63 PF00069 0.378
MOD_ProDKin_1 349 355 PF00069 0.604
TRG_ER_diArg_1 185 187 PF00400 0.245
TRG_ER_diArg_1 2 4 PF00400 0.454
TRG_ER_diArg_1 210 212 PF00400 0.220
TRG_NES_CRM1_1 124 135 PF08389 0.211
TRG_NLS_Bipartite_1 211 228 PF00514 0.226
TRG_NLS_MonoCore_2 222 227 PF00514 0.305
TRG_NLS_MonoExtN_4 222 228 PF00514 0.211
TRG_Pf-PMV_PEXEL_1 225 230 PF00026 0.211

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HTU5 Leptomonas seymouri 85% 99%
A0A0S4INS2 Bodo saltans 62% 100%
A0A1X0NKE1 Trypanosomatidae 70% 83%
A0A3R7M6V7 Trypanosoma rangeli 63% 93%
A0A3S5H5L4 Leishmania donovani 100% 100%
A4H4E9 Leishmania braziliensis 93% 100%
C9ZND8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 67%
E9AKL0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
E9AS80 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
O26788 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 32% 100%
O60121 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 45% 100%
P0AA53 Escherichia coli (strain K12) 36% 100%
P0AA54 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 36% 100%
P0AA55 Escherichia coli O157:H7 36% 100%
P0AA56 Shigella flexneri 36% 100%
P0DKS0 Wigglesworthia glossinidia brevipalpis 33% 100%
P63694 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 32% 94%
P72655 Synechocystis sp. (strain PCC 6803 / Kazusa) 37% 100%
P9WPR8 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 32% 94%
P9WPR9 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 32% 94%
Q32LL2 Bos taurus 47% 100%
Q4FZT0 Rattus norvegicus 47% 100%
Q4QJ98 Leishmania major 99% 100%
Q99JB2 Mus musculus 47% 100%
Q9FHM7 Arabidopsis thaliana 22% 100%
Q9UJZ1 Homo sapiens 45% 100%
V5BBU5 Trypanosoma cruzi 62% 88%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS