Transmembrane protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HSM5_LEIIN

TriTrypDb:

LINF_050015700

Length:

145

Annotations

Annotations by Jardim et al.

Tricarboxylic acid cycle, Succinate dehydrogenase (SDH10)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 8
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HSM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSM5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.612
CLV_NRD_NRD_1	129	131	PF00675	0.289
CLV_PCSK_KEX2_1	11	13	PF00082	0.612
DEG_Nend_UBRbox_3	1	3	PF02207	0.399
DOC_MAPK_gen_1	130	138	PF00069	0.496
DOC_PP2B_LxvP_1	94	97	PF13499	0.327
DOC_USP7_MATH_1	56	60	PF00917	0.390
DOC_USP7_UBL2_3	63	67	PF12436	0.461
DOC_WW_Pin1_4	103	108	PF00397	0.112
DOC_WW_Pin1_4	83	88	PF00397	0.406
LIG_14-3-3_CanoR_1	57	61	PF00244	0.433
LIG_FHA_1	133	139	PF00498	0.515
LIG_LIR_Gen_1	106	117	PF02991	0.252
LIG_LIR_Nem_3	106	112	PF02991	0.245
LIG_LIR_Nem_3	4	8	PF02991	0.472
LIG_LIR_Nem_3	76	82	PF02991	0.370
LIG_Pex14_1	120	124	PF04695	0.234
LIG_SH2_CRK	109	113	PF00017	0.252
LIG_SH2_STAP1	133	137	PF00017	0.506
LIG_SH2_STAT5	109	112	PF00017	0.234
LIG_SH2_STAT5	128	131	PF00017	0.498
LIG_SUMO_SIM_par_1	101	106	PF11976	0.199
LIG_WRC_WIRS_1	82	87	PF05994	0.330
MOD_CK2_1	55	61	PF00069	0.454
MOD_GlcNHglycan	13	16	PF01048	0.580
MOD_GlcNHglycan	64	67	PF01048	0.585
MOD_GlcNHglycan	90	93	PF01048	0.553
MOD_GSK3_1	7	14	PF00069	0.365
MOD_NEK2_1	1	6	PF00069	0.432
MOD_NEK2_1	16	21	PF00069	0.333
MOD_NEK2_1	22	27	PF00069	0.306
MOD_NEK2_1	43	48	PF00069	0.388
MOD_PIKK_1	23	29	PF00454	0.423
MOD_PKA_1	11	17	PF00069	0.352
MOD_PKA_2	11	17	PF00069	0.352
MOD_PKA_2	56	62	PF00069	0.340
MOD_Plk_4	1	7	PF00069	0.509
MOD_Plk_4	132	138	PF00069	0.503
MOD_Plk_4	16	22	PF00069	0.383
MOD_ProDKin_1	103	109	PF00069	0.112
MOD_ProDKin_1	83	89	PF00069	0.404
MOD_SUMO_rev_2	58	65	PF00179	0.397
TRG_ENDOCYTIC_2	109	112	PF00928	0.247
TRG_ENDOCYTIC_2	124	127	PF00928	0.434
TRG_ENDOCYTIC_2	133	136	PF00928	0.537
TRG_ENDOCYTIC_2	82	85	PF00928	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCY8	Leptomonas seymouri	73%	100%
A0A1X0NKT0	Trypanosomatidae	54%	99%
A0A3R7K2B2	Trypanosoma rangeli	58%	100%
A0A3S5H5L3	Leishmania donovani	100%	100%
A4H4E8	Leishmania braziliensis	85%	100%
C9ZND7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AKK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QJ99	Leishmania major	94%	100%
V5BBW2	Trypanosoma cruzi	52%	100%