Methyltransferase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase-like protein

Species:

Leishmania infantum

UniProt:

A4HSM3_LEIIN

TriTrypDb:

LINF_050015500

Length:

614

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HSM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSM3

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009451	RNA modification	5	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0032259	methylation	2	10
GO:0034470	ncRNA processing	7	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034660	ncRNA metabolic process	6	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0043414	macromolecule methylation	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0008168	methyltransferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0004809	tRNA (guanine-N2-)-methyltransferase activity	6	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008173	RNA methyltransferase activity	4	1
GO:0008175	tRNA methyltransferase activity	5	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016423	tRNA (guanine) methyltransferase activity	6	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	277	281	PF00656	0.472
CLV_C14_Caspase3-7	516	520	PF00656	0.489
CLV_C14_Caspase3-7	560	564	PF00656	0.746
CLV_C14_Caspase3-7	573	577	PF00656	0.548
CLV_MEL_PAP_1	468	474	PF00089	0.413
CLV_NRD_NRD_1	222	224	PF00675	0.409
CLV_NRD_NRD_1	301	303	PF00675	0.309
CLV_NRD_NRD_1	379	381	PF00675	0.217
CLV_NRD_NRD_1	478	480	PF00675	0.319
CLV_NRD_NRD_1	483	485	PF00675	0.337
CLV_NRD_NRD_1	531	533	PF00675	0.518
CLV_NRD_NRD_1	567	569	PF00675	0.632
CLV_PCSK_FUR_1	527	531	PF00082	0.572
CLV_PCSK_KEX2_1	149	151	PF00082	0.419
CLV_PCSK_KEX2_1	158	160	PF00082	0.448
CLV_PCSK_KEX2_1	224	226	PF00082	0.217
CLV_PCSK_KEX2_1	301	303	PF00082	0.309
CLV_PCSK_KEX2_1	381	383	PF00082	0.248
CLV_PCSK_KEX2_1	478	480	PF00082	0.319
CLV_PCSK_KEX2_1	529	531	PF00082	0.472
CLV_PCSK_KEX2_1	533	535	PF00082	0.452
CLV_PCSK_KEX2_1	567	569	PF00082	0.667
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.483
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.489
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.230
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.290
CLV_PCSK_PC1ET2_1	529	531	PF00082	0.472
CLV_PCSK_PC1ET2_1	533	535	PF00082	0.452
CLV_PCSK_PC7_1	377	383	PF00082	0.218
CLV_PCSK_SKI1_1	213	217	PF00082	0.452
CLV_PCSK_SKI1_1	302	306	PF00082	0.309
CLV_PCSK_SKI1_1	382	386	PF00082	0.371
CLV_PCSK_SKI1_1	592	596	PF00082	0.581
CLV_PCSK_SKI1_1	69	73	PF00082	0.267
DEG_APCC_DBOX_1	470	478	PF00400	0.344
DEG_APCC_DBOX_1	59	67	PF00400	0.394
DEG_Nend_UBRbox_1	1	4	PF02207	0.401
DOC_CDC14_PxL_1	80	88	PF14671	0.410
DOC_CKS1_1	549	554	PF01111	0.674
DOC_CYCLIN_RxL_1	298	309	PF00134	0.487
DOC_CYCLIN_yCln2_LP_2	28	34	PF00134	0.447
DOC_MAPK_gen_1	475	483	PF00069	0.431
DOC_MAPK_gen_1	484	491	PF00069	0.500
DOC_MAPK_MEF2A_6	503	512	PF00069	0.481
DOC_MAPK_RevD_3	472	485	PF00069	0.394
DOC_PP2B_LxvP_1	28	31	PF13499	0.450
DOC_PP2B_LxvP_1	335	338	PF13499	0.429
DOC_PP4_FxxP_1	16	19	PF00568	0.359
DOC_PP4_FxxP_1	443	446	PF00568	0.340
DOC_PP4_FxxP_1	54	57	PF00568	0.439
DOC_USP7_MATH_1	100	104	PF00917	0.606
DOC_USP7_MATH_1	235	239	PF00917	0.509
DOC_USP7_MATH_1	396	400	PF00917	0.657
DOC_USP7_MATH_1	544	548	PF00917	0.558
DOC_USP7_MATH_1	58	62	PF00917	0.404
DOC_USP7_MATH_1	602	606	PF00917	0.424
DOC_USP7_UBL2_3	529	533	PF12436	0.462
DOC_WW_Pin1_4	291	296	PF00397	0.509
DOC_WW_Pin1_4	501	506	PF00397	0.615
DOC_WW_Pin1_4	53	58	PF00397	0.372
DOC_WW_Pin1_4	545	550	PF00397	0.557
LIG_14-3-3_CanoR_1	29	35	PF00244	0.418
LIG_14-3-3_CanoR_1	342	352	PF00244	0.509
LIG_14-3-3_CanoR_1	382	391	PF00244	0.415
LIG_14-3-3_CanoR_1	471	475	PF00244	0.352
LIG_14-3-3_CanoR_1	74	80	PF00244	0.350
LIG_Actin_WH2_2	461	477	PF00022	0.329
LIG_Actin_WH2_2	59	76	PF00022	0.342
LIG_AP2alpha_2	255	257	PF02296	0.415
LIG_BIR_III_4	278	282	PF00653	0.447
LIG_CSL_BTD_1	443	446	PF09270	0.427
LIG_deltaCOP1_diTrp_1	47	54	PF00928	0.449
LIG_FHA_1	115	121	PF00498	0.574
LIG_FHA_1	123	129	PF00498	0.426
LIG_FHA_1	217	223	PF00498	0.376
LIG_FHA_1	25	31	PF00498	0.353
LIG_FHA_1	258	264	PF00498	0.429
LIG_FHA_1	418	424	PF00498	0.374
LIG_FHA_1	431	437	PF00498	0.411
LIG_FHA_2	31	37	PF00498	0.428
LIG_FHA_2	315	321	PF00498	0.444
LIG_FHA_2	450	456	PF00498	0.389
LIG_FHA_2	552	558	PF00498	0.610
LIG_FHA_2	76	82	PF00498	0.426
LIG_FHA_2	83	89	PF00498	0.407
LIG_LIR_Apic_2	165	171	PF02991	0.511
LIG_LIR_Apic_2	442	446	PF02991	0.370
LIG_LIR_Apic_2	52	57	PF02991	0.372
LIG_LIR_Gen_1	20	28	PF02991	0.421
LIG_LIR_Gen_1	433	441	PF02991	0.317
LIG_LIR_Gen_1	48	58	PF02991	0.330
LIG_LIR_Gen_1	87	95	PF02991	0.469
LIG_LIR_LC3C_4	433	437	PF02991	0.321
LIG_LIR_Nem_3	20	24	PF02991	0.410
LIG_LIR_Nem_3	328	333	PF02991	0.421
LIG_LIR_Nem_3	414	418	PF02991	0.517
LIG_LIR_Nem_3	433	437	PF02991	0.425
LIG_LIR_Nem_3	47	53	PF02991	0.366
LIG_LIR_Nem_3	522	526	PF02991	0.475
LIG_LIR_Nem_3	87	93	PF02991	0.455
LIG_PCNA_yPIPBox_3	196	206	PF02747	0.447
LIG_Pex14_1	50	54	PF04695	0.414
LIG_SH2_CRK	333	337	PF00017	0.509
LIG_SH2_PTP2	176	179	PF00017	0.364
LIG_SH2_PTP2	3	6	PF00017	0.337
LIG_SH2_STAP1	133	137	PF00017	0.396
LIG_SH2_STAP1	144	148	PF00017	0.316
LIG_SH2_STAT3	133	136	PF00017	0.456
LIG_SH2_STAT5	176	179	PF00017	0.423
LIG_SH2_STAT5	227	230	PF00017	0.415
LIG_SH2_STAT5	252	255	PF00017	0.447
LIG_SH2_STAT5	3	6	PF00017	0.393
LIG_SH2_STAT5	308	311	PF00017	0.487
LIG_SH2_STAT5	333	336	PF00017	0.375
LIG_SH2_STAT5	434	437	PF00017	0.415
LIG_SH2_STAT5	451	454	PF00017	0.319
LIG_SH2_STAT5	77	80	PF00017	0.348
LIG_SH3_3	250	256	PF00018	0.444
LIG_SH3_3	454	460	PF00018	0.349
LIG_SH3_3	486	492	PF00018	0.468
LIG_SH3_3	546	552	PF00018	0.550
LIG_TRAF2_1	234	237	PF00917	0.509
LIG_TRAF2_1	317	320	PF00917	0.472
LIG_TRFH_1	333	337	PF08558	0.447
LIG_UBA3_1	480	485	PF00899	0.345
MOD_CDK_SPxxK_3	53	60	PF00069	0.383
MOD_CK1_1	107	113	PF00069	0.585
MOD_CK1_1	131	137	PF00069	0.513
MOD_CK1_1	211	217	PF00069	0.402
MOD_CK1_1	367	373	PF00069	0.514
MOD_CK1_1	458	464	PF00069	0.398
MOD_CK1_1	495	501	PF00069	0.473
MOD_CK1_1	547	553	PF00069	0.639
MOD_CK1_1	56	62	PF00069	0.443
MOD_CK1_1	562	568	PF00069	0.488
MOD_CK1_1	605	611	PF00069	0.489
MOD_CK1_1	9	15	PF00069	0.449
MOD_CK2_1	314	320	PF00069	0.451
MOD_CK2_1	449	455	PF00069	0.397
MOD_CK2_1	49	55	PF00069	0.432
MOD_CK2_1	56	62	PF00069	0.455
MOD_CK2_1	75	81	PF00069	0.203
MOD_Cter_Amidation	140	143	PF01082	0.434
MOD_Cter_Amidation	568	571	PF01082	0.716
MOD_GlcNHglycan	102	105	PF01048	0.618
MOD_GlcNHglycan	144	147	PF01048	0.457
MOD_GlcNHglycan	213	216	PF01048	0.404
MOD_GlcNHglycan	244	247	PF01048	0.270
MOD_GlcNHglycan	345	348	PF01048	0.278
MOD_GlcNHglycan	360	363	PF01048	0.364
MOD_GlcNHglycan	415	418	PF01048	0.485
MOD_GlcNHglycan	542	545	PF01048	0.501
MOD_GlcNHglycan	559	562	PF01048	0.653
MOD_GlcNHglycan	9	12	PF01048	0.373
MOD_GlcNHglycan	98	101	PF01048	0.566
MOD_GSK3_1	107	114	PF00069	0.626
MOD_GSK3_1	122	129	PF00069	0.382
MOD_GSK3_1	382	389	PF00069	0.640
MOD_GSK3_1	397	404	PF00069	0.526
MOD_GSK3_1	413	420	PF00069	0.364
MOD_GSK3_1	445	452	PF00069	0.368
MOD_GSK3_1	45	52	PF00069	0.428
MOD_GSK3_1	495	502	PF00069	0.491
MOD_GSK3_1	540	547	PF00069	0.516
MOD_GSK3_1	605	612	PF00069	0.668
MOD_GSK3_1	75	82	PF00069	0.462
MOD_GSK3_1	96	103	PF00069	0.557
MOD_N-GLC_1	242	247	PF02516	0.309
MOD_N-GLC_1	343	348	PF02516	0.272
MOD_N-GLC_1	602	607	PF02516	0.433
MOD_NEK2_1	128	133	PF00069	0.532
MOD_NEK2_1	257	262	PF00069	0.427
MOD_NEK2_1	343	348	PF00069	0.472
MOD_NEK2_1	430	435	PF00069	0.349
MOD_NEK2_1	49	54	PF00069	0.427
MOD_NEK2_1	7	12	PF00069	0.391
MOD_NEK2_1	79	84	PF00069	0.406
MOD_NEK2_2	75	80	PF00069	0.344
MOD_PKA_1	142	148	PF00069	0.438
MOD_PKA_1	570	576	PF00069	0.608
MOD_PKA_2	470	476	PF00069	0.344
MOD_PKA_2	495	501	PF00069	0.499
MOD_PKB_1	380	388	PF00069	0.556
MOD_PKB_1	568	576	PF00069	0.672
MOD_Plk_1	123	129	PF00069	0.471
MOD_Plk_1	235	241	PF00069	0.472
MOD_Plk_1	343	349	PF00069	0.472
MOD_Plk_2-3	449	455	PF00069	0.485
MOD_Plk_4	235	241	PF00069	0.472
MOD_Plk_4	259	265	PF00069	0.429
MOD_Plk_4	364	370	PF00069	0.509
MOD_Plk_4	430	436	PF00069	0.345
MOD_Plk_4	439	445	PF00069	0.326
MOD_Plk_4	45	51	PF00069	0.498
MOD_Plk_4	75	81	PF00069	0.467
MOD_ProDKin_1	291	297	PF00069	0.509
MOD_ProDKin_1	501	507	PF00069	0.617
MOD_ProDKin_1	53	59	PF00069	0.376
MOD_ProDKin_1	545	551	PF00069	0.562
MOD_SUMO_for_1	528	531	PF00179	0.567
MOD_SUMO_rev_2	145	151	PF00179	0.491
MOD_SUMO_rev_2	56	66	PF00179	0.345
TRG_DiLeu_BaEn_1	68	73	PF01217	0.409
TRG_DiLeu_BaEn_3	236	242	PF01217	0.452
TRG_DiLeu_BaEn_4	318	324	PF01217	0.496
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.467
TRG_DiLeu_BaLyEn_6	476	481	PF01217	0.377
TRG_ENDOCYTIC_2	175	178	PF00928	0.379
TRG_ENDOCYTIC_2	254	257	PF00928	0.460
TRG_ENDOCYTIC_2	3	6	PF00928	0.337
TRG_ENDOCYTIC_2	434	437	PF00928	0.317
TRG_ENDOCYTIC_2	77	80	PF00928	0.348
TRG_ENDOCYTIC_2	90	93	PF00928	0.401
TRG_ER_diArg_1	222	225	PF00400	0.408
TRG_ER_diArg_1	301	303	PF00400	0.509
TRG_ER_diArg_1	340	343	PF00400	0.429
TRG_ER_diArg_1	379	382	PF00400	0.487
TRG_ER_diArg_1	477	479	PF00400	0.316
TRG_ER_diArg_1	567	570	PF00400	0.666
TRG_NLS_MonoExtN_4	377	384	PF00514	0.450
TRG_Pf-PMV_PEXEL_1	509	513	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAW4	Leptomonas seymouri	67%	100%
A0A0S4JG90	Bodo saltans	35%	100%
A0A1X0NLX9	Trypanosomatidae	43%	100%
A0A3S7WP82	Leishmania donovani	100%	100%
A0A422N510	Trypanosoma rangeli	44%	100%
A4H4E6	Leishmania braziliensis	85%	100%
E9AKK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q05B63	Bos taurus	27%	100%
Q12463	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q4QJA1	Leishmania major	95%	100%
Q54QA6	Dictyostelium discoideum	27%	100%
Q5R962	Pongo abelii	28%	100%
Q7TNK6	Rattus norvegicus	27%	100%
Q7Z4G4	Homo sapiens	28%	100%
Q9CWH5	Mus musculus	28%	100%
V5B7D5	Trypanosoma cruzi	45%	100%