LeishMANIAdb
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Dipeptidyl peptidase 3

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Dipeptidyl peptidase 3
Gene product:
metallo-peptidase - Clan M- - Family M49
Species:
Leishmania infantum
UniProt:
A4HSL8_LEIIN
TriTrypDb:
LINF_050014800
Length:
679

Annotations

Annotations by Jardim et al.

Proteases, dipeptidyl-peptidase III

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. yes yes: 1
Forrest at al. (metacyclic) yes yes: 1
Forrest at al. (procyclic) yes yes: 1
Silverman et al. no yes: 1
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 3
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 3
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 7
GO:0110165 cellular anatomical entity 1 7

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HSL8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSL8

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 8
GO:0006807 nitrogen compound metabolic process 2 8
GO:0008152 metabolic process 1 8
GO:0019538 protein metabolic process 3 8
GO:0043170 macromolecule metabolic process 3 8
GO:0044238 primary metabolic process 2 8
GO:0071704 organic substance metabolic process 2 8
GO:1901564 organonitrogen compound metabolic process 3 8
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 8
GO:0004177 aminopeptidase activity 5 7
GO:0005488 binding 1 8
GO:0008233 peptidase activity 3 7
GO:0008235 metalloexopeptidase activity 5 7
GO:0008237 metallopeptidase activity 4 7
GO:0008238 exopeptidase activity 4 7
GO:0008239 dipeptidyl-peptidase activity 5 7
GO:0016787 hydrolase activity 2 8
GO:0043167 ion binding 2 8
GO:0043169 cation binding 3 8
GO:0046872 metal ion binding 4 8
GO:0140096 catalytic activity, acting on a protein 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 441 445 PF00656 0.471
CLV_NRD_NRD_1 242 244 PF00675 0.400
CLV_NRD_NRD_1 635 637 PF00675 0.346
CLV_NRD_NRD_1 638 640 PF00675 0.346
CLV_PCSK_KEX2_1 609 611 PF00082 0.471
CLV_PCSK_KEX2_1 635 637 PF00082 0.400
CLV_PCSK_PC1ET2_1 609 611 PF00082 0.471
CLV_PCSK_SKI1_1 123 127 PF00082 0.483
CLV_PCSK_SKI1_1 160 164 PF00082 0.400
CLV_PCSK_SKI1_1 193 197 PF00082 0.346
CLV_PCSK_SKI1_1 25 29 PF00082 0.444
CLV_PCSK_SKI1_1 345 349 PF00082 0.346
CLV_PCSK_SKI1_1 583 587 PF00082 0.323
CLV_PCSK_SKI1_1 62 66 PF00082 0.459
DEG_APCC_DBOX_1 525 533 PF00400 0.346
DEG_COP1_1 109 119 PF00400 0.432
DOC_CDC14_PxL_1 495 503 PF14671 0.471
DOC_CKS1_1 534 539 PF01111 0.400
DOC_CKS1_1 7 12 PF01111 0.462
DOC_MAPK_MEF2A_6 487 495 PF00069 0.346
DOC_MAPK_MEF2A_6 526 534 PF00069 0.400
DOC_MAPK_MEF2A_6 559 567 PF00069 0.380
DOC_MAPK_MEF2A_6 572 579 PF00069 0.219
DOC_PP4_FxxP_1 348 351 PF00568 0.323
DOC_PP4_FxxP_1 534 537 PF00568 0.346
DOC_SPAK_OSR1_1 550 554 PF12202 0.346
DOC_USP7_UBL2_3 274 278 PF12436 0.346
DOC_USP7_UBL2_3 317 321 PF12436 0.346
DOC_USP7_UBL2_3 341 345 PF12436 0.400
DOC_WW_Pin1_4 131 136 PF00397 0.560
DOC_WW_Pin1_4 164 169 PF00397 0.400
DOC_WW_Pin1_4 25 30 PF00397 0.435
DOC_WW_Pin1_4 347 352 PF00397 0.380
DOC_WW_Pin1_4 51 56 PF00397 0.461
DOC_WW_Pin1_4 533 538 PF00397 0.346
DOC_WW_Pin1_4 6 11 PF00397 0.400
LIG_14-3-3_CanoR_1 379 383 PF00244 0.471
LIG_14-3-3_CanoR_1 583 592 PF00244 0.346
LIG_APCC_ABBA_1 270 275 PF00400 0.258
LIG_BIR_II_1 1 5 PF00653 0.581
LIG_BRCT_BRCA1_1 349 353 PF00533 0.380
LIG_BRCT_BRCA1_1 472 476 PF00533 0.400
LIG_BRCT_BRCA1_1 611 615 PF00533 0.367
LIG_Clathr_ClatBox_1 529 533 PF01394 0.400
LIG_Clathr_ClatBox_1 576 580 PF01394 0.400
LIG_deltaCOP1_diTrp_1 307 311 PF00928 0.346
LIG_deltaCOP1_diTrp_1 336 343 PF00928 0.258
LIG_FHA_1 111 117 PF00498 0.429
LIG_FHA_1 15 21 PF00498 0.420
LIG_FHA_1 199 205 PF00498 0.374
LIG_FHA_1 221 227 PF00498 0.355
LIG_FHA_1 433 439 PF00498 0.355
LIG_FHA_1 651 657 PF00498 0.471
LIG_FHA_2 169 175 PF00498 0.400
LIG_FHA_2 352 358 PF00498 0.370
LIG_FHA_2 395 401 PF00498 0.367
LIG_FHA_2 404 410 PF00498 0.316
LIG_FHA_2 507 513 PF00498 0.400
LIG_Integrin_isoDGR_2 220 222 PF01839 0.400
LIG_LIR_Apic_2 163 168 PF02991 0.400
LIG_LIR_Apic_2 296 301 PF02991 0.346
LIG_LIR_Apic_2 346 351 PF02991 0.323
LIG_LIR_Apic_2 464 468 PF02991 0.403
LIG_LIR_Apic_2 533 537 PF02991 0.346
LIG_LIR_Gen_1 122 131 PF02991 0.410
LIG_LIR_Gen_1 309 315 PF02991 0.346
LIG_LIR_Gen_1 350 361 PF02991 0.348
LIG_LIR_Gen_1 470 479 PF02991 0.400
LIG_LIR_Gen_1 492 502 PF02991 0.400
LIG_LIR_Gen_1 612 621 PF02991 0.352
LIG_LIR_Gen_1 95 104 PF02991 0.363
LIG_LIR_Nem_3 122 127 PF02991 0.416
LIG_LIR_Nem_3 307 311 PF02991 0.346
LIG_LIR_Nem_3 320 326 PF02991 0.346
LIG_LIR_Nem_3 350 356 PF02991 0.348
LIG_LIR_Nem_3 381 387 PF02991 0.471
LIG_LIR_Nem_3 407 413 PF02991 0.346
LIG_LIR_Nem_3 470 475 PF02991 0.355
LIG_LIR_Nem_3 492 497 PF02991 0.393
LIG_LIR_Nem_3 622 628 PF02991 0.371
LIG_LIR_Nem_3 95 100 PF02991 0.349
LIG_MLH1_MIPbox_1 611 615 PF16413 0.367
LIG_PCNA_yPIPBox_3 424 437 PF02747 0.346
LIG_PDZ_Class_2 674 679 PF00595 0.477
LIG_Pex14_1 339 343 PF04695 0.346
LIG_Pex14_2 93 97 PF04695 0.407
LIG_SH2_CRK 15 19 PF00017 0.434
LIG_SH2_CRK 323 327 PF00017 0.400
LIG_SH2_CRK 472 476 PF00017 0.400
LIG_SH2_CRK 7 11 PF00017 0.465
LIG_SH2_GRB2like 101 104 PF00017 0.361
LIG_SH2_NCK_1 472 476 PF00017 0.400
LIG_SH2_PTP2 642 645 PF00017 0.400
LIG_SH2_SRC 261 264 PF00017 0.391
LIG_SH2_SRC 34 37 PF00017 0.431
LIG_SH2_SRC 375 378 PF00017 0.346
LIG_SH2_STAP1 34 38 PF00017 0.377
LIG_SH2_STAP1 472 476 PF00017 0.400
LIG_SH2_STAT5 107 110 PF00017 0.344
LIG_SH2_STAT5 15 18 PF00017 0.357
LIG_SH2_STAT5 261 264 PF00017 0.400
LIG_SH2_STAT5 388 391 PF00017 0.328
LIG_SH2_STAT5 404 407 PF00017 0.398
LIG_SH2_STAT5 494 497 PF00017 0.400
LIG_SH2_STAT5 518 521 PF00017 0.400
LIG_SH2_STAT5 535 538 PF00017 0.400
LIG_SH2_STAT5 614 617 PF00017 0.418
LIG_SH2_STAT5 625 628 PF00017 0.358
LIG_SH2_STAT5 642 645 PF00017 0.400
LIG_SH2_STAT5 7 10 PF00017 0.411
LIG_SH2_STAT5 96 99 PF00017 0.385
LIG_SH3_1 114 120 PF00018 0.362
LIG_SH3_3 114 120 PF00018 0.362
LIG_SH3_4 637 644 PF00018 0.346
LIG_SUMO_SIM_anti_2 354 360 PF11976 0.400
LIG_SUMO_SIM_par_1 575 580 PF11976 0.346
LIG_SUMO_SIM_par_1 652 658 PF11976 0.471
LIG_TRAF2_1 482 485 PF00917 0.346
LIG_TYR_ITIM 13 18 PF00017 0.387
LIG_TYR_ITIM 626 631 PF00017 0.400
LIG_UBA3_1 504 511 PF00899 0.403
LIG_UBA3_1 595 603 PF00899 0.346
LIG_WRC_WIRS_1 107 112 PF05994 0.387
LIG_WRC_WIRS_1 667 672 PF05994 0.400
LIG_WRC_WIRS_1 73 78 PF05994 0.502
MOD_CDK_SPK_2 25 30 PF00069 0.489
MOD_CDK_SPK_2 6 11 PF00069 0.454
MOD_CDK_SPxK_1 533 539 PF00069 0.471
MOD_CDK_SPxxK_3 25 32 PF00069 0.479
MOD_CK1_1 394 400 PF00069 0.380
MOD_CK1_1 416 422 PF00069 0.258
MOD_CK1_1 440 446 PF00069 0.460
MOD_CK1_1 54 60 PF00069 0.342
MOD_CK1_1 650 656 PF00069 0.471
MOD_CK1_1 669 675 PF00069 0.400
MOD_CK2_1 273 279 PF00069 0.400
MOD_CK2_1 478 484 PF00069 0.399
MOD_CK2_1 506 512 PF00069 0.400
MOD_GlcNHglycan 129 132 PF01048 0.469
MOD_GlcNHglycan 300 304 PF01048 0.346
MOD_GlcNHglycan 363 366 PF01048 0.346
MOD_GlcNHglycan 393 396 PF01048 0.380
MOD_GlcNHglycan 457 460 PF01048 0.400
MOD_GlcNHglycan 611 614 PF01048 0.433
MOD_GlcNHglycan 649 652 PF01048 0.471
MOD_GlcNHglycan 68 71 PF01048 0.379
MOD_GSK3_1 106 113 PF00069 0.382
MOD_GSK3_1 127 134 PF00069 0.545
MOD_GSK3_1 160 167 PF00069 0.381
MOD_GSK3_1 347 354 PF00069 0.380
MOD_GSK3_1 387 394 PF00069 0.380
MOD_N-GLC_1 168 173 PF02516 0.400
MOD_N-GLC_1 250 255 PF02516 0.471
MOD_N-GLC_1 616 621 PF02516 0.425
MOD_NEK2_1 110 115 PF00069 0.319
MOD_NEK2_1 181 186 PF00069 0.380
MOD_NEK2_1 294 299 PF00069 0.346
MOD_NEK2_1 361 366 PF00069 0.346
MOD_NEK2_1 418 423 PF00069 0.350
MOD_NEK2_1 99 104 PF00069 0.342
MOD_NEK2_2 72 77 PF00069 0.500
MOD_PIKK_1 273 279 PF00454 0.346
MOD_PK_1 77 83 PF00069 0.468
MOD_PKA_1 609 615 PF00069 0.433
MOD_PKA_2 378 384 PF00069 0.471
MOD_PKA_2 609 615 PF00069 0.484
MOD_PKB_1 581 589 PF00069 0.400
MOD_Plk_1 210 216 PF00069 0.400
MOD_Plk_1 351 357 PF00069 0.346
MOD_Plk_1 450 456 PF00069 0.355
MOD_Plk_1 616 622 PF00069 0.323
MOD_Plk_2-3 151 157 PF00069 0.394
MOD_Plk_2-3 352 358 PF00069 0.400
MOD_Plk_2-3 450 456 PF00069 0.400
MOD_Plk_4 198 204 PF00069 0.400
MOD_Plk_4 413 419 PF00069 0.400
MOD_Plk_4 461 467 PF00069 0.375
MOD_Plk_4 471 477 PF00069 0.346
MOD_Plk_4 489 495 PF00069 0.400
MOD_Plk_4 616 622 PF00069 0.390
MOD_Plk_4 644 650 PF00069 0.468
MOD_Plk_4 666 672 PF00069 0.400
MOD_ProDKin_1 131 137 PF00069 0.554
MOD_ProDKin_1 164 170 PF00069 0.400
MOD_ProDKin_1 25 31 PF00069 0.428
MOD_ProDKin_1 347 353 PF00069 0.380
MOD_ProDKin_1 51 57 PF00069 0.457
MOD_ProDKin_1 533 539 PF00069 0.346
MOD_ProDKin_1 6 12 PF00069 0.408
MOD_SUMO_for_1 195 198 PF00179 0.471
MOD_SUMO_rev_2 109 116 PF00179 0.362
MOD_SUMO_rev_2 149 154 PF00179 0.404
MOD_SUMO_rev_2 444 454 PF00179 0.355
TRG_DiLeu_BaEn_1 198 203 PF01217 0.471
TRG_DiLeu_BaEn_2 306 312 PF01217 0.346
TRG_DiLeu_BaEn_2 88 94 PF01217 0.512
TRG_DiLeu_LyEn_5 56 61 PF01217 0.422
TRG_ENDOCYTIC_2 101 104 PF00928 0.347
TRG_ENDOCYTIC_2 107 110 PF00928 0.365
TRG_ENDOCYTIC_2 15 18 PF00928 0.381
TRG_ENDOCYTIC_2 267 270 PF00928 0.433
TRG_ENDOCYTIC_2 323 326 PF00928 0.400
TRG_ENDOCYTIC_2 375 378 PF00928 0.346
TRG_ENDOCYTIC_2 472 475 PF00928 0.400
TRG_ENDOCYTIC_2 494 497 PF00928 0.400
TRG_ENDOCYTIC_2 628 631 PF00928 0.446
TRG_ENDOCYTIC_2 96 99 PF00928 0.370
TRG_ER_diArg_1 547 550 PF00400 0.346
TRG_NES_CRM1_1 56 71 PF08389 0.503
TRG_NLS_MonoCore_2 635 640 PF00514 0.346
TRG_NLS_MonoExtC_3 635 640 PF00514 0.346
TRG_NLS_MonoExtN_4 635 640 PF00514 0.400
TRG_Pf-PMV_PEXEL_1 437 441 PF00026 0.400

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I084 Leptomonas seymouri 81% 100%
A0A0S4JJ29 Bodo saltans 55% 73%
A0A3S7WP65 Leishmania donovani 100% 100%
A4H4D9 Leishmania braziliensis 89% 100%
A7RZW4 Nematostella vectensis 44% 93%
E9AKK2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O55096 Rattus norvegicus 43% 92%
Q08225 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 37% 95%
Q4QJA6 Leishmania major 97% 100%
Q557H1 Dictyostelium discoideum 43% 98%
Q99KK7 Mus musculus 43% 92%
Q9NY33 Homo sapiens 43% 92%
Q9VHR8 Drosophila melanogaster 42% 86%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS