LeishMANIAdb
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Putative glutaminyl cyclase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative glutaminyl cyclase
Gene product:
glutaminyl cyclase - putative
Species:
Leishmania infantum
UniProt:
A4HSL7_LEIIN
TriTrypDb:
LINF_050014700
Length:
907

Annotations

Annotations by Jardim et al.

tRNA synthetase, glutaminyl cyclase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A4HSL7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSL7

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase 7 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018199 peptidyl-glutamine modification 6 1
GO:0019538 protein metabolic process 3 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044238 primary metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0016603 glutaminyl-peptide cyclotransferase activity 4 5
GO:0016740 transferase activity 2 7
GO:0016746 acyltransferase activity 3 7
GO:0016755 aminoacyltransferase activity 3 5
GO:0140096 catalytic activity, acting on a protein 2 5
GO:0005488 binding 1 1
GO:0008270 zinc ion binding 6 1
GO:0043167 ion binding 2 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1
GO:0046914 transition metal ion binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 183 187 PF00656 0.488
CLV_C14_Caspase3-7 228 232 PF00656 0.435
CLV_C14_Caspase3-7 275 279 PF00656 0.439
CLV_NRD_NRD_1 10 12 PF00675 0.486
CLV_NRD_NRD_1 125 127 PF00675 0.696
CLV_NRD_NRD_1 13 15 PF00675 0.464
CLV_NRD_NRD_1 142 144 PF00675 0.549
CLV_NRD_NRD_1 161 163 PF00675 0.515
CLV_NRD_NRD_1 17 19 PF00675 0.438
CLV_NRD_NRD_1 245 247 PF00675 0.637
CLV_NRD_NRD_1 336 338 PF00675 0.579
CLV_NRD_NRD_1 365 367 PF00675 0.667
CLV_NRD_NRD_1 371 373 PF00675 0.666
CLV_NRD_NRD_1 49 51 PF00675 0.294
CLV_NRD_NRD_1 747 749 PF00675 0.703
CLV_NRD_NRD_1 837 839 PF00675 0.478
CLV_NRD_NRD_1 904 906 PF00675 0.659
CLV_PCSK_FUR_1 11 15 PF00082 0.492
CLV_PCSK_FUR_1 47 51 PF00082 0.386
CLV_PCSK_KEX2_1 13 15 PF00082 0.460
CLV_PCSK_KEX2_1 142 144 PF00082 0.679
CLV_PCSK_KEX2_1 150 152 PF00082 0.567
CLV_PCSK_KEX2_1 161 163 PF00082 0.514
CLV_PCSK_KEX2_1 17 19 PF00082 0.433
CLV_PCSK_KEX2_1 229 231 PF00082 0.583
CLV_PCSK_KEX2_1 244 246 PF00082 0.586
CLV_PCSK_KEX2_1 29 31 PF00082 0.434
CLV_PCSK_KEX2_1 336 338 PF00082 0.579
CLV_PCSK_KEX2_1 364 366 PF00082 0.679
CLV_PCSK_KEX2_1 49 51 PF00082 0.311
CLV_PCSK_KEX2_1 747 749 PF00082 0.709
CLV_PCSK_KEX2_1 837 839 PF00082 0.486
CLV_PCSK_KEX2_1 9 11 PF00082 0.490
CLV_PCSK_PC1ET2_1 150 152 PF00082 0.592
CLV_PCSK_PC1ET2_1 229 231 PF00082 0.583
CLV_PCSK_PC1ET2_1 29 31 PF00082 0.449
CLV_PCSK_PC7_1 9 15 PF00082 0.476
CLV_PCSK_SKI1_1 150 154 PF00082 0.630
CLV_PCSK_SKI1_1 230 234 PF00082 0.677
CLV_PCSK_SKI1_1 26 30 PF00082 0.362
CLV_PCSK_SKI1_1 266 270 PF00082 0.615
CLV_PCSK_SKI1_1 351 355 PF00082 0.701
CLV_PCSK_SKI1_1 373 377 PF00082 0.748
CLV_PCSK_SKI1_1 409 413 PF00082 0.741
CLV_PCSK_SKI1_1 420 424 PF00082 0.730
CLV_PCSK_SKI1_1 485 489 PF00082 0.478
CLV_PCSK_SKI1_1 49 53 PF00082 0.284
CLV_PCSK_SKI1_1 528 532 PF00082 0.659
CLV_PCSK_SKI1_1 692 696 PF00082 0.565
CLV_PCSK_SKI1_1 747 751 PF00082 0.724
CLV_PCSK_SKI1_1 840 844 PF00082 0.508
DEG_APCC_DBOX_1 141 149 PF00400 0.454
DEG_APCC_DBOX_1 48 56 PF00400 0.481
DEG_APCC_DBOX_1 536 544 PF00400 0.363
DEG_APCC_DBOX_1 586 594 PF00400 0.320
DEG_Nend_UBRbox_3 1 3 PF02207 0.690
DOC_CDC14_PxL_1 465 473 PF14671 0.308
DOC_CYCLIN_RxL_1 260 270 PF00134 0.395
DOC_CYCLIN_yCln2_LP_2 543 549 PF00134 0.322
DOC_MAPK_DCC_7 857 866 PF00069 0.337
DOC_MAPK_FxFP_2 200 203 PF00069 0.345
DOC_MAPK_FxFP_2 327 330 PF00069 0.324
DOC_MAPK_gen_1 47 57 PF00069 0.544
DOC_MAPK_gen_1 720 729 PF00069 0.472
DOC_MAPK_gen_1 837 844 PF00069 0.308
DOC_MAPK_MEF2A_6 49 57 PF00069 0.492
DOC_MAPK_MEF2A_6 720 729 PF00069 0.446
DOC_MAPK_MEF2A_6 857 866 PF00069 0.337
DOC_MAPK_MEF2A_6 96 103 PF00069 0.504
DOC_MAPK_RevD_3 232 246 PF00069 0.390
DOC_PP1_RVXF_1 33 40 PF00149 0.611
DOC_PP2B_LxvP_1 201 204 PF13499 0.348
DOC_PP2B_PxIxI_1 596 602 PF00149 0.349
DOC_PP4_FxxP_1 200 203 PF00568 0.345
DOC_PP4_FxxP_1 327 330 PF00568 0.328
DOC_PP4_FxxP_1 557 560 PF00568 0.404
DOC_PP4_FxxP_1 827 830 PF00568 0.278
DOC_USP7_MATH_1 152 156 PF00917 0.453
DOC_USP7_MATH_1 163 167 PF00917 0.457
DOC_USP7_MATH_1 272 276 PF00917 0.394
DOC_USP7_MATH_1 330 334 PF00917 0.322
DOC_USP7_MATH_1 341 345 PF00917 0.424
DOC_USP7_MATH_1 473 477 PF00917 0.298
DOC_USP7_MATH_1 506 510 PF00917 0.463
DOC_USP7_MATH_1 672 676 PF00917 0.429
DOC_USP7_MATH_1 737 741 PF00917 0.443
DOC_USP7_MATH_1 808 812 PF00917 0.419
DOC_USP7_MATH_1 88 92 PF00917 0.566
DOC_WW_Pin1_4 259 264 PF00397 0.483
DOC_WW_Pin1_4 421 426 PF00397 0.469
DOC_WW_Pin1_4 542 547 PF00397 0.329
DOC_WW_Pin1_4 629 634 PF00397 0.411
DOC_WW_Pin1_4 730 735 PF00397 0.483
DOC_WW_Pin1_4 768 773 PF00397 0.524
DOC_WW_Pin1_4 79 84 PF00397 0.523
DOC_WW_Pin1_4 826 831 PF00397 0.278
LIG_14-3-3_CanoR_1 142 146 PF00244 0.464
LIG_14-3-3_CanoR_1 162 172 PF00244 0.338
LIG_14-3-3_CanoR_1 298 304 PF00244 0.326
LIG_14-3-3_CanoR_1 38 43 PF00244 0.697
LIG_14-3-3_CanoR_1 528 536 PF00244 0.386
LIG_14-3-3_CanoR_1 539 544 PF00244 0.338
LIG_14-3-3_CanoR_1 559 564 PF00244 0.331
LIG_14-3-3_CanoR_1 628 633 PF00244 0.470
LIG_14-3-3_CanoR_1 720 725 PF00244 0.413
LIG_14-3-3_CanoR_1 783 791 PF00244 0.275
LIG_Actin_RPEL_3 749 768 PF02755 0.486
LIG_AP2alpha_2 105 107 PF02296 0.478
LIG_AP2alpha_2 724 726 PF02296 0.470
LIG_BIR_III_4 426 430 PF00653 0.525
LIG_BRCT_BRCA1_1 196 200 PF00533 0.390
LIG_BRCT_BRCA1_1 461 465 PF00533 0.337
LIG_BRCT_BRCA1_1 674 678 PF00533 0.412
LIG_deltaCOP1_diTrp_1 294 303 PF00928 0.387
LIG_eIF4E_1 648 654 PF01652 0.369
LIG_FHA_1 305 311 PF00498 0.402
LIG_FHA_1 417 423 PF00498 0.519
LIG_FHA_1 46 52 PF00498 0.605
LIG_FHA_1 60 66 PF00498 0.289
LIG_FHA_1 630 636 PF00498 0.499
LIG_FHA_1 744 750 PF00498 0.423
LIG_FHA_1 783 789 PF00498 0.308
LIG_FHA_1 853 859 PF00498 0.347
LIG_FHA_2 134 140 PF00498 0.430
LIG_FHA_2 166 172 PF00498 0.513
LIG_FHA_2 226 232 PF00498 0.364
LIG_FHA_2 365 371 PF00498 0.574
LIG_FHA_2 530 536 PF00498 0.513
LIG_FHA_2 578 584 PF00498 0.469
LIG_FHA_2 586 592 PF00498 0.307
LIG_FHA_2 782 788 PF00498 0.364
LIG_FHA_2 80 86 PF00498 0.536
LIG_FHA_2 870 876 PF00498 0.334
LIG_FHA_2 882 888 PF00498 0.232
LIG_FHA_2 893 899 PF00498 0.310
LIG_LIR_Apic_2 197 203 PF02991 0.404
LIG_LIR_Gen_1 193 203 PF02991 0.399
LIG_LIR_Gen_1 21 32 PF02991 0.666
LIG_LIR_Gen_1 300 311 PF02991 0.332
LIG_LIR_Gen_1 462 473 PF02991 0.337
LIG_LIR_Gen_1 646 656 PF02991 0.309
LIG_LIR_Gen_1 665 672 PF02991 0.359
LIG_LIR_Gen_1 723 734 PF02991 0.484
LIG_LIR_Gen_1 792 800 PF02991 0.398
LIG_LIR_Nem_3 136 140 PF02991 0.424
LIG_LIR_Nem_3 193 198 PF02991 0.354
LIG_LIR_Nem_3 21 27 PF02991 0.659
LIG_LIR_Nem_3 300 306 PF02991 0.326
LIG_LIR_Nem_3 462 468 PF02991 0.288
LIG_LIR_Nem_3 646 651 PF02991 0.314
LIG_LIR_Nem_3 652 657 PF02991 0.301
LIG_LIR_Nem_3 723 729 PF02991 0.490
LIG_LIR_Nem_3 765 769 PF02991 0.399
LIG_LIR_Nem_3 792 797 PF02991 0.398
LIG_MAD2 857 865 PF02301 0.278
LIG_MLH1_MIPbox_1 461 465 PF16413 0.337
LIG_MYND_1 259 263 PF01753 0.429
LIG_NRBOX 539 545 PF00104 0.335
LIG_NRBOX 887 893 PF00104 0.381
LIG_Pex14_1 460 464 PF04695 0.337
LIG_Pex14_2 790 794 PF04695 0.308
LIG_Pex14_2 866 870 PF04695 0.278
LIG_PTB_Apo_2 321 328 PF02174 0.392
LIG_Rb_pABgroove_1 651 659 PF01858 0.301
LIG_REV1ctd_RIR_1 554 559 PF16727 0.443
LIG_SH2_CRK 679 683 PF00017 0.341
LIG_SH2_CRK 769 773 PF00017 0.384
LIG_SH2_GRB2like 818 821 PF00017 0.317
LIG_SH2_NCK_1 648 652 PF00017 0.374
LIG_SH2_SRC 640 643 PF00017 0.384
LIG_SH2_STAP1 745 749 PF00017 0.462
LIG_SH2_STAT3 671 674 PF00017 0.381
LIG_SH2_STAT5 391 394 PF00017 0.415
LIG_SH2_STAT5 464 467 PF00017 0.398
LIG_SH2_STAT5 555 558 PF00017 0.371
LIG_SH2_STAT5 745 748 PF00017 0.463
LIG_SH2_STAT5 818 821 PF00017 0.337
LIG_SH3_3 100 106 PF00018 0.483
LIG_SH3_3 253 259 PF00018 0.457
LIG_SH3_3 274 280 PF00018 0.435
LIG_SH3_3 402 408 PF00018 0.531
LIG_SH3_3 419 425 PF00018 0.482
LIG_SH3_3 430 436 PF00018 0.434
LIG_SH3_3 80 86 PF00018 0.537
LIG_SH3_3 861 867 PF00018 0.269
LIG_SH3_3 92 98 PF00018 0.442
LIG_SUMO_SIM_anti_2 113 118 PF11976 0.464
LIG_SUMO_SIM_anti_2 62 68 PF11976 0.304
LIG_SUMO_SIM_par_1 774 780 PF11976 0.440
LIG_SUMO_SIM_par_1 894 901 PF11976 0.371
LIG_TRAF2_1 831 834 PF00917 0.317
LIG_TRAF2_2 830 835 PF00917 0.308
LIG_TYR_ITIM 677 682 PF00017 0.407
LIG_UBA3_1 483 488 PF00899 0.316
MOD_CDK_SPK_2 259 264 PF00069 0.530
MOD_CDK_SPxxK_3 259 266 PF00069 0.483
MOD_CDK_SPxxK_3 421 428 PF00069 0.646
MOD_CK1_1 542 548 PF00069 0.467
MOD_CK1_1 631 637 PF00069 0.529
MOD_CK1_1 698 704 PF00069 0.502
MOD_CK1_1 740 746 PF00069 0.456
MOD_CK1_1 755 761 PF00069 0.523
MOD_CK1_1 77 83 PF00069 0.633
MOD_CK1_1 869 875 PF00069 0.419
MOD_CK2_1 133 139 PF00069 0.615
MOD_CK2_1 152 158 PF00069 0.368
MOD_CK2_1 315 321 PF00069 0.523
MOD_CK2_1 529 535 PF00069 0.484
MOD_CK2_1 577 583 PF00069 0.641
MOD_CK2_1 680 686 PF00069 0.445
MOD_CK2_1 730 736 PF00069 0.562
MOD_CK2_1 768 774 PF00069 0.455
MOD_CK2_1 79 85 PF00069 0.665
MOD_CK2_1 828 834 PF00069 0.446
MOD_CK2_1 892 898 PF00069 0.364
MOD_CK2_1 901 907 PF00069 0.586
MOD_CMANNOS 589 592 PF00535 0.366
MOD_Cter_Amidation 159 162 PF01082 0.524
MOD_Cter_Amidation 242 245 PF01082 0.523
MOD_DYRK1A_RPxSP_1 79 83 PF00069 0.590
MOD_GlcNHglycan 165 168 PF01048 0.673
MOD_GlcNHglycan 19 23 PF01048 0.510
MOD_GlcNHglycan 343 346 PF01048 0.546
MOD_GlcNHglycan 438 441 PF01048 0.728
MOD_GlcNHglycan 475 478 PF01048 0.332
MOD_GlcNHglycan 507 511 PF01048 0.679
MOD_GlcNHglycan 613 616 PF01048 0.499
MOD_GlcNHglycan 674 677 PF01048 0.434
MOD_GlcNHglycan 697 700 PF01048 0.579
MOD_GlcNHglycan 887 891 PF01048 0.263
MOD_GSK3_1 341 348 PF00069 0.545
MOD_GSK3_1 38 45 PF00069 0.682
MOD_GSK3_1 631 638 PF00069 0.447
MOD_GSK3_1 643 650 PF00069 0.410
MOD_GSK3_1 694 701 PF00069 0.470
MOD_GSK3_1 758 765 PF00069 0.545
MOD_GSK3_1 777 784 PF00069 0.296
MOD_GSK3_1 882 889 PF00069 0.359
MOD_N-GLC_1 304 309 PF02516 0.392
MOD_N-GLC_1 528 533 PF02516 0.562
MOD_N-GLC_1 752 757 PF02516 0.639
MOD_N-GLC_1 77 82 PF02516 0.530
MOD_NEK2_1 194 199 PF00069 0.560
MOD_NEK2_1 483 488 PF00069 0.364
MOD_NEK2_1 500 505 PF00069 0.458
MOD_NEK2_1 523 528 PF00069 0.479
MOD_NEK2_1 59 64 PF00069 0.376
MOD_NEK2_1 694 699 PF00069 0.497
MOD_NEK2_1 891 896 PF00069 0.368
MOD_PIKK_1 330 336 PF00454 0.369
MOD_PIKK_1 389 395 PF00454 0.614
MOD_PIKK_1 444 450 PF00454 0.596
MOD_PIKK_1 670 676 PF00454 0.446
MOD_PIKK_1 680 686 PF00454 0.403
MOD_PIKK_1 828 834 PF00454 0.465
MOD_PIKK_1 852 858 PF00454 0.316
MOD_PK_1 38 44 PF00069 0.620
MOD_PK_1 559 565 PF00069 0.612
MOD_PKA_1 364 370 PF00069 0.643
MOD_PKA_2 133 139 PF00069 0.615
MOD_PKA_2 141 147 PF00069 0.490
MOD_PKA_2 297 303 PF00069 0.392
MOD_PKA_2 364 370 PF00069 0.585
MOD_PKA_2 755 761 PF00069 0.523
MOD_PKA_2 782 788 PF00069 0.312
MOD_PKB_1 537 545 PF00069 0.496
MOD_Plk_1 18 24 PF00069 0.454
MOD_Plk_1 616 622 PF00069 0.384
MOD_Plk_1 709 715 PF00069 0.628
MOD_Plk_1 809 815 PF00069 0.358
MOD_Plk_2-3 585 591 PF00069 0.438
MOD_Plk_4 133 139 PF00069 0.532
MOD_Plk_4 152 158 PF00069 0.445
MOD_Plk_4 386 392 PF00069 0.588
MOD_Plk_4 539 545 PF00069 0.518
MOD_Plk_4 59 65 PF00069 0.376
MOD_Plk_4 631 637 PF00069 0.537
MOD_Plk_4 643 649 PF00069 0.345
MOD_Plk_4 892 898 PF00069 0.364
MOD_ProDKin_1 259 265 PF00069 0.598
MOD_ProDKin_1 421 427 PF00069 0.583
MOD_ProDKin_1 542 548 PF00069 0.384
MOD_ProDKin_1 629 635 PF00069 0.511
MOD_ProDKin_1 730 736 PF00069 0.602
MOD_ProDKin_1 768 774 PF00069 0.664
MOD_ProDKin_1 79 85 PF00069 0.667
MOD_ProDKin_1 826 832 PF00069 0.316
MOD_SUMO_rev_2 370 375 PF00179 0.621
MOD_SUMO_rev_2 424 430 PF00179 0.615
TRG_DiLeu_BaEn_1 321 326 PF01217 0.478
TRG_DiLeu_BaEn_1 566 571 PF01217 0.570
TRG_DiLeu_BaLyEn_6 23 28 PF01217 0.416
TRG_DiLeu_BaLyEn_6 725 730 PF01217 0.613
TRG_DiLeu_BaLyEn_6 745 750 PF01217 0.620
TRG_ENDOCYTIC_2 137 140 PF00928 0.510
TRG_ENDOCYTIC_2 553 556 PF00928 0.583
TRG_ENDOCYTIC_2 648 651 PF00928 0.417
TRG_ENDOCYTIC_2 657 660 PF00928 0.299
TRG_ENDOCYTIC_2 679 682 PF00928 0.405
TRG_ENDOCYTIC_2 800 803 PF00928 0.316
TRG_ER_diArg_1 117 120 PF00400 0.549
TRG_ER_diArg_1 13 15 PF00400 0.575
TRG_ER_diArg_1 244 246 PF00400 0.550
TRG_ER_diArg_1 335 337 PF00400 0.436
TRG_ER_diArg_1 364 366 PF00400 0.661
TRG_ER_diArg_1 47 50 PF00400 0.510
TRG_ER_diArg_1 636 639 PF00400 0.664
TRG_ER_diArg_1 689 692 PF00400 0.534
TRG_ER_diArg_1 747 749 PF00400 0.614
TRG_ER_diArg_1 836 838 PF00400 0.316
TRG_ER_diArg_1 9 11 PF00400 0.608
TRG_NES_CRM1_1 645 658 PF08389 0.361
TRG_Pf-PMV_PEXEL_1 266 270 PF00026 0.478
TRG_Pf-PMV_PEXEL_1 623 627 PF00026 0.408

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBR2 Leptomonas seymouri 51% 99%
A0A3S7WP80 Leishmania donovani 100% 100%
A4H4D8 Leishmania braziliensis 81% 99%
E9AKK1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4QJA7 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS