Surface antigen-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen-like protein

Species:

Leishmania infantum

UniProt:

A4HSL2_LEIIN

TriTrypDb:

LINF_050014200

Length:

286

Annotations

Annotations by Jardim et al.

Plasma membrane, Surface antigen-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 15, no: 5
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	21
GO:0042995	cell projection	2	21
GO:0043226	organelle	2	21
GO:0043227	membrane-bounded organelle	3	21
GO:0110165	cellular anatomical entity	1	21
GO:0120025	plasma membrane bounded cell projection	3	21
GO:0016020	membrane	2	4

Expansion

Sequence features

A4HSL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSL2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.273
CLV_PCSK_SKI1_1	102	106	PF00082	0.445
CLV_PCSK_SKI1_1	172	176	PF00082	0.565
CLV_PCSK_SKI1_1	5	9	PF00082	0.511
DEG_APCC_DBOX_1	4	12	PF00400	0.449
DOC_MAPK_gen_1	172	182	PF00069	0.261
DOC_USP7_MATH_1	280	284	PF00917	0.302
DOC_USP7_MATH_2	216	222	PF00917	0.259
DOC_USP7_UBL2_3	47	51	PF12436	0.253
DOC_USP7_UBL2_3	57	61	PF12436	0.254
DOC_USP7_UBL2_3	93	97	PF12436	0.273
LIG_14-3-3_CanoR_1	267	271	PF00244	0.279
LIG_Actin_WH2_2	36	53	PF00022	0.234
LIG_BIR_II_1	1	5	PF00653	0.522
LIG_Clathr_ClatBox_1	152	156	PF01394	0.266
LIG_EH1_1	223	231	PF00400	0.264
LIG_eIF4E_1	224	230	PF01652	0.257
LIG_FHA_1	103	109	PF00498	0.351
LIG_FHA_1	244	250	PF00498	0.305
LIG_FHA_1	73	79	PF00498	0.338
LIG_FHA_1	82	88	PF00498	0.371
LIG_FHA_2	29	35	PF00498	0.330
LIG_LIR_Gen_1	176	187	PF02991	0.329
LIG_LIR_Gen_1	221	230	PF02991	0.385
LIG_LIR_Gen_1	37	48	PF02991	0.421
LIG_LIR_Nem_3	120	125	PF02991	0.324
LIG_LIR_Nem_3	176	182	PF02991	0.315
LIG_LIR_Nem_3	198	202	PF02991	0.347
LIG_LIR_Nem_3	37	43	PF02991	0.293
LIG_PDZ_Class_2	281	286	PF00595	0.428
LIG_Pex14_1	44	48	PF04695	0.362
LIG_Pex14_2	40	44	PF04695	0.311
LIG_SH2_CRK	122	126	PF00017	0.249
LIG_SH2_STAT5	132	135	PF00017	0.333
LIG_SH2_STAT5	39	42	PF00017	0.288
LIG_SH2_STAT5	52	55	PF00017	0.360
LIG_SUMO_SIM_anti_2	16	22	PF11976	0.512
LIG_SUMO_SIM_par_1	151	156	PF11976	0.351
LIG_SUMO_SIM_par_1	277	283	PF11976	0.359
LIG_WRC_WIRS_1	196	201	PF05994	0.333
MOD_CK1_1	173	179	PF00069	0.282
MOD_CK1_1	195	201	PF00069	0.308
MOD_CK1_1	203	209	PF00069	0.342
MOD_CK1_1	217	223	PF00069	0.362
MOD_CK1_1	25	31	PF00069	0.592
MOD_CK1_1	266	272	PF00069	0.384
MOD_CK1_1	33	39	PF00069	0.317
MOD_CK1_1	66	72	PF00069	0.353
MOD_GlcNHglycan	44	47	PF01048	0.438
MOD_GlcNHglycan	54	57	PF01048	0.511
MOD_GSK3_1	134	141	PF00069	0.327
MOD_GSK3_1	188	195	PF00069	0.330
MOD_GSK3_1	200	207	PF00069	0.300
MOD_GSK3_1	214	221	PF00069	0.313
MOD_GSK3_1	30	37	PF00069	0.377
MOD_GSK3_1	66	73	PF00069	0.338
MOD_N-GLC_1	134	139	PF02516	0.528
MOD_N-GLC_2	245	247	PF02516	0.478
MOD_NEK2_1	133	138	PF00069	0.299
MOD_NEK2_1	155	160	PF00069	0.296
MOD_NEK2_1	180	185	PF00069	0.303
MOD_NEK2_1	188	193	PF00069	0.297
MOD_NEK2_1	204	209	PF00069	0.298
MOD_NEK2_1	219	224	PF00069	0.289
MOD_NEK2_1	229	234	PF00069	0.311
MOD_NEK2_1	83	88	PF00069	0.330
MOD_OFUCOSY	241	247	PF10250	0.466
MOD_OFUCOSY	60	67	PF10250	0.575
MOD_PIKK_1	229	235	PF00454	0.422
MOD_PIKK_1	34	40	PF00454	0.343
MOD_PKA_2	266	272	PF00069	0.279
MOD_Plk_1	134	140	PF00069	0.304
MOD_Plk_4	13	19	PF00069	0.498
MOD_Plk_4	183	189	PF00069	0.327
MOD_Plk_4	219	225	PF00069	0.312
MOD_Plk_4	280	286	PF00069	0.370
MOD_Plk_4	72	78	PF00069	0.266
TRG_ENDOCYTIC_2	122	125	PF00928	0.350
TRG_ENDOCYTIC_2	179	182	PF00928	0.327
TRG_ENDOCYTIC_2	224	227	PF00928	0.276
TRG_ENDOCYTIC_2	62	65	PF00928	0.331
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P227	Leptomonas seymouri	28%	91%
A0A0N0P2E6	Leptomonas seymouri	23%	100%
A0A0N0P2L4	Leptomonas seymouri	25%	96%
A0A0N0P4M2	Leptomonas seymouri	32%	100%
A0A0S4IN83	Bodo saltans	24%	100%
A0A0S4IQP4	Bodo saltans	30%	73%
A0A0S4IR61	Bodo saltans	23%	71%
A0A0S4IU55	Bodo saltans	26%	100%
A0A0S4IZC7	Bodo saltans	28%	69%
A0A0S4J7Q5	Bodo saltans	27%	82%
A0A0S4JCT9	Bodo saltans	23%	100%
A0A0S4JEK1	Bodo saltans	26%	70%
A0A0S4JMG0	Bodo saltans	24%	83%
A0A0S4JMV1	Bodo saltans	21%	100%
A0A0S4JP43	Bodo saltans	24%	73%
A0A0S4KHE4	Bodo saltans	26%	78%
A0A0S4KMV2	Bodo saltans	22%	73%
A0A1X0NKN8	Trypanosomatidae	32%	100%
A0A3S5H6D6	Leishmania donovani	30%	100%
A0A3S7WP69	Leishmania donovani	100%	100%
A0A3S7WPB2	Leishmania donovani	33%	100%
A4H4D2	Leishmania braziliensis	75%	100%
A4H4G6	Leishmania braziliensis	28%	100%
A4H5P0	Leishmania braziliensis	28%	100%
A4HTX9	Leishmania infantum	31%	100%
E9ACQ0	Leishmania major	31%	100%
E9AG65	Leishmania infantum	33%	100%
E9AGG1	Leishmania infantum	23%	100%
E9AGG5	Leishmania infantum	24%	69%
E9AGH0	Leishmania infantum	21%	76%
E9AKJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AKM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AMQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AP02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	20%	84%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	73%
E9AP07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	78%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	68%
E9B1U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	84%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	68%
F4HTV6	Arabidopsis thaliana	24%	95%
P58822	Phaseolus vulgaris	27%	84%
Q25331	Leishmania major	21%	74%
Q4QGJ4	Leishmania major	21%	74%
Q4QGJ7	Leishmania major	21%	76%
Q4QGK6	Leishmania major	21%	74%
Q4QGL4	Leishmania major	22%	72%
Q4QHW6	Leishmania major	30%	100%
Q4QJB2	Leishmania major	95%	100%