LeishMANIAdb
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RING-type domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
RING-type domain-containing protein
Gene product:
zinc-finger of a C2HC-type - putative
Species:
Leishmania infantum
UniProt:
A4HSK7_LEIIN
TriTrypDb:
LINF_050013700
Length:
666

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005815 microtubule organizing center 2 1
GO:0036064 ciliary basal body 3 1
GO:0051286 cell tip 3 1
GO:0060187 cell pole 2 1
GO:0097542 ciliary tip 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HSK7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSK7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 428 430 PF00675 0.581
CLV_NRD_NRD_1 505 507 PF00675 0.355
CLV_NRD_NRD_1 526 528 PF00675 0.540
CLV_NRD_NRD_1 636 638 PF00675 0.274
CLV_PCSK_KEX2_1 21 23 PF00082 0.457
CLV_PCSK_KEX2_1 211 213 PF00082 0.443
CLV_PCSK_KEX2_1 428 430 PF00082 0.582
CLV_PCSK_KEX2_1 505 507 PF00082 0.330
CLV_PCSK_PC1ET2_1 21 23 PF00082 0.457
CLV_PCSK_PC1ET2_1 211 213 PF00082 0.443
CLV_PCSK_PC7_1 501 507 PF00082 0.306
CLV_PCSK_SKI1_1 126 130 PF00082 0.430
CLV_PCSK_SKI1_1 416 420 PF00082 0.725
CLV_PCSK_SKI1_1 527 531 PF00082 0.483
CLV_PCSK_SKI1_1 650 654 PF00082 0.428
CLV_PCSK_SKI1_1 94 98 PF00082 0.617
DEG_SPOP_SBC_1 239 243 PF00917 0.573
DEG_SPOP_SBC_1 365 369 PF00917 0.675
DEG_SPOP_SBC_1 475 479 PF00917 0.575
DOC_CKS1_1 133 138 PF01111 0.434
DOC_CYCLIN_yCln2_LP_2 291 297 PF00134 0.721
DOC_MAPK_DCC_7 81 90 PF00069 0.649
DOC_MAPK_gen_1 505 511 PF00069 0.434
DOC_MAPK_MEF2A_6 505 513 PF00069 0.411
DOC_MAPK_MEF2A_6 81 90 PF00069 0.649
DOC_PP2B_LxvP_1 291 294 PF13499 0.653
DOC_PP2B_LxvP_1 435 438 PF13499 0.525
DOC_PP2B_LxvP_1 88 91 PF13499 0.661
DOC_PP4_MxPP_1 473 476 PF00568 0.669
DOC_PP4_MxPP_1 615 618 PF00568 0.633
DOC_SPAK_OSR1_1 506 510 PF12202 0.306
DOC_USP7_MATH_1 239 243 PF00917 0.567
DOC_USP7_MATH_1 311 315 PF00917 0.513
DOC_USP7_MATH_1 337 341 PF00917 0.615
DOC_USP7_MATH_1 364 368 PF00917 0.565
DOC_USP7_MATH_1 372 376 PF00917 0.556
DOC_USP7_MATH_1 408 412 PF00917 0.534
DOC_USP7_MATH_1 418 422 PF00917 0.692
DOC_USP7_MATH_1 47 51 PF00917 0.643
DOC_USP7_MATH_1 55 59 PF00917 0.438
DOC_USP7_MATH_1 550 554 PF00917 0.569
DOC_USP7_MATH_1 64 68 PF00917 0.534
DOC_WW_Pin1_4 105 110 PF00397 0.506
DOC_WW_Pin1_4 132 137 PF00397 0.441
DOC_WW_Pin1_4 152 157 PF00397 0.665
DOC_WW_Pin1_4 241 246 PF00397 0.719
DOC_WW_Pin1_4 366 371 PF00397 0.664
DOC_WW_Pin1_4 43 48 PF00397 0.556
DOC_WW_Pin1_4 56 61 PF00397 0.574
DOC_WW_Pin1_4 6 11 PF00397 0.524
DOC_WW_Pin1_4 94 99 PF00397 0.621
LIG_14-3-3_CanoR_1 237 247 PF00244 0.679
LIG_14-3-3_CanoR_1 350 359 PF00244 0.554
LIG_14-3-3_CanoR_1 43 47 PF00244 0.570
LIG_14-3-3_CanoR_1 434 438 PF00244 0.599
LIG_14-3-3_CanoR_1 506 512 PF00244 0.280
LIG_14-3-3_CanoR_1 8 18 PF00244 0.486
LIG_Actin_WH2_2 191 206 PF00022 0.478
LIG_BRCT_BRCA1_1 374 378 PF00533 0.547
LIG_FHA_1 10 16 PF00498 0.483
LIG_FHA_1 352 358 PF00498 0.723
LIG_LIR_Gen_1 59 68 PF02991 0.621
LIG_LIR_Nem_3 59 65 PF02991 0.619
LIG_NRP_CendR_1 665 666 PF00754 0.572
LIG_Pex14_1 465 469 PF04695 0.525
LIG_PTB_Apo_2 170 177 PF02174 0.571
LIG_PTB_Phospho_1 170 176 PF10480 0.567
LIG_SH2_CRK 405 409 PF00017 0.622
LIG_SH2_CRK 62 66 PF00017 0.622
LIG_SH2_NCK_1 62 66 PF00017 0.692
LIG_SH2_STAP1 626 630 PF00017 0.466
LIG_SH2_STAT5 119 122 PF00017 0.456
LIG_SH2_STAT5 209 212 PF00017 0.575
LIG_SH2_STAT5 62 65 PF00017 0.693
LIG_SH3_3 150 156 PF00018 0.516
LIG_SH3_3 404 410 PF00018 0.568
LIG_SH3_3 615 621 PF00018 0.526
LIG_SH3_3 627 633 PF00018 0.272
LIG_SH3_3 80 86 PF00018 0.693
LIG_SUMO_SIM_par_1 166 172 PF11976 0.659
LIG_TRAF2_1 496 499 PF00917 0.372
MOD_CDC14_SPxK_1 108 111 PF00782 0.620
MOD_CDC14_SPxK_1 46 49 PF00782 0.552
MOD_CDK_SPK_2 56 61 PF00069 0.564
MOD_CDK_SPxK_1 105 111 PF00069 0.631
MOD_CDK_SPxK_1 43 49 PF00069 0.528
MOD_CK1_1 102 108 PF00069 0.694
MOD_CK1_1 164 170 PF00069 0.575
MOD_CK1_1 172 178 PF00069 0.676
MOD_CK1_1 199 205 PF00069 0.428
MOD_CK1_1 241 247 PF00069 0.519
MOD_CK1_1 335 341 PF00069 0.576
MOD_CK1_1 433 439 PF00069 0.666
MOD_CK2_1 311 317 PF00069 0.606
MOD_Cter_Amidation 503 506 PF01082 0.306
MOD_Cter_Amidation 635 638 PF01082 0.274
MOD_DYRK1A_RPxSP_1 152 156 PF00069 0.660
MOD_GlcNHglycan 101 104 PF01048 0.619
MOD_GlcNHglycan 156 159 PF01048 0.529
MOD_GlcNHglycan 178 181 PF01048 0.597
MOD_GlcNHglycan 299 302 PF01048 0.687
MOD_GlcNHglycan 340 343 PF01048 0.579
MOD_GlcNHglycan 374 377 PF01048 0.700
MOD_GlcNHglycan 380 383 PF01048 0.596
MOD_GlcNHglycan 411 414 PF01048 0.676
MOD_GlcNHglycan 420 423 PF01048 0.573
MOD_GlcNHglycan 441 444 PF01048 0.646
MOD_GlcNHglycan 49 52 PF01048 0.626
MOD_GlcNHglycan 552 555 PF01048 0.647
MOD_GlcNHglycan 66 69 PF01048 0.696
MOD_GSK3_1 172 179 PF00069 0.563
MOD_GSK3_1 185 192 PF00069 0.455
MOD_GSK3_1 199 206 PF00069 0.437
MOD_GSK3_1 229 236 PF00069 0.533
MOD_GSK3_1 241 248 PF00069 0.505
MOD_GSK3_1 331 338 PF00069 0.612
MOD_GSK3_1 348 355 PF00069 0.460
MOD_GSK3_1 420 427 PF00069 0.623
MOD_GSK3_1 43 50 PF00069 0.615
MOD_GSK3_1 546 553 PF00069 0.602
MOD_GSK3_1 56 63 PF00069 0.577
MOD_GSK3_1 66 73 PF00069 0.551
MOD_GSK3_1 90 97 PF00069 0.588
MOD_N-GLC_1 172 177 PF02516 0.538
MOD_N-GLC_1 56 61 PF02516 0.639
MOD_NEK2_1 169 174 PF00069 0.531
MOD_NEK2_1 194 199 PF00069 0.500
MOD_NEK2_1 203 208 PF00069 0.424
MOD_NEK2_1 240 245 PF00069 0.647
MOD_NEK2_1 247 252 PF00069 0.681
MOD_NEK2_1 255 260 PF00069 0.456
MOD_NEK2_1 297 302 PF00069 0.627
MOD_NEK2_1 378 383 PF00069 0.659
MOD_NEK2_1 507 512 PF00069 0.284
MOD_PIKK_1 126 132 PF00454 0.433
MOD_PIKK_1 253 259 PF00454 0.571
MOD_PKA_2 203 209 PF00069 0.426
MOD_PKA_2 297 303 PF00069 0.623
MOD_PKA_2 352 358 PF00069 0.517
MOD_PKA_2 42 48 PF00069 0.569
MOD_PKA_2 433 439 PF00069 0.690
MOD_PKA_2 507 513 PF00069 0.274
MOD_Plk_1 172 178 PF00069 0.576
MOD_Plk_4 164 170 PF00069 0.516
MOD_ProDKin_1 105 111 PF00069 0.505
MOD_ProDKin_1 132 138 PF00069 0.440
MOD_ProDKin_1 152 158 PF00069 0.665
MOD_ProDKin_1 241 247 PF00069 0.721
MOD_ProDKin_1 366 372 PF00069 0.665
MOD_ProDKin_1 43 49 PF00069 0.562
MOD_ProDKin_1 56 62 PF00069 0.577
MOD_ProDKin_1 6 12 PF00069 0.517
MOD_ProDKin_1 94 100 PF00069 0.624
MOD_SUMO_for_1 210 213 PF00179 0.432
MOD_SUMO_rev_2 122 128 PF00179 0.413
TRG_ENDOCYTIC_2 62 65 PF00928 0.623
TRG_ER_diArg_1 428 430 PF00400 0.580
TRG_ER_diArg_1 505 507 PF00400 0.327
TRG_ER_diArg_1 664 666 PF00400 0.563
TRG_ER_diArg_1 91 94 PF00400 0.690
TRG_NLS_MonoCore_2 346 351 PF00514 0.578
TRG_Pf-PMV_PEXEL_1 259 263 PF00026 0.631
TRG_Pf-PMV_PEXEL_1 264 269 PF00026 0.522
TRG_Pf-PMV_PEXEL_1 30 34 PF00026 0.466

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1II98 Leptomonas seymouri 56% 100%
A0A3S7WP70 Leishmania donovani 98% 100%
A4H4C7 Leishmania braziliensis 73% 99%
E9AKJ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 96%
Q4QJB7 Leishmania major 93% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS