Polyamine metabolism, methylthioadenosine phosphorylase
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | yes | yes: 4 |
| Forrest at al. (procyclic) | yes | yes: 4 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | yes | yes: 15 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 5 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | yes | yes: 10 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 9 |
| NetGPI | no | yes: 0, no: 9 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005634 | nucleus | 5 | 10 |
| GO:0005737 | cytoplasm | 2 | 9 |
| GO:0043226 | organelle | 2 | 10 |
| GO:0043227 | membrane-bounded organelle | 3 | 10 |
| GO:0043229 | intracellular organelle | 3 | 10 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 10 |
| GO:0110165 | cellular anatomical entity | 1 | 10 |
| GO:0005829 | cytosol | 2 | 1 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pescher et al. (upgregulation) | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
|
Lahav et al. - mRNA
- Protein
|
Related structures:
AlphaFold database: A4HSK5
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0000096 | sulfur amino acid metabolic process | 4 | 8 |
| GO:0000097 | sulfur amino acid biosynthetic process | 5 | 8 |
| GO:0006082 | organic acid metabolic process | 3 | 8 |
| GO:0006139 | nucleobase-containing compound metabolic process | 3 | 10 |
| GO:0006166 | purine ribonucleoside salvage | 5 | 10 |
| GO:0006520 | amino acid metabolic process | 3 | 8 |
| GO:0006555 | methionine metabolic process | 5 | 8 |
| GO:0006725 | cellular aromatic compound metabolic process | 3 | 10 |
| GO:0006790 | sulfur compound metabolic process | 3 | 8 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 10 |
| GO:0008152 | metabolic process | 1 | 10 |
| GO:0008652 | amino acid biosynthetic process | 4 | 8 |
| GO:0009058 | biosynthetic process | 2 | 10 |
| GO:0009066 | aspartate family amino acid metabolic process | 5 | 8 |
| GO:0009067 | aspartate family amino acid biosynthetic process | 6 | 8 |
| GO:0009086 | methionine biosynthetic process | 6 | 8 |
| GO:0009116 | nucleoside metabolic process | 4 | 10 |
| GO:0009119 | ribonucleoside metabolic process | 5 | 10 |
| GO:0009163 | nucleoside biosynthetic process | 5 | 10 |
| GO:0009987 | cellular process | 1 | 10 |
| GO:0016053 | organic acid biosynthetic process | 4 | 8 |
| GO:0018130 | heterocycle biosynthetic process | 4 | 10 |
| GO:0019438 | aromatic compound biosynthetic process | 4 | 10 |
| GO:0019509 | L-methionine salvage from methylthioadenosine | 6 | 8 |
| GO:0019752 | carboxylic acid metabolic process | 5 | 8 |
| GO:0034404 | nucleobase-containing small molecule biosynthetic process | 4 | 10 |
| GO:0034641 | cellular nitrogen compound metabolic process | 3 | 10 |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 4 | 10 |
| GO:0042278 | purine nucleoside metabolic process | 5 | 10 |
| GO:0042451 | purine nucleoside biosynthetic process | 6 | 10 |
| GO:0042455 | ribonucleoside biosynthetic process | 6 | 10 |
| GO:0043094 | cellular metabolic compound salvage | 3 | 10 |
| GO:0043101 | purine-containing compound salvage | 4 | 10 |
| GO:0043102 | amino acid salvage | 4 | 8 |
| GO:0043174 | nucleoside salvage | 4 | 10 |
| GO:0043436 | oxoacid metabolic process | 4 | 8 |
| GO:0044237 | cellular metabolic process | 2 | 10 |
| GO:0044238 | primary metabolic process | 2 | 10 |
| GO:0044249 | cellular biosynthetic process | 3 | 10 |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 4 | 10 |
| GO:0044272 | sulfur compound biosynthetic process | 4 | 8 |
| GO:0044281 | small molecule metabolic process | 2 | 10 |
| GO:0044283 | small molecule biosynthetic process | 3 | 10 |
| GO:0046128 | purine ribonucleoside metabolic process | 6 | 10 |
| GO:0046129 | purine ribonucleoside biosynthetic process | 7 | 10 |
| GO:0046394 | carboxylic acid biosynthetic process | 5 | 8 |
| GO:0046483 | heterocycle metabolic process | 3 | 10 |
| GO:0055086 | nucleobase-containing small molecule metabolic process | 3 | 10 |
| GO:0071265 | L-methionine biosynthetic process | 7 | 8 |
| GO:0071267 | L-methionine salvage | 5 | 8 |
| GO:0071704 | organic substance metabolic process | 2 | 10 |
| GO:0072521 | purine-containing compound metabolic process | 4 | 10 |
| GO:0072522 | purine-containing compound biosynthetic process | 5 | 10 |
| GO:1901135 | carbohydrate derivative metabolic process | 3 | 10 |
| GO:1901137 | carbohydrate derivative biosynthetic process | 4 | 10 |
| GO:1901360 | organic cyclic compound metabolic process | 3 | 10 |
| GO:1901362 | organic cyclic compound biosynthetic process | 4 | 10 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 10 |
| GO:1901566 | organonitrogen compound biosynthetic process | 4 | 10 |
| GO:1901576 | organic substance biosynthetic process | 3 | 10 |
| GO:1901605 | alpha-amino acid metabolic process | 4 | 8 |
| GO:1901607 | alpha-amino acid biosynthetic process | 5 | 8 |
| GO:1901657 | glycosyl compound metabolic process | 4 | 10 |
| GO:1901659 | glycosyl compound biosynthetic process | 5 | 10 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 10 |
| GO:0004731 | purine-nucleoside phosphorylase activity | 5 | 10 |
| GO:0016740 | transferase activity | 2 | 10 |
| GO:0016757 | glycosyltransferase activity | 3 | 10 |
| GO:0016763 | pentosyltransferase activity | 4 | 10 |
| GO:0017061 | S-methyl-5-thioadenosine phosphorylase activity | 6 | 10 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 223 | 227 | PF00656 | 0.317 |
| CLV_NRD_NRD_1 | 119 | 121 | PF00675 | 0.320 |
| CLV_PCSK_SKI1_1 | 120 | 124 | PF00082 | 0.380 |
| CLV_PCSK_SKI1_1 | 87 | 91 | PF00082 | 0.375 |
| DEG_Nend_Nbox_1 | 1 | 3 | PF02207 | 0.576 |
| DOC_CKS1_1 | 34 | 39 | PF01111 | 0.317 |
| DOC_MAPK_DCC_7 | 49 | 58 | PF00069 | 0.419 |
| DOC_MAPK_JIP1_4 | 103 | 109 | PF00069 | 0.401 |
| DOC_MAPK_MEF2A_6 | 49 | 58 | PF00069 | 0.419 |
| DOC_MAPK_MEF2A_6 | 7 | 14 | PF00069 | 0.408 |
| DOC_PP4_FxxP_1 | 135 | 138 | PF00568 | 0.416 |
| DOC_PP4_FxxP_1 | 266 | 269 | PF00568 | 0.398 |
| DOC_USP7_MATH_1 | 94 | 98 | PF00917 | 0.293 |
| DOC_WW_Pin1_4 | 33 | 38 | PF00397 | 0.317 |
| LIG_14-3-3_CanoR_1 | 120 | 125 | PF00244 | 0.321 |
| LIG_BRCT_BRCA1_1 | 139 | 143 | PF00533 | 0.318 |
| LIG_Clathr_ClatBox_1 | 173 | 177 | PF01394 | 0.458 |
| LIG_FHA_1 | 137 | 143 | PF00498 | 0.431 |
| LIG_FHA_1 | 162 | 168 | PF00498 | 0.404 |
| LIG_FHA_2 | 121 | 127 | PF00498 | 0.373 |
| LIG_FHA_2 | 181 | 187 | PF00498 | 0.317 |
| LIG_FHA_2 | 221 | 227 | PF00498 | 0.319 |
| LIG_FHA_2 | 278 | 284 | PF00498 | 0.433 |
| LIG_LIR_Apic_2 | 134 | 138 | PF02991 | 0.293 |
| LIG_LIR_Apic_2 | 36 | 41 | PF02991 | 0.319 |
| LIG_LIR_Gen_1 | 140 | 151 | PF02991 | 0.459 |
| LIG_LIR_Gen_1 | 213 | 222 | PF02991 | 0.317 |
| LIG_LIR_Gen_1 | 273 | 282 | PF02991 | 0.503 |
| LIG_LIR_Nem_3 | 140 | 146 | PF02991 | 0.313 |
| LIG_LIR_Nem_3 | 213 | 219 | PF02991 | 0.307 |
| LIG_LIR_Nem_3 | 273 | 279 | PF02991 | 0.499 |
| LIG_LIR_Nem_3 | 28 | 34 | PF02991 | 0.293 |
| LIG_LIR_Nem_3 | 299 | 304 | PF02991 | 0.468 |
| LIG_SH2_CRK | 2 | 6 | PF00017 | 0.454 |
| LIG_SH2_CRK | 216 | 220 | PF00017 | 0.416 |
| LIG_SH2_CRK | 276 | 280 | PF00017 | 0.457 |
| LIG_SH2_CRK | 32 | 36 | PF00017 | 0.407 |
| LIG_SH2_CRK | 38 | 42 | PF00017 | 0.430 |
| LIG_SH2_NCK_1 | 216 | 220 | PF00017 | 0.416 |
| LIG_SH2_NCK_1 | 276 | 280 | PF00017 | 0.457 |
| LIG_SH2_NCK_1 | 32 | 36 | PF00017 | 0.369 |
| LIG_SH2_SRC | 276 | 279 | PF00017 | 0.487 |
| LIG_SH2_STAP1 | 118 | 122 | PF00017 | 0.432 |
| LIG_SH2_STAP1 | 216 | 220 | PF00017 | 0.416 |
| LIG_SH2_STAT5 | 88 | 91 | PF00017 | 0.317 |
| LIG_SH3_3 | 276 | 282 | PF00018 | 0.508 |
| LIG_SH3_3 | 31 | 37 | PF00018 | 0.438 |
| LIG_SH3_3 | 53 | 59 | PF00018 | 0.419 |
| LIG_TYR_ITIM | 214 | 219 | PF00017 | 0.409 |
| LIG_TYR_ITIM | 274 | 279 | PF00017 | 0.480 |
| MOD_CK1_1 | 169 | 175 | PF00069 | 0.458 |
| MOD_CK2_1 | 120 | 126 | PF00069 | 0.321 |
| MOD_CK2_1 | 180 | 186 | PF00069 | 0.317 |
| MOD_CK2_1 | 199 | 205 | PF00069 | 0.317 |
| MOD_CK2_1 | 277 | 283 | PF00069 | 0.426 |
| MOD_CK2_1 | 94 | 100 | PF00069 | 0.341 |
| MOD_GlcNHglycan | 169 | 172 | PF01048 | 0.325 |
| MOD_GlcNHglycan | 17 | 20 | PF01048 | 0.317 |
| MOD_GlcNHglycan | 201 | 204 | PF01048 | 0.380 |
| MOD_GlcNHglycan | 41 | 44 | PF01048 | 0.317 |
| MOD_GSK3_1 | 180 | 187 | PF00069 | 0.317 |
| MOD_GSK3_1 | 94 | 101 | PF00069 | 0.458 |
| MOD_N-GLC_2 | 77 | 79 | PF02516 | 0.416 |
| MOD_NEK2_1 | 296 | 301 | PF00069 | 0.422 |
| MOD_NEK2_1 | 98 | 103 | PF00069 | 0.458 |
| MOD_PKA_1 | 120 | 126 | PF00069 | 0.318 |
| MOD_Plk_1 | 114 | 120 | PF00069 | 0.329 |
| MOD_Plk_4 | 120 | 126 | PF00069 | 0.305 |
| MOD_Plk_4 | 169 | 175 | PF00069 | 0.333 |
| MOD_Plk_4 | 184 | 190 | PF00069 | 0.238 |
| MOD_ProDKin_1 | 33 | 39 | PF00069 | 0.317 |
| TRG_ENDOCYTIC_2 | 216 | 219 | PF00928 | 0.297 |
| TRG_ENDOCYTIC_2 | 276 | 279 | PF00928 | 0.462 |
| TRG_ENDOCYTIC_2 | 301 | 304 | PF00928 | 0.415 |
| TRG_ENDOCYTIC_2 | 31 | 34 | PF00928 | 0.316 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1HYQ0 | Leptomonas seymouri | 68% | 99% |
| A0A1X0NKF0 | Trypanosomatidae | 59% | 95% |
| A0A3S5H5K5 | Leishmania donovani | 100% | 100% |
| A0A422NJG4 | Trypanosoma rangeli | 60% | 100% |
| A0QR54 | Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) | 43% | 100% |
| A0RVQ7 | Cenarchaeum symbiosum (strain A) | 38% | 100% |
| A1RXU2 | Thermofilum pendens (strain DSM 2475 / Hrk 5) | 44% | 100% |
| A2BIU4 | Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5) | 44% | 100% |
| A4H4C5 | Leishmania braziliensis | 84% | 100% |
| A7EAA1 | Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) | 42% | 100% |
| A7SN31 | Nematostella vectensis | 39% | 100% |
| A8P7Y3 | Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) | 43% | 94% |
| A8XGS6 | Caenorhabditis briggsae | 42% | 100% |
| A9A3N5 | Nitrosopumilus maritimus (strain SCM1) | 40% | 100% |
| A9WAL0 | Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) | 50% | 100% |
| B1L719 | Korarchaeum cryptofilum (strain OPF8) | 31% | 100% |
| B5YKP5 | Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87) | 36% | 100% |
| B8E181 | Dictyoglomus turgidum (strain DSM 6724 / Z-1310) | 38% | 100% |
| C0NRX4 | Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) | 40% | 98% |
| C4YQD9 | Candida albicans (strain WO-1) | 39% | 89% |
| C7YLQ3 | Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4) | 44% | 100% |
| C8VP37 | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) | 42% | 86% |
| C9ZU87 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 59% | 99% |
| D5GFR0 | Tuber melanosporum (strain Mel28) | 42% | 99% |
| E3K7C1 | Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL) | 37% | 100% |
| E3K7C3 | Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL) | 40% | 100% |
| E3XFR6 | Anopheles darlingi | 39% | 100% |
| E9AKI9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 94% | 100% |
| F6RQL9 | Macaca mulatta | 38% | 100% |
| F6V515 | Xenopus tropicalis | 40% | 100% |
| F6X2V8 | Ciona intestinalis | 40% | 100% |
| O06401 | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | 38% | 100% |
| O27633 | Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) | 38% | 100% |
| O28486 | Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) | 28% | 100% |
| O57865 | Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) | 43% | 100% |
| O66839 | Aquifex aeolicus (strain VF5) | 30% | 100% |
| P0DJF8 | Synechocystis sp. (strain PCC 6803 / Kazusa) | 44% | 94% |
| P0DJF9 | Synechocystis sp. (strain PCC 6803 / GT-S) | 44% | 94% |
| P45563 | Escherichia coli (strain K12) | 26% | 100% |
| Q07938 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 35% | 91% |
| Q09438 | Caenorhabditis elegans | 41% | 100% |
| Q09816 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 38% | 100% |
| Q0U796 | Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) | 43% | 89% |
| Q13126 | Homo sapiens | 38% | 100% |
| Q16MW6 | Aedes aegypti | 41% | 100% |
| Q1INC3 | Koribacter versatilis (strain Ellin345) | 40% | 100% |
| Q291H4 | Drosophila pseudoobscura pseudoobscura | 38% | 100% |
| Q297F5 | Drosophila pseudoobscura pseudoobscura | 35% | 100% |
| Q2RKL6 | Moorella thermoacetica (strain ATCC 39073 / JCM 9320) | 38% | 100% |
| Q2RXH9 | Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1) | 45% | 100% |
| Q3J5E8 | Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) | 44% | 100% |
| Q3MHF7 | Bos taurus | 38% | 100% |
| Q4PH43 | Ustilago maydis (strain 521 / FGSC 9021) | 39% | 97% |
| Q4QJB9 | Leishmania major | 96% | 100% |
| Q4WMU1 | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) | 40% | 89% |
| Q59ST1 | Candida albicans (strain SC5314 / ATCC MYA-2876) | 40% | 89% |
| Q5JEQ6 | Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) | 45% | 100% |
| Q5JJB8 | Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) | 41% | 100% |
| Q5KPU2 | Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) | 36% | 100% |
| Q6CES3 | Yarrowia lipolytica (strain CLIB 122 / E 150) | 39% | 95% |
| Q72LZ4 | Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130) | 42% | 100% |
| Q74E52 | Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) | 42% | 100% |
| Q7NHW1 | Gloeobacter violaceus (strain ATCC 29082 / PCC 7421) | 42% | 100% |
| Q7Q9N9 | Anopheles gambiae | 41% | 100% |
| Q7RZA5 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 41% | 99% |
| Q7VDN6 | Prochlorococcus marinus (strain SARG / CCMP1375 / SS120) | 41% | 97% |
| Q7ZV22 | Danio rerio | 40% | 100% |
| Q87BR7 | Xylella fastidiosa (strain Temecula1 / ATCC 700964) | 38% | 100% |
| Q87ZC3 | Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) | 33% | 100% |
| Q89VT5 | Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) | 43% | 100% |
| Q8CXR2 | Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) | 42% | 100% |
| Q8DJE4 | Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1) | 45% | 100% |
| Q8IMU4 | Drosophila melanogaster | 34% | 100% |
| Q8PB40 | Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) | 39% | 100% |
| Q8TQX8 | Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) | 29% | 100% |
| Q8TZB4 | Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) | 35% | 100% |
| Q8U2I1 | Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) | 40% | 100% |
| Q8U4Q8 | Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) | 43% | 100% |
| Q8ZTB2 | Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) | 38% | 100% |
| Q97W94 | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) | 42% | 100% |
| Q9CQ65 | Mus musculus | 39% | 100% |
| Q9HL98 | Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) | 42% | 100% |
| Q9HZK1 | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 33% | 100% |
| Q9KYV7 | Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) | 40% | 100% |
| Q9PAZ2 | Xylella fastidiosa (strain 9a5c) | 40% | 100% |
| Q9UTG1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 26% | 97% |
| Q9V2F1 | Pyrococcus abyssi (strain GE5 / Orsay) | 43% | 100% |
| Q9V813 | Drosophila melanogaster | 39% | 100% |
| Q9YAQ8 | Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) | 45% | 100% |