MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HSK4_LEIIN

TriTrypDb:

LINF_050013400

Length:

941

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HSK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSK4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.787
CLV_C14_Caspase3-7	405	409	PF00656	0.354
CLV_C14_Caspase3-7	916	920	PF00656	0.443
CLV_MEL_PAP_1	426	432	PF00089	0.676
CLV_MEL_PAP_1	760	766	PF00089	0.300
CLV_NRD_NRD_1	199	201	PF00675	0.396
CLV_NRD_NRD_1	245	247	PF00675	0.452
CLV_NRD_NRD_1	336	338	PF00675	0.316
CLV_NRD_NRD_1	732	734	PF00675	0.355
CLV_NRD_NRD_1	8	10	PF00675	0.595
CLV_NRD_NRD_1	839	841	PF00675	0.373
CLV_NRD_NRD_1	899	901	PF00675	0.542
CLV_PCSK_KEX2_1	198	200	PF00082	0.397
CLV_PCSK_KEX2_1	244	246	PF00082	0.486
CLV_PCSK_KEX2_1	335	337	PF00082	0.322
CLV_PCSK_KEX2_1	7	9	PF00082	0.579
CLV_PCSK_KEX2_1	839	841	PF00082	0.371
CLV_PCSK_KEX2_1	890	892	PF00082	0.554
CLV_PCSK_KEX2_1	898	900	PF00082	0.526
CLV_PCSK_KEX2_1	908	910	PF00082	0.552
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.335
CLV_PCSK_PC1ET2_1	890	892	PF00082	0.554
CLV_PCSK_PC1ET2_1	898	900	PF00082	0.526
CLV_PCSK_PC1ET2_1	908	910	PF00082	0.552
CLV_PCSK_PC7_1	241	247	PF00082	0.410
CLV_PCSK_PC7_1	332	338	PF00082	0.334
CLV_PCSK_SKI1_1	137	141	PF00082	0.410
CLV_PCSK_SKI1_1	332	336	PF00082	0.369
CLV_PCSK_SKI1_1	585	589	PF00082	0.525
CLV_PCSK_SKI1_1	673	677	PF00082	0.375
CLV_PCSK_SKI1_1	800	804	PF00082	0.326
CLV_PCSK_SKI1_1	818	822	PF00082	0.345
DEG_APCC_DBOX_1	672	680	PF00400	0.543
DEG_APCC_DBOX_1	799	807	PF00400	0.523
DEG_APCC_DBOX_1	839	847	PF00400	0.530
DEG_ODPH_VHL_1	471	484	PF01847	0.542
DEG_SPOP_SBC_1	299	303	PF00917	0.584
DEG_SPOP_SBC_1	379	383	PF00917	0.540
DOC_CYCLIN_RxL_1	477	488	PF00134	0.549
DOC_CYCLIN_RxL_1	815	822	PF00134	0.593
DOC_CYCLIN_yClb5_NLxxxL_5	252	258	PF00134	0.466
DOC_MAPK_gen_1	890	897	PF00069	0.375
DOC_MAPK_MEF2A_6	419	426	PF00069	0.429
DOC_MAPK_MEF2A_6	890	897	PF00069	0.416
DOC_PP1_RVXF_1	250	257	PF00149	0.595
DOC_PP1_RVXF_1	583	590	PF00149	0.499
DOC_PP1_RVXF_1	761	767	PF00149	0.524
DOC_PP2B_LxvP_1	658	661	PF13499	0.408
DOC_PP4_FxxP_1	98	101	PF00568	0.682
DOC_USP7_MATH_1	165	169	PF00917	0.666
DOC_USP7_MATH_1	236	240	PF00917	0.720
DOC_USP7_MATH_1	267	271	PF00917	0.584
DOC_USP7_MATH_1	322	326	PF00917	0.704
DOC_USP7_MATH_1	379	383	PF00917	0.543
DOC_USP7_MATH_1	388	392	PF00917	0.518
DOC_USP7_MATH_1	627	631	PF00917	0.413
DOC_USP7_MATH_1	661	665	PF00917	0.447
DOC_USP7_MATH_1	768	772	PF00917	0.615
DOC_USP7_MATH_1	812	816	PF00917	0.640
DOC_USP7_UBL2_3	11	15	PF12436	0.826
DOC_USP7_UBL2_3	937	941	PF12436	0.439
DOC_WW_Pin1_4	111	116	PF00397	0.630
DOC_WW_Pin1_4	354	359	PF00397	0.514
DOC_WW_Pin1_4	389	394	PF00397	0.545
DOC_WW_Pin1_4	44	49	PF00397	0.714
DOC_WW_Pin1_4	588	593	PF00397	0.453
DOC_WW_Pin1_4	829	834	PF00397	0.682
DOC_WW_Pin1_4	914	919	PF00397	0.453
DOC_WW_Pin1_4	96	101	PF00397	0.705
LIG_14-3-3_CanoR_1	297	307	PF00244	0.577
LIG_14-3-3_CanoR_1	429	436	PF00244	0.464
LIG_14-3-3_CanoR_1	459	463	PF00244	0.447
LIG_14-3-3_CanoR_1	528	538	PF00244	0.597
LIG_14-3-3_CanoR_1	763	767	PF00244	0.595
LIG_14-3-3_CanoR_1	775	782	PF00244	0.569
LIG_14-3-3_CanoR_1	9	18	PF00244	0.820
LIG_Actin_WH2_2	70	87	PF00022	0.600
LIG_APCC_ABBA_1	864	869	PF00400	0.331
LIG_APCC_ABBAyCdc20_2	682	688	PF00400	0.622
LIG_BIR_III_2	112	116	PF00653	0.779
LIG_BRCT_BRCA1_1	381	385	PF00533	0.499
LIG_Clathr_ClatBox_1	290	294	PF01394	0.608
LIG_eIF4E_1	578	584	PF01652	0.355
LIG_EVH1_2	42	46	PF00568	0.689
LIG_FHA_1	112	118	PF00498	0.804
LIG_FHA_1	150	156	PF00498	0.644
LIG_FHA_1	249	255	PF00498	0.585
LIG_FHA_1	284	290	PF00498	0.558
LIG_FHA_1	347	353	PF00498	0.438
LIG_FHA_1	398	404	PF00498	0.367
LIG_FHA_1	459	465	PF00498	0.417
LIG_FHA_1	524	530	PF00498	0.596
LIG_FHA_1	610	616	PF00498	0.501
LIG_FHA_1	653	659	PF00498	0.313
LIG_FHA_1	711	717	PF00498	0.592
LIG_FHA_1	905	911	PF00498	0.426
LIG_FHA_2	107	113	PF00498	0.786
LIG_FHA_2	125	131	PF00498	0.629
LIG_FHA_2	23	29	PF00498	0.750
LIG_FHA_2	300	306	PF00498	0.623
LIG_FHA_2	403	409	PF00498	0.379
LIG_FHA_2	752	758	PF00498	0.578
LIG_FHA_2	860	866	PF00498	0.445
LIG_GBD_Chelix_1	474	482	PF00786	0.531
LIG_GBD_Chelix_1	652	660	PF00786	0.562
LIG_LIR_Apic_2	586	592	PF02991	0.448
LIG_LIR_Apic_2	99	105	PF02991	0.742
LIG_LIR_Gen_1	301	312	PF02991	0.631
LIG_LIR_Gen_1	57	66	PF02991	0.571
LIG_LIR_Gen_1	822	829	PF02991	0.598
LIG_LIR_Gen_1	921	930	PF02991	0.394
LIG_LIR_LC3C_4	152	155	PF02991	0.557
LIG_LIR_Nem_3	204	209	PF02991	0.653
LIG_LIR_Nem_3	301	307	PF02991	0.576
LIG_LIR_Nem_3	45	49	PF02991	0.671
LIG_LIR_Nem_3	57	63	PF02991	0.581
LIG_LIR_Nem_3	671	675	PF02991	0.538
LIG_LIR_Nem_3	69	75	PF02991	0.585
LIG_LIR_Nem_3	822	827	PF02991	0.595
LIG_LIR_Nem_3	921	926	PF02991	0.366
LIG_LIR_Nem_3	931	936	PF02991	0.304
LIG_NRBOX	288	294	PF00104	0.534
LIG_NRBOX	351	357	PF00104	0.397
LIG_NRBOX	453	459	PF00104	0.384
LIG_NRBOX	91	97	PF00104	0.578
LIG_RPA_C_Fungi	523	535	PF08784	0.460
LIG_SH2_CRK	824	828	PF00017	0.493
LIG_SH2_NCK_1	102	106	PF00017	0.707
LIG_SH2_SRC	102	105	PF00017	0.601
LIG_SH2_STAP1	315	319	PF00017	0.621
LIG_SH2_STAP1	824	828	PF00017	0.454
LIG_SH2_STAT5	255	258	PF00017	0.477
LIG_SH2_STAT5	72	75	PF00017	0.441
LIG_SH2_STAT5	896	899	PF00017	0.476
LIG_SH3_3	114	120	PF00018	0.744
LIG_SH3_3	33	39	PF00018	0.713
LIG_SH3_3	600	606	PF00018	0.686
LIG_SH3_3	830	836	PF00018	0.539
LIG_SH3_3	873	879	PF00018	0.370
LIG_SH3_3	98	104	PF00018	0.650
LIG_SH3_5	310	314	PF00018	0.417
LIG_SUMO_SIM_anti_2	284	294	PF11976	0.465
LIG_SUMO_SIM_anti_2	351	357	PF11976	0.480
LIG_SUMO_SIM_anti_2	654	660	PF11976	0.381
LIG_SUMO_SIM_anti_2	754	762	PF11976	0.426
LIG_SUMO_SIM_par_1	151	158	PF11976	0.454
LIG_SUMO_SIM_par_1	263	270	PF11976	0.467
LIG_SUMO_SIM_par_1	284	294	PF11976	0.418
LIG_SUMO_SIM_par_1	351	357	PF11976	0.479
LIG_SUMO_SIM_par_1	639	646	PF11976	0.412
LIG_TRAF2_1	128	131	PF00917	0.812
LIG_TYR_ITIM	70	75	PF00017	0.347
LIG_UBA3_1	727	734	PF00899	0.384
LIG_WRC_WIRS_1	435	440	PF05994	0.526
MOD_CK1_1	248	254	PF00069	0.498
MOD_CK1_1	284	290	PF00069	0.526
MOD_CK1_1	381	387	PF00069	0.691
MOD_CK1_1	431	437	PF00069	0.492
MOD_CK1_1	591	597	PF00069	0.615
MOD_CK1_1	710	716	PF00069	0.519
MOD_CK1_1	736	742	PF00069	0.578
MOD_CK1_1	769	775	PF00069	0.513
MOD_CK1_1	914	920	PF00069	0.571
MOD_CK2_1	124	130	PF00069	0.811
MOD_CK2_1	22	28	PF00069	0.713
MOD_CK2_1	299	305	PF00069	0.463
MOD_CK2_1	692	698	PF00069	0.616
MOD_Cter_Amidation	816	819	PF01082	0.438
MOD_GlcNHglycan	12	15	PF01048	0.816
MOD_GlcNHglycan	122	125	PF01048	0.779
MOD_GlcNHglycan	167	170	PF01048	0.659
MOD_GlcNHglycan	174	177	PF01048	0.639
MOD_GlcNHglycan	219	222	PF01048	0.728
MOD_GlcNHglycan	237	241	PF01048	0.540
MOD_GlcNHglycan	247	250	PF01048	0.466
MOD_GlcNHglycan	286	289	PF01048	0.355
MOD_GlcNHglycan	310	313	PF01048	0.590
MOD_GlcNHglycan	386	389	PF01048	0.763
MOD_GlcNHglycan	572	575	PF01048	0.480
MOD_GlcNHglycan	595	599	PF01048	0.751
MOD_GlcNHglycan	700	703	PF01048	0.654
MOD_GlcNHglycan	709	712	PF01048	0.480
MOD_GlcNHglycan	738	741	PF01048	0.645
MOD_GlcNHglycan	767	771	PF01048	0.519
MOD_GlcNHglycan	930	933	PF01048	0.381
MOD_GSK3_1	116	123	PF00069	0.764
MOD_GSK3_1	279	286	PF00069	0.521
MOD_GSK3_1	299	306	PF00069	0.214
MOD_GSK3_1	341	348	PF00069	0.480
MOD_GSK3_1	380	387	PF00069	0.707
MOD_GSK3_1	389	396	PF00069	0.559
MOD_GSK3_1	739	746	PF00069	0.657
MOD_GSK3_1	762	769	PF00069	0.511
MOD_LATS_1	243	249	PF00433	0.442
MOD_N-GLC_1	359	364	PF02516	0.493
MOD_N-GLC_1	549	554	PF02516	0.641
MOD_N-GLC_1	928	933	PF02516	0.372
MOD_NEK2_1	1	6	PF00069	0.823
MOD_NEK2_1	283	288	PF00069	0.453
MOD_NEK2_1	341	346	PF00069	0.447
MOD_NEK2_1	402	407	PF00069	0.448
MOD_NEK2_1	458	463	PF00069	0.384
MOD_NEK2_1	485	490	PF00069	0.508
MOD_NEK2_1	529	534	PF00069	0.525
MOD_NEK2_1	707	712	PF00069	0.547
MOD_NEK2_1	727	732	PF00069	0.207
MOD_NEK2_1	774	779	PF00069	0.452
MOD_NEK2_1	785	790	PF00069	0.399
MOD_NEK2_2	851	856	PF00069	0.447
MOD_PIKK_1	529	535	PF00454	0.480
MOD_PKA_1	245	251	PF00069	0.447
MOD_PKA_1	733	739	PF00069	0.512
MOD_PKA_2	245	251	PF00069	0.546
MOD_PKA_2	428	434	PF00069	0.574
MOD_PKA_2	458	464	PF00069	0.447
MOD_PKA_2	529	535	PF00069	0.493
MOD_PKA_2	54	60	PF00069	0.520
MOD_PKA_2	762	768	PF00069	0.500
MOD_PKA_2	774	780	PF00069	0.457
MOD_Plk_1	359	365	PF00069	0.498
MOD_Plk_1	397	403	PF00069	0.548
MOD_Plk_1	431	437	PF00069	0.501
MOD_Plk_1	485	491	PF00069	0.504
MOD_Plk_4	303	309	PF00069	0.404
MOD_Plk_4	402	408	PF00069	0.365
MOD_Plk_4	434	440	PF00069	0.496
MOD_Plk_4	652	658	PF00069	0.335
MOD_Plk_4	769	775	PF00069	0.432
MOD_Plk_4	859	865	PF00069	0.509
MOD_ProDKin_1	111	117	PF00069	0.540
MOD_ProDKin_1	354	360	PF00069	0.511
MOD_ProDKin_1	389	395	PF00069	0.684
MOD_ProDKin_1	44	50	PF00069	0.642
MOD_ProDKin_1	588	594	PF00069	0.586
MOD_ProDKin_1	829	835	PF00069	0.619
MOD_ProDKin_1	914	920	PF00069	0.571
MOD_ProDKin_1	96	102	PF00069	0.652
MOD_SUMO_rev_2	904	910	PF00179	0.523
MOD_SUMO_rev_2	931	938	PF00179	0.360
TRG_DiLeu_BaEn_1	756	761	PF01217	0.252
TRG_DiLeu_BaEn_2	397	403	PF01217	0.544
TRG_DiLeu_BaEn_4	263	269	PF01217	0.498
TRG_DiLeu_BaLyEn_6	480	485	PF01217	0.495
TRG_DiLeu_BaLyEn_6	501	506	PF01217	0.400
TRG_DiLeu_BaLyEn_6	534	539	PF01217	0.493
TRG_ENDOCYTIC_2	255	258	PF00928	0.477
TRG_ENDOCYTIC_2	60	63	PF00928	0.505
TRG_ENDOCYTIC_2	72	75	PF00928	0.529
TRG_ENDOCYTIC_2	824	827	PF00928	0.498
TRG_ENDOCYTIC_2	877	880	PF00928	0.405
TRG_ER_diArg_1	198	200	PF00400	0.530
TRG_ER_diArg_1	244	246	PF00400	0.616
TRG_ER_diArg_1	6	9	PF00400	0.752
TRG_ER_diArg_1	839	841	PF00400	0.471
TRG_NES_CRM1_1	639	651	PF08389	0.496
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	452	456	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	623	628	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	673	677	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF34	Leptomonas seymouri	60%	100%
A0A1X0NLT0	Trypanosomatidae	34%	100%
A0A3S5H5K4	Leishmania donovani	100%	100%
A0A422NJC1	Trypanosoma rangeli	35%	100%
A4H4C4	Leishmania braziliensis	77%	98%
C9ZU88	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	98%
E9AKI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QJC0	Leishmania major	92%	100%
V5BBH0	Trypanosoma cruzi	34%	96%