Vesicle transport protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Got1/Sft2-like family - putative

Species:

Leishmania infantum

UniProt:

A4HSK3_LEIIN

TriTrypDb:

LINF_050013300

Length:

163

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A4HSK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSK3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	13
GO:0008104	protein localization	4	13
GO:0009987	cellular process	1	13
GO:0015031	protein transport	4	13
GO:0016192	vesicle-mediated transport	4	13
GO:0033036	macromolecule localization	2	13
GO:0045184	establishment of protein localization	3	13
GO:0051179	localization	1	13
GO:0051234	establishment of localization	2	13
GO:0051641	cellular localization	2	13
GO:0070727	cellular macromolecule localization	3	13
GO:0071702	organic substance transport	4	13
GO:0071705	nitrogen compound transport	4	13

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.667
CLV_PCSK_SKI1_1	154	158	PF00082	0.366
CLV_PCSK_SKI1_1	90	94	PF00082	0.242
DEG_MDM2_SWIB_1	52	59	PF02201	0.279
DEG_Nend_UBRbox_2	1	3	PF02207	0.609
LIG_14-3-3_CanoR_1	100	109	PF00244	0.258
LIG_14-3-3_CanoR_1	90	96	PF00244	0.438
LIG_BRCT_BRCA1_1	30	34	PF00533	0.529
LIG_FHA_1	103	109	PF00498	0.266
LIG_FHA_1	3	9	PF00498	0.607
LIG_FHA_1	56	62	PF00498	0.313
LIG_FHA_1	80	86	PF00498	0.275
LIG_LIR_Gen_1	55	64	PF02991	0.248
LIG_LIR_Nem_3	144	148	PF02991	0.234
LIG_LIR_Nem_3	55	59	PF02991	0.240
LIG_LIR_Nem_3	63	69	PF02991	0.186
LIG_Pex14_1	56	60	PF04695	0.289
LIG_Pex14_2	52	56	PF04695	0.349
LIG_Pex14_2	67	71	PF04695	0.184
LIG_Pex14_2	92	96	PF04695	0.504
LIG_SH2_STAT5	107	110	PF00017	0.269
LIG_SH2_STAT5	141	144	PF00017	0.276
LIG_SH2_STAT5	145	148	PF00017	0.273
LIG_SH2_STAT5	64	67	PF00017	0.358
LIG_SUMO_SIM_par_1	5	13	PF11976	0.601
LIG_SxIP_EBH_1	139	150	PF03271	0.229
LIG_Vh1_VBS_1	102	120	PF01044	0.240
MOD_CK1_1	24	30	PF00069	0.545
MOD_CK1_1	55	61	PF00069	0.299
MOD_CK1_1	6	12	PF00069	0.510
MOD_GlcNHglycan	12	15	PF01048	0.451
MOD_GlcNHglycan	122	125	PF01048	0.300
MOD_GSK3_1	107	114	PF00069	0.295
MOD_GSK3_1	120	127	PF00069	0.385
MOD_GSK3_1	2	9	PF00069	0.532
MOD_GSK3_1	24	31	PF00069	0.538
MOD_NEK2_1	111	116	PF00069	0.292
MOD_NEK2_1	120	125	PF00069	0.312
MOD_NEK2_1	52	57	PF00069	0.394
MOD_NEK2_1	79	84	PF00069	0.328
MOD_NEK2_2	30	35	PF00069	0.493
MOD_PIKK_1	21	27	PF00454	0.564
MOD_PK_1	3	9	PF00069	0.520
MOD_Plk_4	102	108	PF00069	0.184
MOD_Plk_4	111	117	PF00069	0.126
MOD_Plk_4	124	130	PF00069	0.295
MOD_Plk_4	141	147	PF00069	0.242
MOD_Plk_4	3	9	PF00069	0.487
MOD_Plk_4	52	58	PF00069	0.274
MOD_Plk_4	72	78	PF00069	0.355
MOD_Plk_4	79	85	PF00069	0.269
MOD_Plk_4	91	97	PF00069	0.225
TRG_ENDOCYTIC_2	145	148	PF00928	0.253
TRG_ENDOCYTIC_2	64	67	PF00928	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A7	Leptomonas seymouri	35%	100%
A0A0N1I3M5	Leptomonas seymouri	43%	92%
A0A0N1I5N1	Leptomonas seymouri	64%	97%
A0A0S4JF33	Bodo saltans	36%	100%
A0A0S4JFY8	Bodo saltans	47%	100%
A0A1X0NLN3	Trypanosomatidae	49%	96%
A0A1X0P315	Trypanosomatidae	46%	96%
A0A1X0P7F6	Trypanosomatidae	32%	100%
A0A1X0P987	Trypanosomatidae	32%	78%
A0A3Q8IBK0	Leishmania donovani	34%	100%
A0A3S5H567	Leishmania donovani	38%	75%
A0A3S5H5K3	Leishmania donovani	100%	100%
A0A422MRP4	Trypanosoma rangeli	36%	100%
A0A422N175	Trypanosoma rangeli	36%	93%
A0A422NC91	Trypanosoma rangeli	44%	95%
A0A422NJC0	Trypanosoma rangeli	49%	97%
A4H3Q4	Leishmania braziliensis	41%	75%
A4HDV3	Leishmania braziliensis	34%	100%
A4HRX8	Leishmania infantum	39%	75%
A4I148	Leishmania infantum	34%	100%
C9ZJ62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZU90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	98%
D0A8W1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	94%
E9ACN7	Leishmania major	41%	75%
E9AJX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	75%
E9AKI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AX82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
O95562	Homo sapiens	37%	100%
Q4FZV2	Rattus norvegicus	37%	100%
Q4QA90	Leishmania major	36%	100%
Q4QJC1	Leishmania major	96%	100%
Q5SSN7	Mus musculus	36%	100%
Q5U3Y5	Rattus norvegicus	36%	100%
Q8VD57	Mus musculus	41%	100%
Q8WV19	Homo sapiens	36%	100%