Mitochondrial glyco protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial glycoprotein - putative

Species:

Leishmania infantum

UniProt:

A4HSK1_LEIIN

TriTrypDb:

LINF_050013100

Length:

390

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	11
GO:0031974	membrane-enclosed lumen	2	11
GO:0043233	organelle lumen	3	11
GO:0070013	intracellular organelle lumen	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0016020	membrane	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HSK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSK1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.686
CLV_C14_Caspase3-7	214	218	PF00656	0.533
CLV_C14_Caspase3-7	291	295	PF00656	0.412
CLV_C14_Caspase3-7	343	347	PF00656	0.433
CLV_NRD_NRD_1	145	147	PF00675	0.398
CLV_NRD_NRD_1	170	172	PF00675	0.722
CLV_NRD_NRD_1	27	29	PF00675	0.646
CLV_NRD_NRD_1	3	5	PF00675	0.676
CLV_PCSK_FUR_1	25	29	PF00082	0.624
CLV_PCSK_KEX2_1	145	147	PF00082	0.398
CLV_PCSK_KEX2_1	170	172	PF00082	0.549
CLV_PCSK_KEX2_1	27	29	PF00082	0.646
CLV_PCSK_KEX2_1	3	5	PF00082	0.680
CLV_PCSK_SKI1_1	109	113	PF00082	0.470
CLV_PCSK_SKI1_1	195	199	PF00082	0.650
CLV_PCSK_SKI1_1	206	210	PF00082	0.398
CLV_PCSK_SKI1_1	3	7	PF00082	0.447
CLV_PCSK_SKI1_1	88	92	PF00082	0.541
DEG_Nend_Nbox_1	1	3	PF02207	0.555
DEG_SPOP_SBC_1	152	156	PF00917	0.588
DEG_SPOP_SBC_1	314	318	PF00917	0.662
DEG_SPOP_SBC_1	33	37	PF00917	0.653
DOC_MAPK_MEF2A_6	206	213	PF00069	0.370
DOC_PP2B_LxvP_1	147	150	PF13499	0.560
DOC_PP4_MxPP_1	149	152	PF00568	0.542
DOC_USP7_MATH_1	153	157	PF00917	0.610
DOC_USP7_MATH_1	174	178	PF00917	0.647
DOC_USP7_MATH_1	264	268	PF00917	0.708
DOC_USP7_MATH_1	315	319	PF00917	0.707
DOC_USP7_MATH_1	33	37	PF00917	0.701
DOC_USP7_MATH_1	99	103	PF00917	0.449
DOC_USP7_UBL2_3	105	109	PF12436	0.394
DOC_WW_Pin1_4	156	161	PF00397	0.589
DOC_WW_Pin1_4	197	202	PF00397	0.624
DOC_WW_Pin1_4	48	53	PF00397	0.713
LIG_14-3-3_CanoR_1	15	24	PF00244	0.536
LIG_14-3-3_CanoR_1	210	220	PF00244	0.421
LIG_14-3-3_CanoR_1	39	47	PF00244	0.618
LIG_CSL_BTD_1	147	150	PF09270	0.417
LIG_EH_1	326	330	PF12763	0.580
LIG_FHA_1	137	143	PF00498	0.490
LIG_FHA_2	212	218	PF00498	0.412
LIG_Integrin_RGD_1	171	173	PF01839	0.551
LIG_LIR_Gen_1	205	213	PF02991	0.479
LIG_LIR_Nem_3	205	211	PF02991	0.473
LIG_LIR_Nem_3	326	332	PF02991	0.541
LIG_PDZ_Class_2	385	390	PF00595	0.433
LIG_Pex14_2	231	235	PF04695	0.425
LIG_REV1ctd_RIR_1	233	241	PF16727	0.454
LIG_SH2_CRK	304	308	PF00017	0.562
LIG_SH2_CRK	325	329	PF00017	0.484
LIG_SH2_GRB2like	282	285	PF00017	0.536
LIG_SH2_GRB2like	325	328	PF00017	0.532
LIG_SH2_NCK_1	325	329	PF00017	0.508
LIG_SH2_STAP1	368	372	PF00017	0.433
LIG_SH2_STAP1	377	381	PF00017	0.433
LIG_SH2_STAT5	325	328	PF00017	0.603
LIG_SH2_STAT5	387	390	PF00017	0.581
LIG_SH3_1	304	310	PF00018	0.531
LIG_SH3_3	122	128	PF00018	0.442
LIG_SH3_3	147	153	PF00018	0.450
LIG_SH3_3	304	310	PF00018	0.581
LIG_TRAF2_1	178	181	PF00917	0.722
LIG_TRAF2_1	275	278	PF00917	0.541
MOD_CK1_1	154	160	PF00069	0.596
MOD_CK1_1	161	167	PF00069	0.606
MOD_CK1_1	41	47	PF00069	0.695
MOD_CK2_1	175	181	PF00069	0.717
MOD_CK2_1	254	260	PF00069	0.733
MOD_CK2_1	272	278	PF00069	0.319
MOD_CK2_1	91	97	PF00069	0.630
MOD_Cter_Amidation	143	146	PF01082	0.377
MOD_GlcNHglycan	163	166	PF01048	0.682
MOD_GlcNHglycan	246	251	PF01048	0.628
MOD_GlcNHglycan	257	260	PF01048	0.620
MOD_GlcNHglycan	317	320	PF01048	0.630
MOD_GlcNHglycan	88	91	PF01048	0.581
MOD_GlcNHglycan	93	96	PF01048	0.552
MOD_GSK3_1	129	136	PF00069	0.508
MOD_GSK3_1	151	158	PF00069	0.592
MOD_GSK3_1	175	182	PF00069	0.713
MOD_GSK3_1	212	219	PF00069	0.442
MOD_GSK3_1	251	258	PF00069	0.634
MOD_GSK3_1	309	316	PF00069	0.637
MOD_GSK3_1	34	41	PF00069	0.633
MOD_NEK2_1	34	39	PF00069	0.646
MOD_PIKK_1	176	182	PF00454	0.716
MOD_PIKK_1	264	270	PF00454	0.644
MOD_PKA_2	255	261	PF00069	0.663
MOD_PKA_2	323	329	PF00069	0.623
MOD_PKA_2	38	44	PF00069	0.619
MOD_Plk_1	216	222	PF00069	0.548
MOD_Plk_1	277	283	PF00069	0.429
MOD_Plk_1	99	105	PF00069	0.439
MOD_Plk_4	137	143	PF00069	0.389
MOD_Plk_4	277	283	PF00069	0.530
MOD_Plk_4	347	353	PF00069	0.507
MOD_Plk_4	366	372	PF00069	0.314
MOD_Plk_4	99	105	PF00069	0.492
MOD_ProDKin_1	156	162	PF00069	0.590
MOD_ProDKin_1	197	203	PF00069	0.608
MOD_ProDKin_1	48	54	PF00069	0.716
MOD_SUMO_rev_2	108	116	PF00179	0.542
MOD_SUMO_rev_2	194	200	PF00179	0.587
TRG_DiLeu_BaEn_2	136	142	PF01217	0.504
TRG_ER_diArg_1	145	147	PF00400	0.417
TRG_ER_diArg_1	2	4	PF00400	0.610
TRG_ER_diArg_1	24	27	PF00400	0.645
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.267

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDY6	Leptomonas seymouri	56%	100%
A0A1X0NK60	Trypanosomatidae	42%	100%
A0A3S5H5K1	Leishmania donovani	98%	100%
A0A422NJ89	Trypanosoma rangeli	49%	100%
A4H4C2	Leishmania braziliensis	80%	98%
C9ZU92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AKI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4QJC3	Leishmania major	92%	99%
V5B710	Trypanosoma cruzi	48%	99%