Vta1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vta1 like - putative

Species:

Leishmania infantum

UniProt:

A4HSJ6_LEIIN

TriTrypDb:

LINF_050012600

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0010008	endosome membrane	5	8
GO:0012506	vesicle membrane	4	8
GO:0016020	membrane	2	8
GO:0030659	cytoplasmic vesicle membrane	5	8
GO:0031090	organelle membrane	3	8
GO:0098588	bounding membrane of organelle	4	8
GO:0110165	cellular anatomical entity	1	8
GO:0005768	endosome	7	1
GO:0005770	late endosome	8	1
GO:0005771	multivesicular body	9	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A4HSJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSJ6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	8
GO:0007034	vacuolar transport	4	8
GO:0008104	protein localization	4	8
GO:0009987	cellular process	1	8
GO:0015031	protein transport	4	8
GO:0016192	vesicle-mediated transport	4	8
GO:0016197	endosomal transport	4	8
GO:0032509	endosome transport via multivesicular body sorting pathway	5	8
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	8
GO:0033036	macromolecule localization	2	8
GO:0045184	establishment of protein localization	3	8
GO:0045324	late endosome to vacuole transport	5	8
GO:0046907	intracellular transport	3	8
GO:0051179	localization	1	8
GO:0051234	establishment of localization	2	8
GO:0051641	cellular localization	2	8
GO:0051649	establishment of localization in cell	3	8
GO:0070727	cellular macromolecule localization	3	8
GO:0071702	organic substance transport	4	8
GO:0071705	nitrogen compound transport	4	8
GO:0071985	multivesicular body sorting pathway	5	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	65	69	PF00656	0.577
CLV_PCSK_SKI1_1	146	150	PF00082	0.304
CLV_PCSK_SKI1_1	156	160	PF00082	0.265
CLV_PCSK_SKI1_1	20	24	PF00082	0.287
CLV_PCSK_SKI1_1	87	91	PF00082	0.324
CLV_PCSK_SKI1_1	92	96	PF00082	0.306
DEG_COP1_1	286	294	PF00400	0.647
DEG_SPOP_SBC_1	296	300	PF00917	0.601
DOC_CKS1_1	230	235	PF01111	0.613
DOC_CKS1_1	240	245	PF01111	0.637
DOC_PP2B_LxvP_1	226	229	PF13499	0.777
DOC_PP4_FxxP_1	202	205	PF00568	0.693
DOC_USP7_MATH_1	136	140	PF00917	0.528
DOC_USP7_MATH_1	142	146	PF00917	0.600
DOC_USP7_MATH_1	217	221	PF00917	0.635
DOC_USP7_MATH_1	290	294	PF00917	0.792
DOC_USP7_MATH_1	296	300	PF00917	0.639
DOC_USP7_MATH_1	307	311	PF00917	0.672
DOC_USP7_UBL2_3	157	161	PF12436	0.507
DOC_WW_Pin1_4	164	169	PF00397	0.555
DOC_WW_Pin1_4	229	234	PF00397	0.700
DOC_WW_Pin1_4	239	244	PF00397	0.754
DOC_WW_Pin1_4	256	261	PF00397	0.672
DOC_WW_Pin1_4	305	310	PF00397	0.651
LIG_14-3-3_CanoR_1	116	125	PF00244	0.530
LIG_14-3-3_CanoR_1	284	294	PF00244	0.639
LIG_BIR_III_4	177	181	PF00653	0.673
LIG_BRCT_BRCA1_1	121	125	PF00533	0.513
LIG_BRCT_BRCA1_1	25	29	PF00533	0.530
LIG_eIF4E_1	119	125	PF01652	0.487
LIG_EVH1_1	226	230	PF00568	0.730
LIG_FHA_1	118	124	PF00498	0.530
LIG_FHA_1	235	241	PF00498	0.643
LIG_FHA_1	58	64	PF00498	0.487
LIG_FHA_2	219	225	PF00498	0.803
LIG_FHA_2	63	69	PF00498	0.578
LIG_LIR_Apic_2	163	168	PF02991	0.526
LIG_LIR_Apic_2	200	205	PF02991	0.678
LIG_LIR_Gen_1	91	101	PF02991	0.530
LIG_LIR_Nem_3	145	150	PF02991	0.473
LIG_MYND_1	292	296	PF01753	0.631
LIG_NRBOX	62	68	PF00104	0.553
LIG_PTB_Apo_2	264	271	PF02174	0.569
LIG_PTB_Phospho_1	264	270	PF10480	0.571
LIG_SH2_CRK	231	235	PF00017	0.667
LIG_SH2_CRK	270	274	PF00017	0.641
LIG_SH2_GRB2like	346	349	PF00017	0.513
LIG_SH2_NCK_1	231	235	PF00017	0.667
LIG_SH2_NCK_1	270	274	PF00017	0.641
LIG_SH2_PTP2	165	168	PF00017	0.515
LIG_SH2_SRC	270	273	PF00017	0.638
LIG_SH2_SRC	346	349	PF00017	0.513
LIG_SH2_STAP1	119	123	PF00017	0.487
LIG_SH2_STAP1	147	151	PF00017	0.487
LIG_SH2_STAP1	247	251	PF00017	0.651
LIG_SH2_STAT5	119	122	PF00017	0.530
LIG_SH2_STAT5	150	153	PF00017	0.487
LIG_SH2_STAT5	165	168	PF00017	0.455
LIG_SH2_STAT5	231	234	PF00017	0.721
LIG_SH2_STAT5	247	250	PF00017	0.598
LIG_SH2_STAT5	39	42	PF00017	0.501
LIG_SH3_3	224	230	PF00018	0.737
LIG_SH3_3	240	246	PF00018	0.589
LIG_SH3_3	257	263	PF00018	0.653
LIG_SH3_3	269	275	PF00018	0.690
LIG_SH3_3	289	295	PF00018	0.645
LIG_SH3_3	8	14	PF00018	0.484
LIG_UBA3_1	66	74	PF00899	0.492
LIG_WW_1	244	247	PF00397	0.641
MOD_CDC14_SPxK_1	167	170	PF00782	0.569
MOD_CDK_SPxK_1	164	170	PF00069	0.560
MOD_CK1_1	207	213	PF00069	0.727
MOD_CK1_1	286	292	PF00069	0.765
MOD_CK1_1	3	9	PF00069	0.516
MOD_CK2_1	218	224	PF00069	0.645
MOD_CK2_1	3	9	PF00069	0.497
MOD_DYRK1A_RPxSP_1	256	260	PF00069	0.623
MOD_GlcNHglycan	288	291	PF01048	0.811
MOD_GlcNHglycan	299	302	PF01048	0.664
MOD_GlcNHglycan	3	6	PF01048	0.460
MOD_GlcNHglycan	309	312	PF01048	0.642
MOD_GlcNHglycan	338	341	PF01048	0.343
MOD_GSK3_1	104	111	PF00069	0.533
MOD_GSK3_1	125	132	PF00069	0.530
MOD_GSK3_1	188	195	PF00069	0.710
MOD_GSK3_1	204	211	PF00069	0.709
MOD_GSK3_1	250	257	PF00069	0.837
MOD_GSK3_1	286	293	PF00069	0.801
MOD_GSK3_1	305	312	PF00069	0.652
MOD_GSK3_1	332	339	PF00069	0.540
MOD_N-GLC_1	108	113	PF02516	0.341
MOD_NEK2_1	1	6	PF00069	0.496
MOD_NEK2_1	117	122	PF00069	0.500
MOD_NEK2_1	125	130	PF00069	0.471
MOD_NEK2_1	285	290	PF00069	0.702
MOD_NEK2_1	353	358	PF00069	0.593
MOD_NEK2_1	62	67	PF00069	0.530
MOD_NEK2_1	70	75	PF00069	0.530
MOD_PIKK_1	204	210	PF00454	0.667
MOD_PIKK_1	234	240	PF00454	0.690
MOD_PIKK_1	245	251	PF00454	0.760
MOD_PIKK_1	276	282	PF00454	0.669
MOD_PIKK_1	332	338	PF00454	0.554
MOD_PIKK_1	76	82	PF00454	0.491
MOD_PKA_2	283	289	PF00069	0.704
MOD_Plk_1	108	114	PF00069	0.541
MOD_Plk_4	119	125	PF00069	0.502
MOD_Plk_4	261	267	PF00069	0.563
MOD_Plk_4	3	9	PF00069	0.587
MOD_Plk_4	62	68	PF00069	0.543
MOD_ProDKin_1	164	170	PF00069	0.570
MOD_ProDKin_1	229	235	PF00069	0.703
MOD_ProDKin_1	239	245	PF00069	0.749
MOD_ProDKin_1	256	262	PF00069	0.742
MOD_ProDKin_1	305	311	PF00069	0.648
MOD_SUMO_rev_2	26	34	PF00179	0.541
TRG_DiLeu_BaEn_2	57	63	PF01217	0.484
TRG_ER_diArg_1	49	52	PF00400	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8N6	Leptomonas seymouri	56%	97%
A0A0S4IWD6	Bodo saltans	43%	100%
A0A3S5H5J7	Leishmania donovani	100%	100%
A4H4B7	Leishmania braziliensis	73%	100%
E9AKI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q32L63	Bos taurus	26%	100%
Q4QJC8	Leishmania major	92%	100%
Q5R5W5	Pongo abelii	26%	100%
Q9CR26	Mus musculus	28%	100%
Q9NP79	Homo sapiens	26%	100%