LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HSJ5_LEIIN
TriTrypDb:
LINF_050012500 *
Length:
609

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HSJ5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSJ5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 75 79 PF00656 0.594
CLV_NRD_NRD_1 173 175 PF00675 0.576
CLV_NRD_NRD_1 259 261 PF00675 0.640
CLV_NRD_NRD_1 420 422 PF00675 0.654
CLV_NRD_NRD_1 447 449 PF00675 0.586
CLV_NRD_NRD_1 455 457 PF00675 0.529
CLV_PCSK_FUR_1 575 579 PF00082 0.472
CLV_PCSK_KEX2_1 161 163 PF00082 0.464
CLV_PCSK_KEX2_1 173 175 PF00082 0.576
CLV_PCSK_KEX2_1 259 261 PF00082 0.719
CLV_PCSK_KEX2_1 419 421 PF00082 0.660
CLV_PCSK_KEX2_1 447 449 PF00082 0.576
CLV_PCSK_KEX2_1 577 579 PF00082 0.477
CLV_PCSK_PC1ET2_1 161 163 PF00082 0.464
CLV_PCSK_PC1ET2_1 577 579 PF00082 0.447
CLV_PCSK_SKI1_1 39 43 PF00082 0.583
CLV_PCSK_SKI1_1 578 582 PF00082 0.471
DEG_APCC_DBOX_1 542 550 PF00400 0.383
DEG_SCF_FBW7_1 392 399 PF00400 0.652
DEG_SPOP_SBC_1 46 50 PF00917 0.658
DEG_SPOP_SBC_1 72 76 PF00917 0.597
DOC_CKS1_1 393 398 PF01111 0.649
DOC_MAPK_gen_1 102 109 PF00069 0.625
DOC_MAPK_MEF2A_6 102 109 PF00069 0.563
DOC_MAPK_MEF2A_6 548 557 PF00069 0.498
DOC_PP1_RVXF_1 583 589 PF00149 0.454
DOC_PP2B_LxvP_1 152 155 PF13499 0.552
DOC_PP2B_LxvP_1 234 237 PF13499 0.599
DOC_USP7_MATH_1 190 194 PF00917 0.490
DOC_USP7_MATH_1 221 225 PF00917 0.601
DOC_USP7_MATH_1 298 302 PF00917 0.621
DOC_USP7_MATH_1 308 312 PF00917 0.586
DOC_USP7_MATH_1 316 320 PF00917 0.536
DOC_USP7_MATH_1 348 352 PF00917 0.696
DOC_USP7_MATH_1 46 50 PF00917 0.680
DOC_USP7_UBL2_3 479 483 PF12436 0.429
DOC_USP7_UBL2_3 577 581 PF12436 0.453
DOC_WW_Pin1_4 107 112 PF00397 0.660
DOC_WW_Pin1_4 134 139 PF00397 0.660
DOC_WW_Pin1_4 167 172 PF00397 0.558
DOC_WW_Pin1_4 219 224 PF00397 0.647
DOC_WW_Pin1_4 337 342 PF00397 0.656
DOC_WW_Pin1_4 392 397 PF00397 0.652
DOC_WW_Pin1_4 448 453 PF00397 0.623
DOC_WW_Pin1_4 460 465 PF00397 0.444
DOC_WW_Pin1_4 601 606 PF00397 0.585
DOC_WW_Pin1_4 77 82 PF00397 0.633
LIG_14-3-3_CanoR_1 131 136 PF00244 0.541
LIG_14-3-3_CanoR_1 211 221 PF00244 0.615
LIG_14-3-3_CanoR_1 283 292 PF00244 0.536
LIG_14-3-3_CanoR_1 332 338 PF00244 0.636
LIG_14-3-3_CanoR_1 420 426 PF00244 0.659
LIG_14-3-3_CanoR_1 447 451 PF00244 0.611
LIG_14-3-3_CanoR_1 51 61 PF00244 0.668
LIG_14-3-3_CanoR_1 568 576 PF00244 0.501
LIG_Actin_WH2_2 576 593 PF00022 0.463
LIG_EVH1_1 234 238 PF00568 0.571
LIG_FHA_1 393 399 PF00498 0.601
LIG_FHA_1 500 506 PF00498 0.610
LIG_FHA_1 52 58 PF00498 0.616
LIG_FHA_2 130 136 PF00498 0.548
LIG_FHA_2 527 533 PF00498 0.524
LIG_FHA_2 542 548 PF00498 0.557
LIG_FHA_2 73 79 PF00498 0.595
LIG_LIR_Gen_1 566 576 PF02991 0.511
LIG_LIR_Nem_3 289 295 PF02991 0.630
LIG_LIR_Nem_3 566 572 PF02991 0.526
LIG_PCNA_yPIPBox_3 568 580 PF02747 0.492
LIG_PDZ_Class_1 604 609 PF00595 0.561
LIG_SH2_CRK 292 296 PF00017 0.537
LIG_SH2_CRK 44 48 PF00017 0.615
LIG_SH2_CRK 569 573 PF00017 0.503
LIG_SH2_STAP1 73 77 PF00017 0.596
LIG_SH2_STAT5 394 397 PF00017 0.602
LIG_SH2_STAT5 504 507 PF00017 0.612
LIG_SH2_STAT5 569 572 PF00017 0.503
LIG_SH2_STAT5 73 76 PF00017 0.625
LIG_SH3_1 133 139 PF00018 0.591
LIG_SH3_3 133 139 PF00018 0.591
LIG_SH3_3 163 169 PF00018 0.532
LIG_SH3_3 232 238 PF00018 0.656
LIG_SH3_3 357 363 PF00018 0.660
LIG_SH3_3 390 396 PF00018 0.647
LIG_SH3_3 407 413 PF00018 0.486
LIG_SH3_3 426 432 PF00018 0.689
LIG_SH3_3 489 495 PF00018 0.541
LIG_SH3_4 39 46 PF00018 0.611
LIG_SH3_CIN85_PxpxPR_1 93 98 PF14604 0.623
LIG_TRAF2_1 176 179 PF00917 0.505
LIG_TRAF2_1 185 188 PF00917 0.423
LIG_TRAF2_1 530 533 PF00917 0.506
LIG_TYR_ITIM 42 47 PF00017 0.587
MOD_CDC14_SPxK_1 170 173 PF00782 0.527
MOD_CDK_SPxK_1 167 173 PF00069 0.528
MOD_CDK_SPxK_1 396 402 PF00069 0.652
MOD_CDK_SPxxK_3 167 174 PF00069 0.582
MOD_CK1_1 134 140 PF00069 0.703
MOD_CK1_1 206 212 PF00069 0.620
MOD_CK1_1 222 228 PF00069 0.552
MOD_CK1_1 248 254 PF00069 0.637
MOD_CK1_1 26 32 PF00069 0.491
MOD_CK1_1 270 276 PF00069 0.666
MOD_CK1_1 281 287 PF00069 0.595
MOD_CK1_1 311 317 PF00069 0.668
MOD_CK1_1 331 337 PF00069 0.507
MOD_CK1_1 353 359 PF00069 0.654
MOD_CK1_1 463 469 PF00069 0.516
MOD_CK1_1 49 55 PF00069 0.741
MOD_CK1_1 7 13 PF00069 0.741
MOD_CK1_1 76 82 PF00069 0.615
MOD_CK2_1 2 8 PF00069 0.641
MOD_CK2_1 435 441 PF00069 0.621
MOD_CK2_1 526 532 PF00069 0.534
MOD_CK2_1 541 547 PF00069 0.473
MOD_Cter_Amidation 454 457 PF01082 0.500
MOD_DYRK1A_RPxSP_1 460 464 PF00069 0.542
MOD_DYRK1A_RPxSP_1 601 605 PF00069 0.525
MOD_GlcNHglycan 121 124 PF01048 0.684
MOD_GlcNHglycan 139 142 PF01048 0.562
MOD_GlcNHglycan 193 196 PF01048 0.588
MOD_GlcNHglycan 214 217 PF01048 0.564
MOD_GlcNHglycan 228 231 PF01048 0.613
MOD_GlcNHglycan 262 265 PF01048 0.670
MOD_GlcNHglycan 280 283 PF01048 0.474
MOD_GlcNHglycan 300 303 PF01048 0.618
MOD_GlcNHglycan 323 326 PF01048 0.680
MOD_GlcNHglycan 452 455 PF01048 0.660
MOD_GlcNHglycan 606 609 PF01048 0.668
MOD_GlcNHglycan 75 78 PF01048 0.655
MOD_GSK3_1 156 163 PF00069 0.502
MOD_GSK3_1 219 226 PF00069 0.653
MOD_GSK3_1 23 30 PF00069 0.637
MOD_GSK3_1 270 277 PF00069 0.690
MOD_GSK3_1 307 314 PF00069 0.686
MOD_GSK3_1 316 323 PF00069 0.638
MOD_GSK3_1 328 335 PF00069 0.594
MOD_GSK3_1 350 357 PF00069 0.705
MOD_GSK3_1 382 389 PF00069 0.628
MOD_GSK3_1 392 399 PF00069 0.546
MOD_GSK3_1 431 438 PF00069 0.686
MOD_GSK3_1 446 453 PF00069 0.529
MOD_GSK3_1 45 52 PF00069 0.710
MOD_GSK3_1 499 506 PF00069 0.661
MOD_GSK3_1 537 544 PF00069 0.508
MOD_GSK3_1 567 574 PF00069 0.516
MOD_GSK3_1 597 604 PF00069 0.643
MOD_GSK3_1 72 79 PF00069 0.646
MOD_N-GLC_1 434 439 PF02516 0.624
MOD_NEK2_1 330 335 PF00069 0.700
MOD_NEK2_1 47 52 PF00069 0.636
MOD_NEK2_1 503 508 PF00069 0.611
MOD_NEK2_1 551 556 PF00069 0.453
MOD_NEK2_2 499 504 PF00069 0.611
MOD_PIKK_1 382 388 PF00454 0.628
MOD_PIKK_1 423 429 PF00454 0.662
MOD_PIKK_1 435 441 PF00454 0.440
MOD_PIKK_1 541 547 PF00454 0.473
MOD_PIKK_1 567 573 PF00454 0.518
MOD_PIKK_1 599 605 PF00454 0.512
MOD_PIKK_1 81 87 PF00454 0.656
MOD_PK_1 53 59 PF00069 0.617
MOD_PKA_1 259 265 PF00069 0.646
MOD_PKA_2 10 16 PF00069 0.646
MOD_PKA_2 206 212 PF00069 0.591
MOD_PKA_2 259 265 PF00069 0.649
MOD_PKA_2 268 274 PF00069 0.594
MOD_PKA_2 331 337 PF00069 0.558
MOD_PKA_2 401 407 PF00069 0.662
MOD_PKA_2 446 452 PF00069 0.555
MOD_PKA_2 52 58 PF00069 0.660
MOD_PKA_2 567 573 PF00069 0.518
MOD_PKA_2 597 603 PF00069 0.486
MOD_PKB_1 419 427 PF00069 0.585
MOD_PKB_1 51 59 PF00069 0.617
MOD_Plk_1 435 441 PF00069 0.621
MOD_Plk_1 526 532 PF00069 0.499
MOD_Plk_1 537 543 PF00069 0.362
MOD_Plk_1 551 557 PF00069 0.464
MOD_Plk_4 245 251 PF00069 0.618
MOD_Plk_4 440 446 PF00069 0.724
MOD_Plk_4 499 505 PF00069 0.611
MOD_Plk_4 53 59 PF00069 0.667
MOD_Plk_4 537 543 PF00069 0.388
MOD_ProDKin_1 107 113 PF00069 0.658
MOD_ProDKin_1 134 140 PF00069 0.660
MOD_ProDKin_1 167 173 PF00069 0.559
MOD_ProDKin_1 219 225 PF00069 0.650
MOD_ProDKin_1 337 343 PF00069 0.657
MOD_ProDKin_1 392 398 PF00069 0.651
MOD_ProDKin_1 448 454 PF00069 0.624
MOD_ProDKin_1 460 466 PF00069 0.437
MOD_ProDKin_1 601 607 PF00069 0.595
MOD_ProDKin_1 77 83 PF00069 0.631
MOD_SUMO_rev_2 187 193 PF00179 0.520
TRG_DiLeu_BaEn_2 464 470 PF01217 0.549
TRG_DiLeu_BaEn_4 178 184 PF01217 0.507
TRG_DiLeu_BaLyEn_6 163 168 PF01217 0.532
TRG_ENDOCYTIC_2 292 295 PF00928 0.539
TRG_ENDOCYTIC_2 44 47 PF00928 0.662
TRG_ENDOCYTIC_2 569 572 PF00928 0.503
TRG_ER_diArg_1 258 260 PF00400 0.620
TRG_ER_diArg_1 419 421 PF00400 0.663
TRG_ER_diArg_1 95 98 PF00400 0.629
TRG_Pf-PMV_PEXEL_1 483 487 PF00026 0.621

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WP68 Leishmania donovani 100% 82%
A4H4B6 Leishmania braziliensis 48% 80%
E9AKH9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4QJC9 Leishmania major 90% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS