LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative kinesin

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative kinesin
Gene product:
kinesin - putative
Species:
Leishmania infantum
UniProt:
A4HSI5_LEIIN
TriTrypDb:
LINF_050011400 *
Length:
1069

Annotations

Annotations by Jardim et al.

Structural Proteins, kinesin

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005815 microtubule organizing center 2 1
GO:0005871 kinesin complex 3 1
GO:0005874 microtubule 6 1
GO:0005875 microtubule associated complex 2 1
GO:0032991 protein-containing complex 1 1
GO:0036064 ciliary basal body 3 1
GO:0097542 ciliary tip 2 1
GO:0099080 supramolecular complex 2 1
GO:0099081 supramolecular polymer 3 1
GO:0099512 supramolecular fiber 4 1
GO:0099513 polymeric cytoskeletal fiber 5 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HSI5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSI5

Function

Biological processes
Term Name Level Count
GO:0007017 microtubule-based process 2 8
GO:0007018 microtubule-based movement 3 8
GO:0009987 cellular process 1 8
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 8
GO:0003774 cytoskeletal motor activity 1 8
GO:0003777 microtubule motor activity 2 8
GO:0003824 catalytic activity 1 5
GO:0005488 binding 1 8
GO:0005515 protein binding 2 8
GO:0005524 ATP binding 5 8
GO:0008017 microtubule binding 5 8
GO:0008092 cytoskeletal protein binding 3 8
GO:0015631 tubulin binding 4 8
GO:0016787 hydrolase activity 2 5
GO:0017076 purine nucleotide binding 4 8
GO:0030554 adenyl nucleotide binding 5 8
GO:0032553 ribonucleotide binding 3 8
GO:0032555 purine ribonucleotide binding 4 8
GO:0032559 adenyl ribonucleotide binding 5 8
GO:0035639 purine ribonucleoside triphosphate binding 4 8
GO:0036094 small molecule binding 2 8
GO:0043167 ion binding 2 8
GO:0043168 anion binding 3 8
GO:0097159 organic cyclic compound binding 2 8
GO:0097367 carbohydrate derivative binding 2 8
GO:0140657 ATP-dependent activity 1 8
GO:1901265 nucleoside phosphate binding 3 8
GO:1901363 heterocyclic compound binding 2 8
GO:0016462 pyrophosphatase activity 5 1
GO:0016817 hydrolase activity, acting on acid anhydrides 3 1
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 1
GO:0016887 ATP hydrolysis activity 7 1
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 137 141 PF00656 0.394
CLV_C14_Caspase3-7 714 718 PF00656 0.513
CLV_C14_Caspase3-7 746 750 PF00656 0.450
CLV_C14_Caspase3-7 799 803 PF00656 0.579
CLV_C14_Caspase3-7 871 875 PF00656 0.555
CLV_C14_Caspase3-7 928 932 PF00656 0.681
CLV_NRD_NRD_1 1064 1066 PF00675 0.539
CLV_NRD_NRD_1 185 187 PF00675 0.327
CLV_NRD_NRD_1 308 310 PF00675 0.529
CLV_NRD_NRD_1 46 48 PF00675 0.310
CLV_NRD_NRD_1 529 531 PF00675 0.534
CLV_NRD_NRD_1 544 546 PF00675 0.619
CLV_NRD_NRD_1 55 57 PF00675 0.342
CLV_NRD_NRD_1 704 706 PF00675 0.525
CLV_NRD_NRD_1 790 792 PF00675 0.625
CLV_PCSK_KEX2_1 185 187 PF00082 0.324
CLV_PCSK_KEX2_1 308 310 PF00082 0.529
CLV_PCSK_KEX2_1 45 47 PF00082 0.309
CLV_PCSK_KEX2_1 529 531 PF00082 0.529
CLV_PCSK_KEX2_1 544 546 PF00082 0.634
CLV_PCSK_KEX2_1 55 57 PF00082 0.342
CLV_PCSK_KEX2_1 598 600 PF00082 0.590
CLV_PCSK_KEX2_1 703 705 PF00082 0.517
CLV_PCSK_KEX2_1 790 792 PF00082 0.663
CLV_PCSK_KEX2_1 796 798 PF00082 0.688
CLV_PCSK_PC1ET2_1 598 600 PF00082 0.565
CLV_PCSK_PC1ET2_1 796 798 PF00082 0.560
CLV_PCSK_SKI1_1 287 291 PF00082 0.391
CLV_PCSK_SKI1_1 340 344 PF00082 0.535
CLV_PCSK_SKI1_1 670 674 PF00082 0.501
CLV_PCSK_SKI1_1 695 699 PF00082 0.449
CLV_PCSK_SKI1_1 805 809 PF00082 0.636
CLV_Separin_Metazoa 386 390 PF03568 0.477
DEG_APCC_DBOX_1 185 193 PF00400 0.311
DEG_APCC_KENBOX_2 429 433 PF00400 0.468
DEG_COP1_1 907 916 PF00400 0.651
DEG_Nend_UBRbox_3 1 3 PF02207 0.228
DEG_SCF_FBW7_1 825 832 PF00400 0.625
DOC_CDC14_PxL_1 876 884 PF14671 0.641
DOC_CKS1_1 918 923 PF01111 0.587
DOC_MAPK_DCC_7 108 118 PF00069 0.317
DOC_MAPK_gen_1 185 194 PF00069 0.349
DOC_MAPK_MEF2A_6 214 222 PF00069 0.424
DOC_MAPK_MEF2A_6 634 641 PF00069 0.611
DOC_MAPK_MEF2A_6 773 781 PF00069 0.527
DOC_MAPK_RevD_3 295 309 PF00069 0.503
DOC_MAPK_RevD_3 586 599 PF00069 0.435
DOC_MAPK_RevD_3 689 705 PF00069 0.485
DOC_USP7_MATH_1 1023 1027 PF00917 0.659
DOC_USP7_MATH_1 179 183 PF00917 0.353
DOC_USP7_MATH_1 449 453 PF00917 0.665
DOC_USP7_MATH_1 710 714 PF00917 0.568
DOC_USP7_MATH_1 872 876 PF00917 0.598
DOC_USP7_MATH_1 883 887 PF00917 0.548
DOC_USP7_MATH_1 977 981 PF00917 0.645
DOC_WW_Pin1_4 154 159 PF00397 0.376
DOC_WW_Pin1_4 472 477 PF00397 0.642
DOC_WW_Pin1_4 808 813 PF00397 0.653
DOC_WW_Pin1_4 825 830 PF00397 0.669
DOC_WW_Pin1_4 853 858 PF00397 0.641
DOC_WW_Pin1_4 917 922 PF00397 0.706
DOC_WW_Pin1_4 944 949 PF00397 0.636
DOC_WW_Pin1_4 955 960 PF00397 0.583
DOC_WW_Pin1_4 989 994 PF00397 0.683
LIG_14-3-3_CanoR_1 177 184 PF00244 0.387
LIG_14-3-3_CanoR_1 244 248 PF00244 0.413
LIG_14-3-3_CanoR_1 258 264 PF00244 0.376
LIG_14-3-3_CanoR_1 340 349 PF00244 0.514
LIG_14-3-3_CanoR_1 424 428 PF00244 0.532
LIG_14-3-3_CanoR_1 544 551 PF00244 0.535
LIG_14-3-3_CanoR_1 573 578 PF00244 0.549
LIG_14-3-3_CanoR_1 768 777 PF00244 0.522
LIG_14-3-3_CanoR_1 924 930 PF00244 0.661
LIG_14-3-3_CanoR_1 943 947 PF00244 0.695
LIG_APCC_ABBA_1 170 175 PF00400 0.317
LIG_APCC_ABBA_1 90 95 PF00400 0.317
LIG_APCC_ABBAyCdc20_2 529 535 PF00400 0.580
LIG_BIR_III_4 74 78 PF00653 0.316
LIG_BRCT_BRCA1_1 2 6 PF00533 0.317
LIG_BRCT_BRCA1_1 218 222 PF00533 0.376
LIG_BRCT_BRCA1_1 851 855 PF00533 0.763
LIG_CaM_IQ_9 279 294 PF13499 0.365
LIG_eIF4E_1 26 32 PF01652 0.376
LIG_FHA_1 14 20 PF00498 0.317
LIG_FHA_1 148 154 PF00498 0.349
LIG_FHA_1 169 175 PF00498 0.317
LIG_FHA_1 247 253 PF00498 0.340
LIG_FHA_1 260 266 PF00498 0.360
LIG_FHA_1 299 305 PF00498 0.503
LIG_FHA_1 424 430 PF00498 0.538
LIG_FHA_1 448 454 PF00498 0.613
LIG_FHA_1 590 596 PF00498 0.538
LIG_FHA_1 799 805 PF00498 0.577
LIG_FHA_1 80 86 PF00498 0.376
LIG_FHA_1 822 828 PF00498 0.629
LIG_FHA_1 913 919 PF00498 0.674
LIG_FHA_2 107 113 PF00498 0.365
LIG_FHA_2 115 121 PF00498 0.252
LIG_FHA_2 135 141 PF00498 0.317
LIG_FHA_2 341 347 PF00498 0.546
LIG_FHA_2 582 588 PF00498 0.537
LIG_FHA_2 633 639 PF00498 0.682
LIG_FHA_2 926 932 PF00498 0.684
LIG_GSK3_LRP6_1 829 834 PF00069 0.620
LIG_IBAR_NPY_1 1036 1038 PF08397 0.545
LIG_Integrin_RGD_1 834 836 PF01839 0.625
LIG_LIR_Gen_1 246 252 PF02991 0.390
LIG_LIR_Gen_1 86 93 PF02991 0.321
LIG_LIR_Gen_1 996 1004 PF02991 0.838
LIG_LIR_Nem_3 1035 1041 PF02991 0.592
LIG_LIR_Nem_3 852 858 PF02991 0.636
LIG_LIR_Nem_3 86 92 PF02991 0.321
LIG_LIR_Nem_3 996 1002 PF02991 0.837
LIG_NRBOX 433 439 PF00104 0.551
LIG_Pex14_2 766 770 PF04695 0.479
LIG_Pex14_2 855 859 PF04695 0.734
LIG_RPA_C_Fungi 304 316 PF08784 0.386
LIG_SH2_CRK 469 473 PF00017 0.629
LIG_SH2_NCK_1 40 44 PF00017 0.317
LIG_SH2_NCK_1 469 473 PF00017 0.652
LIG_SH2_SRC 173 176 PF00017 0.317
LIG_SH2_SRC 40 43 PF00017 0.317
LIG_SH2_SRC 868 871 PF00017 0.634
LIG_SH2_STAP1 40 44 PF00017 0.317
LIG_SH2_STAP1 83 87 PF00017 0.376
LIG_SH2_STAP1 868 872 PF00017 0.677
LIG_SH2_STAT3 660 663 PF00017 0.518
LIG_SH2_STAT5 1038 1041 PF00017 0.622
LIG_SH2_STAT5 154 157 PF00017 0.317
LIG_SH2_STAT5 173 176 PF00017 0.317
LIG_SH2_STAT5 323 326 PF00017 0.492
LIG_SH2_STAT5 357 360 PF00017 0.494
LIG_SH2_STAT5 382 385 PF00017 0.405
LIG_SH2_STAT5 754 757 PF00017 0.505
LIG_SH2_STAT5 83 86 PF00017 0.359
LIG_SH2_STAT5 839 842 PF00017 0.639
LIG_SH2_STAT5 89 92 PF00017 0.311
LIG_SH3_3 1031 1037 PF00018 0.593
LIG_SH3_3 824 830 PF00018 0.619
LIG_SH3_3 851 857 PF00018 0.617
LIG_SH3_3 877 883 PF00018 0.624
LIG_SH3_3 891 897 PF00018 0.610
LIG_SH3_3 992 998 PF00018 0.679
LIG_SH3_CIN85_PxpxPR_1 829 834 PF14604 0.620
LIG_SUMO_SIM_anti_2 300 308 PF11976 0.502
LIG_SUMO_SIM_anti_2 635 643 PF11976 0.598
LIG_SUMO_SIM_par_1 226 232 PF11976 0.376
LIG_SUMO_SIM_par_1 261 267 PF11976 0.382
LIG_SUMO_SIM_par_1 914 920 PF11976 0.732
LIG_TRAF2_1 109 112 PF00917 0.406
LIG_TRFH_1 1039 1043 PF08558 0.571
LIG_TRFH_1 999 1003 PF08558 0.699
LIG_UBA3_1 437 443 PF00899 0.510
LIG_Vh1_VBS_1 264 282 PF01044 0.376
MOD_CDC14_SPxK_1 994 997 PF00782 0.683
MOD_CDK_SPK_2 829 834 PF00069 0.620
MOD_CDK_SPxK_1 991 997 PF00069 0.680
MOD_CDK_SPxxK_3 154 161 PF00069 0.317
MOD_CDK_SPxxK_3 917 924 PF00069 0.589
MOD_CK1_1 1026 1032 PF00069 0.674
MOD_CK1_1 13 19 PF00069 0.317
MOD_CK1_1 134 140 PF00069 0.317
MOD_CK1_1 163 169 PF00069 0.317
MOD_CK1_1 178 184 PF00069 0.317
MOD_CK1_1 246 252 PF00069 0.376
MOD_CK1_1 369 375 PF00069 0.524
MOD_CK1_1 502 508 PF00069 0.655
MOD_CK1_1 842 848 PF00069 0.664
MOD_CK1_1 912 918 PF00069 0.672
MOD_CK1_1 955 961 PF00069 0.662
MOD_CK2_1 106 112 PF00069 0.380
MOD_CK2_1 114 120 PF00069 0.468
MOD_CK2_1 340 346 PF00069 0.461
MOD_CK2_1 562 568 PF00069 0.520
MOD_CK2_1 581 587 PF00069 0.577
MOD_CK2_1 594 600 PF00069 0.636
MOD_CK2_1 726 732 PF00069 0.479
MOD_GlcNHglycan 1025 1028 PF01048 0.635
MOD_GlcNHglycan 12 15 PF01048 0.309
MOD_GlcNHglycan 133 136 PF01048 0.317
MOD_GlcNHglycan 177 180 PF01048 0.353
MOD_GlcNHglycan 205 208 PF01048 0.351
MOD_GlcNHglycan 330 333 PF01048 0.622
MOD_GlcNHglycan 483 486 PF01048 0.722
MOD_GlcNHglycan 505 508 PF01048 0.687
MOD_GlcNHglycan 509 512 PF01048 0.671
MOD_GlcNHglycan 545 548 PF01048 0.552
MOD_GlcNHglycan 58 61 PF01048 0.294
MOD_GlcNHglycan 621 624 PF01048 0.759
MOD_GlcNHglycan 625 628 PF01048 0.698
MOD_GlcNHglycan 72 78 PF01048 0.271
MOD_GlcNHglycan 770 773 PF01048 0.485
MOD_GlcNHglycan 859 862 PF01048 0.675
MOD_GlcNHglycan 870 873 PF01048 0.533
MOD_GlcNHglycan 885 888 PF01048 0.730
MOD_GlcNHglycan 891 894 PF01048 0.680
MOD_GlcNHglycan 921 924 PF01048 0.738
MOD_GlcNHglycan 935 938 PF01048 0.702
MOD_GSK3_1 1005 1012 PF00069 0.749
MOD_GSK3_1 13 20 PF00069 0.317
MOD_GSK3_1 159 166 PF00069 0.338
MOD_GSK3_1 175 182 PF00069 0.317
MOD_GSK3_1 194 201 PF00069 0.469
MOD_GSK3_1 328 335 PF00069 0.590
MOD_GSK3_1 365 372 PF00069 0.508
MOD_GSK3_1 497 504 PF00069 0.708
MOD_GSK3_1 524 531 PF00069 0.551
MOD_GSK3_1 619 626 PF00069 0.687
MOD_GSK3_1 79 86 PF00069 0.314
MOD_GSK3_1 821 828 PF00069 0.729
MOD_GSK3_1 839 846 PF00069 0.694
MOD_GSK3_1 849 856 PF00069 0.689
MOD_GSK3_1 868 875 PF00069 0.723
MOD_GSK3_1 885 892 PF00069 0.602
MOD_GSK3_1 908 915 PF00069 0.680
MOD_GSK3_1 942 949 PF00069 0.646
MOD_GSK3_1 955 962 PF00069 0.644
MOD_GSK3_1 973 980 PF00069 0.524
MOD_GSK3_1 989 996 PF00069 0.601
MOD_LATS_1 53 59 PF00433 0.261
MOD_N-GLC_1 1 6 PF02516 0.317
MOD_N-GLC_1 1010 1015 PF02516 0.571
MOD_N-GLC_1 159 164 PF02516 0.317
MOD_N-GLC_1 216 221 PF02516 0.317
MOD_N-GLC_1 883 888 PF02516 0.596
MOD_N-GLC_2 688 690 PF02516 0.466
MOD_NEK2_1 1 6 PF00069 0.402
MOD_NEK2_1 1004 1009 PF00069 0.741
MOD_NEK2_1 147 152 PF00069 0.317
MOD_NEK2_1 159 164 PF00069 0.317
MOD_NEK2_1 252 257 PF00069 0.338
MOD_NEK2_1 264 269 PF00069 0.335
MOD_NEK2_1 423 428 PF00069 0.559
MOD_NEK2_1 436 441 PF00069 0.614
MOD_NEK2_1 497 502 PF00069 0.735
MOD_NEK2_1 528 533 PF00069 0.689
MOD_NEK2_1 54 59 PF00069 0.396
MOD_NEK2_1 543 548 PF00069 0.564
MOD_NEK2_1 594 599 PF00069 0.553
MOD_NEK2_1 916 921 PF00069 0.736
MOD_NEK2_1 925 930 PF00069 0.711
MOD_NEK2_2 114 119 PF00069 0.390
MOD_NEK2_2 168 173 PF00069 0.317
MOD_NEK2_2 524 529 PF00069 0.472
MOD_PIKK_1 270 276 PF00454 0.376
MOD_PIKK_1 400 406 PF00454 0.611
MOD_PIKK_1 549 555 PF00454 0.595
MOD_PIKK_1 844 850 PF00454 0.610
MOD_PIKK_1 897 903 PF00454 0.635
MOD_PK_1 15 21 PF00069 0.317
MOD_PKA_1 1032 1038 PF00069 0.633
MOD_PKA_1 55 61 PF00069 0.437
MOD_PKA_2 184 190 PF00069 0.309
MOD_PKA_2 198 204 PF00069 0.317
MOD_PKA_2 243 249 PF00069 0.377
MOD_PKA_2 252 258 PF00069 0.318
MOD_PKA_2 369 375 PF00069 0.524
MOD_PKA_2 423 429 PF00069 0.545
MOD_PKA_2 502 508 PF00069 0.642
MOD_PKA_2 528 534 PF00069 0.692
MOD_PKA_2 54 60 PF00069 0.439
MOD_PKA_2 543 549 PF00069 0.542
MOD_PKA_2 572 578 PF00069 0.545
MOD_PKA_2 673 679 PF00069 0.374
MOD_PKA_2 942 948 PF00069 0.575
MOD_Plk_1 1 7 PF00069 0.317
MOD_Plk_1 216 222 PF00069 0.317
MOD_Plk_1 338 344 PF00069 0.562
MOD_Plk_1 345 351 PF00069 0.419
MOD_Plk_1 524 530 PF00069 0.540
MOD_Plk_1 563 569 PF00069 0.674
MOD_Plk_1 725 731 PF00069 0.363
MOD_Plk_2-3 106 112 PF00069 0.376
MOD_Plk_2-3 726 732 PF00069 0.458
MOD_Plk_4 1 7 PF00069 0.360
MOD_Plk_4 179 185 PF00069 0.376
MOD_Plk_4 205 211 PF00069 0.317
MOD_Plk_4 243 249 PF00069 0.323
MOD_Plk_4 259 265 PF00069 0.257
MOD_Plk_4 436 442 PF00069 0.567
MOD_Plk_4 85 91 PF00069 0.378
MOD_Plk_4 872 878 PF00069 0.633
MOD_Plk_4 979 985 PF00069 0.628
MOD_ProDKin_1 154 160 PF00069 0.376
MOD_ProDKin_1 472 478 PF00069 0.642
MOD_ProDKin_1 808 814 PF00069 0.660
MOD_ProDKin_1 825 831 PF00069 0.667
MOD_ProDKin_1 853 859 PF00069 0.650
MOD_ProDKin_1 917 923 PF00069 0.705
MOD_ProDKin_1 944 950 PF00069 0.637
MOD_ProDKin_1 955 961 PF00069 0.584
MOD_ProDKin_1 989 995 PF00069 0.682
MOD_SUMO_for_1 317 320 PF00179 0.510
MOD_SUMO_rev_2 206 216 PF00179 0.330
MOD_SUMO_rev_2 339 349 PF00179 0.481
MOD_SUMO_rev_2 484 492 PF00179 0.600
MOD_SUMO_rev_2 667 672 PF00179 0.501
MOD_SUMO_rev_2 793 798 PF00179 0.521
TRG_DiLeu_BaEn_1 433 438 PF01217 0.552
TRG_DiLeu_BaEn_1 668 673 PF01217 0.490
TRG_DiLeu_BaEn_4 719 725 PF01217 0.487
TRG_ENDOCYTIC_2 1038 1041 PF00928 0.598
TRG_ENDOCYTIC_2 385 388 PF00928 0.413
TRG_ENDOCYTIC_2 40 43 PF00928 0.317
TRG_ENDOCYTIC_2 469 472 PF00928 0.615
TRG_ENDOCYTIC_2 89 92 PF00928 0.317
TRG_ER_diArg_1 184 186 PF00400 0.317
TRG_ER_diArg_1 307 309 PF00400 0.399
TRG_ER_diArg_1 45 47 PF00400 0.367
TRG_ER_diArg_1 528 530 PF00400 0.544
TRG_ER_diArg_1 54 56 PF00400 0.394
TRG_ER_diArg_1 543 545 PF00400 0.644
TRG_ER_diArg_1 703 705 PF00400 0.517
TRG_ER_diArg_1 864 867 PF00400 0.554
TRG_Pf-PMV_PEXEL_1 108 112 PF00026 0.365
TRG_Pf-PMV_PEXEL_1 308 313 PF00026 0.502
TRG_Pf-PMV_PEXEL_1 340 345 PF00026 0.470

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P345 Leptomonas seymouri 57% 88%
A0A3S7WP55 Leishmania donovani 100% 87%
A4HD46 Leishmania braziliensis 75% 100%
C9ZUB9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9AKG9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4QJD9 Leishmania major 93% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS