Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Surp module - putative

Species:

Leishmania infantum

UniProt:

A4HSI3_LEIIN

TriTrypDb:

LINF_050011200

Length:

980

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HSI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSI3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	331	335	PF00656	0.710
CLV_C14_Caspase3-7	517	521	PF00656	0.709
CLV_NRD_NRD_1	15	17	PF00675	0.648
CLV_NRD_NRD_1	296	298	PF00675	0.521
CLV_NRD_NRD_1	360	362	PF00675	0.736
CLV_NRD_NRD_1	421	423	PF00675	0.755
CLV_NRD_NRD_1	532	534	PF00675	0.628
CLV_NRD_NRD_1	673	675	PF00675	0.489
CLV_NRD_NRD_1	717	719	PF00675	0.687
CLV_NRD_NRD_1	724	726	PF00675	0.621
CLV_PCSK_FUR_1	356	360	PF00082	0.729
CLV_PCSK_FUR_1	714	718	PF00082	0.741
CLV_PCSK_KEX2_1	15	17	PF00082	0.545
CLV_PCSK_KEX2_1	244	246	PF00082	0.313
CLV_PCSK_KEX2_1	296	298	PF00082	0.580
CLV_PCSK_KEX2_1	358	360	PF00082	0.737
CLV_PCSK_KEX2_1	375	377	PF00082	0.757
CLV_PCSK_KEX2_1	532	534	PF00082	0.582
CLV_PCSK_KEX2_1	673	675	PF00082	0.489
CLV_PCSK_KEX2_1	716	718	PF00082	0.685
CLV_PCSK_KEX2_1	724	726	PF00082	0.617
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.346
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.784
CLV_PCSK_PC7_1	356	362	PF00082	0.678
CLV_PCSK_PC7_1	720	726	PF00082	0.810
CLV_PCSK_SKI1_1	426	430	PF00082	0.706
CLV_PCSK_SKI1_1	489	493	PF00082	0.593
CLV_PCSK_SKI1_1	539	543	PF00082	0.616
CLV_PCSK_SKI1_1	776	780	PF00082	0.830
CLV_PCSK_SKI1_1	879	883	PF00082	0.543
DEG_APCC_DBOX_1	269	277	PF00400	0.546
DEG_Nend_UBRbox_2	1	3	PF02207	0.631
DEG_SCF_FBW7_1	832	839	PF00400	0.690
DEG_SIAH_1	575	583	PF03145	0.572
DEG_SPOP_SBC_1	803	807	PF00917	0.716
DEG_SPOP_SBC_1	863	867	PF00917	0.764
DOC_CKS1_1	25	30	PF01111	0.798
DOC_CYCLIN_yCln2_LP_2	136	139	PF00134	0.793
DOC_CYCLIN_yCln2_LP_2	201	207	PF00134	0.588
DOC_CYCLIN_yCln2_LP_2	322	328	PF00134	0.706
DOC_CYCLIN_yCln2_LP_2	506	512	PF00134	0.656
DOC_MAPK_gen_1	209	218	PF00069	0.536
DOC_MAPK_gen_1	296	302	PF00069	0.542
DOC_MAPK_gen_1	673	679	PF00069	0.512
DOC_MAPK_MEF2A_6	879	886	PF00069	0.560
DOC_PP2B_LxvP_1	136	139	PF13499	0.722
DOC_PP2B_LxvP_1	201	204	PF13499	0.593
DOC_PP2B_LxvP_1	205	208	PF13499	0.574
DOC_PP2B_LxvP_1	210	213	PF13499	0.516
DOC_PP2B_LxvP_1	473	476	PF13499	0.657
DOC_PP2B_LxvP_1	892	895	PF13499	0.665
DOC_PP4_FxxP_1	122	125	PF00568	0.775
DOC_PP4_FxxP_1	261	264	PF00568	0.546
DOC_USP7_MATH_1	125	129	PF00917	0.793
DOC_USP7_MATH_1	172	176	PF00917	0.805
DOC_USP7_MATH_1	183	187	PF00917	0.614
DOC_USP7_MATH_1	328	332	PF00917	0.766
DOC_USP7_MATH_1	388	392	PF00917	0.653
DOC_USP7_MATH_1	453	457	PF00917	0.741
DOC_USP7_MATH_1	576	580	PF00917	0.732
DOC_USP7_MATH_1	582	586	PF00917	0.463
DOC_USP7_MATH_1	610	614	PF00917	0.797
DOC_USP7_MATH_1	638	642	PF00917	0.666
DOC_USP7_MATH_1	681	685	PF00917	0.713
DOC_USP7_MATH_1	693	697	PF00917	0.612
DOC_USP7_MATH_1	708	712	PF00917	0.661
DOC_USP7_MATH_1	803	807	PF00917	0.814
DOC_USP7_MATH_1	847	851	PF00917	0.733
DOC_USP7_MATH_1	862	866	PF00917	0.660
DOC_USP7_MATH_1	898	902	PF00917	0.709
DOC_USP7_MATH_1	929	933	PF00917	0.678
DOC_USP7_UBL2_3	790	794	PF12436	0.815
DOC_WW_Pin1_4	175	180	PF00397	0.795
DOC_WW_Pin1_4	2	7	PF00397	0.682
DOC_WW_Pin1_4	20	25	PF00397	0.693
DOC_WW_Pin1_4	448	453	PF00397	0.735
DOC_WW_Pin1_4	606	611	PF00397	0.738
DOC_WW_Pin1_4	658	663	PF00397	0.621
DOC_WW_Pin1_4	682	687	PF00397	0.704
DOC_WW_Pin1_4	701	706	PF00397	0.764
DOC_WW_Pin1_4	709	714	PF00397	0.701
DOC_WW_Pin1_4	723	728	PF00397	0.695
DOC_WW_Pin1_4	81	86	PF00397	0.693
DOC_WW_Pin1_4	832	837	PF00397	0.671
DOC_WW_Pin1_4	841	846	PF00397	0.628
DOC_WW_Pin1_4	894	899	PF00397	0.766
LIG_14-3-3_CanoR_1	148	158	PF00244	0.714
LIG_14-3-3_CanoR_1	272	277	PF00244	0.531
LIG_14-3-3_CanoR_1	426	431	PF00244	0.707
LIG_14-3-3_CanoR_1	483	492	PF00244	0.714
LIG_14-3-3_CanoR_1	680	686	PF00244	0.690
LIG_14-3-3_CanoR_1	975	979	PF00244	0.542
LIG_BRCT_BRCA1_1	976	980	PF00533	0.560
LIG_Clathr_ClatBox_1	944	948	PF01394	0.752
LIG_CSL_BTD_1	300	303	PF09270	0.587
LIG_deltaCOP1_diTrp_1	591	597	PF00928	0.510
LIG_eIF4E_1	958	964	PF01652	0.642
LIG_FHA_1	196	202	PF00498	0.754
LIG_FHA_1	21	27	PF00498	0.679
LIG_FHA_1	219	225	PF00498	0.569
LIG_FHA_1	227	233	PF00498	0.533
LIG_FHA_1	49	55	PF00498	0.720
LIG_FHA_1	502	508	PF00498	0.529
LIG_FHA_1	575	581	PF00498	0.694
LIG_FHA_1	808	814	PF00498	0.788
LIG_FHA_1	837	843	PF00498	0.806
LIG_FHA_1	932	938	PF00498	0.767
LIG_FHA_2	161	167	PF00498	0.760
LIG_FHA_2	180	186	PF00498	0.520
LIG_FHA_2	220	226	PF00498	0.411
LIG_FHA_2	235	241	PF00498	0.546
LIG_FHA_2	453	459	PF00498	0.816
LIG_FHA_2	515	521	PF00498	0.711
LIG_FHA_2	739	745	PF00498	0.524
LIG_FHA_2	85	91	PF00498	0.629
LIG_IBAR_NPY_1	508	510	PF08397	0.671
LIG_Integrin_RGD_1	433	435	PF01839	0.644
LIG_LIR_Apic_2	120	125	PF02991	0.780
LIG_LIR_Apic_2	126	132	PF02991	0.694
LIG_LIR_Apic_2	259	264	PF02991	0.546
LIG_LIR_Gen_1	34	41	PF02991	0.744
LIG_LIR_Gen_1	501	511	PF02991	0.583
LIG_LIR_Gen_1	666	677	PF02991	0.681
LIG_LIR_Gen_1	84	94	PF02991	0.686
LIG_LIR_Gen_1	974	980	PF02991	0.510
LIG_LIR_Nem_3	34	39	PF02991	0.605
LIG_LIR_Nem_3	5	11	PF02991	0.595
LIG_LIR_Nem_3	501	506	PF02991	0.567
LIG_LIR_Nem_3	591	597	PF02991	0.510
LIG_LIR_Nem_3	666	672	PF02991	0.678
LIG_LIR_Nem_3	84	89	PF02991	0.691
LIG_LIR_Nem_3	974	979	PF02991	0.504
LIG_MYND_1	134	138	PF01753	0.770
LIG_MYND_1	24	28	PF01753	0.656
LIG_NRBOX	222	228	PF00104	0.411
LIG_NRBOX	272	278	PF00104	0.520
LIG_NRBOX	553	559	PF00104	0.507
LIG_PCNA_yPIPBox_3	98	109	PF02747	0.725
LIG_PDZ_Class_2	975	980	PF00595	0.564
LIG_Pex14_1	877	881	PF04695	0.622
LIG_Pex14_2	881	885	PF04695	0.646
LIG_PTB_Apo_2	248	255	PF02174	0.530
LIG_SH2_CRK	129	133	PF00017	0.799
LIG_SH2_CRK	274	278	PF00017	0.586
LIG_SH2_CRK	958	962	PF00017	0.662
LIG_SH2_CRK	976	980	PF00017	0.560
LIG_SH2_GRB2like	141	144	PF00017	0.728
LIG_SH2_NCK_1	510	514	PF00017	0.681
LIG_SH2_PTP2	299	302	PF00017	0.499
LIG_SH2_STAP1	976	980	PF00017	0.560
LIG_SH2_STAT3	93	96	PF00017	0.728
LIG_SH2_STAT5	141	144	PF00017	0.806
LIG_SH2_STAT5	299	302	PF00017	0.499
LIG_SH2_STAT5	566	569	PF00017	0.645
LIG_SH2_STAT5	588	591	PF00017	0.549
LIG_SH2_STAT5	595	598	PF00017	0.476
LIG_SH2_STAT5	86	89	PF00017	0.628
LIG_SH3_2	303	308	PF14604	0.647
LIG_SH3_3	165	171	PF00018	0.720
LIG_SH3_3	22	28	PF00018	0.746
LIG_SH3_3	297	303	PF00018	0.514
LIG_SH3_3	4	10	PF00018	0.675
LIG_SH3_3	468	474	PF00018	0.703
LIG_SH3_3	683	689	PF00018	0.672
LIG_SH3_3	777	783	PF00018	0.825
LIG_SH3_3	892	898	PF00018	0.694
LIG_SH3_3	908	914	PF00018	0.756
LIG_SUMO_SIM_anti_2	221	229	PF11976	0.513
LIG_SUMO_SIM_par_1	49	58	PF11976	0.590
LIG_TRAF2_1	237	240	PF00917	0.546
LIG_TRAF2_1	342	345	PF00917	0.723
LIG_TYR_ITIM	593	598	PF00017	0.513
LIG_UBA3_1	874	879	PF00899	0.546
LIG_WW_1	138	141	PF00397	0.788
MOD_CDK_SPK_2	709	714	PF00069	0.717
MOD_CDK_SPxxK_3	709	716	PF00069	0.730
MOD_CDK_SPxxK_3	723	730	PF00069	0.544
MOD_CK1_1	161	167	PF00069	0.632
MOD_CK1_1	175	181	PF00069	0.703
MOD_CK1_1	18	24	PF00069	0.679
MOD_CK1_1	284	290	PF00069	0.627
MOD_CK1_1	395	401	PF00069	0.728
MOD_CK1_1	403	409	PF00069	0.707
MOD_CK1_1	410	416	PF00069	0.575
MOD_CK1_1	613	619	PF00069	0.732
MOD_CK1_1	641	647	PF00069	0.753
MOD_CK1_1	658	664	PF00069	0.507
MOD_CK1_1	696	702	PF00069	0.707
MOD_CK1_1	704	710	PF00069	0.750
MOD_CK1_1	71	77	PF00069	0.751
MOD_CK1_1	795	801	PF00069	0.707
MOD_CK1_1	802	808	PF00069	0.733
MOD_CK1_1	84	90	PF00069	0.562
MOD_CK1_1	843	849	PF00069	0.685
MOD_CK1_1	850	856	PF00069	0.655
MOD_CK1_1	865	871	PF00069	0.720
MOD_CK2_1	160	166	PF00069	0.758
MOD_CK2_1	179	185	PF00069	0.629
MOD_CK2_1	234	240	PF00069	0.546
MOD_CK2_1	374	380	PF00069	0.731
MOD_CK2_1	408	414	PF00069	0.785
MOD_CK2_1	452	458	PF00069	0.770
MOD_CK2_1	723	729	PF00069	0.674
MOD_CK2_1	738	744	PF00069	0.524
MOD_CK2_1	795	801	PF00069	0.725
MOD_CK2_1	84	90	PF00069	0.629
MOD_GlcNHglycan	145	148	PF01048	0.695
MOD_GlcNHglycan	160	163	PF01048	0.566
MOD_GlcNHglycan	168	171	PF01048	0.751
MOD_GlcNHglycan	17	20	PF01048	0.769
MOD_GlcNHglycan	172	175	PF01048	0.693
MOD_GlcNHglycan	185	188	PF01048	0.515
MOD_GlcNHglycan	330	333	PF01048	0.764
MOD_GlcNHglycan	366	369	PF01048	0.742
MOD_GlcNHglycan	394	397	PF01048	0.733
MOD_GlcNHglycan	403	406	PF01048	0.622
MOD_GlcNHglycan	43	46	PF01048	0.734
MOD_GlcNHglycan	455	458	PF01048	0.753
MOD_GlcNHglycan	476	479	PF01048	0.608
MOD_GlcNHglycan	57	60	PF01048	0.647
MOD_GlcNHglycan	611	615	PF01048	0.717
MOD_GlcNHglycan	640	643	PF01048	0.797
MOD_GlcNHglycan	696	699	PF01048	0.683
MOD_GlcNHglycan	70	73	PF01048	0.768
MOD_GlcNHglycan	706	709	PF01048	0.706
MOD_GlcNHglycan	76	79	PF01048	0.611
MOD_GlcNHglycan	801	804	PF01048	0.756
MOD_GlcNHglycan	845	848	PF01048	0.661
MOD_GlcNHglycan	849	852	PF01048	0.674
MOD_GlcNHglycan	853	856	PF01048	0.492
MOD_GlcNHglycan	867	870	PF01048	0.584
MOD_GlcNHglycan	900	903	PF01048	0.774
MOD_GlcNHglycan	964	967	PF01048	0.577
MOD_GSK3_1	11	18	PF00069	0.740
MOD_GSK3_1	166	173	PF00069	0.767
MOD_GSK3_1	175	182	PF00069	0.683
MOD_GSK3_1	20	27	PF00069	0.628
MOD_GSK3_1	388	395	PF00069	0.762
MOD_GSK3_1	396	403	PF00069	0.603
MOD_GSK3_1	404	411	PF00069	0.735
MOD_GSK3_1	438	445	PF00069	0.715
MOD_GSK3_1	448	455	PF00069	0.699
MOD_GSK3_1	479	486	PF00069	0.705
MOD_GSK3_1	606	613	PF00069	0.659
MOD_GSK3_1	68	75	PF00069	0.796
MOD_GSK3_1	681	688	PF00069	0.666
MOD_GSK3_1	694	701	PF00069	0.815
MOD_GSK3_1	704	711	PF00069	0.723
MOD_GSK3_1	795	802	PF00069	0.709
MOD_GSK3_1	803	810	PF00069	0.705
MOD_GSK3_1	828	835	PF00069	0.770
MOD_GSK3_1	836	843	PF00069	0.587
MOD_GSK3_1	847	854	PF00069	0.570
MOD_GSK3_1	858	865	PF00069	0.752
MOD_GSK3_1	894	901	PF00069	0.697
MOD_LATS_1	362	368	PF00433	0.752
MOD_N-GLC_1	388	393	PF02516	0.721
MOD_N-GLC_1	41	46	PF02516	0.647
MOD_N-GLC_1	604	609	PF02516	0.593
MOD_N-GLC_1	622	627	PF02516	0.542
MOD_N-GLC_1	940	945	PF02516	0.569
MOD_NEK2_1	1	6	PF00069	0.639
MOD_NEK2_1	11	16	PF00069	0.597
MOD_NEK2_1	218	223	PF00069	0.522
MOD_NEK2_1	226	231	PF00069	0.546
MOD_NEK2_1	48	53	PF00069	0.709
MOD_NEK2_1	55	60	PF00069	0.671
MOD_NEK2_1	604	609	PF00069	0.601
MOD_NEK2_1	804	809	PF00069	0.717
MOD_NEK2_2	117	122	PF00069	0.617
MOD_NEK2_2	817	822	PF00069	0.697
MOD_PIKK_1	127	133	PF00454	0.794
MOD_PIKK_1	284	290	PF00454	0.627
MOD_PIKK_1	442	448	PF00454	0.753
MOD_PIKK_1	759	765	PF00454	0.721
MOD_PIKK_1	948	954	PF00454	0.765
MOD_PKA_1	15	21	PF00069	0.658
MOD_PKA_2	15	21	PF00069	0.522
MOD_PKA_2	974	980	PF00069	0.565
MOD_PKB_1	209	217	PF00069	0.512
MOD_PKB_1	270	278	PF00069	0.546
MOD_PKB_1	390	398	PF00069	0.736
MOD_Plk_1	125	131	PF00069	0.719
MOD_Plk_1	218	224	PF00069	0.513
MOD_Plk_1	48	54	PF00069	0.723
MOD_Plk_1	929	935	PF00069	0.665
MOD_Plk_1	940	946	PF00069	0.620
MOD_Plk_2-3	219	225	PF00069	0.502
MOD_Plk_4	100	106	PF00069	0.681
MOD_Plk_4	117	123	PF00069	0.508
MOD_Plk_4	219	225	PF00069	0.502
MOD_Plk_4	272	278	PF00069	0.546
MOD_Plk_4	49	55	PF00069	0.678
MOD_Plk_4	552	558	PF00069	0.456
MOD_Plk_4	738	744	PF00069	0.500
MOD_Plk_4	84	90	PF00069	0.664
MOD_Plk_4	913	919	PF00069	0.718
MOD_Plk_4	940	946	PF00069	0.731
MOD_Plk_4	974	980	PF00069	0.528
MOD_ProDKin_1	175	181	PF00069	0.796
MOD_ProDKin_1	2	8	PF00069	0.685
MOD_ProDKin_1	20	26	PF00069	0.694
MOD_ProDKin_1	448	454	PF00069	0.732
MOD_ProDKin_1	606	612	PF00069	0.745
MOD_ProDKin_1	658	664	PF00069	0.616
MOD_ProDKin_1	682	688	PF00069	0.705
MOD_ProDKin_1	701	707	PF00069	0.765
MOD_ProDKin_1	709	715	PF00069	0.702
MOD_ProDKin_1	723	729	PF00069	0.548
MOD_ProDKin_1	81	87	PF00069	0.694
MOD_ProDKin_1	832	838	PF00069	0.672
MOD_ProDKin_1	841	847	PF00069	0.626
MOD_ProDKin_1	894	900	PF00069	0.764
MOD_SUMO_for_1	243	246	PF00179	0.546
MOD_SUMO_rev_2	103	111	PF00179	0.715
TRG_DiLeu_BaEn_1	219	224	PF01217	0.506
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.792
TRG_DiLeu_BaLyEn_6	959	964	PF01217	0.627
TRG_ENDOCYTIC_2	274	277	PF00928	0.583
TRG_ENDOCYTIC_2	299	302	PF00928	0.499
TRG_ENDOCYTIC_2	595	598	PF00928	0.512
TRG_ENDOCYTIC_2	669	672	PF00928	0.699
TRG_ENDOCYTIC_2	86	89	PF00928	0.693
TRG_ENDOCYTIC_2	976	979	PF00928	0.550
TRG_ER_diArg_1	208	211	PF00400	0.545
TRG_ER_diArg_1	356	359	PF00400	0.727
TRG_ER_diArg_1	531	533	PF00400	0.582
TRG_ER_diArg_1	672	674	PF00400	0.490
TRG_ER_diArg_1	713	716	PF00400	0.685
TRG_ER_diArg_1	717	720	PF00400	0.679
TRG_NES_CRM1_1	548	559	PF08389	0.545
TRG_NLS_Bipartite_1	358	379	PF00514	0.668
TRG_NLS_MonoExtC_3	374	380	PF00514	0.684
TRG_Pf-PMV_PEXEL_1	529	534	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAE1	Leptomonas seymouri	41%	100%
A0A3S7WP43	Leishmania donovani	99%	100%
A4HD48	Leishmania braziliensis	73%	99%
E9AKG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QJE1	Leishmania major	91%	99%