Conserved oligomeric Golgi complex subunit 4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

COG4 transport protein - putative

Species:

Leishmania infantum

UniProt:

A4HSI2_LEIIN

TriTrypDb:

LINF_050011100

Length:

906

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	12
GO:0016020	membrane	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HSI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSI2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.599
CLV_C14_Caspase3-7	433	437	PF00656	0.399
CLV_MEL_PAP_1	816	822	PF00089	0.529
CLV_NRD_NRD_1	256	258	PF00675	0.309
CLV_NRD_NRD_1	26	28	PF00675	0.487
CLV_NRD_NRD_1	325	327	PF00675	0.395
CLV_NRD_NRD_1	370	372	PF00675	0.297
CLV_NRD_NRD_1	394	396	PF00675	0.415
CLV_NRD_NRD_1	654	656	PF00675	0.738
CLV_NRD_NRD_1	805	807	PF00675	0.381
CLV_NRD_NRD_1	816	818	PF00675	0.368
CLV_NRD_NRD_1	88	90	PF00675	0.488
CLV_NRD_NRD_1	896	898	PF00675	0.435
CLV_PCSK_FUR_1	86	90	PF00082	0.574
CLV_PCSK_KEX2_1	25	27	PF00082	0.480
CLV_PCSK_KEX2_1	325	327	PF00082	0.301
CLV_PCSK_KEX2_1	370	372	PF00082	0.297
CLV_PCSK_KEX2_1	402	404	PF00082	0.383
CLV_PCSK_KEX2_1	653	655	PF00082	0.742
CLV_PCSK_KEX2_1	805	807	PF00082	0.371
CLV_PCSK_KEX2_1	818	820	PF00082	0.362
CLV_PCSK_KEX2_1	85	87	PF00082	0.469
CLV_PCSK_KEX2_1	88	90	PF00082	0.474
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.383
CLV_PCSK_PC1ET2_1	818	820	PF00082	0.465
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.568
CLV_PCSK_PC7_1	21	27	PF00082	0.525
CLV_PCSK_SKI1_1	141	145	PF00082	0.498
CLV_PCSK_SKI1_1	327	331	PF00082	0.341
CLV_PCSK_SKI1_1	335	339	PF00082	0.364
CLV_PCSK_SKI1_1	402	406	PF00082	0.390
CLV_PCSK_SKI1_1	678	682	PF00082	0.518
CLV_PCSK_SKI1_1	806	810	PF00082	0.418
CLV_PCSK_SKI1_1	836	840	PF00082	0.374
CLV_PCSK_SKI1_1	851	855	PF00082	0.379
CLV_PCSK_SKI1_1	887	891	PF00082	0.364
DEG_Nend_Nbox_1	1	3	PF02207	0.600
DEG_SPOP_SBC_1	349	353	PF00917	0.335
DEG_SPOP_SBC_1	632	636	PF00917	0.645
DOC_CKS1_1	664	669	PF01111	0.541
DOC_CYCLIN_RxL_1	885	895	PF00134	0.493
DOC_MAPK_gen_1	805	816	PF00069	0.461
DOC_MAPK_gen_1	897	904	PF00069	0.497
DOC_MAPK_HePTP_8	894	906	PF00069	0.522
DOC_MAPK_MEF2A_6	897	906	PF00069	0.524
DOC_PP1_RVXF_1	891	897	PF00149	0.404
DOC_PP2B_LxvP_1	169	172	PF13499	0.535
DOC_PP4_FxxP_1	664	667	PF00568	0.472
DOC_USP7_MATH_1	115	119	PF00917	0.574
DOC_USP7_MATH_1	156	160	PF00917	0.683
DOC_USP7_MATH_1	230	234	PF00917	0.424
DOC_USP7_MATH_1	271	275	PF00917	0.335
DOC_USP7_MATH_1	283	287	PF00917	0.383
DOC_USP7_MATH_1	412	416	PF00917	0.455
DOC_USP7_MATH_1	514	518	PF00917	0.361
DOC_USP7_MATH_1	535	539	PF00917	0.371
DOC_USP7_MATH_1	562	566	PF00917	0.415
DOC_USP7_MATH_1	632	636	PF00917	0.655
DOC_USP7_MATH_1	644	648	PF00917	0.734
DOC_USP7_MATH_1	75	79	PF00917	0.476
DOC_USP7_MATH_1	751	755	PF00917	0.473
DOC_USP7_MATH_1	80	84	PF00917	0.438
DOC_USP7_MATH_1	834	838	PF00917	0.474
DOC_WW_Pin1_4	144	149	PF00397	0.578
DOC_WW_Pin1_4	663	668	PF00397	0.559
DOC_WW_Pin1_4	698	703	PF00397	0.565
DOC_WW_Pin1_4	845	850	PF00397	0.496
LIG_14-3-3_CanoR_1	141	151	PF00244	0.518
LIG_14-3-3_CanoR_1	193	197	PF00244	0.369
LIG_14-3-3_CanoR_1	310	318	PF00244	0.347
LIG_14-3-3_CanoR_1	348	354	PF00244	0.366
LIG_14-3-3_CanoR_1	395	404	PF00244	0.444
LIG_14-3-3_CanoR_1	440	447	PF00244	0.415
LIG_14-3-3_CanoR_1	678	683	PF00244	0.477
LIG_14-3-3_CanoR_1	817	823	PF00244	0.440
LIG_14-3-3_CanoR_1	833	839	PF00244	0.299
LIG_14-3-3_CanoR_1	96	104	PF00244	0.563
LIG_APCC_ABBA_1	743	748	PF00400	0.484
LIG_APCC_ABBAyCdc20_2	35	41	PF00400	0.612
LIG_BH_BH3_1	675	691	PF00452	0.503
LIG_EH1_1	853	861	PF00400	0.473
LIG_FHA_1	218	224	PF00498	0.311
LIG_FHA_1	860	866	PF00498	0.380
LIG_FHA_1	868	874	PF00498	0.483
LIG_FHA_1	98	104	PF00498	0.516
LIG_FHA_2	389	395	PF00498	0.490
LIG_FHA_2	396	402	PF00498	0.415
LIG_FHA_2	579	585	PF00498	0.313
LIG_FHA_2	664	670	PF00498	0.535
LIG_FHA_2	699	705	PF00498	0.550
LIG_FHA_2	719	725	PF00498	0.384
LIG_FHA_2	880	886	PF00498	0.427
LIG_FHA_2	890	896	PF00498	0.336
LIG_GBD_Chelix_1	248	256	PF00786	0.433
LIG_GBD_Chelix_1	807	815	PF00786	0.328
LIG_HP1_1	300	304	PF01393	0.240
LIG_LIR_Gen_1	289	300	PF02991	0.351
LIG_LIR_Gen_1	732	742	PF02991	0.407
LIG_LIR_Gen_1	748	757	PF02991	0.316
LIG_LIR_Gen_1	852	861	PF02991	0.374
LIG_LIR_Nem_3	289	295	PF02991	0.430
LIG_LIR_Nem_3	462	467	PF02991	0.368
LIG_LIR_Nem_3	570	574	PF02991	0.384
LIG_LIR_Nem_3	584	590	PF02991	0.237
LIG_LIR_Nem_3	706	711	PF02991	0.528
LIG_LIR_Nem_3	732	737	PF02991	0.400
LIG_LIR_Nem_3	748	753	PF02991	0.318
LIG_LIR_Nem_3	759	765	PF02991	0.363
LIG_LIR_Nem_3	821	826	PF02991	0.354
LIG_LIR_Nem_3	852	857	PF02991	0.364
LIG_LRP6_Inhibitor_1	29	35	PF00058	0.513
LIG_NRBOX	89	95	PF00104	0.441
LIG_PCNA_PIPBox_1	525	534	PF02747	0.313
LIG_PCNA_yPIPBox_3	190	204	PF02747	0.477
LIG_PDZ_Class_2	901	906	PF00595	0.382
LIG_Pex14_1	730	734	PF04695	0.378
LIG_PTB_Apo_2	50	57	PF02174	0.563
LIG_PTB_Phospho_1	50	56	PF10480	0.563
LIG_REV1ctd_RIR_1	585	595	PF16727	0.333
LIG_REV1ctd_RIR_1	836	846	PF16727	0.368
LIG_RPA_C_Fungi	188	200	PF08784	0.290
LIG_RPA_C_Fungi	229	241	PF08784	0.272
LIG_SH2_NCK_1	136	140	PF00017	0.431
LIG_SH2_PTP2	457	460	PF00017	0.433
LIG_SH2_STAP1	236	240	PF00017	0.389
LIG_SH2_STAP1	400	404	PF00017	0.433
LIG_SH2_STAP1	469	473	PF00017	0.415
LIG_SH2_STAT3	785	788	PF00017	0.509
LIG_SH2_STAT5	389	392	PF00017	0.365
LIG_SH2_STAT5	457	460	PF00017	0.338
LIG_SH2_STAT5	464	467	PF00017	0.288
LIG_SH2_STAT5	573	576	PF00017	0.411
LIG_SH2_STAT5	62	65	PF00017	0.573
LIG_SH2_STAT5	682	685	PF00017	0.445
LIG_SH2_STAT5	785	788	PF00017	0.456
LIG_SH3_3	453	459	PF00018	0.320
LIG_SH3_3	513	519	PF00018	0.336
LIG_SH3_3	577	583	PF00018	0.399
LIG_SH3_3	739	745	PF00018	0.411
LIG_Sin3_3	796	803	PF02671	0.382
LIG_SUMO_SIM_anti_2	212	218	PF11976	0.333
LIG_SUMO_SIM_anti_2	268	274	PF11976	0.319
LIG_SUMO_SIM_anti_2	855	862	PF11976	0.430
LIG_SUMO_SIM_par_1	150	155	PF11976	0.476
LIG_SUMO_SIM_par_1	861	867	PF11976	0.351
LIG_TRAF2_1	286	289	PF00917	0.418
LIG_TRAF2_1	564	567	PF00917	0.383
LIG_TRAF2_1	721	724	PF00917	0.319
LIG_TRAF2_1	872	875	PF00917	0.555
LIG_TRFH_1	56	60	PF08558	0.574
LIG_TYR_ITSM	460	467	PF00017	0.351
LIG_UBA3_1	822	830	PF00899	0.460
LIG_UBA3_1	859	868	PF00899	0.442
LIG_WRC_WIRS_1	389	394	PF05994	0.357
LIG_WRC_WIRS_1	568	573	PF05994	0.351
LIG_WRC_WIRS_1	835	840	PF05994	0.403
MOD_CDK_SPxK_1	845	851	PF00069	0.497
MOD_CK1_1	147	153	PF00069	0.625
MOD_CK1_1	170	176	PF00069	0.629
MOD_CK1_1	309	315	PF00069	0.313
MOD_CK1_1	344	350	PF00069	0.361
MOD_CK1_1	517	523	PF00069	0.356
MOD_CK1_1	645	651	PF00069	0.735
MOD_CK2_1	283	289	PF00069	0.418
MOD_CK2_1	388	394	PF00069	0.460
MOD_CK2_1	395	401	PF00069	0.366
MOD_CK2_1	412	418	PF00069	0.340
MOD_CK2_1	44	50	PF00069	0.577
MOD_CK2_1	535	541	PF00069	0.364
MOD_CK2_1	663	669	PF00069	0.554
MOD_CK2_1	718	724	PF00069	0.406
MOD_CK2_1	75	81	PF00069	0.477
MOD_CK2_1	879	885	PF00069	0.448
MOD_CK2_1	889	895	PF00069	0.391
MOD_Cter_Amidation	651	654	PF01082	0.717
MOD_GlcNHglycan	122	125	PF01048	0.497
MOD_GlcNHglycan	144	147	PF01048	0.544
MOD_GlcNHglycan	169	172	PF01048	0.698
MOD_GlcNHglycan	173	176	PF01048	0.596
MOD_GlcNHglycan	260	264	PF01048	0.468
MOD_GlcNHglycan	367	370	PF01048	0.449
MOD_GlcNHglycan	406	409	PF01048	0.403
MOD_GlcNHglycan	414	417	PF01048	0.388
MOD_GlcNHglycan	516	519	PF01048	0.319
MOD_GlcNHglycan	525	528	PF01048	0.313
MOD_GlcNHglycan	537	540	PF01048	0.244
MOD_GlcNHglycan	551	554	PF01048	0.418
MOD_GlcNHglycan	560	563	PF01048	0.380
MOD_GlcNHglycan	601	604	PF01048	0.315
MOD_GlcNHglycan	606	609	PF01048	0.280
MOD_GlcNHglycan	611	614	PF01048	0.273
MOD_GlcNHglycan	647	650	PF01048	0.738
MOD_GlcNHglycan	65	68	PF01048	0.449
MOD_GlcNHglycan	698	701	PF01048	0.503
MOD_GSK3_1	116	123	PF00069	0.573
MOD_GSK3_1	156	163	PF00069	0.711
MOD_GSK3_1	167	174	PF00069	0.645
MOD_GSK3_1	230	237	PF00069	0.438
MOD_GSK3_1	261	268	PF00069	0.351
MOD_GSK3_1	344	351	PF00069	0.359
MOD_GSK3_1	377	384	PF00069	0.297
MOD_GSK3_1	39	46	PF00069	0.445
MOD_GSK3_1	459	466	PF00069	0.418
MOD_GSK3_1	499	506	PF00069	0.376
MOD_GSK3_1	523	530	PF00069	0.314
MOD_GSK3_1	558	565	PF00069	0.485
MOD_GSK3_1	694	701	PF00069	0.555
MOD_GSK3_1	714	721	PF00069	0.456
MOD_GSK3_1	855	862	PF00069	0.400
MOD_GSK3_1	863	870	PF00069	0.460
MOD_N-GLC_1	645	650	PF02516	0.718
MOD_N-GLC_1	75	80	PF02516	0.577
MOD_NEK2_1	217	222	PF00069	0.349
MOD_NEK2_1	259	264	PF00069	0.415
MOD_NEK2_1	404	409	PF00069	0.347
MOD_NEK2_1	44	49	PF00069	0.580
MOD_NEK2_1	446	451	PF00069	0.313
MOD_NEK2_1	460	465	PF00069	0.313
MOD_NEK2_1	542	547	PF00069	0.361
MOD_NEK2_1	670	675	PF00069	0.357
MOD_NEK2_1	69	74	PF00069	0.482
MOD_NEK2_1	718	723	PF00069	0.450
MOD_NEK2_1	859	864	PF00069	0.393
MOD_NEK2_2	527	532	PF00069	0.385
MOD_NEK2_2	834	839	PF00069	0.477
MOD_PIKK_1	271	277	PF00454	0.433
MOD_PKA_1	395	401	PF00069	0.433
MOD_PKA_1	818	824	PF00069	0.424
MOD_PKA_2	192	198	PF00069	0.347
MOD_PKA_2	309	315	PF00069	0.339
MOD_PKA_2	34	40	PF00069	0.610
MOD_PKA_2	347	353	PF00069	0.395
MOD_PKA_2	439	445	PF00069	0.415
MOD_PKA_2	81	87	PF00069	0.461
MOD_PKA_2	818	824	PF00069	0.427
MOD_Plk_1	241	247	PF00069	0.297
MOD_Plk_1	288	294	PF00069	0.351
MOD_Plk_1	377	383	PF00069	0.299
MOD_Plk_1	418	424	PF00069	0.320
MOD_Plk_1	694	700	PF00069	0.558
MOD_Plk_1	703	709	PF00069	0.505
MOD_Plk_1	75	81	PF00069	0.578
MOD_Plk_2-3	288	294	PF00069	0.351
MOD_Plk_4	116	122	PF00069	0.521
MOD_Plk_4	147	153	PF00069	0.522
MOD_Plk_4	388	394	PF00069	0.397
MOD_Plk_4	460	466	PF00069	0.320
MOD_Plk_4	520	526	PF00069	0.333
MOD_Plk_4	527	533	PF00069	0.333
MOD_Plk_4	567	573	PF00069	0.415
MOD_Plk_4	626	632	PF00069	0.536
MOD_Plk_4	678	684	PF00069	0.509
MOD_Plk_4	738	744	PF00069	0.465
MOD_Plk_4	810	816	PF00069	0.372
MOD_Plk_4	818	824	PF00069	0.344
MOD_Plk_4	855	861	PF00069	0.382
MOD_ProDKin_1	144	150	PF00069	0.583
MOD_ProDKin_1	663	669	PF00069	0.554
MOD_ProDKin_1	698	704	PF00069	0.558
MOD_ProDKin_1	845	851	PF00069	0.497
MOD_SUMO_for_1	757	760	PF00179	0.491
MOD_SUMO_rev_2	884	889	PF00179	0.514
TRG_DiLeu_BaEn_3	377	383	PF01217	0.415
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.437
TRG_DiLeu_BaLyEn_6	617	622	PF01217	0.433
TRG_ENDOCYTIC_2	292	295	PF00928	0.351
TRG_ENDOCYTIC_2	389	392	PF00928	0.299
TRG_ENDOCYTIC_2	457	460	PF00928	0.401
TRG_ENDOCYTIC_2	464	467	PF00928	0.409
TRG_ENDOCYTIC_2	56	59	PF00928	0.574
TRG_ER_diArg_1	24	27	PF00400	0.496
TRG_ER_diArg_1	653	655	PF00400	0.734
TRG_ER_diArg_1	805	807	PF00400	0.381
TRG_ER_diArg_1	816	819	PF00400	0.441
TRG_ER_diArg_1	86	89	PF00400	0.477
TRG_NLS_Bipartite_1	805	821	PF00514	0.485
TRG_NLS_MonoExtC_3	84	89	PF00514	0.568
TRG_NLS_MonoExtN_4	82	89	PF00514	0.567
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	478	482	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	620	624	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	720	724	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU85	Leptomonas seymouri	66%	98%
A0A0S4IPR3	Bodo saltans	29%	100%
A0A1X0NK43	Trypanosomatidae	37%	94%
A0A3R7LU72	Trypanosoma rangeli	37%	100%
A0A3S7WP44	Leishmania donovani	100%	100%
A4HD49	Leishmania braziliensis	81%	98%
C9ZUC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	89%
E9AKG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QJE2	Leishmania major	94%	100%
V5BAR5	Trypanosoma cruzi	35%	99%