LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HSI0_LEIIN
TriTrypDb:
LINF_050010900
Length:
779

Annotations

LeishMANIAdb annotations

This Kinetoplastid-unique protein has a 4TM central helical bundle and long cytoplasmic termini with strikingly low complexity. Its function is unknown.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 4
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0000123 histone acetyltransferase complex 4 1
GO:0000124 SAGA complex 4 1
GO:0005815 microtubule organizing center 2 1
GO:0016020 membrane 2 5
GO:0031248 protein acetyltransferase complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0036064 ciliary basal body 3 1
GO:0070461 SAGA-type complex 5 1
GO:0110165 cellular anatomical entity 1 5
GO:0140535 intracellular protein-containing complex 2 1
GO:1902493 acetyltransferase complex 4 1
GO:1902494 catalytic complex 2 1
GO:1905368 peptidase complex 3 1
GO:1990234 transferase complex 3 1

Phosphorylation

Amastigote: 11, 663
Promastigote: 757
Promastigote/Amastigote: 330, 659, 748

Expansion

Sequence features

A4HSI0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSI0

Function

Biological processes
Term Name Level Count
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0006357 regulation of transcription by RNA polymerase II 7 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0003712 transcription coregulator activity 2 4
GO:0003713 transcription coactivator activity 3 4
GO:0140110 transcription regulator activity 1 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 190 194 PF00656 0.308
CLV_C14_Caspase3-7 757 761 PF00656 0.732
CLV_NRD_NRD_1 134 136 PF00675 0.503
CLV_NRD_NRD_1 260 262 PF00675 0.631
CLV_NRD_NRD_1 315 317 PF00675 0.412
CLV_NRD_NRD_1 448 450 PF00675 0.542
CLV_NRD_NRD_1 641 643 PF00675 0.531
CLV_NRD_NRD_1 649 651 PF00675 0.523
CLV_NRD_NRD_1 681 683 PF00675 0.550
CLV_NRD_NRD_1 728 730 PF00675 0.545
CLV_NRD_NRD_1 731 733 PF00675 0.517
CLV_PCSK_FUR_1 679 683 PF00082 0.545
CLV_PCSK_FUR_1 729 733 PF00082 0.526
CLV_PCSK_KEX2_1 134 136 PF00082 0.503
CLV_PCSK_KEX2_1 259 261 PF00082 0.595
CLV_PCSK_KEX2_1 315 317 PF00082 0.412
CLV_PCSK_KEX2_1 491 493 PF00082 0.410
CLV_PCSK_KEX2_1 523 525 PF00082 0.374
CLV_PCSK_KEX2_1 639 641 PF00082 0.539
CLV_PCSK_KEX2_1 649 651 PF00082 0.517
CLV_PCSK_KEX2_1 681 683 PF00082 0.545
CLV_PCSK_KEX2_1 727 729 PF00082 0.528
CLV_PCSK_KEX2_1 731 733 PF00082 0.525
CLV_PCSK_PC1ET2_1 491 493 PF00082 0.410
CLV_PCSK_PC1ET2_1 523 525 PF00082 0.374
CLV_PCSK_PC1ET2_1 639 641 PF00082 0.579
CLV_PCSK_PC7_1 487 493 PF00082 0.392
CLV_PCSK_PC7_1 636 642 PF00082 0.576
CLV_PCSK_PC7_1 677 683 PF00082 0.568
CLV_PCSK_PC7_1 727 733 PF00082 0.528
CLV_PCSK_SKI1_1 260 264 PF00082 0.608
CLV_PCSK_SKI1_1 498 502 PF00082 0.415
CLV_PCSK_SKI1_1 540 544 PF00082 0.401
CLV_PCSK_SKI1_1 697 701 PF00082 0.520
DEG_APCC_DBOX_1 290 298 PF00400 0.294
DEG_APCC_KENBOX_2 671 675 PF00400 0.756
DEG_Nend_UBRbox_2 1 3 PF02207 0.771
DOC_AGCK_PIF_1 425 430 PF00069 0.383
DOC_CKS1_1 395 400 PF01111 0.585
DOC_CKS1_1 99 104 PF01111 0.684
DOC_CYCLIN_RxL_1 255 265 PF00134 0.407
DOC_CYCLIN_yCln2_LP_2 479 485 PF00134 0.394
DOC_MAPK_gen_1 449 457 PF00069 0.344
DOC_PP1_RVXF_1 388 395 PF00149 0.663
DOC_PP1_RVXF_1 521 528 PF00149 0.586
DOC_PP2B_LxvP_1 479 482 PF13499 0.394
DOC_PP2B_PxIxI_1 206 212 PF00149 0.434
DOC_PP4_FxxP_1 331 334 PF00568 0.664
DOC_PP4_MxPP_1 574 577 PF00568 0.626
DOC_USP7_MATH_1 239 243 PF00917 0.458
DOC_USP7_MATH_1 326 330 PF00917 0.700
DOC_USP7_MATH_1 617 621 PF00917 0.730
DOC_WW_Pin1_4 129 134 PF00397 0.720
DOC_WW_Pin1_4 32 37 PF00397 0.735
DOC_WW_Pin1_4 334 339 PF00397 0.618
DOC_WW_Pin1_4 345 350 PF00397 0.599
DOC_WW_Pin1_4 39 44 PF00397 0.712
DOC_WW_Pin1_4 394 399 PF00397 0.574
DOC_WW_Pin1_4 586 591 PF00397 0.690
DOC_WW_Pin1_4 6 11 PF00397 0.755
DOC_WW_Pin1_4 612 617 PF00397 0.809
DOC_WW_Pin1_4 621 626 PF00397 0.863
DOC_WW_Pin1_4 85 90 PF00397 0.649
DOC_WW_Pin1_4 98 103 PF00397 0.637
LIG_14-3-3_CanoR_1 25 34 PF00244 0.726
LIG_14-3-3_CanoR_1 315 323 PF00244 0.591
LIG_14-3-3_CanoR_1 327 332 PF00244 0.720
LIG_14-3-3_CanoR_1 487 491 PF00244 0.585
LIG_AP2alpha_2 127 129 PF02296 0.652
LIG_BRCT_BRCA1_1 371 375 PF00533 0.663
LIG_deltaCOP1_diTrp_1 151 155 PF00928 0.329
LIG_FHA_1 151 157 PF00498 0.329
LIG_FHA_1 206 212 PF00498 0.447
LIG_FHA_1 225 231 PF00498 0.407
LIG_FHA_1 277 283 PF00498 0.348
LIG_FHA_1 291 297 PF00498 0.294
LIG_FHA_1 40 46 PF00498 0.812
LIG_FHA_1 416 422 PF00498 0.392
LIG_FHA_1 435 441 PF00498 0.253
LIG_FHA_1 452 458 PF00498 0.232
LIG_FHA_2 188 194 PF00498 0.431
LIG_FHA_2 238 244 PF00498 0.472
LIG_FHA_2 534 540 PF00498 0.589
LIG_LIR_Apic_2 329 334 PF02991 0.667
LIG_LIR_Apic_2 393 398 PF02991 0.591
LIG_LIR_Gen_1 151 160 PF02991 0.404
LIG_LIR_Gen_1 178 189 PF02991 0.399
LIG_LIR_Gen_1 302 311 PF02991 0.375
LIG_LIR_Gen_1 342 349 PF02991 0.597
LIG_LIR_Gen_1 397 408 PF02991 0.583
LIG_LIR_Gen_1 427 433 PF02991 0.375
LIG_LIR_Gen_1 513 522 PF02991 0.593
LIG_LIR_LC3C_4 472 475 PF02991 0.295
LIG_LIR_LC3C_4 748 752 PF02991 0.712
LIG_LIR_Nem_3 144 150 PF02991 0.630
LIG_LIR_Nem_3 151 155 PF02991 0.384
LIG_LIR_Nem_3 178 184 PF02991 0.347
LIG_LIR_Nem_3 265 269 PF02991 0.428
LIG_LIR_Nem_3 302 306 PF02991 0.325
LIG_LIR_Nem_3 396 402 PF02991 0.599
LIG_LIR_Nem_3 424 428 PF02991 0.384
LIG_LIR_Nem_3 429 433 PF02991 0.328
LIG_LIR_Nem_3 513 519 PF02991 0.587
LIG_MYND_1 249 253 PF01753 0.415
LIG_MYND_1 499 503 PF01753 0.629
LIG_Pex14_1 143 147 PF04695 0.646
LIG_Pex14_1 426 430 PF04695 0.354
LIG_Pex14_2 150 154 PF04695 0.494
LIG_Pex14_2 355 359 PF04695 0.621
LIG_Pex14_2 405 409 PF04695 0.466
LIG_Pex14_2 422 426 PF04695 0.262
LIG_Pex14_2 515 519 PF04695 0.594
LIG_SH2_CRK 301 305 PF00017 0.329
LIG_SH2_CRK 308 312 PF00017 0.329
LIG_SH2_GRB2like 276 279 PF00017 0.355
LIG_SH2_NCK_1 395 399 PF00017 0.590
LIG_SH2_STAP1 235 239 PF00017 0.436
LIG_SH2_STAP1 276 280 PF00017 0.349
LIG_SH2_STAP1 308 312 PF00017 0.309
LIG_SH2_STAP1 447 451 PF00017 0.325
LIG_SH2_STAT3 100 103 PF00017 0.681
LIG_SH2_STAT3 15 18 PF00017 0.760
LIG_SH2_STAT5 100 103 PF00017 0.681
LIG_SH2_STAT5 149 152 PF00017 0.609
LIG_SH2_STAT5 199 202 PF00017 0.337
LIG_SH2_STAT5 430 433 PF00017 0.337
LIG_SH2_STAT5 447 450 PF00017 0.310
LIG_SH2_STAT5 509 512 PF00017 0.585
LIG_SH3_3 119 125 PF00018 0.639
LIG_SH3_3 130 136 PF00018 0.668
LIG_SH3_3 496 502 PF00018 0.620
LIG_SH3_3 584 590 PF00018 0.702
LIG_SH3_3 701 707 PF00018 0.722
LIG_SH3_3 749 755 PF00018 0.760
LIG_SUMO_SIM_anti_2 302 308 PF11976 0.329
LIG_SUMO_SIM_anti_2 454 459 PF11976 0.341
LIG_SUMO_SIM_anti_2 472 478 PF11976 0.226
LIG_SUMO_SIM_par_1 169 174 PF11976 0.489
LIG_SUMO_SIM_par_1 207 212 PF11976 0.418
LIG_TYR_ITIM 306 311 PF00017 0.329
LIG_WRC_WIRS_1 263 268 PF05994 0.419
LIG_WRC_WIRS_1 300 305 PF05994 0.297
LIG_WRC_WIRS_1 412 417 PF05994 0.371
LIG_WRC_WIRS_1 422 427 PF05994 0.300
MOD_CDK_SPK_2 129 134 PF00069 0.720
MOD_CDK_SPxK_1 129 135 PF00069 0.718
MOD_CK1_1 242 248 PF00069 0.453
MOD_CK1_1 302 308 PF00069 0.497
MOD_CK1_1 319 325 PF00069 0.698
MOD_CK1_1 35 41 PF00069 0.754
MOD_CK1_1 4 10 PF00069 0.811
MOD_CK1_1 410 416 PF00069 0.329
MOD_CK1_1 424 430 PF00069 0.386
MOD_CK1_1 586 592 PF00069 0.674
MOD_CK1_1 71 77 PF00069 0.704
MOD_CK1_1 85 91 PF00069 0.622
MOD_CK1_1 98 104 PF00069 0.617
MOD_CK2_1 237 243 PF00069 0.445
MOD_CK2_1 262 268 PF00069 0.428
MOD_CK2_1 533 539 PF00069 0.599
MOD_GlcNHglycan 10 13 PF01048 0.622
MOD_GlcNHglycan 214 217 PF01048 0.601
MOD_GlcNHglycan 37 40 PF01048 0.591
MOD_GlcNHglycan 371 374 PF01048 0.560
MOD_GlcNHglycan 409 412 PF01048 0.329
MOD_GlcNHglycan 60 63 PF01048 0.571
MOD_GlcNHglycan 609 613 PF01048 0.521
MOD_GlcNHglycan 66 69 PF01048 0.584
MOD_GlcNHglycan 663 666 PF01048 0.539
MOD_GlcNHglycan 71 74 PF01048 0.472
MOD_GlcNHglycan 745 750 PF01048 0.525
MOD_GlcNHglycan 84 87 PF01048 0.448
MOD_GSK3_1 110 117 PF00069 0.676
MOD_GSK3_1 212 219 PF00069 0.432
MOD_GSK3_1 237 244 PF00069 0.469
MOD_GSK3_1 35 42 PF00069 0.824
MOD_GSK3_1 4 11 PF00069 0.783
MOD_GSK3_1 407 414 PF00069 0.328
MOD_GSK3_1 608 615 PF00069 0.804
MOD_GSK3_1 617 624 PF00069 0.669
MOD_GSK3_1 64 71 PF00069 0.733
MOD_GSK3_1 656 663 PF00069 0.794
MOD_GSK3_1 681 688 PF00069 0.781
MOD_GSK3_1 689 696 PF00069 0.704
MOD_GSK3_1 730 737 PF00069 0.740
MOD_LATS_1 685 691 PF00433 0.771
MOD_LATS_1 730 736 PF00433 0.728
MOD_N-GLC_1 187 192 PF02516 0.680
MOD_N-GLC_1 25 30 PF02516 0.523
MOD_N-GLC_1 255 260 PF02516 0.545
MOD_N-GLC_1 673 678 PF02516 0.557
MOD_N-GLC_2 76 78 PF02516 0.505
MOD_NEK2_1 1 6 PF00069 0.760
MOD_NEK2_1 150 155 PF00069 0.494
MOD_NEK2_1 262 267 PF00069 0.417
MOD_NEK2_1 299 304 PF00069 0.329
MOD_NEK2_1 415 420 PF00069 0.329
MOD_NEK2_1 421 426 PF00069 0.329
MOD_NEK2_1 451 456 PF00069 0.361
MOD_NEK2_1 525 530 PF00069 0.592
MOD_NEK2_1 570 575 PF00069 0.660
MOD_NEK2_1 608 613 PF00069 0.837
MOD_NEK2_1 64 69 PF00069 0.696
MOD_NEK2_1 660 665 PF00069 0.747
MOD_NEK2_2 142 147 PF00069 0.603
MOD_NEK2_2 442 447 PF00069 0.294
MOD_PIKK_1 101 107 PF00454 0.680
MOD_PIKK_1 110 116 PF00454 0.624
MOD_PIKK_1 25 31 PF00454 0.725
MOD_PIKK_1 374 380 PF00454 0.681
MOD_PIKK_1 501 507 PF00454 0.585
MOD_PIKK_1 555 561 PF00454 0.648
MOD_PIKK_1 600 606 PF00454 0.741
MOD_PIKK_1 702 708 PF00454 0.726
MOD_PKA_1 681 687 PF00069 0.770
MOD_PKA_2 290 296 PF00069 0.294
MOD_PKA_2 326 332 PF00069 0.749
MOD_PKA_2 433 439 PF00069 0.387
MOD_PKA_2 486 492 PF00069 0.590
MOD_PKA_2 681 687 PF00069 0.770
MOD_PKA_2 730 736 PF00069 0.741
MOD_PKA_2 755 761 PF00069 0.727
MOD_PKB_1 640 648 PF00069 0.728
MOD_PKB_1 679 687 PF00069 0.754
MOD_PKB_1 691 699 PF00069 0.689
MOD_Plk_1 1 7 PF00069 0.759
MOD_Plk_1 114 120 PF00069 0.671
MOD_Plk_1 150 156 PF00069 0.529
MOD_Plk_1 187 193 PF00069 0.455
MOD_Plk_1 242 248 PF00069 0.568
MOD_Plk_1 451 457 PF00069 0.380
MOD_Plk_2-3 547 553 PF00069 0.673
MOD_Plk_4 142 148 PF00069 0.606
MOD_Plk_4 161 167 PF00069 0.368
MOD_Plk_4 205 211 PF00069 0.400
MOD_Plk_4 282 288 PF00069 0.368
MOD_Plk_4 290 296 PF00069 0.263
MOD_Plk_4 299 305 PF00069 0.274
MOD_Plk_4 327 333 PF00069 0.671
MOD_Plk_4 451 457 PF00069 0.319
MOD_Plk_4 570 576 PF00069 0.615
MOD_Plk_4 583 589 PF00069 0.680
MOD_Plk_4 617 623 PF00069 0.695
MOD_Plk_4 95 101 PF00069 0.680
MOD_ProDKin_1 129 135 PF00069 0.718
MOD_ProDKin_1 32 38 PF00069 0.734
MOD_ProDKin_1 334 340 PF00069 0.614
MOD_ProDKin_1 345 351 PF00069 0.596
MOD_ProDKin_1 39 45 PF00069 0.712
MOD_ProDKin_1 394 400 PF00069 0.570
MOD_ProDKin_1 586 592 PF00069 0.693
MOD_ProDKin_1 6 12 PF00069 0.755
MOD_ProDKin_1 612 618 PF00069 0.809
MOD_ProDKin_1 621 627 PF00069 0.863
MOD_ProDKin_1 85 91 PF00069 0.645
MOD_ProDKin_1 98 104 PF00069 0.637
MOD_SUMO_rev_2 518 525 PF00179 0.595
TRG_DiLeu_BaEn_1 472 477 PF01217 0.394
TRG_ENDOCYTIC_2 147 150 PF00928 0.615
TRG_ENDOCYTIC_2 301 304 PF00928 0.329
TRG_ENDOCYTIC_2 308 311 PF00928 0.329
TRG_ENDOCYTIC_2 400 403 PF00928 0.560
TRG_ENDOCYTIC_2 430 433 PF00928 0.347
TRG_ER_diArg_1 133 135 PF00400 0.715
TRG_ER_diArg_1 259 261 PF00400 0.395
TRG_ER_diArg_1 314 316 PF00400 0.608
TRG_ER_diArg_1 640 642 PF00400 0.733
TRG_ER_diArg_1 679 682 PF00400 0.745
TRG_ER_diArg_1 727 729 PF00400 0.727
TRG_NLS_MonoCore_2 638 643 PF00514 0.777
TRG_NLS_MonoExtN_4 636 643 PF00514 0.776

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I288 Leptomonas seymouri 50% 90%
A0A3S7WP32 Leishmania donovani 100% 100%
A4H4A9 Leishmania braziliensis 67% 98%
E9AKG4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4QJE4 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS