Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HSG9_LEIIN

TriTrypDb:

LINF_050009700

Length:

242

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HSG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSG9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.444
CLV_NRD_NRD_1	188	190	PF00675	0.525
CLV_NRD_NRD_1	191	193	PF00675	0.492
CLV_NRD_NRD_1	210	212	PF00675	0.605
CLV_NRD_NRD_1	223	225	PF00675	0.489
CLV_NRD_NRD_1	229	231	PF00675	0.506
CLV_NRD_NRD_1	92	94	PF00675	0.518
CLV_PCSK_FUR_1	189	193	PF00082	0.466
CLV_PCSK_FUR_1	227	231	PF00082	0.501
CLV_PCSK_KEX2_1	142	144	PF00082	0.725
CLV_PCSK_KEX2_1	188	190	PF00082	0.534
CLV_PCSK_KEX2_1	191	193	PF00082	0.507
CLV_PCSK_KEX2_1	210	212	PF00082	0.602
CLV_PCSK_KEX2_1	229	231	PF00082	0.506
CLV_PCSK_KEX2_1	92	94	PF00082	0.518
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.725
CLV_PCSK_SKI1_1	150	154	PF00082	0.735
CLV_PCSK_SKI1_1	191	195	PF00082	0.485
CLV_Separin_Metazoa	214	218	PF03568	0.539
DEG_APCC_DBOX_1	190	198	PF00400	0.470
DOC_CKS1_1	151	156	PF01111	0.608
DOC_CYCLIN_RxL_1	188	200	PF00134	0.490
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	124	130	PF00134	0.598
DOC_MAPK_gen_1	188	196	PF00069	0.541
DOC_PP1_RVXF_1	190	197	PF00149	0.492
DOC_PP2B_LxvP_1	102	105	PF13499	0.625
DOC_USP7_MATH_1	112	116	PF00917	0.600
DOC_USP7_MATH_1	129	133	PF00917	0.668
DOC_USP7_MATH_1	141	145	PF00917	0.620
DOC_WW_Pin1_4	119	124	PF00397	0.607
DOC_WW_Pin1_4	135	140	PF00397	0.508
DOC_WW_Pin1_4	150	155	PF00397	0.616
LIG_14-3-3_CanoR_1	107	114	PF00244	0.532
LIG_14-3-3_CanoR_1	143	152	PF00244	0.726
LIG_14-3-3_CanoR_1	92	101	PF00244	0.548
LIG_BRCT_BRCA1_1	40	44	PF00533	0.558
LIG_FHA_1	76	82	PF00498	0.614
LIG_FHA_2	159	165	PF00498	0.668
LIG_FHA_2	180	186	PF00498	0.466
LIG_GBD_Chelix_1	13	21	PF00786	0.444
LIG_MYND_1	123	127	PF01753	0.561
LIG_MYND_1	135	139	PF01753	0.549
LIG_SH2_CRK	31	35	PF00017	0.499
LIG_SH2_GRB2like	204	207	PF00017	0.445
LIG_SH2_STAP1	31	35	PF00017	0.499
LIG_SH2_STAT5	204	207	PF00017	0.445
LIG_SH3_3	130	136	PF00018	0.665
LIG_SH3_3	148	154	PF00018	0.601
LIG_SH3_3	173	179	PF00018	0.643
LIG_SH3_3	66	72	PF00018	0.576
LIG_SH3_3	84	90	PF00018	0.520
LIG_SH3_3	98	104	PF00018	0.591
MOD_CDK_SPK_2	150	155	PF00069	0.644
MOD_CDK_SPxxK_3	135	142	PF00069	0.545
MOD_CK1_1	115	121	PF00069	0.576
MOD_CK1_1	144	150	PF00069	0.671
MOD_CK1_1	3	9	PF00069	0.573
MOD_CK2_1	179	185	PF00069	0.478
MOD_CK2_1	52	58	PF00069	0.531
MOD_GlcNHglycan	108	111	PF01048	0.643
MOD_GlcNHglycan	143	146	PF01048	0.729
MOD_GlcNHglycan	54	57	PF01048	0.571
MOD_GlcNHglycan	84	87	PF01048	0.547
MOD_GSK3_1	112	119	PF00069	0.564
MOD_N-GLC_1	3	8	PF02516	0.577
MOD_NEK2_1	106	111	PF00069	0.599
MOD_NEK2_1	128	133	PF00069	0.622
MOD_NEK2_1	234	239	PF00069	0.482
MOD_NEK2_2	158	163	PF00069	0.555
MOD_PKA_1	92	98	PF00069	0.512
MOD_PKA_2	106	112	PF00069	0.552
MOD_PKA_2	92	98	PF00069	0.535
MOD_Plk_1	3	9	PF00069	0.573
MOD_Plk_4	49	55	PF00069	0.570
MOD_ProDKin_1	119	125	PF00069	0.609
MOD_ProDKin_1	135	141	PF00069	0.506
MOD_ProDKin_1	150	156	PF00069	0.616
MOD_SUMO_for_1	70	73	PF00179	0.577
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.531
TRG_ENDOCYTIC_2	31	34	PF00928	0.497
TRG_ER_diArg_1	188	191	PF00400	0.494
TRG_ER_diArg_1	227	230	PF00400	0.509
TRG_ER_diArg_1	91	93	PF00400	0.680
TRG_NLS_Bipartite_1	210	228	PF00514	0.499
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZW8	Leptomonas seymouri	34%	100%
A0A3S5H5I0	Leishmania donovani	100%	100%
A4H493	Leishmania braziliensis	61%	82%
E9AKF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QJF5	Leishmania major	90%	100%