Nucleolar GTP-binding protein 2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTPase - putative

Species:

Leishmania infantum

UniProt:

A4HSG8_LEIIN

TriTrypDb:

LINF_050009600

Length:

627

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, GTPase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005739	mitochondrion	5	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HSG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSG8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016787	hydrolase activity	2	5
GO:0017076	purine nucleotide binding	4	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	526	530	PF00656	0.615
CLV_C14_Caspase3-7	534	538	PF00656	0.691
CLV_NRD_NRD_1	129	131	PF00675	0.323
CLV_NRD_NRD_1	144	146	PF00675	0.164
CLV_NRD_NRD_1	20	22	PF00675	0.497
CLV_NRD_NRD_1	242	244	PF00675	0.368
CLV_NRD_NRD_1	339	341	PF00675	0.204
CLV_NRD_NRD_1	583	585	PF00675	0.429
CLV_NRD_NRD_1	587	589	PF00675	0.419
CLV_NRD_NRD_1	591	593	PF00675	0.422
CLV_NRD_NRD_1	595	597	PF00675	0.405
CLV_NRD_NRD_1	76	78	PF00675	0.239
CLV_PCSK_KEX2_1	146	148	PF00082	0.239
CLV_PCSK_KEX2_1	20	22	PF00082	0.478
CLV_PCSK_KEX2_1	242	244	PF00082	0.494
CLV_PCSK_KEX2_1	313	315	PF00082	0.485
CLV_PCSK_KEX2_1	339	341	PF00082	0.204
CLV_PCSK_KEX2_1	36	38	PF00082	0.374
CLV_PCSK_KEX2_1	46	48	PF00082	0.227
CLV_PCSK_KEX2_1	587	589	PF00082	0.460
CLV_PCSK_KEX2_1	591	593	PF00082	0.482
CLV_PCSK_KEX2_1	76	78	PF00082	0.239
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.239
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.485
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.409
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.227
CLV_PCSK_PC1ET2_1	591	593	PF00082	0.513
CLV_PCSK_PC7_1	587	593	PF00082	0.513
CLV_PCSK_SKI1_1	10	14	PF00082	0.543
CLV_PCSK_SKI1_1	233	237	PF00082	0.465
CLV_PCSK_SKI1_1	33	37	PF00082	0.413
CLV_PCSK_SKI1_1	363	367	PF00082	0.204
CLV_PCSK_SKI1_1	410	414	PF00082	0.476
CLV_PCSK_SKI1_1	435	439	PF00082	0.323
CLV_PCSK_SKI1_1	456	460	PF00082	0.347
CLV_PCSK_SKI1_1	491	495	PF00082	0.382
DEG_APCC_DBOX_1	146	154	PF00400	0.239
DOC_CYCLIN_RxL_1	6	16	PF00134	0.573
DOC_MAPK_gen_1	100	109	PF00069	0.239
DOC_MAPK_gen_1	110	118	PF00069	0.239
DOC_MAPK_gen_1	142	150	PF00069	0.239
DOC_MAPK_gen_1	242	253	PF00069	0.304
DOC_MAPK_gen_1	313	323	PF00069	0.358
DOC_MAPK_gen_1	424	432	PF00069	0.385
DOC_MAPK_MEF2A_6	110	118	PF00069	0.239
DOC_MAPK_MEF2A_6	274	281	PF00069	0.283
DOC_MAPK_MEF2A_6	314	323	PF00069	0.347
DOC_PP2B_LxvP_1	12	15	PF13499	0.515
DOC_PP4_FxxP_1	470	473	PF00568	0.352
DOC_USP7_MATH_1	474	478	PF00917	0.413
DOC_USP7_UBL2_3	142	146	PF12436	0.239
DOC_USP7_UBL2_3	182	186	PF12436	0.639
DOC_USP7_UBL2_3	3	7	PF12436	0.551
DOC_USP7_UBL2_3	341	345	PF12436	0.428
DOC_USP7_UBL2_3	42	46	PF12436	0.384
DOC_USP7_UBL2_3	438	442	PF12436	0.353
DOC_USP7_UBL2_3	593	597	PF12436	0.473
DOC_WW_Pin1_4	314	319	PF00397	0.386
LIG_14-3-3_CanoR_1	20	24	PF00244	0.617
LIG_14-3-3_CanoR_1	339	344	PF00244	0.447
LIG_CaM_NSCaTE_8	618	625	PF13499	0.415
LIG_deltaCOP1_diTrp_1	132	139	PF00928	0.243
LIG_deltaCOP1_diTrp_1	425	432	PF00928	0.330
LIG_deltaCOP1_diTrp_1	461	469	PF00928	0.318
LIG_deltaCOP1_diTrp_1	614	621	PF00928	0.435
LIG_eIF4E_1	247	253	PF01652	0.427
LIG_FHA_1	360	366	PF00498	0.404
LIG_FHA_1	400	406	PF00498	0.310
LIG_FHA_1	418	424	PF00498	0.318
LIG_FHA_1	499	505	PF00498	0.433
LIG_FHA_1	555	561	PF00498	0.630
LIG_FHA_1	80	86	PF00498	0.239
LIG_FHA_2	136	142	PF00498	0.266
LIG_Integrin_RGD_1	511	513	PF01839	0.674
LIG_LIR_Gen_1	103	109	PF02991	0.239
LIG_LIR_Gen_1	265	276	PF02991	0.279
LIG_LIR_Gen_1	353	361	PF02991	0.411
LIG_LIR_Gen_1	497	505	PF02991	0.406
LIG_LIR_Gen_1	615	625	PF02991	0.435
LIG_LIR_Nem_3	103	108	PF02991	0.239
LIG_LIR_Nem_3	209	214	PF02991	0.334
LIG_LIR_Nem_3	244	250	PF02991	0.308
LIG_LIR_Nem_3	265	271	PF02991	0.270
LIG_LIR_Nem_3	273	279	PF02991	0.322
LIG_LIR_Nem_3	353	359	PF02991	0.411
LIG_LIR_Nem_3	425	429	PF02991	0.353
LIG_LIR_Nem_3	497	502	PF02991	0.372
LIG_LIR_Nem_3	615	621	PF02991	0.430
LIG_LYPXL_yS_3	276	279	PF13949	0.269
LIG_LYPXL_yS_3	326	329	PF13949	0.404
LIG_PCNA_yPIPBox_3	377	391	PF02747	0.404
LIG_Pex14_1	135	139	PF04695	0.239
LIG_Pex14_1	207	211	PF04695	0.299
LIG_Pex14_2	236	240	PF04695	0.465
LIG_SH2_CRK	105	109	PF00017	0.239
LIG_SH2_GRB2like	168	171	PF00017	0.322
LIG_SH2_PTP2	358	361	PF00017	0.404
LIG_SH2_STAP1	105	109	PF00017	0.239
LIG_SH2_STAT3	460	463	PF00017	0.296
LIG_SH2_STAT5	222	225	PF00017	0.301
LIG_SH2_STAT5	358	361	PF00017	0.404
LIG_SH2_STAT5	575	578	PF00017	0.497
LIG_SH3_2	15	20	PF14604	0.499
LIG_SH3_2	551	556	PF14604	0.564
LIG_SH3_3	12	18	PF00018	0.611
LIG_SH3_3	282	288	PF00018	0.337
LIG_SH3_3	548	554	PF00018	0.695
LIG_SH3_4	3	10	PF00018	0.555
LIG_SUMO_SIM_par_1	114	121	PF11976	0.239
LIG_TRAF2_1	530	533	PF00917	0.564
LIG_TRAF2_1	624	627	PF00917	0.366
LIG_TYR_ITIM	324	329	PF00017	0.404
LIG_UBA3_1	334	341	PF00899	0.408
LIG_WRC_WIRS_1	499	504	PF05994	0.406
MOD_CK1_1	312	318	PF00069	0.532
MOD_CK1_1	552	558	PF00069	0.531
MOD_CK2_1	114	120	PF00069	0.241
MOD_CK2_1	535	541	PF00069	0.744
MOD_Cter_Amidation	4	7	PF01082	0.552
MOD_GlcNHglycan	233	236	PF01048	0.413
MOD_GlcNHglycan	537	540	PF01048	0.751
MOD_GlcNHglycan	605	608	PF01048	0.650
MOD_GSK3_1	153	160	PF00069	0.323
MOD_GSK3_1	196	203	PF00069	0.449
MOD_GSK3_1	305	312	PF00069	0.408
MOD_GSK3_1	330	337	PF00069	0.407
MOD_GSK3_1	564	571	PF00069	0.571
MOD_N-GLC_1	24	29	PF02516	0.575
MOD_N-GLC_1	305	310	PF02516	0.396
MOD_N-GLC_2	255	257	PF02516	0.262
MOD_NEK2_1	262	267	PF00069	0.264
MOD_NEK2_1	281	286	PF00069	0.312
MOD_NEK2_1	334	339	PF00069	0.415
MOD_NEK2_1	361	366	PF00069	0.415
MOD_NEK2_1	40	45	PF00069	0.239
MOD_NEK2_1	79	84	PF00069	0.239
MOD_PIKK_1	564	570	PF00454	0.692
MOD_PK_1	339	345	PF00069	0.447
MOD_PKA_1	339	345	PF00069	0.447
MOD_PKA_2	19	25	PF00069	0.619
MOD_PKA_2	309	315	PF00069	0.449
MOD_PKA_2	339	345	PF00069	0.446
MOD_PKA_2	376	382	PF00069	0.415
MOD_PKA_2	610	616	PF00069	0.477
MOD_Plk_1	135	141	PF00069	0.249
MOD_Plk_1	153	159	PF00069	0.254
MOD_Plk_1	24	30	PF00069	0.570
MOD_Plk_1	505	511	PF00069	0.630
MOD_Plk_1	523	529	PF00069	0.771
MOD_Plk_2-3	523	529	PF00069	0.677
MOD_Plk_2-3	537	543	PF00069	0.533
MOD_Plk_2-3	610	616	PF00069	0.601
MOD_Plk_4	103	109	PF00069	0.239
MOD_Plk_4	114	120	PF00069	0.239
MOD_Plk_4	330	336	PF00069	0.404
MOD_Plk_4	404	410	PF00069	0.307
MOD_Plk_4	54	60	PF00069	0.239
MOD_Plk_4	571	577	PF00069	0.437
MOD_ProDKin_1	314	320	PF00069	0.375
MOD_SUMO_rev_2	117	125	PF00179	0.333
MOD_SUMO_rev_2	187	192	PF00179	0.484
TRG_ENDOCYTIC_2	105	108	PF00928	0.239
TRG_ENDOCYTIC_2	211	214	PF00928	0.331
TRG_ENDOCYTIC_2	247	250	PF00928	0.299
TRG_ENDOCYTIC_2	276	279	PF00928	0.293
TRG_ENDOCYTIC_2	326	329	PF00928	0.404
TRG_ENDOCYTIC_2	358	361	PF00928	0.404
TRG_ENDOCYTIC_2	499	502	PF00928	0.362
TRG_ER_diArg_1	145	148	PF00400	0.239
TRG_ER_diArg_1	241	243	PF00400	0.473
TRG_ER_diArg_1	338	340	PF00400	0.404
TRG_ER_diArg_1	464	467	PF00400	0.330
TRG_ER_diArg_1	76	78	PF00400	0.239
TRG_NES_CRM1_1	382	394	PF08389	0.419
TRG_NLS_Bipartite_1	130	150	PF00514	0.384
TRG_NLS_Bipartite_1	20	40	PF00514	0.449
TRG_NLS_MonoExtC_3	144	149	PF00514	0.239
TRG_NLS_MonoExtC_3	583	588	PF00514	0.387
TRG_NLS_MonoExtN_4	142	149	PF00514	0.239
TRG_NLS_MonoExtN_4	310	317	PF00514	0.455
TRG_NLS_MonoExtN_4	33	40	PF00514	0.400
TRG_NLS_MonoExtN_4	582	588	PF00514	0.435
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.239

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P303	Leptomonas seymouri	83%	100%
A0A0S4JVL9	Bodo saltans	67%	100%
A0A1X0NJV6	Trypanosomatidae	71%	100%
A0A3S5H5H9	Leishmania donovani	100%	100%
A0A422N2R2	Trypanosoma rangeli	70%	100%
A2XGQ1	Oryza sativa subsp. indica	51%	100%
A4H492	Leishmania braziliensis	87%	100%
C9ZUE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9AKF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
J9VQ03	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	47%	87%
O14236	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	100%
P0CS94	Cryptococcus neoformans var. grubii	46%	90%
P53742	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	100%
Q10LF7	Oryza sativa subsp. japonica	51%	100%
Q13823	Homo sapiens	47%	86%
Q4QJF6	Leishmania major	96%	100%
Q6C036	Yarrowia lipolytica (strain CLIB 122 / E 150)	45%	100%
Q6CSP9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	45%	100%
Q6FWS1	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	46%	100%
Q6TGJ8	Cryptococcus gattii	45%	86%
Q75DA4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	47%	100%
Q7SHR8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	44%	100%
Q99LH1	Mus musculus	52%	86%
Q9C3Z4	Pneumocystis carinii	44%	100%
Q9C923	Arabidopsis thaliana	51%	100%
Q9SJF1	Arabidopsis thaliana	27%	100%
V5BAQ6	Trypanosoma cruzi	68%	100%