Metallophos domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HSG5_LEIIN

TriTrypDb:

LINF_050009300

Length:

675

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HSG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSG5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016787	hydrolase activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	499	503	PF00656	0.365
CLV_NRD_NRD_1	10	12	PF00675	0.311
CLV_NRD_NRD_1	153	155	PF00675	0.488
CLV_NRD_NRD_1	279	281	PF00675	0.371
CLV_NRD_NRD_1	3	5	PF00675	0.508
CLV_NRD_NRD_1	520	522	PF00675	0.392
CLV_NRD_NRD_1	613	615	PF00675	0.506
CLV_PCSK_FUR_1	8	12	PF00082	0.411
CLV_PCSK_KEX2_1	10	12	PF00082	0.313
CLV_PCSK_KEX2_1	152	154	PF00082	0.485
CLV_PCSK_KEX2_1	279	281	PF00082	0.404
CLV_PCSK_KEX2_1	3	5	PF00082	0.506
CLV_PCSK_KEX2_1	520	522	PF00082	0.482
CLV_PCSK_KEX2_1	613	615	PF00082	0.506
CLV_PCSK_KEX2_1	673	675	PF00082	0.577
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.485
CLV_PCSK_PC1ET2_1	673	675	PF00082	0.601
CLV_PCSK_SKI1_1	146	150	PF00082	0.403
CLV_PCSK_SKI1_1	216	220	PF00082	0.526
CLV_PCSK_SKI1_1	625	629	PF00082	0.461
DEG_APCC_DBOX_1	279	287	PF00400	0.402
DEG_Nend_Nbox_1	1	3	PF02207	0.535
DEG_SCF_FBW7_1	393	400	PF00400	0.484
DEG_SPOP_SBC_1	593	597	PF00917	0.534
DOC_ANK_TNKS_1	576	583	PF00023	0.433
DOC_CYCLIN_RxL_1	143	150	PF00134	0.397
DOC_MAPK_gen_1	152	161	PF00069	0.481
DOC_MAPK_gen_1	520	528	PF00069	0.472
DOC_MAPK_MEF2A_6	154	163	PF00069	0.474
DOC_MAPK_MEF2A_6	340	348	PF00069	0.401
DOC_MAPK_MEF2A_6	521	530	PF00069	0.342
DOC_PP1_RVXF_1	117	123	PF00149	0.466
DOC_PP1_RVXF_1	31	38	PF00149	0.314
DOC_PP2B_LxvP_1	196	199	PF13499	0.509
DOC_PP2B_LxvP_1	74	77	PF13499	0.421
DOC_PP4_FxxP_1	530	533	PF00568	0.412
DOC_USP7_MATH_1	189	193	PF00917	0.468
DOC_USP7_MATH_1	397	401	PF00917	0.682
DOC_USP7_MATH_1	42	46	PF00917	0.689
DOC_USP7_MATH_1	503	507	PF00917	0.312
DOC_USP7_MATH_1	53	57	PF00917	0.511
DOC_USP7_MATH_1	549	553	PF00917	0.592
DOC_USP7_MATH_1	593	597	PF00917	0.536
DOC_USP7_MATH_1	68	72	PF00917	0.537
DOC_USP7_MATH_1	75	79	PF00917	0.636
DOC_USP7_MATH_1	86	90	PF00917	0.606
DOC_USP7_UBL2_3	669	673	PF12436	0.699
DOC_WW_Pin1_4	194	199	PF00397	0.537
DOC_WW_Pin1_4	237	242	PF00397	0.683
DOC_WW_Pin1_4	393	398	PF00397	0.644
DOC_WW_Pin1_4	485	490	PF00397	0.361
DOC_WW_Pin1_4	560	565	PF00397	0.345
DOC_WW_Pin1_4	95	100	PF00397	0.710
LIG_14-3-3_CanoR_1	10	15	PF00244	0.328
LIG_14-3-3_CanoR_1	205	210	PF00244	0.448
LIG_14-3-3_CanoR_1	613	619	PF00244	0.575
LIG_14-3-3_CanoR_1	625	632	PF00244	0.420
LIG_APCC_ABBA_1	542	547	PF00400	0.459
LIG_APCC_ABBA_1	567	572	PF00400	0.464
LIG_BRCT_BRCA1_1	595	599	PF00533	0.493
LIG_BRCT_BRCA1_1	77	81	PF00533	0.697
LIG_CaM_IQ_9	612	627	PF13499	0.409
LIG_CSL_BTD_1	383	386	PF09270	0.476
LIG_DLG_GKlike_1	205	213	PF00625	0.425
LIG_EVH1_2	48	52	PF00568	0.494
LIG_FHA_1	208	214	PF00498	0.541
LIG_FHA_1	254	260	PF00498	0.338
LIG_FHA_1	401	407	PF00498	0.414
LIG_FHA_1	486	492	PF00498	0.368
LIG_FHA_1	88	94	PF00498	0.717
LIG_FHA_1	96	102	PF00498	0.648
LIG_FHA_2	14	20	PF00498	0.295
LIG_FHA_2	497	503	PF00498	0.518
LIG_FHA_2	561	567	PF00498	0.462
LIG_FHA_2	626	632	PF00498	0.390
LIG_FHA_2	654	660	PF00498	0.625
LIG_Integrin_isoDGR_2	63	65	PF01839	0.395
LIG_LIR_Apic_2	527	533	PF02991	0.389
LIG_LIR_Gen_1	106	115	PF02991	0.535
LIG_LIR_Gen_1	19	29	PF02991	0.395
LIG_LIR_Gen_1	581	591	PF02991	0.494
LIG_LIR_Nem_3	106	112	PF02991	0.565
LIG_LIR_Nem_3	19	25	PF02991	0.332
LIG_LIR_Nem_3	566	570	PF02991	0.448
LIG_LIR_Nem_3	581	587	PF02991	0.442
LIG_LYPXL_S_1	173	177	PF13949	0.485
LIG_LYPXL_S_1	438	442	PF13949	0.495
LIG_LYPXL_yS_3	174	177	PF13949	0.491
LIG_LYPXL_yS_3	439	442	PF13949	0.438
LIG_MYND_3	366	370	PF01753	0.402
LIG_Pex14_1	264	268	PF04695	0.377
LIG_Pex14_2	151	155	PF04695	0.474
LIG_Pex14_2	514	518	PF04695	0.462
LIG_PTB_Apo_2	359	366	PF02174	0.251
LIG_SH2_CRK	109	113	PF00017	0.382
LIG_SH2_CRK	9	13	PF00017	0.382
LIG_SH2_PTP2	437	440	PF00017	0.471
LIG_SH2_PTP2	461	464	PF00017	0.353
LIG_SH2_SRC	336	339	PF00017	0.345
LIG_SH2_SRC	437	440	PF00017	0.423
LIG_SH2_STAP1	315	319	PF00017	0.363
LIG_SH2_STAP1	374	378	PF00017	0.379
LIG_SH2_STAT3	374	377	PF00017	0.522
LIG_SH2_STAT3	469	472	PF00017	0.391
LIG_SH2_STAT5	109	112	PF00017	0.442
LIG_SH2_STAT5	14	17	PF00017	0.322
LIG_SH2_STAT5	24	27	PF00017	0.249
LIG_SH2_STAT5	338	341	PF00017	0.297
LIG_SH2_STAT5	437	440	PF00017	0.401
LIG_SH2_STAT5	461	464	PF00017	0.358
LIG_SH2_STAT5	469	472	PF00017	0.356
LIG_SH2_STAT5	507	510	PF00017	0.361
LIG_SH2_STAT5	578	581	PF00017	0.399
LIG_SH3_3	439	445	PF00018	0.355
LIG_SH3_3	45	51	PF00018	0.542
LIG_SH3_3	545	551	PF00018	0.502
LIG_SH3_3	582	588	PF00018	0.476
LIG_SUMO_SIM_par_1	111	116	PF11976	0.486
LIG_TRAF2_1	389	392	PF00917	0.473
LIG_TRAF2_1	656	659	PF00917	0.592
LIG_TRFH_1	194	198	PF08558	0.585
LIG_TYR_ITIM	334	339	PF00017	0.279
LIG_WW_3	47	51	PF00397	0.557
MOD_CK1_1	13	19	PF00069	0.464
MOD_CK1_1	140	146	PF00069	0.368
MOD_CK1_1	192	198	PF00069	0.532
MOD_CK1_1	200	206	PF00069	0.569
MOD_CK1_1	246	252	PF00069	0.616
MOD_CK1_1	324	330	PF00069	0.438
MOD_CK1_1	400	406	PF00069	0.578
MOD_CK1_1	56	62	PF00069	0.524
MOD_CK2_1	13	19	PF00069	0.293
MOD_CK2_1	205	211	PF00069	0.565
MOD_CK2_1	370	376	PF00069	0.431
MOD_CK2_1	560	566	PF00069	0.336
MOD_CK2_1	625	631	PF00069	0.415
MOD_CK2_1	653	659	PF00069	0.540
MOD_GlcNHglycan	249	252	PF01048	0.634
MOD_GlcNHglycan	400	403	PF01048	0.576
MOD_GlcNHglycan	472	475	PF01048	0.344
MOD_GlcNHglycan	641	644	PF01048	0.589
MOD_GlcNHglycan	70	73	PF01048	0.582
MOD_GlcNHglycan	77	80	PF01048	0.671
MOD_GSK3_1	243	250	PF00069	0.717
MOD_GSK3_1	253	260	PF00069	0.433
MOD_GSK3_1	365	372	PF00069	0.492
MOD_GSK3_1	391	398	PF00069	0.645
MOD_GSK3_1	470	477	PF00069	0.398
MOD_GSK3_1	589	596	PF00069	0.556
MOD_GSK3_1	621	628	PF00069	0.512
MOD_GSK3_1	639	646	PF00069	0.425
MOD_GSK3_1	95	102	PF00069	0.721
MOD_N-GLC_1	358	363	PF02516	0.443
MOD_N-GLC_1	56	61	PF02516	0.711
MOD_NEK2_1	369	374	PF00069	0.522
MOD_NEK2_1	470	475	PF00069	0.339
MOD_NEK2_1	93	98	PF00069	0.621
MOD_NEK2_2	189	194	PF00069	0.326
MOD_NEK2_2	551	556	PF00069	0.387
MOD_PIKK_1	612	618	PF00454	0.549
MOD_PIKK_1	87	93	PF00454	0.568
MOD_PKA_1	10	16	PF00069	0.371
MOD_PKA_2	10	16	PF00069	0.317
MOD_PKA_2	612	618	PF00069	0.489
MOD_PKA_2	653	659	PF00069	0.616
MOD_PKB_1	8	16	PF00069	0.380
MOD_Plk_1	113	119	PF00069	0.437
MOD_Plk_1	140	146	PF00069	0.378
MOD_Plk_1	189	195	PF00069	0.337
MOD_Plk_1	369	375	PF00069	0.529
MOD_Plk_1	503	509	PF00069	0.344
MOD_Plk_1	621	627	PF00069	0.595
MOD_Plk_2-3	370	376	PF00069	0.533
MOD_Plk_4	189	195	PF00069	0.337
MOD_Plk_4	257	263	PF00069	0.286
MOD_Plk_4	321	327	PF00069	0.376
MOD_Plk_4	342	348	PF00069	0.367
MOD_Plk_4	449	455	PF00069	0.357
MOD_ProDKin_1	194	200	PF00069	0.539
MOD_ProDKin_1	237	243	PF00069	0.684
MOD_ProDKin_1	393	399	PF00069	0.650
MOD_ProDKin_1	485	491	PF00069	0.359
MOD_ProDKin_1	560	566	PF00069	0.348
MOD_ProDKin_1	95	101	PF00069	0.708
TRG_DiLeu_BaEn_1	108	113	PF01217	0.322
TRG_ENDOCYTIC_2	109	112	PF00928	0.532
TRG_ENDOCYTIC_2	174	177	PF00928	0.491
TRG_ENDOCYTIC_2	215	218	PF00928	0.453
TRG_ENDOCYTIC_2	336	339	PF00928	0.280
TRG_ENDOCYTIC_2	439	442	PF00928	0.445
TRG_ENDOCYTIC_2	461	464	PF00928	0.408
TRG_ENDOCYTIC_2	9	12	PF00928	0.538
TRG_ER_diArg_1	153	155	PF00400	0.488
TRG_ER_diArg_1	2	4	PF00400	0.516
TRG_ER_diArg_1	612	614	PF00400	0.465
TRG_ER_diArg_1	9	11	PF00400	0.341
TRG_ER_diLys_1	671	675	PF00400	0.692
TRG_NES_CRM1_1	337	349	PF08389	0.448
TRG_NLS_MonoExtC_3	151	156	PF00514	0.481
TRG_Pf-PMV_PEXEL_1	33	38	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P332	Leptomonas seymouri	54%	98%
A0A0S4IZM9	Bodo saltans	28%	100%
A0A0S4J2Q8	Bodo saltans	29%	100%
A0A1X0P0G0	Trypanosomatidae	34%	100%
A0A3S5H5H7	Leishmania donovani	99%	100%
A0A422N0S3	Trypanosoma rangeli	36%	100%
A4H489	Leishmania braziliensis	79%	100%
D0A4G6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AKE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QJF9	Leishmania major	91%	100%
V5B0Z2	Trypanosoma cruzi	37%	100%