Uncharacterized protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase - putative

Species:

Leishmania infantum

UniProt:

A4HSG1_LEIIN

TriTrypDb:

LINF_050008900

Length:

789

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Annotations by Jardim et al.

Protein kinase, kinase Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Previous1Next

Phosphorylation

Amastigote: 109, 421, 423, 424, 781, 786

Expansion

Sequence features

A4HSG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSG1

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12

Previous1 2Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12

Previous1 2 3Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.651
CLV_C14_Caspase3-7	224	228	PF00656	0.339
CLV_C14_Caspase3-7	245	249	PF00656	0.466
CLV_C14_Caspase3-7	316	320	PF00656	0.436
CLV_C14_Caspase3-7	377	381	PF00656	0.579
CLV_C14_Caspase3-7	394	398	PF00656	0.502
CLV_NRD_NRD_1	438	440	PF00675	0.680
CLV_NRD_NRD_1	465	467	PF00675	0.717
CLV_NRD_NRD_1	562	564	PF00675	0.351
CLV_NRD_NRD_1	787	789	PF00675	0.566

Previous1 2 3 4 5…23Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZR8	Leptomonas seymouri	64%	99%
A0A0S4J7Q1	Bodo saltans	54%	100%
A0A1X0P0R3	Trypanosomatidae	64%	100%
A0A3S7WP16	Leishmania donovani	100%	100%
A0A422N0Q9	Trypanosoma rangeli	61%	100%
A4H485	Leishmania braziliensis	84%	100%
D0A4H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AKE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QJG3	Leishmania major	95%	100%
V5D179	Trypanosoma cruzi	62%	100%

Previous1Next