LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
protein kinase - putative
Species:
Leishmania infantum
UniProt:
A4HSG1_LEIIN
TriTrypDb:
LINF_050008900
Length:
789

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Annotations by Jardim et al.

Protein kinase, kinase Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 109, 421, 423, 424, 781, 786

Expansion

Sequence features

A4HSG1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSG1

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016310 phosphorylation 5 12
GO:0019538 protein metabolic process 3 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004672 protein kinase activity 3 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016301 kinase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140096 catalytic activity, acting on a protein 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 149 153 PF00656 0.651
CLV_C14_Caspase3-7 224 228 PF00656 0.339
CLV_C14_Caspase3-7 245 249 PF00656 0.466
CLV_C14_Caspase3-7 316 320 PF00656 0.436
CLV_C14_Caspase3-7 377 381 PF00656 0.579
CLV_C14_Caspase3-7 394 398 PF00656 0.502
CLV_NRD_NRD_1 438 440 PF00675 0.680
CLV_NRD_NRD_1 465 467 PF00675 0.717
CLV_NRD_NRD_1 562 564 PF00675 0.351
CLV_NRD_NRD_1 787 789 PF00675 0.566
CLV_PCSK_KEX2_1 438 440 PF00082 0.680
CLV_PCSK_KEX2_1 562 564 PF00082 0.302
CLV_PCSK_SKI1_1 247 251 PF00082 0.357
CLV_PCSK_SKI1_1 633 637 PF00082 0.312
DEG_SCF_FBW7_1 390 396 PF00400 0.665
DOC_CKS1_1 390 395 PF01111 0.667
DOC_CKS1_1 673 678 PF01111 0.297
DOC_CYCLIN_yCln2_LP_2 291 297 PF00134 0.529
DOC_CYCLIN_yCln2_LP_2 767 773 PF00134 0.357
DOC_MAPK_gen_1 553 560 PF00069 0.297
DOC_MAPK_gen_1 633 642 PF00069 0.297
DOC_MAPK_HePTP_8 576 588 PF00069 0.389
DOC_MAPK_MEF2A_6 579 588 PF00069 0.297
DOC_MAPK_MEF2A_6 636 644 PF00069 0.297
DOC_PP2B_LxvP_1 495 498 PF13499 0.670
DOC_PP4_FxxP_1 476 479 PF00568 0.540
DOC_USP7_MATH_1 393 397 PF00917 0.675
DOC_USP7_MATH_1 411 415 PF00917 0.680
DOC_USP7_MATH_1 457 461 PF00917 0.714
DOC_USP7_MATH_1 53 57 PF00917 0.709
DOC_USP7_MATH_1 79 83 PF00917 0.733
DOC_USP7_MATH_1 95 99 PF00917 0.784
DOC_USP7_UBL2_3 351 355 PF12436 0.401
DOC_USP7_UBL2_3 514 518 PF12436 0.297
DOC_USP7_UBL2_3 785 789 PF12436 0.530
DOC_WW_Pin1_4 25 30 PF00397 0.735
DOC_WW_Pin1_4 389 394 PF00397 0.667
DOC_WW_Pin1_4 486 491 PF00397 0.549
DOC_WW_Pin1_4 508 513 PF00397 0.532
DOC_WW_Pin1_4 672 677 PF00397 0.297
DOC_WW_Pin1_4 778 783 PF00397 0.588
LIG_14-3-3_CanoR_1 115 123 PF00244 0.769
LIG_14-3-3_CanoR_1 385 391 PF00244 0.545
LIG_14-3-3_CanoR_1 462 466 PF00244 0.628
LIG_14-3-3_CanoR_1 530 536 PF00244 0.433
LIG_Actin_WH2_2 446 464 PF00022 0.504
LIG_Actin_WH2_2 517 532 PF00022 0.433
LIG_APCC_ABBA_1 347 352 PF00400 0.433
LIG_APCC_ABBA_1 584 589 PF00400 0.297
LIG_BIR_II_1 1 5 PF00653 0.691
LIG_BIR_III_4 248 252 PF00653 0.357
LIG_BIR_III_4 397 401 PF00653 0.651
LIG_BRCT_BRCA1_1 487 491 PF00533 0.577
LIG_BRCT_BRCA1_1 767 771 PF00533 0.351
LIG_Clathr_ClatBox_1 641 645 PF01394 0.297
LIG_deltaCOP1_diTrp_1 361 368 PF00928 0.300
LIG_eIF4E_1 165 171 PF01652 0.547
LIG_FHA_1 10 16 PF00498 0.596
LIG_FHA_1 17 23 PF00498 0.777
LIG_FHA_1 52 58 PF00498 0.804
LIG_FHA_1 524 530 PF00498 0.433
LIG_FHA_1 581 587 PF00498 0.320
LIG_FHA_1 595 601 PF00498 0.333
LIG_FHA_1 774 780 PF00498 0.598
LIG_FHA_2 143 149 PF00498 0.696
LIG_FHA_2 185 191 PF00498 0.321
LIG_FHA_2 222 228 PF00498 0.343
LIG_FHA_2 314 320 PF00498 0.338
LIG_FHA_2 481 487 PF00498 0.722
LIG_FHA_2 701 707 PF00498 0.297
LIG_FHA_2 760 766 PF00498 0.336
LIG_Integrin_isoDGR_2 333 335 PF01839 0.433
LIG_Integrin_isoDGR_2 531 533 PF01839 0.389
LIG_LIR_Apic_2 475 479 PF02991 0.537
LIG_LIR_Apic_2 675 681 PF02991 0.297
LIG_LIR_Gen_1 470 479 PF02991 0.642
LIG_LIR_Gen_1 719 728 PF02991 0.297
LIG_LIR_Nem_3 164 168 PF02991 0.568
LIG_LIR_Nem_3 470 476 PF02991 0.720
LIG_LIR_Nem_3 508 513 PF02991 0.408
LIG_LIR_Nem_3 520 524 PF02991 0.279
LIG_LIR_Nem_3 719 724 PF02991 0.297
LIG_MYND_1 757 761 PF01753 0.433
LIG_NRBOX 744 750 PF00104 0.433
LIG_Pex14_1 721 725 PF04695 0.297
LIG_Pex14_2 599 603 PF04695 0.297
LIG_PTB_Apo_2 104 111 PF02174 0.619
LIG_SH2_CRK 165 169 PF00017 0.557
LIG_SH2_CRK 525 529 PF00017 0.397
LIG_SH2_CRK 616 620 PF00017 0.357
LIG_SH2_STAP1 525 529 PF00017 0.303
LIG_SH2_STAT5 165 168 PF00017 0.518
LIG_SH2_STAT5 184 187 PF00017 0.297
LIG_SH2_STAT5 223 226 PF00017 0.389
LIG_SH2_STAT5 235 238 PF00017 0.297
LIG_SH2_STAT5 253 256 PF00017 0.206
LIG_SH2_STAT5 338 341 PF00017 0.313
LIG_SH2_STAT5 346 349 PF00017 0.313
LIG_SH2_STAT5 525 528 PF00017 0.433
LIG_SH2_STAT5 590 593 PF00017 0.428
LIG_SH2_STAT5 624 627 PF00017 0.306
LIG_SH3_3 132 138 PF00018 0.793
LIG_SH3_3 156 162 PF00018 0.622
LIG_SH3_3 387 393 PF00018 0.651
LIG_SH3_3 425 431 PF00018 0.701
LIG_SH3_3 441 447 PF00018 0.660
LIG_SH3_3 670 676 PF00018 0.297
LIG_SH3_3 709 715 PF00018 0.297
LIG_SH3_3 776 782 PF00018 0.563
LIG_SUMO_SIM_anti_2 557 562 PF11976 0.297
LIG_SUMO_SIM_par_1 18 24 PF11976 0.558
LIG_SUMO_SIM_par_1 538 544 PF11976 0.302
LIG_SUMO_SIM_par_1 640 645 PF11976 0.313
LIG_TRAF2_1 483 486 PF00917 0.586
LIG_TRAF2_1 547 550 PF00917 0.433
LIG_TYR_ITIM 163 168 PF00017 0.568
LIG_WRC_WIRS_1 596 601 PF05994 0.313
MOD_CDK_SPxK_1 508 514 PF00069 0.533
MOD_CDK_SPxxK_3 486 493 PF00069 0.565
MOD_CDK_SPxxK_3 778 785 PF00069 0.500
MOD_CK1_1 10 16 PF00069 0.590
MOD_CK1_1 117 123 PF00069 0.793
MOD_CK1_1 136 142 PF00069 0.714
MOD_CK1_1 2 8 PF00069 0.581
MOD_CK1_1 204 210 PF00069 0.347
MOD_CK1_1 21 27 PF00069 0.519
MOD_CK1_1 34 40 PF00069 0.805
MOD_CK1_1 381 387 PF00069 0.640
MOD_CK1_1 414 420 PF00069 0.732
MOD_CK1_1 421 427 PF00069 0.678
MOD_CK1_1 460 466 PF00069 0.672
MOD_CK1_1 592 598 PF00069 0.310
MOD_CK1_1 60 66 PF00069 0.747
MOD_CK2_1 184 190 PF00069 0.313
MOD_CK2_1 20 26 PF00069 0.619
MOD_CK2_1 32 38 PF00069 0.541
MOD_CK2_1 480 486 PF00069 0.622
MOD_CK2_1 502 508 PF00069 0.553
MOD_CK2_1 544 550 PF00069 0.318
MOD_CK2_1 700 706 PF00069 0.297
MOD_CK2_1 778 784 PF00069 0.740
MOD_CK2_1 95 101 PF00069 0.599
MOD_Cter_Amidation 786 789 PF01082 0.530
MOD_GlcNHglycan 117 120 PF01048 0.555
MOD_GlcNHglycan 203 206 PF01048 0.399
MOD_GlcNHglycan 287 290 PF01048 0.437
MOD_GlcNHglycan 453 456 PF01048 0.732
MOD_GlcNHglycan 475 479 PF01048 0.643
MOD_GlcNHglycan 591 594 PF01048 0.297
MOD_GlcNHglycan 663 666 PF01048 0.433
MOD_GlcNHglycan 7 10 PF01048 0.722
MOD_GlcNHglycan 70 73 PF01048 0.773
MOD_GlcNHglycan 784 788 PF01048 0.525
MOD_GlcNHglycan 97 100 PF01048 0.791
MOD_GSK3_1 16 23 PF00069 0.597
MOD_GSK3_1 247 254 PF00069 0.313
MOD_GSK3_1 27 34 PF00069 0.721
MOD_GSK3_1 389 396 PF00069 0.753
MOD_GSK3_1 414 421 PF00069 0.746
MOD_GSK3_1 447 454 PF00069 0.642
MOD_GSK3_1 457 464 PF00069 0.661
MOD_GSK3_1 5 12 PF00069 0.756
MOD_GSK3_1 508 515 PF00069 0.591
MOD_GSK3_1 53 60 PF00069 0.733
MOD_GSK3_1 663 670 PF00069 0.320
MOD_GSK3_1 692 699 PF00069 0.301
MOD_GSK3_1 728 735 PF00069 0.299
MOD_N-GLC_1 115 120 PF02516 0.745
MOD_N-GLC_1 451 456 PF02516 0.629
MOD_N-GLC_1 467 472 PF02516 0.674
MOD_N-GLC_1 61 66 PF02516 0.747
MOD_N-GLC_1 728 733 PF02516 0.389
MOD_NEK2_1 114 119 PF00069 0.568
MOD_NEK2_1 420 425 PF00069 0.715
MOD_NEK2_1 451 456 PF00069 0.498
MOD_NEK2_1 461 466 PF00069 0.717
MOD_NEK2_1 491 496 PF00069 0.610
MOD_NEK2_1 61 66 PF00069 0.745
MOD_NEK2_1 653 658 PF00069 0.297
MOD_NEK2_1 783 788 PF00069 0.747
MOD_NEK2_2 457 462 PF00069 0.612
MOD_NEK2_2 607 612 PF00069 0.433
MOD_PIKK_1 27 33 PF00454 0.609
MOD_PIKK_1 378 384 PF00454 0.602
MOD_PK_1 602 608 PF00069 0.433
MOD_PKA_1 466 472 PF00069 0.637
MOD_PKA_2 114 120 PF00069 0.788
MOD_PKA_2 334 340 PF00069 0.433
MOD_PKA_2 414 420 PF00069 0.728
MOD_PKA_2 461 467 PF00069 0.708
MOD_PKA_2 759 765 PF00069 0.313
MOD_Plk_1 46 52 PF00069 0.718
MOD_Plk_1 61 67 PF00069 0.727
MOD_Plk_2-3 399 405 PF00069 0.662
MOD_Plk_2-3 541 547 PF00069 0.347
MOD_Plk_4 136 142 PF00069 0.668
MOD_Plk_4 334 340 PF00069 0.333
MOD_Plk_4 386 392 PF00069 0.735
MOD_Plk_4 595 601 PF00069 0.313
MOD_Plk_4 668 674 PF00069 0.297
MOD_Plk_4 700 706 PF00069 0.297
MOD_Plk_4 716 722 PF00069 0.297
MOD_ProDKin_1 25 31 PF00069 0.735
MOD_ProDKin_1 389 395 PF00069 0.666
MOD_ProDKin_1 486 492 PF00069 0.547
MOD_ProDKin_1 508 514 PF00069 0.533
MOD_ProDKin_1 672 678 PF00069 0.297
MOD_ProDKin_1 778 784 PF00069 0.591
MOD_SUMO_for_1 684 687 PF00179 0.313
MOD_SUMO_rev_2 241 249 PF00179 0.433
MOD_SUMO_rev_2 575 580 PF00179 0.418
TRG_DiLeu_BaEn_1 744 749 PF01217 0.407
TRG_DiLeu_BaEn_4 549 555 PF01217 0.357
TRG_DiLeu_BaLyEn_6 166 171 PF01217 0.438
TRG_ENDOCYTIC_2 165 168 PF00928 0.562
TRG_ENDOCYTIC_2 265 268 PF00928 0.426
TRG_ENDOCYTIC_2 346 349 PF00928 0.435
TRG_ENDOCYTIC_2 473 476 PF00928 0.729
TRG_ENDOCYTIC_2 525 528 PF00928 0.317
TRG_ENDOCYTIC_2 573 576 PF00928 0.433
TRG_ENDOCYTIC_2 616 619 PF00928 0.357
TRG_ER_diArg_1 236 239 PF00400 0.451
TRG_ER_diArg_1 437 439 PF00400 0.666
TRG_ER_diArg_1 561 563 PF00400 0.351
TRG_Pf-PMV_PEXEL_1 438 442 PF00026 0.571
TRG_Pf-PMV_PEXEL_1 623 627 PF00026 0.415

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZR8 Leptomonas seymouri 64% 99%
A0A0S4J7Q1 Bodo saltans 54% 100%
A0A1X0P0R3 Trypanosomatidae 64% 100%
A0A3S7WP16 Leishmania donovani 100% 100%
A0A422N0Q9 Trypanosoma rangeli 61% 100%
A4H485 Leishmania braziliensis 84% 100%
D0A4H1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9AKE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QJG3 Leishmania major 95% 100%
V5D179 Trypanosoma cruzi 62% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS