LeishMANIAdb
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Trypanothione reductase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Trypanothione reductase
Gene product:
trypanothione reductase
Species:
Leishmania infantum
UniProt:
A4HSF7_LEIIN
TriTrypDb:
LINF_050008500
Length:
491

Annotations

Annotations by Jardim et al.

Redox homeostasis, Trypanothione reductase TRYR PE=1 SV=1 - [A4HSF7_LEIIN]

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 2
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 4
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HSF7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSF7

PDB structure(s): 2jk6_A , 2jk6_B , 2w0h_A , 2w0h_B , 2x50_A , 2x50_B , 2yau_A , 2yau_B , 4adw_A , 4adw_B , 4apn_A , 4apn_B , 5ebk_A , 5ebk_B , 6er5_A , 6i7n_A , 6i7n_B , 6t95_A , 6t97_A , 6t98_A

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 7
GO:0019725 cellular homeostasis 2 7
GO:0042592 homeostatic process 3 7
GO:0045454 cell redox homeostasis 3 7
GO:0050789 regulation of biological process 2 7
GO:0050794 regulation of cellular process 3 7
GO:0065007 biological regulation 1 7
GO:0065008 regulation of biological quality 2 7
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 7
GO:0003824 catalytic activity 1 7
GO:0005488 binding 1 7
GO:0015036 disulfide oxidoreductase activity 4 7
GO:0015042 trypanothione-disulfide reductase activity 5 7
GO:0016491 oxidoreductase activity 2 7
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3 7
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 4 7
GO:0036094 small molecule binding 2 7
GO:0043167 ion binding 2 7
GO:0043168 anion binding 3 7
GO:0050660 flavin adenine dinucleotide binding 4 7
GO:0097159 organic cyclic compound binding 2 7
GO:1901265 nucleoside phosphate binding 3 7
GO:1901363 heterocyclic compound binding 2 7
GO:0004791 thioredoxin-disulfide reductase activity 2 1
GO:0015035 protein-disulfide reductase activity 3 1
GO:0016209 antioxidant activity 1 1
GO:0047134 protein-disulfide reductase (NAD(P)) activity 4 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 317 321 PF00656 0.353
CLV_NRD_NRD_1 137 139 PF00675 0.272
CLV_NRD_NRD_1 234 236 PF00675 0.372
CLV_PCSK_KEX2_1 189 191 PF00082 0.282
CLV_PCSK_KEX2_1 482 484 PF00082 0.447
CLV_PCSK_PC1ET2_1 189 191 PF00082 0.282
CLV_PCSK_PC1ET2_1 482 484 PF00082 0.447
CLV_PCSK_SKI1_1 111 115 PF00082 0.307
CLV_PCSK_SKI1_1 189 193 PF00082 0.302
CLV_PCSK_SKI1_1 236 240 PF00082 0.311
CLV_PCSK_SKI1_1 331 335 PF00082 0.315
CLV_PCSK_SKI1_1 414 418 PF00082 0.282
DEG_APCC_DBOX_1 330 338 PF00400 0.282
DEG_Kelch_Keap1_1 418 423 PF01344 0.225
DOC_ANK_TNKS_1 165 172 PF00023 0.283
DOC_CKS1_1 333 338 PF01111 0.282
DOC_CKS1_1 471 476 PF01111 0.363
DOC_MAPK_DCC_7 331 339 PF00069 0.282
DOC_MAPK_gen_1 28 36 PF00069 0.266
DOC_MAPK_gen_1 287 296 PF00069 0.282
DOC_MAPK_gen_1 302 311 PF00069 0.282
DOC_MAPK_gen_1 407 415 PF00069 0.341
DOC_PP2B_LxvP_1 167 170 PF13499 0.282
DOC_PP4_FxxP_1 367 370 PF00568 0.282
DOC_USP7_MATH_1 159 163 PF00917 0.282
DOC_USP7_UBL2_3 236 240 PF12436 0.353
DOC_USP7_UBL2_3 446 450 PF12436 0.264
DOC_USP7_UBL2_3 482 486 PF12436 0.455
DOC_WW_Pin1_4 332 337 PF00397 0.282
DOC_WW_Pin1_4 394 399 PF00397 0.282
DOC_WW_Pin1_4 470 475 PF00397 0.384
LIG_14-3-3_CanoR_1 235 239 PF00244 0.353
LIG_14-3-3_CanoR_1 287 296 PF00244 0.261
LIG_14-3-3_CanoR_1 355 362 PF00244 0.398
LIG_BIR_II_1 1 5 PF00653 0.386
LIG_BRCT_BRCA1_1 75 79 PF00533 0.282
LIG_FHA_1 115 121 PF00498 0.282
LIG_FHA_1 132 138 PF00498 0.282
LIG_FHA_1 151 157 PF00498 0.460
LIG_FHA_1 237 243 PF00498 0.261
LIG_FHA_1 327 333 PF00498 0.317
LIG_FHA_1 386 392 PF00498 0.304
LIG_FHA_1 455 461 PF00498 0.282
LIG_FHA_2 175 181 PF00498 0.282
LIG_FHA_2 257 263 PF00498 0.311
LIG_FHA_2 272 278 PF00498 0.217
LIG_FHA_2 315 321 PF00498 0.282
LIG_FHA_2 376 382 PF00498 0.353
LIG_FHA_2 461 467 PF00498 0.282
LIG_Integrin_RGD_1 222 224 PF01839 0.307
LIG_KLC1_Yacidic_2 180 185 PF13176 0.282
LIG_LIR_Gen_1 152 159 PF02991 0.282
LIG_LIR_Gen_1 2 12 PF02991 0.261
LIG_LIR_Gen_1 275 285 PF02991 0.282
LIG_LIR_LC3C_4 6 9 PF02991 0.281
LIG_LIR_Nem_3 152 158 PF02991 0.282
LIG_LIR_Nem_3 2 8 PF02991 0.261
LIG_LIR_Nem_3 202 206 PF02991 0.319
LIG_LIR_Nem_3 275 281 PF02991 0.282
LIG_LIR_Nem_3 394 399 PF02991 0.283
LIG_LRP6_Inhibitor_1 242 248 PF00058 0.330
LIG_PDZ_Class_1 486 491 PF00595 0.399
LIG_Pex14_2 122 126 PF04695 0.282
LIG_Pex14_2 203 207 PF04695 0.282
LIG_SH2_CRK 278 282 PF00017 0.282
LIG_SH2_CRK 5 9 PF00017 0.282
LIG_SH2_NCK_1 386 390 PF00017 0.255
LIG_SH2_PTP2 155 158 PF00017 0.282
LIG_SH2_PTP2 198 201 PF00017 0.282
LIG_SH2_PTP2 216 219 PF00017 0.399
LIG_SH2_SRC 323 326 PF00017 0.282
LIG_SH2_STAP1 278 282 PF00017 0.282
LIG_SH2_STAP1 386 390 PF00017 0.274
LIG_SH2_STAP1 392 396 PF00017 0.291
LIG_SH2_STAP1 5 9 PF00017 0.282
LIG_SH2_STAT5 155 158 PF00017 0.282
LIG_SH2_STAT5 183 186 PF00017 0.321
LIG_SH2_STAT5 198 201 PF00017 0.309
LIG_SH2_STAT5 216 219 PF00017 0.399
LIG_SH2_STAT5 476 479 PF00017 0.344
LIG_SUMO_SIM_anti_2 6 11 PF11976 0.282
LIG_SUMO_SIM_par_1 335 341 PF11976 0.282
LIG_TRAF2_1 378 381 PF00917 0.353
LIG_TRAF2_1 464 467 PF00917 0.282
LIG_TYR_ITSM 151 158 PF00017 0.261
LIG_UBA3_1 399 407 PF00899 0.353
MOD_CK1_1 109 115 PF00069 0.283
MOD_CK1_1 162 168 PF00069 0.424
MOD_CK1_1 315 321 PF00069 0.482
MOD_CK1_1 394 400 PF00069 0.341
MOD_CK1_1 470 476 PF00069 0.366
MOD_CK2_1 102 108 PF00069 0.353
MOD_CK2_1 174 180 PF00069 0.282
MOD_CK2_1 256 262 PF00069 0.395
MOD_CK2_1 375 381 PF00069 0.353
MOD_CK2_1 417 423 PF00069 0.336
MOD_CK2_1 430 436 PF00069 0.254
MOD_CK2_1 460 466 PF00069 0.282
MOD_Cter_Amidation 480 483 PF01082 0.461
MOD_GlcNHglycan 13 16 PF01048 0.282
MOD_GlcNHglycan 403 406 PF01048 0.282
MOD_GlcNHglycan 432 435 PF01048 0.281
MOD_GlcNHglycan 463 466 PF01048 0.294
MOD_GlcNHglycan 479 482 PF01048 0.477
MOD_GlcNHglycan 75 78 PF01048 0.291
MOD_GSK3_1 102 109 PF00069 0.292
MOD_GSK3_1 114 121 PF00069 0.353
MOD_GSK3_1 371 378 PF00069 0.353
MOD_GSK3_1 449 456 PF00069 0.314
MOD_N-GLC_1 106 111 PF02516 0.282
MOD_N-GLC_1 401 406 PF02516 0.282
MOD_N-GLC_1 417 422 PF02516 0.248
MOD_NEK2_1 157 162 PF00069 0.432
MOD_NEK2_1 174 179 PF00069 0.183
MOD_NEK2_1 345 350 PF00069 0.344
MOD_NEK2_1 430 435 PF00069 0.284
MOD_NEK2_1 454 459 PF00069 0.282
MOD_NEK2_1 477 482 PF00069 0.309
MOD_NEK2_1 48 53 PF00069 0.299
MOD_NEK2_1 62 67 PF00069 0.380
MOD_PIKK_1 288 294 PF00454 0.261
MOD_PKA_2 137 143 PF00069 0.282
MOD_PKA_2 234 240 PF00069 0.353
MOD_PKA_2 354 360 PF00069 0.377
MOD_PKA_2 73 79 PF00069 0.282
MOD_PKA_2 84 90 PF00069 0.282
MOD_Plk_1 106 112 PF00069 0.282
MOD_Plk_4 109 115 PF00069 0.341
MOD_Plk_4 131 137 PF00069 0.307
MOD_Plk_4 345 351 PF00069 0.356
MOD_Plk_4 91 97 PF00069 0.307
MOD_ProDKin_1 332 338 PF00069 0.282
MOD_ProDKin_1 394 400 PF00069 0.282
MOD_ProDKin_1 470 476 PF00069 0.377
TRG_DiLeu_BaEn_2 340 346 PF01217 0.336
TRG_ENDOCYTIC_2 110 113 PF00928 0.324
TRG_ENDOCYTIC_2 155 158 PF00928 0.282
TRG_ENDOCYTIC_2 198 201 PF00928 0.309
TRG_ENDOCYTIC_2 216 219 PF00928 0.399
TRG_ENDOCYTIC_2 278 281 PF00928 0.282
TRG_ENDOCYTIC_2 386 389 PF00928 0.263
TRG_ENDOCYTIC_2 5 8 PF00928 0.282
TRG_ENDOCYTIC_2 69 72 PF00928 0.272
TRG_ER_diArg_1 247 250 PF00400 0.283

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P491 Leptomonas seymouri 28% 100%
A0A0N1I1H2 Leptomonas seymouri 80% 100%
A0A0N1IHT7 Leptomonas seymouri 24% 96%
A0A0N1IIN8 Leptomonas seymouri 24% 94%
A0A0S4J6A3 Bodo saltans 66% 99%
A0A0S4JDA8 Bodo saltans 29% 100%
A0A1X0NJ18 Trypanosomatidae 23% 77%
A0A1X0NK15 Trypanosomatidae 21% 84%
A0A1X0NRW2 Trypanosomatidae 28% 100%
A0A1X0NZX1 Trypanosomatidae 22% 97%
A0A1X0P0G9 Trypanosomatidae 67% 100%
A0A3Q8IDT8 Leishmania donovani 24% 97%
A0A3Q8ITM5 Leishmania donovani 28% 100%
A0A3R7KY91 Trypanosoma rangeli 30% 100%
A0A3R7NB58 Trypanosoma rangeli 66% 100%
A0A3S7WP12 Leishmania donovani 100% 100%
A0A3S7X4X4 Leishmania donovani 23% 100%
A0A422NPA5 Trypanosoma rangeli 24% 79%
A0A422NPB5 Trypanosoma rangeli 21% 84%
A1AIE2 Escherichia coli O1:K1 / APEC 26% 100%
A1JI37 Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) 25% 100%
A1KM51 Mycobacterium bovis (strain BCG / Pasteur 1173P2) 27% 100%
A1U1Y5 Marinobacter nauticus (strain ATCC 700491 / DSM 11845 / VT8) 27% 100%
A2TIL1 Callithrix jacchus 36% 94%
A4H480 Leishmania braziliensis 84% 100%
A4HIY7 Leishmania braziliensis 23% 100%
A4HJQ2 Leishmania braziliensis 24% 100%
A4HKX6 Leishmania braziliensis 27% 100%
A4I4P1 Leishmania infantum 25% 97%
A4I8F6 Leishmania infantum 28% 100%
A4TRG4 Yersinia pestis (strain Pestoides F) 26% 100%
A4VMU6 Pseudomonas stutzeri (strain A1501) 29% 100%
A4WG49 Enterobacter sp. (strain 638) 26% 100%
A4XSQ1 Pseudomonas mendocina (strain ymp) 30% 100%
A5F4K5 Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395) 26% 100%
A5U665 Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) 27% 100%
A5W6F5 Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) 28% 100%
A6TGE6 Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) 25% 100%
A6V3A6 Pseudomonas aeruginosa (strain PA7) 28% 100%
A6VW16 Marinomonas sp. (strain MWYL1) 27% 100%
A7FD10 Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) 26% 100%
A7ZUI2 Escherichia coli O139:H28 (strain E24377A / ETEC) 26% 100%
A8A770 Escherichia coli O9:H4 (strain HS) 26% 100%
A8AKW0 Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) 26% 100%
A8GL77 Serratia proteamaculans (strain 568) 26% 100%
A8MS68 Arabidopsis thaliana 30% 79%
A9N0H2 Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) 26% 100%
A9R6N5 Yersinia pestis bv. Antiqua (strain Angola) 26% 100%
B0KH90 Pseudomonas putida (strain GB-1) 28% 100%
B1IVB6 Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks) 26% 100%
B1J606 Pseudomonas putida (strain W619) 28% 100%
B1JQ50 Yersinia pseudotuberculosis serotype O:3 (strain YPIII) 26% 100%
B1LNS2 Escherichia coli (strain SMS-3-5 / SECEC) 26% 100%
B1XBX3 Escherichia coli (strain K12 / DH10B) 26% 100%
B2JZF3 Yersinia pseudotuberculosis serotype IB (strain PB1/+) 26% 100%
B2TWF7 Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) 26% 100%
B2VGA0 Erwinia tasmaniensis (strain DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB 4357 / Et1/99) 25% 100%
B4F1H1 Proteus mirabilis (strain HI4320) 26% 100%
B5BJN6 Salmonella paratyphi A (strain AKU_12601) 26% 100%
B5QXQ7 Salmonella enteritidis PT4 (strain P125109) 26% 100%
B5REZ6 Salmonella gallinarum (strain 287/91 / NCTC 13346) 26% 100%
B5XZ14 Klebsiella pneumoniae (strain 342) 25% 100%
B5Z064 Escherichia coli O157:H7 (strain EC4115 / EHEC) 26% 100%
B6I5I0 Escherichia coli (strain SE11) 26% 100%
B7LA64 Escherichia coli (strain 55989 / EAEC) 26% 100%
B7LUN3 Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73) 26% 100%
B7M718 Escherichia coli O8 (strain IAI1) 26% 100%
B7MIA0 Escherichia coli O45:K1 (strain S88 / ExPEC) 26% 100%
B7MR55 Escherichia coli O81 (strain ED1a) 26% 100%
B7NFR2 Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) 26% 100%
B7NU38 Escherichia coli O7:K1 (strain IAI39 / ExPEC) 26% 100%
B7UNU0 Escherichia coli O127:H6 (strain E2348/69 / EPEC) 26% 100%
B7UZU5 Pseudomonas aeruginosa (strain LESB58) 27% 100%
B7VM91 Vibrio atlanticus (strain LGP32) 25% 100%
B9A1H3 Emiliania huxleyi 34% 99%
C0Q478 Salmonella paratyphi C (strain RKS4594) 26% 100%
C1AFH2 Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019) 27% 100%
C1DR10 Azotobacter vinelandii (strain DJ / ATCC BAA-1303) 28% 100%
C3K4W1 Pseudomonas fluorescens (strain SBW25) 28% 100%
C3LPZ2 Vibrio cholerae serotype O1 (strain M66-2) 26% 100%
C4K3I8 Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT) 25% 100%
C5A0R1 Escherichia coli (strain K12 / MC4100 / BW2952) 26% 100%
C9ZLC8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 97%
C9ZMF4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 20% 81%
C9ZWN2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 21% 90%
D0A4H8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 67% 100%
D0AAR5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
D0VWY5 Marichromatium gracile 35% 100%
E9AE44 Leishmania major 22% 100%
E9AKE1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9ALP1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9B263 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9B3B4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
F4JLP5 Arabidopsis thaliana 29% 87%
G0SB20 Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) 28% 97%
O00087 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 96%
O04955 Brassica rapa subsp. pekinensis 40% 98%
O05139 Pseudomonas fluorescens 28% 100%
O05940 Rhizobium etli (strain CFN 42 / ATCC 51251) 28% 100%
O08749 Mus musculus 27% 96%
O15770 Plasmodium falciparum (isolate 3D7) 32% 90%
O17953 Caenorhabditis elegans 28% 99%
O18480 Manduca sexta 30% 99%
O34324 Bacillus subtilis (strain 168) 28% 100%
O50286 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) 26% 100%
O50311 Chlorobaculum parvum (strain DSM 263 / NCIMB 8327) 29% 100%
O62768 Bos taurus 32% 98%
O84561 Chlamydia trachomatis (strain D/UW-3/Cx) 28% 100%
O89049 Rattus norvegicus 31% 98%
P00390 Homo sapiens 35% 94%
P00392 Pseudomonas aeruginosa 28% 88%
P06715 Escherichia coli (strain K12) 36% 100%
P08332 Shigella flexneri 27% 87%
P09063 Pseudomonas putida 27% 100%
P09622 Homo sapiens 28% 96%
P09623 Sus scrofa 28% 96%
P09624 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 98%
P0A0E4 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 27% 90%
P0A0E5 Staphylococcus aureus 27% 90%
P0A0E6 Staphylococcus aureus (strain Mu50 / ATCC 700699) 27% 100%
P0A0E7 Staphylococcus aureus (strain MW2) 27% 100%
P0A0E8 Staphylococcus aureus 27% 100%
P0A9P0 Escherichia coli (strain K12) 28% 100%
P0A9P1 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 28% 100%
P0A9P2 Escherichia coli O157:H7 28% 100%
P0A9P3 Shigella flexneri 28% 100%
P11959 Geobacillus stearothermophilus 28% 100%
P13110 Trypanosoma congolense 68% 100%
P14218 Pseudomonas fluorescens 27% 100%
P16171 Bacillus cereus 28% 78%
P17239 Acidithiobacillus ferrooxidans 27% 90%
P18925 Azotobacter vinelandii 28% 100%
P21880 Bacillus subtilis (strain 168) 29% 100%
P23189 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 41% 100%
P27306 Escherichia coli (strain K12) 26% 100%
P27456 Pisum sativum 41% 89%
P28593 Trypanosoma cruzi 67% 100%
P30341 Streptomyces lividans 26% 100%
P30635 Caenorhabditis elegans 32% 98%
P31023 Pisum sativum 28% 98%
P31046 Pseudomonas putida 30% 100%
P31052 Pseudomonas putida 28% 100%
P39040 Crithidia fasciculata 79% 100%
P39050 Leishmania donovani 98% 100%
P39051 Trypanosoma brucei brucei 67% 100%
P41921 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 33% 100%
P42770 Arabidopsis thaliana 43% 87%
P43783 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 36% 100%
P43784 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 28% 100%
P47513 Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) 27% 100%
P47791 Mus musculus 34% 98%
P48638 Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) 39% 100%
P48639 Burkholderia cepacia 39% 100%
P48640 Glycine max 41% 90%
P48641 Arabidopsis thaliana 39% 98%
P48642 Oryza sativa subsp. japonica 43% 99%
P49819 Canis lupus familiaris 28% 96%
P50529 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 26% 100%
P50970 Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) 27% 100%
P52992 Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) 27% 100%
P54533 Bacillus subtilis (strain 168) 29% 100%
P57112 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 27% 100%
P57303 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 28% 100%
P61076 Plasmodium falciparum (isolate 3D7) 31% 80%
P66005 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 28% 100%
P66007 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 27% 100%
P66008 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 26% 100%
P66009 Salmonella typhi 26% 100%
P70619 Rattus norvegicus 34% 100%
P72740 Synechocystis sp. (strain PCC 6803 / Kazusa) 25% 100%
P75393 Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) 28% 100%
P77212 Escherichia coli (strain K12) 27% 100%
P78965 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 34% 100%
P80461 Nicotiana tabacum 42% 88%
P85207 Thermus scotoductus (strain ATCC 700910 / SA-01) 31% 100%
P90597 Trypanosoma cruzi 28% 100%
P91938 Drosophila melanogaster 32% 82%
P94188 Alcaligenes sp. 27% 88%
P94702 Enterobacter agglomerans 27% 88%
P95596 Rhodobacter capsulatus 27% 100%
P99084 Staphylococcus aureus (strain N315) 27% 100%
P9WHH2 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 26% 100%
P9WHH3 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 26% 100%
P9WHH4 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 27% 100%
P9WHH5 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 27% 100%
P9WHH6 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 25% 100%
P9WHH7 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 25% 100%
P9WHH8 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 28% 100%
P9WHH9 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 28% 100%
Q02733 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 98%
Q02PF5 Pseudomonas aeruginosa (strain UCBPP-PA14) 27% 100%
Q04829 Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) 31% 100%
Q04933 Trypanosoma brucei brucei 27% 100%
Q0TA96 Escherichia coli O6:K15:H31 (strain 536 / UPEC) 26% 100%
Q16881 Homo sapiens 32% 76%
Q17745 Caenorhabditis elegans 31% 74%
Q1CBU5 Yersinia pestis bv. Antiqua (strain Antiqua) 26% 100%
Q1CNP4 Yersinia pestis bv. Antiqua (strain Nepal516) 26% 100%
Q1I7F0 Pseudomonas entomophila (strain L48) 28% 100%
Q1QX78 Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11) 27% 100%
Q1R3U7 Escherichia coli (strain UTI89 / UPEC) 26% 100%
Q25861 Plasmodium falciparum (isolate FCH-5) 31% 91%
Q2NQZ3 Sodalis glossinidius (strain morsitans) 25% 100%
Q2SIP2 Hahella chejuensis (strain KCTC 2396) 27% 100%
Q3K9F5 Pseudomonas fluorescens (strain Pf0-1) 28% 100%
Q41219 Glycine max 28% 94%
Q43154 Spinacia oleracea 40% 100%
Q43621 Pisum sativum 40% 99%
Q48A14 Colwellia psychrerythraea (strain 34H / ATCC BAA-681) 27% 100%
Q48KI8 Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) 27% 100%
Q4KFA6 Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) 28% 100%
Q4Q4U1 Leishmania major 27% 100%
Q4Q5Z7 Leishmania major 24% 100%
Q4QJG7 Leishmania major 96% 100%
Q4ZV77 Pseudomonas syringae pv. syringae (strain B728a) 27% 100%
Q50068 Mycobacterium leprae (strain TN) 30% 100%
Q51772 Pseudomonas fluorescens 28% 90%
Q52109 Acinetobacter calcoaceticus 28% 88%
Q54465 Shewanella putrefaciens 27% 88%
Q54EW8 Dictyostelium discoideum 28% 100%
Q56839 Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) 24% 94%
Q57H91 Salmonella choleraesuis (strain SC-B67) 26% 100%
Q58065 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 26% 100%
Q5E212 Aliivibrio fischeri (strain ATCC 700601 / ES114) 26% 100%
Q5HGY8 Staphylococcus aureus (strain COL) 27% 100%
Q5JGP4 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 27% 100%
Q5NVA2 Pongo abelii 32% 98%
Q5PK71 Salmonella paratyphi A (strain ATCC 9150 / SARB42) 26% 100%
Q5R4B1 Pongo abelii 28% 96%
Q5UWH2 Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) 27% 100%
Q5UYG6 Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) 28% 100%
Q60151 Streptococcus thermophilus 37% 100%
Q60HG3 Macaca fascicularis 28% 96%
Q66G61 Yersinia pseudotuberculosis serotype I (strain IP32953) 26% 100%
Q6BPI1 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 31% 100%
Q6C5H4 Yarrowia lipolytica (strain CLIB 122 / E 150) 37% 100%
Q6CZB1 Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 26% 100%
Q6FRV2 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 36% 100%
Q6GAB8 Staphylococcus aureus (strain MSSA476) 27% 100%
Q6GHY9 Staphylococcus aureus (strain MRSA252) 27% 100%
Q6HA23 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 34% 100%
Q6LLT9 Photobacterium profundum (strain SS9) 27% 100%
Q6P6R2 Rattus norvegicus 27% 96%
Q74ZK4 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 34% 100%
Q7MBG9 Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) 26% 100%
Q7MQ83 Vibrio vulnificus (strain YJ016) 26% 100%
Q811C4 Mesocricetus auratus 28% 100%
Q83MI1 Shigella flexneri 26% 100%
Q86VQ6 Homo sapiens 32% 76%
Q873E8 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 34% 100%
Q87KN5 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) 26% 100%
Q884I6 Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) 27% 100%
Q88KY8 Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) 28% 100%
Q89AQ8 Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) 28% 100%
Q8CIZ7 Cricetulus griseus 28% 96%
Q8DD46 Vibrio vulnificus (strain CMCP6) 26% 100%
Q8FB93 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 26% 100%
Q8K9T7 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) 27% 100%
Q8KCW2 Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) 27% 100%
Q8NTE1 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) 29% 100%
Q8T137 Dictyostelium discoideum 34% 100%
Q8U1M0 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 26% 100%
Q8X727 Escherichia coli O157:H7 26% 100%
Q8ZA97 Yersinia pestis 26% 100%
Q93379 Caenorhabditis elegans 34% 100%
Q94655 Plasmodium falciparum (isolate K1 / Thailand) 32% 98%
Q99MD6 Mus musculus 33% 75%
Q9HN74 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 29% 100%
Q9HUY1 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 27% 100%
Q9I1L9 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 27% 100%
Q9I3D1 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 27% 100%
Q9JLT4 Mus musculus 35% 94%
Q9JMH6 Mus musculus 32% 80%
Q9KPF6 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 28% 100%
Q9M5K2 Arabidopsis thaliana 28% 97%
Q9M5K3 Arabidopsis thaliana 28% 97%
Q9MYY8 Sus scrofa 32% 98%
Q9N2I8 Bos taurus 35% 96%
Q9NNW7 Homo sapiens 34% 94%
Q9PJI3 Chlamydia muridarum (strain MoPn / Nigg) 27% 100%
Q9SPB1 Vigna unguiculata 28% 94%
Q9UYU5 Pyrococcus abyssi (strain GE5 / Orsay) 26% 100%
Q9VNT5 Drosophila melanogaster 32% 95%
Q9XBQ9 Azotobacter vinelandii 28% 100%
Q9Z0J5 Rattus norvegicus 35% 93%
Q9Z773 Chlamydia pneumoniae 27% 100%
V5AJG2 Trypanosoma cruzi 67% 100%
V5B6P6 Trypanosoma cruzi 22% 89%
V5BB90 Trypanosoma cruzi 22% 89%
V5BDX2 Trypanosoma cruzi 20% 96%
V5BVJ1 Trypanosoma cruzi 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS