Putative viscerotropic leishmaniasis antigen

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4HSF6_LEIIN

TriTrypDb:

Length:

854

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HSF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSF6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	201	203	PF00675	0.447
CLV_NRD_NRD_1	380	382	PF00675	0.487
CLV_NRD_NRD_1	784	786	PF00675	0.468
CLV_PCSK_FUR_1	782	786	PF00082	0.467
CLV_PCSK_KEX2_1	304	306	PF00082	0.504
CLV_PCSK_KEX2_1	782	784	PF00082	0.468
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.504
CLV_PCSK_PC7_1	779	785	PF00082	0.458
CLV_PCSK_SKI1_1	13	17	PF00082	0.283
CLV_Separin_Metazoa	60	64	PF03568	0.420
DEG_SPOP_SBC_1	295	299	PF00917	0.709
DEG_SPOP_SBC_1	43	47	PF00917	0.405
DOC_CKS1_1	236	241	PF01111	0.784
DOC_MAPK_DCC_7	171	181	PF00069	0.467
DOC_MAPK_gen_1	171	181	PF00069	0.467
DOC_MAPK_MEF2A_6	174	183	PF00069	0.366
DOC_PP1_RVXF_1	109	116	PF00149	0.455
DOC_PP2B_LxvP_1	17	20	PF13499	0.258
DOC_PP2B_PxIxI_1	177	183	PF00149	0.283
DOC_PP4_FxxP_1	269	272	PF00568	0.694
DOC_USP7_MATH_1	223	227	PF00917	0.769
DOC_USP7_MATH_1	349	353	PF00917	0.766
DOC_USP7_MATH_1	43	47	PF00917	0.405
DOC_USP7_MATH_1	66	70	PF00917	0.382
DOC_WW_Pin1_4	219	224	PF00397	0.726
DOC_WW_Pin1_4	235	240	PF00397	0.675
DOC_WW_Pin1_4	282	287	PF00397	0.703
DOC_WW_Pin1_4	771	776	PF00397	0.668
LIG_14-3-3_CanoR_1	131	141	PF00244	0.366
LIG_14-3-3_CanoR_1	240	249	PF00244	0.782
LIG_14-3-3_CanoR_1	25	29	PF00244	0.258
LIG_14-3-3_CanoR_1	329	338	PF00244	0.813
LIG_14-3-3_CanoR_1	74	81	PF00244	0.307
LIG_BIR_II_1	1	5	PF00653	0.695
LIG_BRCT_BRCA1_1	32	36	PF00533	0.316
LIG_BRCT_BRCA1_1	45	49	PF00533	0.355
LIG_eIF4E_1	370	376	PF01652	0.685
LIG_FHA_1	143	149	PF00498	0.403
LIG_FHA_1	158	164	PF00498	0.291
LIG_FHA_1	283	289	PF00498	0.745
LIG_FHA_1	341	347	PF00498	0.785
LIG_FHA_1	358	364	PF00498	0.622
LIG_FHA_1	370	376	PF00498	0.685
LIG_FHA_1	89	95	PF00498	0.330
LIG_FHA_2	331	337	PF00498	0.812
LIG_FHA_2	55	61	PF00498	0.460
LIG_FHA_2	741	747	PF00498	0.550
LIG_LIR_Apic_2	266	272	PF02991	0.692
LIG_LIR_Apic_2	777	781	PF02991	0.647
LIG_LIR_Gen_1	147	158	PF02991	0.427
LIG_LIR_Gen_1	46	56	PF02991	0.438
LIG_LIR_Nem_3	147	153	PF02991	0.433
LIG_LIR_Nem_3	80	84	PF02991	0.328
LIG_Pex14_2	86	90	PF04695	0.305
LIG_SH2_NCK_1	150	154	PF00017	0.455
LIG_SH2_STAP1	54	58	PF00017	0.421
LIG_SH2_STAT5	143	146	PF00017	0.340
LIG_SH2_STAT5	200	203	PF00017	0.451
LIG_SH2_STAT5	71	74	PF00017	0.466
LIG_SH3_3	119	125	PF00018	0.434
LIG_SH3_3	233	239	PF00018	0.770
LIG_SH3_3	313	319	PF00018	0.801
LIG_SH3_3	351	357	PF00018	0.754
LIG_SH3_3	790	796	PF00018	0.630
LIG_SH3_CIN85_PxpxPR_1	401	406	PF14604	0.653
LIG_SH3_CIN85_PxpxPR_1	764	769	PF14604	0.675
LIG_SUMO_SIM_par_1	27	33	PF11976	0.316
LIG_TRAF2_1	417	420	PF00917	0.659
LIG_TRAF2_1	450	453	PF00917	0.639
LIG_TRAF2_1	483	486	PF00917	0.657
LIG_TRAF2_1	516	519	PF00917	0.670
LIG_TRAF2_1	549	552	PF00917	0.657
LIG_TRAF2_1	582	585	PF00917	0.733
LIG_TRAF2_1	615	618	PF00917	0.654
LIG_TRAF2_1	648	651	PF00917	0.666
LIG_TRAF2_1	681	684	PF00917	0.647
LIG_TRAF2_1	714	717	PF00917	0.645
LIG_TRAF2_1	747	750	PF00917	0.639
LIG_TRAF2_1	813	816	PF00917	0.641
LIG_TRAF2_2	276	281	PF00917	0.702
LIG_TYR_ITIM	148	153	PF00017	0.436
LIG_WW_3	60	64	PF00397	0.420
MOD_CDK_SPK_2	235	240	PF00069	0.785
MOD_CDK_SPK_2	771	776	PF00069	0.668
MOD_CDK_SPxxK_3	282	289	PF00069	0.706
MOD_CK1_1	135	141	PF00069	0.445
MOD_CK1_1	241	247	PF00069	0.776
MOD_CK1_1	290	296	PF00069	0.706
MOD_CK1_1	359	365	PF00069	0.717
MOD_CK1_1	371	377	PF00069	0.717
MOD_CK1_1	69	75	PF00069	0.387
MOD_CK1_1	77	83	PF00069	0.316
MOD_CK1_1	774	780	PF00069	0.654
MOD_CK2_1	54	60	PF00069	0.462
MOD_CK2_1	740	746	PF00069	0.551
MOD_GlcNHglycan	118	121	PF01048	0.627
MOD_GlcNHglycan	134	137	PF01048	0.641
MOD_GlcNHglycan	293	296	PF01048	0.569
MOD_GlcNHglycan	32	35	PF01048	0.302
MOD_GlcNHglycan	351	354	PF01048	0.500
MOD_GlcNHglycan	390	393	PF01048	0.509
MOD_GSK3_1	153	160	PF00069	0.426
MOD_GSK3_1	219	226	PF00069	0.785
MOD_GSK3_1	234	241	PF00069	0.674
MOD_GSK3_1	253	260	PF00069	0.822
MOD_GSK3_1	287	294	PF00069	0.709
MOD_GSK3_1	336	343	PF00069	0.754
MOD_GSK3_1	69	76	PF00069	0.366
MOD_GSK3_1	787	794	PF00069	0.648
MOD_N-GLC_1	113	118	PF02516	0.691
MOD_N-GLC_1	132	137	PF02516	0.631
MOD_N-GLC_1	153	158	PF02516	0.628
MOD_N-GLC_1	388	393	PF02516	0.553
MOD_N-GLC_2	157	159	PF02516	0.608
MOD_NEK2_1	1	6	PF00069	0.695
MOD_NEK2_1	132	137	PF00069	0.436
MOD_NEK2_1	242	247	PF00069	0.697
MOD_NEK2_1	288	293	PF00069	0.711
MOD_NEK2_1	29	34	PF00069	0.397
MOD_NEK2_1	35	40	PF00069	0.306
MOD_NEK2_1	368	373	PF00069	0.736
MOD_NEK2_1	388	393	PF00069	0.790
MOD_NEK2_1	44	49	PF00069	0.350
MOD_NEK2_1	88	93	PF00069	0.308
MOD_PIKK_1	795	801	PF00454	0.578
MOD_PK_1	118	124	PF00069	0.430
MOD_PKA_2	24	30	PF00069	0.258
MOD_PKA_2	288	294	PF00069	0.710
MOD_PKA_2	328	334	PF00069	0.750
MOD_PKA_2	349	355	PF00069	0.715
MOD_PKA_2	69	75	PF00069	0.381
MOD_PKA_2	791	797	PF00069	0.616
MOD_Plk_1	280	286	PF00069	0.703
MOD_Plk_1	430	436	PF00069	0.743
MOD_Plk_1	463	469	PF00069	0.608
MOD_Plk_1	496	502	PF00069	0.630
MOD_Plk_1	529	535	PF00069	0.632
MOD_Plk_1	562	568	PF00069	0.652
MOD_Plk_1	595	601	PF00069	0.646
MOD_Plk_1	628	634	PF00069	0.627
MOD_Plk_1	66	72	PF00069	0.405
MOD_Plk_1	661	667	PF00069	0.625
MOD_Plk_1	694	700	PF00069	0.610
MOD_Plk_1	727	733	PF00069	0.611
MOD_Plk_1	826	832	PF00069	0.613
MOD_Plk_4	24	30	PF00069	0.316
MOD_Plk_4	362	368	PF00069	0.686
MOD_Plk_4	371	377	PF00069	0.649
MOD_Plk_4	45	51	PF00069	0.385
MOD_ProDKin_1	219	225	PF00069	0.728
MOD_ProDKin_1	235	241	PF00069	0.675
MOD_ProDKin_1	282	288	PF00069	0.704
MOD_ProDKin_1	771	777	PF00069	0.665
MOD_SUMO_for_1	303	306	PF00179	0.703
MOD_SUMO_rev_2	251	256	PF00179	0.685
TRG_DiLeu_BaEn_4	419	425	PF01217	0.620
TRG_DiLeu_BaEn_4	452	458	PF01217	0.648
TRG_DiLeu_BaEn_4	485	491	PF01217	0.666
TRG_DiLeu_BaEn_4	518	524	PF01217	0.677
TRG_DiLeu_BaEn_4	551	557	PF01217	0.626
TRG_DiLeu_BaEn_4	584	590	PF01217	0.734
TRG_DiLeu_BaEn_4	617	623	PF01217	0.622
TRG_DiLeu_BaEn_4	650	656	PF01217	0.632
TRG_DiLeu_BaEn_4	683	689	PF01217	0.611
TRG_DiLeu_BaEn_4	716	722	PF01217	0.613
TRG_DiLeu_BaEn_4	749	755	PF01217	0.655
TRG_ENDOCYTIC_2	150	153	PF00928	0.459
TRG_ER_diArg_1	405	408	PF00400	0.623
TRG_ER_diArg_1	68	71	PF00400	0.373
TRG_ER_diArg_1	768	771	PF00400	0.676
TRG_ER_diArg_1	781	784	PF00400	0.631
TRG_ER_diArg_1	839	842	PF00400	0.564
TRG_NLS_Bipartite_1	381	403	PF00514	0.706
TRG_NLS_MonoCore_2	398	403	PF00514	0.674
TRG_NLS_MonoExtC_3	397	402	PF00514	0.679
TRG_NLS_MonoExtN_4	324	330	PF00514	0.732
TRG_NLS_MonoExtN_4	397	403	PF00514	0.713
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5G8	Leishmania donovani	92%	89%
Q4QJH9	Leishmania major	66%	69%