Putative hydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrogenase - putative

Species:

Leishmania infantum

UniProt:

A4HSF5_LEIIN

TriTrypDb:

LINF_050007200

Length:

633

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HSF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSF5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0051536	iron-sulfur cluster binding	3	1
GO:0051539	4 iron, 4 sulfur cluster binding	4	1
GO:0051540	metal cluster binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	602	606	PF00656	0.510
CLV_NRD_NRD_1	228	230	PF00675	0.269
CLV_NRD_NRD_1	296	298	PF00675	0.221
CLV_NRD_NRD_1	582	584	PF00675	0.607
CLV_PCSK_FUR_1	226	230	PF00082	0.286
CLV_PCSK_KEX2_1	226	228	PF00082	0.264
CLV_PCSK_KEX2_1	279	281	PF00082	0.238
CLV_PCSK_KEX2_1	40	42	PF00082	0.769
CLV_PCSK_KEX2_1	447	449	PF00082	0.221
CLV_PCSK_KEX2_1	483	485	PF00082	0.235
CLV_PCSK_KEX2_1	581	583	PF00082	0.531
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.238
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.777
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.216
CLV_PCSK_PC1ET2_1	483	485	PF00082	0.235
CLV_PCSK_PC7_1	479	485	PF00082	0.322
CLV_PCSK_SKI1_1	479	483	PF00082	0.233
DEG_APCC_DBOX_1	114	122	PF00400	0.368
DEG_Nend_UBRbox_2	1	3	PF02207	0.524
DEG_SPOP_SBC_1	100	104	PF00917	0.599
DEG_SPOP_SBC_1	383	387	PF00917	0.392
DEG_SPOP_SBC_1	429	433	PF00917	0.542
DOC_ANK_TNKS_1	418	425	PF00023	0.448
DOC_CKS1_1	436	441	PF01111	0.568
DOC_USP7_MATH_1	101	105	PF00917	0.643
DOC_USP7_MATH_1	266	270	PF00917	0.527
DOC_USP7_MATH_1	29	33	PF00917	0.687
DOC_USP7_MATH_1	302	306	PF00917	0.537
DOC_USP7_MATH_1	390	394	PF00917	0.526
DOC_USP7_MATH_1	427	431	PF00917	0.546
DOC_USP7_MATH_1	546	550	PF00917	0.680
DOC_USP7_MATH_1	563	567	PF00917	0.732
DOC_WW_Pin1_4	168	173	PF00397	0.561
DOC_WW_Pin1_4	386	391	PF00397	0.505
DOC_WW_Pin1_4	430	435	PF00397	0.532
DOC_WW_Pin1_4	96	101	PF00397	0.598
LIG_14-3-3_CanoR_1	149	157	PF00244	0.495
LIG_14-3-3_CanoR_1	489	494	PF00244	0.440
LIG_14-3-3_CanoR_1	609	613	PF00244	0.453
LIG_BRCT_BRCA1_1	392	396	PF00533	0.448
LIG_deltaCOP1_diTrp_1	585	591	PF00928	0.438
LIG_deltaCOP1_diTrp_1	605	612	PF00928	0.497
LIG_eIF4E_1	491	497	PF01652	0.421
LIG_FHA_1	108	114	PF00498	0.461
LIG_FHA_1	152	158	PF00498	0.523
LIG_FHA_1	231	237	PF00498	0.380
LIG_FHA_1	323	329	PF00498	0.413
LIG_FHA_1	593	599	PF00498	0.537
LIG_FHA_1	79	85	PF00498	0.412
LIG_FHA_2	218	224	PF00498	0.421
LIG_FHA_2	490	496	PF00498	0.421
LIG_FHA_2	609	615	PF00498	0.498
LIG_FHA_2	63	69	PF00498	0.430
LIG_FHA_2	75	81	PF00498	0.397
LIG_GBD_Chelix_1	129	137	PF00786	0.326
LIG_LIR_Apic_2	2	6	PF02991	0.480
LIG_LIR_Gen_1	492	500	PF02991	0.424
LIG_LIR_Gen_1	616	623	PF02991	0.525
LIG_LIR_Nem_3	492	496	PF02991	0.424
LIG_LIR_Nem_3	585	591	PF02991	0.558
LIG_MYND_1	262	266	PF01753	0.435
LIG_MYND_1	46	50	PF01753	0.587
LIG_Pex14_1	608	612	PF04695	0.370
LIG_RPA_C_Fungi	414	426	PF08784	0.257
LIG_SH2_NCK_1	141	145	PF00017	0.387
LIG_SH2_PTP2	3	6	PF00017	0.488
LIG_SH2_STAP1	141	145	PF00017	0.452
LIG_SH2_STAP1	277	281	PF00017	0.240
LIG_SH2_STAP1	324	328	PF00017	0.261
LIG_SH2_STAP1	528	532	PF00017	0.488
LIG_SH2_STAT3	469	472	PF00017	0.261
LIG_SH2_STAT5	205	208	PF00017	0.239
LIG_SH2_STAT5	252	255	PF00017	0.261
LIG_SH2_STAT5	3	6	PF00017	0.490
LIG_SH2_STAT5	324	327	PF00017	0.261
LIG_SH2_STAT5	491	494	PF00017	0.261
LIG_SH3_2	343	348	PF14604	0.351
LIG_SH3_3	110	116	PF00018	0.527
LIG_SH3_3	23	29	PF00018	0.570
LIG_SH3_3	340	346	PF00018	0.401
LIG_SH3_3	433	439	PF00018	0.385
LIG_SH3_3	44	50	PF00018	0.607
LIG_SH3_3	595	601	PF00018	0.509
LIG_SUMO_SIM_anti_2	492	498	PF11976	0.261
LIG_SUMO_SIM_par_1	117	123	PF11976	0.323
LIG_SUMO_SIM_par_1	205	210	PF11976	0.385
LIG_SUMO_SIM_par_1	239	245	PF11976	0.401
LIG_SUMO_SIM_par_1	593	599	PF11976	0.367
LIG_TRAF2_1	220	223	PF00917	0.284
LIG_UBA3_1	334	339	PF00899	0.394
LIG_WRPW_2	588	591	PF00400	0.299
LIG_WW_1	202	205	PF00397	0.298
MOD_CDK_SPK_2	168	173	PF00069	0.244
MOD_CK1_1	120	126	PF00069	0.323
MOD_CK1_1	182	188	PF00069	0.451
MOD_CK1_1	305	311	PF00069	0.372
MOD_CK1_1	386	392	PF00069	0.230
MOD_CK1_1	430	436	PF00069	0.436
MOD_CK1_1	549	555	PF00069	0.713
MOD_CK1_1	99	105	PF00069	0.669
MOD_CK2_1	195	201	PF00069	0.298
MOD_CK2_1	217	223	PF00069	0.261
MOD_CK2_1	327	333	PF00069	0.303
MOD_CK2_1	489	495	PF00069	0.261
MOD_CK2_1	74	80	PF00069	0.463
MOD_CK2_1	85	91	PF00069	0.414
MOD_GlcNHglycan	17	20	PF01048	0.566
MOD_GlcNHglycan	179	184	PF01048	0.403
MOD_GlcNHglycan	215	218	PF01048	0.401
MOD_GlcNHglycan	257	260	PF01048	0.369
MOD_GlcNHglycan	268	271	PF01048	0.389
MOD_GlcNHglycan	31	34	PF01048	0.636
MOD_GlcNHglycan	392	395	PF01048	0.358
MOD_GlcNHglycan	407	410	PF01048	0.184
MOD_GlcNHglycan	549	552	PF01048	0.698
MOD_GlcNHglycan	559	562	PF01048	0.564
MOD_GlcNHglycan	7	10	PF01048	0.624
MOD_GlcNHglycan	72	75	PF01048	0.467
MOD_GlcNHglycan	93	96	PF01048	0.498
MOD_GSK3_1	107	114	PF00069	0.698
MOD_GSK3_1	11	18	PF00069	0.478
MOD_GSK3_1	179	186	PF00069	0.446
MOD_GSK3_1	213	220	PF00069	0.271
MOD_GSK3_1	27	34	PF00069	0.522
MOD_GSK3_1	302	309	PF00069	0.438
MOD_GSK3_1	382	389	PF00069	0.395
MOD_GSK3_1	428	435	PF00069	0.412
MOD_GSK3_1	528	535	PF00069	0.524
MOD_GSK3_1	542	549	PF00069	0.731
MOD_GSK3_1	592	599	PF00069	0.525
MOD_GSK3_1	70	77	PF00069	0.403
MOD_GSK3_1	91	98	PF00069	0.490
MOD_GSK3_1	99	106	PF00069	0.611
MOD_N-GLC_1	353	358	PF02516	0.370
MOD_NEK2_1	133	138	PF00069	0.401
MOD_NEK2_1	148	153	PF00069	0.317
MOD_NEK2_1	15	20	PF00069	0.521
MOD_NEK2_1	241	246	PF00069	0.269
MOD_NEK2_1	306	311	PF00069	0.205
MOD_NEK2_1	405	410	PF00069	0.261
MOD_NEK2_1	554	559	PF00069	0.643
MOD_NEK2_1	70	75	PF00069	0.416
MOD_NEK2_2	608	613	PF00069	0.548
MOD_PIKK_1	120	126	PF00454	0.390
MOD_PIKK_1	373	379	PF00454	0.338
MOD_PK_1	117	123	PF00069	0.448
MOD_PKA_2	148	154	PF00069	0.459
MOD_PKA_2	302	308	PF00069	0.356
MOD_PKA_2	608	614	PF00069	0.444
MOD_PKB_1	115	123	PF00069	0.460
MOD_PKB_1	348	356	PF00069	0.271
MOD_Plk_1	592	598	PF00069	0.445
MOD_Plk_4	11	17	PF00069	0.539
MOD_Plk_4	489	495	PF00069	0.291
MOD_Plk_4	78	84	PF00069	0.431
MOD_ProDKin_1	168	174	PF00069	0.457
MOD_ProDKin_1	386	392	PF00069	0.377
MOD_ProDKin_1	430	436	PF00069	0.415
MOD_ProDKin_1	96	102	PF00069	0.612
MOD_SUMO_for_1	176	179	PF00179	0.271
MOD_SUMO_rev_2	290	299	PF00179	0.261
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.351
TRG_ENDOCYTIC_2	141	144	PF00928	0.369
TRG_ENDOCYTIC_2	491	494	PF00928	0.261
TRG_ER_diArg_1	115	118	PF00400	0.481
TRG_ER_diArg_1	226	229	PF00400	0.321
TRG_ER_diArg_1	347	350	PF00400	0.271
TRG_ER_diArg_1	419	422	PF00400	0.230
TRG_ER_diArg_1	581	583	PF00400	0.674
TRG_NLS_MonoExtC_3	481	486	PF00514	0.394
TRG_NLS_MonoExtN_4	479	486	PF00514	0.261

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2B2	Leptomonas seymouri	54%	98%
A0A0S4J2N1	Bodo saltans	35%	100%
A0A1X0P0T4	Trypanosomatidae	38%	100%
A0A3S7WP18	Leishmania donovani	100%	100%
A0A422NE31	Trypanosoma rangeli	37%	100%
A1CWD8	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	28%	100%
A2Q9A9	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	28%	100%
A3LYR2	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	25%	100%
A4FV58	Bos taurus	28%	100%
A4H468	Leishmania braziliensis	76%	100%
A5DKC0	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	25%	100%
A5DSI2	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	27%	100%
A6ZRK3	Saccharomyces cerevisiae (strain YJM789)	22%	100%
A7E7C4	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	27%	100%
A7SDA8	Nematostella vectensis	26%	100%
A7TQP0	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	22%	100%
B0WU52	Culex quinquefasciatus	27%	100%
B3N018	Drosophila ananassae	27%	100%
B3NKH7	Drosophila erecta	27%	100%
B4GXC8	Drosophila persimilis	27%	100%
B4IMH3	Drosophila sechellia	25%	100%
B4ISL0	Drosophila yakuba	28%	100%
B4JBE6	Drosophila grimshawi	28%	100%
B4KFU7	Drosophila mojavensis	28%	100%
B4LQR5	Drosophila virilis	28%	100%
B4MUM8	Drosophila willistoni	27%	100%
B4NSS7	Drosophila simulans	26%	100%
B5DK31	Drosophila pseudoobscura pseudoobscura	27%	100%
B6HUC4	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	26%	100%
B6K2N0	Schizosaccharomyces japonicus (strain yFS275 / FY16936)	26%	100%
B6QQH9	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	27%	100%
B8N122	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	26%	100%
B9W8S4	Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)	24%	100%
D0A4K1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AKC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
P23503	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P53998	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	100%
Q0UM75	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	29%	100%
Q16ML2	Aedes aegypti	26%	100%
Q1E736	Coccidioides immitis (strain RS)	26%	100%
Q2HEF1	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	28%	100%
Q2UJY8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	26%	100%
Q2YDU6	Rattus norvegicus	27%	100%
Q4QJI0	Leishmania major	89%	100%
Q5APK7	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	100%
Q5B748	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	26%	100%
Q5BK18	Rattus norvegicus	27%	100%
Q5RF36	Pongo abelii	28%	100%
Q6BUI4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	24%	100%
Q6CFR3	Yarrowia lipolytica (strain CLIB 122 / E 150)	27%	100%
Q6DHP6	Danio rerio	25%	100%
Q6GP25	Xenopus laevis	26%	100%
Q75E78	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	23%	100%
Q7PWB8	Anopheles gambiae	26%	100%
Q7SGW5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	29%	100%
Q8SYS7	Drosophila melanogaster	26%	100%
Q94CL6	Arabidopsis thaliana	28%	100%
Q9CYQ7	Mus musculus	27%	100%
Q9H6Q4	Homo sapiens	28%	100%
Q9N392	Caenorhabditis elegans	26%	100%
Q9UHQ1	Homo sapiens	27%	100%
Q9Y7N7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
V5DC01	Trypanosoma cruzi	39%	100%