LeishMANIAdb
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Dual specificity phosphatase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Dual specificity phosphatase-like protein
Gene product:
dual specificity phosphatase-like protein
Species:
Leishmania infantum
UniProt:
A4HSF4_LEIIN
TriTrypDb:
LINF_050007100
Length:
671

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HSF4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSF4

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 6
GO:0006793 phosphorus metabolic process 3 6
GO:0006796 phosphate-containing compound metabolic process 4 6
GO:0006807 nitrogen compound metabolic process 2 6
GO:0008152 metabolic process 1 6
GO:0009987 cellular process 1 6
GO:0016311 dephosphorylation 5 6
GO:0019538 protein metabolic process 3 6
GO:0036211 protein modification process 4 6
GO:0043170 macromolecule metabolic process 3 6
GO:0043412 macromolecule modification 4 6
GO:0044237 cellular metabolic process 2 6
GO:0044238 primary metabolic process 2 6
GO:0071704 organic substance metabolic process 2 6
GO:1901564 organonitrogen compound metabolic process 3 6
GO:0009966 regulation of signal transduction 4 1
GO:0009968 negative regulation of signal transduction 5 1
GO:0010646 regulation of cell communication 4 1
GO:0010648 negative regulation of cell communication 5 1
GO:0023051 regulation of signaling 3 1
GO:0023057 negative regulation of signaling 4 1
GO:0043408 regulation of MAPK cascade 6 1
GO:0043409 negative regulation of MAPK cascade 7 1
GO:0048519 negative regulation of biological process 3 1
GO:0048523 negative regulation of cellular process 4 1
GO:0048583 regulation of response to stimulus 3 1
GO:0048585 negative regulation of response to stimulus 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
GO:1902531 regulation of intracellular signal transduction 5 1
GO:1902532 negative regulation of intracellular signal transduction 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0004721 phosphoprotein phosphatase activity 3 6
GO:0004725 protein tyrosine phosphatase activity 4 6
GO:0008138 protein tyrosine/serine/threonine phosphatase activity 4 6
GO:0016787 hydrolase activity 2 6
GO:0016788 hydrolase activity, acting on ester bonds 3 6
GO:0016791 phosphatase activity 5 6
GO:0042578 phosphoric ester hydrolase activity 4 6
GO:0140096 catalytic activity, acting on a protein 2 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 507 511 PF00656 0.743
CLV_C14_Caspase3-7 86 90 PF00656 0.526
CLV_NRD_NRD_1 167 169 PF00675 0.532
CLV_NRD_NRD_1 199 201 PF00675 0.464
CLV_NRD_NRD_1 371 373 PF00675 0.844
CLV_NRD_NRD_1 440 442 PF00675 0.812
CLV_NRD_NRD_1 460 462 PF00675 0.505
CLV_NRD_NRD_1 575 577 PF00675 0.759
CLV_PCSK_KEX2_1 167 169 PF00082 0.516
CLV_PCSK_KEX2_1 199 201 PF00082 0.475
CLV_PCSK_KEX2_1 37 39 PF00082 0.648
CLV_PCSK_KEX2_1 371 373 PF00082 0.844
CLV_PCSK_KEX2_1 440 442 PF00082 0.812
CLV_PCSK_PC1ET2_1 37 39 PF00082 0.699
CLV_PCSK_SKI1_1 102 106 PF00082 0.526
CLV_PCSK_SKI1_1 194 198 PF00082 0.388
CLV_PCSK_SKI1_1 291 295 PF00082 0.688
CLV_PCSK_SKI1_1 440 444 PF00082 0.719
CLV_PCSK_SKI1_1 576 580 PF00082 0.711
DEG_APCC_DBOX_1 439 447 PF00400 0.812
DEG_SCF_FBW7_2 409 416 PF00400 0.746
DEG_SPOP_SBC_1 2 6 PF00917 0.639
DEG_SPOP_SBC_1 293 297 PF00917 0.781
DEG_SPOP_SBC_1 451 455 PF00917 0.663
DOC_CYCLIN_yCln2_LP_2 285 288 PF00134 0.669
DOC_MAPK_gen_1 199 207 PF00069 0.526
DOC_MAPK_MEF2A_6 199 207 PF00069 0.526
DOC_PP2B_LxvP_1 284 287 PF13499 0.725
DOC_PP4_FxxP_1 223 226 PF00568 0.656
DOC_USP7_MATH_1 246 250 PF00917 0.769
DOC_USP7_MATH_1 25 29 PF00917 0.709
DOC_USP7_MATH_1 268 272 PF00917 0.809
DOC_USP7_MATH_1 314 318 PF00917 0.781
DOC_USP7_MATH_1 358 362 PF00917 0.641
DOC_USP7_MATH_1 449 453 PF00917 0.674
DOC_USP7_MATH_1 520 524 PF00917 0.745
DOC_USP7_MATH_1 83 87 PF00917 0.401
DOC_USP7_MATH_2 287 293 PF00917 0.675
DOC_WW_Pin1_4 23 28 PF00397 0.703
DOC_WW_Pin1_4 239 244 PF00397 0.756
DOC_WW_Pin1_4 396 401 PF00397 0.684
DOC_WW_Pin1_4 409 414 PF00397 0.686
DOC_WW_Pin1_4 430 435 PF00397 0.736
DOC_WW_Pin1_4 529 534 PF00397 0.807
DOC_WW_Pin1_4 558 563 PF00397 0.738
DOC_WW_Pin1_4 607 612 PF00397 0.750
DOC_WW_Pin1_4 646 651 PF00397 0.825
LIG_14-3-3_CanoR_1 154 163 PF00244 0.399
LIG_14-3-3_CanoR_1 199 207 PF00244 0.471
LIG_14-3-3_CanoR_1 212 218 PF00244 0.349
LIG_14-3-3_CanoR_1 305 312 PF00244 0.786
LIG_14-3-3_CanoR_1 388 394 PF00244 0.713
LIG_14-3-3_CanoR_1 466 475 PF00244 0.713
LIG_14-3-3_CanoR_1 665 670 PF00244 0.712
LIG_Actin_WH2_2 36 53 PF00022 0.697
LIG_BIR_II_1 1 5 PF00653 0.645
LIG_BRCT_BRCA1_1 218 222 PF00533 0.686
LIG_FHA_1 136 142 PF00498 0.433
LIG_FHA_1 384 390 PF00498 0.722
LIG_FHA_1 397 403 PF00498 0.642
LIG_FHA_1 480 486 PF00498 0.818
LIG_FHA_1 77 83 PF00498 0.583
LIG_FHA_2 351 357 PF00498 0.826
LIG_FHA_2 57 63 PF00498 0.611
LIG_LIR_Apic_2 220 226 PF02991 0.634
LIG_LYPXL_L_2 72 81 PF13949 0.420
LIG_MLH1_MIPbox_1 219 223 PF16413 0.601
LIG_MYND_1 283 287 PF01753 0.682
LIG_PCNA_yPIPBox_3 118 131 PF02747 0.526
LIG_RPA_C_Fungi 163 175 PF08784 0.526
LIG_SH2_SRC 189 192 PF00017 0.526
LIG_SH2_STAP1 189 193 PF00017 0.501
LIG_SH2_STAT3 634 637 PF00017 0.741
LIG_SH2_STAT5 103 106 PF00017 0.526
LIG_SH2_STAT5 180 183 PF00017 0.412
LIG_SH3_2 24 29 PF14604 0.664
LIG_SH3_3 12 18 PF00018 0.704
LIG_SH3_3 21 27 PF00018 0.668
LIG_SH3_3 428 434 PF00018 0.798
LIG_SH3_3 530 536 PF00018 0.737
LIG_SH3_3 644 650 PF00018 0.780
LIG_SUMO_SIM_par_1 79 86 PF11976 0.578
LIG_TRAF2_1 113 116 PF00917 0.532
LIG_TRAF2_1 208 211 PF00917 0.386
LIG_TRAF2_1 469 472 PF00917 0.700
LIG_TRAF2_1 504 507 PF00917 0.792
LIG_TRAF2_1 52 55 PF00917 0.671
LIG_TRAF2_2 276 281 PF00917 0.740
MOD_CDC14_SPxK_1 26 29 PF00782 0.659
MOD_CDK_SPK_2 529 534 PF00069 0.838
MOD_CDK_SPxK_1 23 29 PF00069 0.665
MOD_CK1_1 157 163 PF00069 0.339
MOD_CK1_1 201 207 PF00069 0.526
MOD_CK1_1 242 248 PF00069 0.711
MOD_CK1_1 28 34 PF00069 0.700
MOD_CK1_1 292 298 PF00069 0.757
MOD_CK1_1 300 306 PF00069 0.639
MOD_CK1_1 332 338 PF00069 0.803
MOD_CK1_1 346 352 PF00069 0.604
MOD_CK1_1 390 396 PF00069 0.688
MOD_CK1_1 417 423 PF00069 0.840
MOD_CK1_1 452 458 PF00069 0.800
MOD_CK1_1 516 522 PF00069 0.815
MOD_CK1_1 580 586 PF00069 0.792
MOD_CK1_1 664 670 PF00069 0.700
MOD_CK1_1 76 82 PF00069 0.397
MOD_CK2_1 350 356 PF00069 0.750
MOD_CK2_1 466 472 PF00069 0.790
MOD_CK2_1 543 549 PF00069 0.783
MOD_CK2_1 56 62 PF00069 0.594
MOD_CK2_1 586 592 PF00069 0.745
MOD_CK2_1 88 94 PF00069 0.353
MOD_Cter_Amidation 438 441 PF01082 0.812
MOD_GlcNHglycan 172 175 PF01048 0.526
MOD_GlcNHglycan 244 247 PF01048 0.767
MOD_GlcNHglycan 264 267 PF01048 0.542
MOD_GlcNHglycan 307 310 PF01048 0.785
MOD_GlcNHglycan 331 334 PF01048 0.724
MOD_GlcNHglycan 345 348 PF01048 0.574
MOD_GlcNHglycan 373 376 PF01048 0.762
MOD_GlcNHglycan 389 392 PF01048 0.623
MOD_GlcNHglycan 403 406 PF01048 0.593
MOD_GlcNHglycan 454 457 PF01048 0.809
MOD_GlcNHglycan 468 471 PF01048 0.611
MOD_GlcNHglycan 518 521 PF01048 0.785
MOD_GlcNHglycan 540 543 PF01048 0.844
MOD_GlcNHglycan 579 582 PF01048 0.767
MOD_GlcNHglycan 637 640 PF01048 0.705
MOD_GSK3_1 131 138 PF00069 0.517
MOD_GSK3_1 181 188 PF00069 0.526
MOD_GSK3_1 194 201 PF00069 0.314
MOD_GSK3_1 242 249 PF00069 0.730
MOD_GSK3_1 289 296 PF00069 0.816
MOD_GSK3_1 297 304 PF00069 0.681
MOD_GSK3_1 325 332 PF00069 0.721
MOD_GSK3_1 338 345 PF00069 0.657
MOD_GSK3_1 346 353 PF00069 0.647
MOD_GSK3_1 367 374 PF00069 0.712
MOD_GSK3_1 380 387 PF00069 0.613
MOD_GSK3_1 450 457 PF00069 0.751
MOD_GSK3_1 475 482 PF00069 0.790
MOD_GSK3_1 515 522 PF00069 0.763
MOD_GSK3_1 552 559 PF00069 0.756
MOD_GSK3_1 577 584 PF00069 0.743
MOD_GSK3_1 607 614 PF00069 0.820
MOD_GSK3_1 629 636 PF00069 0.762
MOD_GSK3_1 660 667 PF00069 0.699
MOD_GSK3_1 73 80 PF00069 0.546
MOD_N-GLC_1 268 273 PF02516 0.700
MOD_N-GLC_1 520 525 PF02516 0.734
MOD_N-GLC_1 552 557 PF02516 0.713
MOD_N-GLC_1 581 586 PF02516 0.768
MOD_N-GLC_1 593 598 PF02516 0.713
MOD_N-GLC_1 607 612 PF02516 0.594
MOD_N-GLC_2 493 495 PF02516 0.699
MOD_NEK2_1 133 138 PF00069 0.526
MOD_NEK2_1 244 249 PF00069 0.614
MOD_NEK2_1 380 385 PF00069 0.718
MOD_NEK2_1 474 479 PF00069 0.749
MOD_NEK2_1 481 486 PF00069 0.730
MOD_NEK2_1 619 624 PF00069 0.722
MOD_PIKK_1 135 141 PF00454 0.526
MOD_PIKK_1 225 231 PF00454 0.699
MOD_PIKK_1 269 275 PF00454 0.748
MOD_PIKK_1 312 318 PF00454 0.828
MOD_PIKK_1 566 572 PF00454 0.751
MOD_PIKK_1 633 639 PF00454 0.835
MOD_PK_1 325 331 PF00069 0.673
MOD_PKA_1 371 377 PF00069 0.742
MOD_PKA_2 198 204 PF00069 0.454
MOD_PKA_2 211 217 PF00069 0.314
MOD_PKA_2 28 34 PF00069 0.700
MOD_PKA_2 304 310 PF00069 0.782
MOD_PKA_2 342 348 PF00069 0.755
MOD_PKA_2 371 377 PF00069 0.831
MOD_PKA_2 387 393 PF00069 0.542
MOD_PKA_2 444 450 PF00069 0.747
MOD_PKA_2 513 519 PF00069 0.738
MOD_PKA_2 538 544 PF00069 0.820
MOD_PKA_2 664 670 PF00069 0.712
MOD_PKB_1 607 615 PF00069 0.704
MOD_Plk_1 157 163 PF00069 0.377
MOD_Plk_1 62 68 PF00069 0.692
MOD_Plk_1 76 82 PF00069 0.554
MOD_Plk_2-3 185 191 PF00069 0.526
MOD_Plk_4 248 254 PF00069 0.599
MOD_Plk_4 325 331 PF00069 0.701
MOD_Plk_4 485 491 PF00069 0.731
MOD_Plk_4 56 62 PF00069 0.594
MOD_Plk_4 654 660 PF00069 0.685
MOD_Plk_4 77 83 PF00069 0.444
MOD_ProDKin_1 23 29 PF00069 0.703
MOD_ProDKin_1 239 245 PF00069 0.754
MOD_ProDKin_1 396 402 PF00069 0.685
MOD_ProDKin_1 409 415 PF00069 0.686
MOD_ProDKin_1 430 436 PF00069 0.733
MOD_ProDKin_1 529 535 PF00069 0.804
MOD_ProDKin_1 558 564 PF00069 0.737
MOD_ProDKin_1 607 613 PF00069 0.749
MOD_ProDKin_1 646 652 PF00069 0.827
MOD_SUMO_rev_2 110 120 PF00179 0.526
TRG_DiLeu_BaLyEn_6 280 285 PF01217 0.740
TRG_ER_diArg_1 573 576 PF00400 0.750

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H5G7 Leishmania donovani 99% 100%
A4H479 Leishmania braziliensis 59% 100%
E9AKC6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 98%
Q4QJI1 Leishmania major 90% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS