LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HSF3_LEIIN
TriTrypDb:
LINF_050008400
Length:
371

Annotations

Annotations by Jardim et al.

Translation, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 12
GO:0043226 organelle 2 12
GO:0043228 non-membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043232 intracellular non-membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:0032991 protein-containing complex 1 10
GO:1990904 ribonucleoprotein complex 2 10

Expansion

Sequence features

A4HSF3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSF3

PDB structure(s): 7ane_f

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 12
GO:0006518 peptide metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009058 biosynthetic process 2 12
GO:0009059 macromolecule biosynthetic process 4 12
GO:0009987 cellular process 1 12
GO:0019538 protein metabolic process 3 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 12
GO:0043043 peptide biosynthetic process 5 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043603 amide metabolic process 3 12
GO:0043604 amide biosynthetic process 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044249 cellular biosynthetic process 3 12
GO:0044260 obsolete cellular macromolecule metabolic process 3 12
GO:0044271 cellular nitrogen compound biosynthetic process 4 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901566 organonitrogen compound biosynthetic process 4 12
GO:1901576 organic substance biosynthetic process 3 12
Molecular functions
Term Name Level Count
GO:0003735 structural constituent of ribosome 2 12
GO:0005198 structural molecule activity 1 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 150 154 PF00656 0.636
CLV_C14_Caspase3-7 49 53 PF00656 0.568
CLV_C14_Caspase3-7 75 79 PF00656 0.752
CLV_NRD_NRD_1 10 12 PF00675 0.515
CLV_NRD_NRD_1 246 248 PF00675 0.396
CLV_NRD_NRD_1 26 28 PF00675 0.481
CLV_PCSK_KEX2_1 10 12 PF00082 0.515
CLV_PCSK_KEX2_1 245 247 PF00082 0.413
CLV_PCSK_KEX2_1 259 261 PF00082 0.427
CLV_PCSK_KEX2_1 26 28 PF00082 0.496
CLV_PCSK_PC1ET2_1 259 261 PF00082 0.443
CLV_PCSK_SKI1_1 259 263 PF00082 0.419
CLV_PCSK_SKI1_1 270 274 PF00082 0.466
CLV_PCSK_SKI1_1 367 371 PF00082 0.501
DEG_Nend_Nbox_1 1 3 PF02207 0.631
DEG_SPOP_SBC_1 167 171 PF00917 0.750
DOC_ANK_TNKS_1 148 155 PF00023 0.623
DOC_CDC14_PxL_1 25 33 PF14671 0.495
DOC_MAPK_gen_1 316 326 PF00069 0.400
DOC_MAPK_MEF2A_6 235 242 PF00069 0.433
DOC_MAPK_MEF2A_6 316 324 PF00069 0.408
DOC_USP7_MATH_1 157 161 PF00917 0.727
DOC_USP7_MATH_1 167 171 PF00917 0.658
DOC_USP7_MATH_1 209 213 PF00917 0.675
DOC_USP7_MATH_1 67 71 PF00917 0.703
DOC_USP7_MATH_1 84 88 PF00917 0.548
DOC_WW_Pin1_4 155 160 PF00397 0.710
DOC_WW_Pin1_4 205 210 PF00397 0.589
DOC_WW_Pin1_4 353 358 PF00397 0.437
LIG_14-3-3_CanoR_1 147 155 PF00244 0.652
LIG_14-3-3_CanoR_1 245 251 PF00244 0.388
LIG_APCC_ABBAyCdc20_2 17 23 PF00400 0.513
LIG_BRCT_BRCA1_1 233 237 PF00533 0.547
LIG_BRCT_BRCA1_1 343 347 PF00533 0.530
LIG_CaM_IQ_9 113 128 PF13499 0.619
LIG_eIF4E_1 256 262 PF01652 0.544
LIG_eIF4E_1 41 47 PF01652 0.510
LIG_FHA_1 247 253 PF00498 0.360
LIG_FHA_2 113 119 PF00498 0.399
LIG_FHA_2 148 154 PF00498 0.620
LIG_FHA_2 73 79 PF00498 0.645
LIG_Integrin_isoDGR_2 331 333 PF01839 0.400
LIG_Integrin_RGD_1 280 282 PF01839 0.595
LIG_LIR_Gen_1 234 243 PF02991 0.392
LIG_LIR_LC3C_4 321 324 PF02991 0.380
LIG_LIR_Nem_3 23 28 PF02991 0.473
LIG_LIR_Nem_3 234 240 PF02991 0.388
LIG_PCNA_yPIPBox_3 110 124 PF02747 0.405
LIG_PCNA_yPIPBox_3 98 108 PF02747 0.608
LIG_Pex14_2 195 199 PF04695 0.451
LIG_SH2_CRK 201 205 PF00017 0.478
LIG_SH2_CRK 25 29 PF00017 0.494
LIG_SH2_GRB2like 295 298 PF00017 0.416
LIG_SH2_GRB2like 41 44 PF00017 0.575
LIG_SH2_NCK_1 250 254 PF00017 0.393
LIG_SH2_STAP1 233 237 PF00017 0.435
LIG_SH2_STAP1 250 254 PF00017 0.377
LIG_SH2_STAT5 194 197 PF00017 0.438
LIG_SH2_STAT5 241 244 PF00017 0.363
LIG_SH2_STAT5 265 268 PF00017 0.438
LIG_SH2_STAT5 295 298 PF00017 0.386
LIG_SH2_STAT5 351 354 PF00017 0.427
LIG_SH2_STAT5 41 44 PF00017 0.511
LIG_SH3_3 360 366 PF00018 0.495
LIG_SH3_3 94 100 PF00018 0.626
LIG_SUMO_SIM_anti_2 318 324 PF11976 0.384
LIG_SUMO_SIM_anti_2 4 10 PF11976 0.577
LIG_TRAF2_1 115 118 PF00917 0.507
MOD_CK1_1 169 175 PF00069 0.772
MOD_CK2_1 108 114 PF00069 0.523
MOD_CK2_1 155 161 PF00069 0.646
MOD_CK2_1 168 174 PF00069 0.690
MOD_Cter_Amidation 257 260 PF01082 0.442
MOD_GlcNHglycan 176 179 PF01048 0.693
MOD_GlcNHglycan 210 214 PF01048 0.557
MOD_GlcNHglycan 309 312 PF01048 0.598
MOD_GlcNHglycan 342 346 PF01048 0.537
MOD_GlcNHglycan 48 51 PF01048 0.554
MOD_GlcNHglycan 62 65 PF01048 0.731
MOD_GlcNHglycan 69 72 PF01048 0.757
MOD_GSK3_1 108 115 PF00069 0.505
MOD_GSK3_1 162 169 PF00069 0.715
MOD_GSK3_1 205 212 PF00069 0.589
MOD_LATS_1 145 151 PF00433 0.572
MOD_N-GLC_1 79 84 PF02516 0.644
MOD_NEK2_1 1 6 PF00069 0.555
MOD_NEK2_1 108 113 PF00069 0.605
MOD_NEK2_1 199 204 PF00069 0.461
MOD_NEK2_1 46 51 PF00069 0.481
MOD_PIKK_1 128 134 PF00454 0.565
MOD_PKA_1 246 252 PF00069 0.382
MOD_PKA_2 246 252 PF00069 0.382
MOD_PKB_1 110 118 PF00069 0.582
MOD_Plk_1 90 96 PF00069 0.717
MOD_Plk_4 199 205 PF00069 0.474
MOD_Plk_4 2 8 PF00069 0.611
MOD_Plk_4 290 296 PF00069 0.413
MOD_ProDKin_1 155 161 PF00069 0.710
MOD_ProDKin_1 205 211 PF00069 0.588
MOD_ProDKin_1 353 359 PF00069 0.445
MOD_SUMO_rev_2 114 123 PF00179 0.613
MOD_SUMO_rev_2 255 261 PF00179 0.577
TRG_AP2beta_CARGO_1 236 246 PF09066 0.391
TRG_DiLeu_BaEn_1 119 124 PF01217 0.517
TRG_DiLeu_BaEn_1 318 323 PF01217 0.404
TRG_DiLeu_BaLyEn_6 257 262 PF01217 0.543
TRG_ENDOCYTIC_2 201 204 PF00928 0.472
TRG_ENDOCYTIC_2 221 224 PF00928 0.280
TRG_ENDOCYTIC_2 25 28 PF00928 0.495
TRG_ER_diArg_1 14 17 PF00400 0.498
TRG_ER_diArg_1 245 247 PF00400 0.414
TRG_ER_diArg_1 25 27 PF00400 0.502
TRG_ER_diArg_1 347 350 PF00400 0.539
TRG_ER_diArg_1 9 11 PF00400 0.536
TRG_Pf-PMV_PEXEL_1 183 187 PF00026 0.573
TRG_Pf-PMV_PEXEL_1 188 192 PF00026 0.463
TRG_Pf-PMV_PEXEL_1 350 354 PF00026 0.534
TRG_Pf-PMV_PEXEL_1 74 78 PF00026 0.680

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HUU3 Leptomonas seymouri 69% 98%
A0A0S4J6I9 Bodo saltans 51% 100%
A0A1X0P0T0 Trypanosomatidae 59% 100%
A0A3S5H5H3 Leishmania donovani 100% 100%
A0A422NDL4 Trypanosoma rangeli 60% 100%
A4H478 Leishmania braziliensis 82% 97%
D0A4H9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9AKE0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QJG8 Leishmania major 95% 100%
V5AZT2 Trypanosoma cruzi 60% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS